Marginal zone B cells emerge as a critical component of pregnancy well-being

• Autores: Muzzio, Damián Oscar; Ziegler, Katharina B.; Ehrhardt, Jens; Zygmunt, Marek; Jensen, Cristian Federico
• Año de publicación: 2015
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: B Cells; Pregnancy; Tolerance
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

The success of eutherian mammal evolution was certainly supported by the ability of the already existing immune system to adapt to the presence of the semi-allogeneic fetus without losing the capability to defend the mother against infections. This required the acquisition of highly regulated and coordinated immunological mechanisms. Failures in the development of these strategies not only lead to the interruption of pregnancy but also compromise maternal health. Alongside changes on the cytokine profile - expansion of tolerogenic dendritic and regulatory T cells - a profound adaptation of the B cell compartment during pregnancy was recently described. Among others, the suppression of B cell lymphopoiesis and B cell lymphopenia were proposed to be protective mechanisms tending to reduce the occurrence of autoreactive B cells that might recognize fetal structures and put pregnancy on risk. On the other hand, expansion of the pre-activated marginal zone (MZ) B cell phenotype was described as a compensatory strategy launched to overcome B cell lymphopenia thus ensuring a proper defense. In this work, using an animal model of pregnancy disturbances, we demonstrated that the suppression of B cell lymphopoiesis as well as splenic B cell lymphopenia occur independently of pregnancy outcome. However, only animals undergoing normal pregnancies, but not those suffering from pregnancy disturbances, could induce an expansion and activation of the MZ B cells. Hence, our results clearly show that MZ B cells, probably due to the production of natural protective antibodies, participate in the fine balance of immune activation required for pregnancy well-being.
Fil: Muzzio, Damián Oscar. University of Greifswald; Alemania
Fil: Ziegler, Katharina B.. University of Greifswald; Alemania
Fil: Ehrhardt, Jens. University of Greifswald; Alemania
Fil: Zygmunt, Marek. University of Greifswald; Alemania
Fil: Jensen, Cristian Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina. University of Greifswald; Alemania. Universidad Nacional Arturo Jauretche; Argentina