Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats

Autores
Gigli, Isabel; Bussmann, Leonardo Edmundo
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The relationships between exercise and metabolites as well as between exercise and sarcoplasmic reticulum function were studied in gastrocnemius muscle of ovariectomized-trained rats. Prolonged moderate-intensity exercise, treadmill up-hill run for 90 min with a 10 degree incline, decreased the muscle glycogen content. Exercise until exhaustion further lowered the glycogen concentration to 13% of the control, together with a significant decrease of ATP and glucose-6-phosphate concentrations. Also, Ag+-induced Ca2+ release, measured in whole muscle homogenate, showed a 30% reduction on exhaustion, while Ca2+ uptake was unaffected by this exercise. ATPase activities, of both homogenate and SR vesicles, and Ca2+ transport in the latter preparation were not altered on exhaustion. It could be concluded from these results that muscular fatigue in ovariectomized rats after aerobic exercise is caused by the change in energy supply and Ca2+ release from the SR, this latter possibly due to metabolites generated by the exercise.
Fil: Gigli, Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Bussmann, Leonardo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia
Adenosine Triphosphate
Glycogen
Gonadal Steroid Hormones
Ovariectomy
Sarcoplasmic Reticulum
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31328
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/31328
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized ratsGigli, IsabelBussmann, Leonardo EdmundoAdenosine TriphosphateGlycogenGonadal Steroid HormonesOvariectomySarcoplasmic Reticulumhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The relationships between exercise and metabolites as well as between exercise and sarcoplasmic reticulum function were studied in gastrocnemius muscle of ovariectomized-trained rats. Prolonged moderate-intensity exercise, treadmill up-hill run for 90 min with a 10 degree incline, decreased the muscle glycogen content. Exercise until exhaustion further lowered the glycogen concentration to 13% of the control, together with a significant decrease of ATP and glucose-6-phosphate concentrations. Also, Ag+-induced Ca2+ release, measured in whole muscle homogenate, showed a 30% reduction on exhaustion, while Ca2+ uptake was unaffected by this exercise. ATPase activities, of both homogenate and SR vesicles, and Ca2+ transport in the latter preparation were not altered on exhaustion. It could be concluded from these results that muscular fatigue in ovariectomized rats after aerobic exercise is caused by the change in energy supply and Ca2+ release from the SR, this latter possibly due to metabolites generated by the exercise.Fil: Gigli, Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Bussmann, Leonardo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaCzech Academy of Sciences2002-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31328Gigli, Isabel; Bussmann, Leonardo Edmundo; Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats; Czech Academy of Sciences; Physiological research; 51; 3; 12-2002; 247-2540862-8408CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.biomed.cas.cz/physiolres/2002/issue3/gigli.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:54Zoai:ri.conicet.gov.ar:11336/31328instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:54.494CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats
title Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats
spellingShingle Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats
Gigli, Isabel
Adenosine Triphosphate
Glycogen
Gonadal Steroid Hormones
Ovariectomy
Sarcoplasmic Reticulum
title_short Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats
title_full Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats
title_fullStr Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats
title_full_unstemmed Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats
title_sort Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats
dc.creator.none.fl_str_mv Gigli, Isabel
Bussmann, Leonardo Edmundo
author Gigli, Isabel
author_facet Gigli, Isabel
Bussmann, Leonardo Edmundo
author_role author
author2 Bussmann, Leonardo Edmundo
author2_role author
dc.subject.none.fl_str_mv Adenosine Triphosphate
Glycogen
Gonadal Steroid Hormones
Ovariectomy
Sarcoplasmic Reticulum
topic Adenosine Triphosphate
Glycogen
Gonadal Steroid Hormones
Ovariectomy
Sarcoplasmic Reticulum
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The relationships between exercise and metabolites as well as between exercise and sarcoplasmic reticulum function were studied in gastrocnemius muscle of ovariectomized-trained rats. Prolonged moderate-intensity exercise, treadmill up-hill run for 90 min with a 10 degree incline, decreased the muscle glycogen content. Exercise until exhaustion further lowered the glycogen concentration to 13% of the control, together with a significant decrease of ATP and glucose-6-phosphate concentrations. Also, Ag+-induced Ca2+ release, measured in whole muscle homogenate, showed a 30% reduction on exhaustion, while Ca2+ uptake was unaffected by this exercise. ATPase activities, of both homogenate and SR vesicles, and Ca2+ transport in the latter preparation were not altered on exhaustion. It could be concluded from these results that muscular fatigue in ovariectomized rats after aerobic exercise is caused by the change in energy supply and Ca2+ release from the SR, this latter possibly due to metabolites generated by the exercise.
Fil: Gigli, Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Bussmann, Leonardo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description The relationships between exercise and metabolites as well as between exercise and sarcoplasmic reticulum function were studied in gastrocnemius muscle of ovariectomized-trained rats. Prolonged moderate-intensity exercise, treadmill up-hill run for 90 min with a 10 degree incline, decreased the muscle glycogen content. Exercise until exhaustion further lowered the glycogen concentration to 13% of the control, together with a significant decrease of ATP and glucose-6-phosphate concentrations. Also, Ag+-induced Ca2+ release, measured in whole muscle homogenate, showed a 30% reduction on exhaustion, while Ca2+ uptake was unaffected by this exercise. ATPase activities, of both homogenate and SR vesicles, and Ca2+ transport in the latter preparation were not altered on exhaustion. It could be concluded from these results that muscular fatigue in ovariectomized rats after aerobic exercise is caused by the change in energy supply and Ca2+ release from the SR, this latter possibly due to metabolites generated by the exercise.
publishDate 2002
dc.date.none.fl_str_mv 2002-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31328
Gigli, Isabel; Bussmann, Leonardo Edmundo; Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats; Czech Academy of Sciences; Physiological research; 51; 3; 12-2002; 247-254
0862-8408
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31328
identifier_str_mv Gigli, Isabel; Bussmann, Leonardo Edmundo; Effects of exercise on muscle metabolites and sarcoplasmic reticulum function in ovariectomized rats; Czech Academy of Sciences; Physiological research; 51; 3; 12-2002; 247-254
0862-8408
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.biomed.cas.cz/physiolres/2002/issue3/gigli.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Czech Academy of Sciences
publisher.none.fl_str_mv Czech Academy of Sciences
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614318146977792
score 13.070432

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