Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression

Autores
Tirado González, Irene; Barrientos, Gabriela Laura; Freitag, Nancy; Otto, Teresa; Thijssen, Victor L. J. L.; Moschansky, Petra; von Kwiatkowski, Petra; Klapp, Burghard F.; Winterhager, Elke; Bauersachs, Stefan; Blois, Sandra M.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive. Using two different strategies to manipulate the frequency of NK cells and DC during gestation, we investigated their relative impact on the decidualization process and on angiogenic responses that characterize murine implantation. Manipulation of the frequency of NK cells, DC or both lead to a defective decidual response characterized by decreased proliferation and differentiation of stromal cells. Whereas no detrimental effects were evident upon expansion of DC, NK cell ablation in such expanded DC mice severely compromised decidual development and led to early pregnancy loss. Pregnancy failure in these mice was associated with an unbalanced production of anti-angiogenic signals and most notably, with increased expression of genes related to inflammation and immunogenic activation of DC. Thus, NK cells appear to play an important role counteracting potential anomalies raised by DC expansion and overactivity in the decidua, becoming critical for normal pregnancy progression.
Fil: Tirado González, Irene. Humboldt-Universität zu Berlin; Alemania
Fil: Barrientos, Gabriela Laura. Humboldt-Universität zu Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Freitag, Nancy. Humboldt-Universität zu Berlin; Alemania
Fil: Otto, Teresa. Universitat Essen; Alemania
Fil: Thijssen, Victor L. J. L.. Humboldt-Universität zu Berlin; Alemania
Fil: Moschansky, Petra. Humboldt-Universität zu Berlin; Alemania
Fil: von Kwiatkowski, Petra. Humboldt-Universität zu Berlin; Alemania
Fil: Klapp, Burghard F.. Humboldt-Universität zu Berlin; Alemania
Fil: Winterhager, Elke. Universitat Essen; Alemania
Fil: Bauersachs, Stefan. Ludwig Maximilians Universitat; Alemania
Fil: Blois, Sandra M.. Humboldt-Universität zu Berlin; Alemania
Materia
natural killer cells
dendritic cells
mouse pregnancy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/197534
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/197534
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy ProgressionTirado González, IreneBarrientos, Gabriela LauraFreitag, NancyOtto, TeresaThijssen, Victor L. J. L.Moschansky, Petravon Kwiatkowski, PetraKlapp, Burghard F.Winterhager, ElkeBauersachs, StefanBlois, Sandra M.natural killer cellsdendritic cellsmouse pregnancyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive. Using two different strategies to manipulate the frequency of NK cells and DC during gestation, we investigated their relative impact on the decidualization process and on angiogenic responses that characterize murine implantation. Manipulation of the frequency of NK cells, DC or both lead to a defective decidual response characterized by decreased proliferation and differentiation of stromal cells. Whereas no detrimental effects were evident upon expansion of DC, NK cell ablation in such expanded DC mice severely compromised decidual development and led to early pregnancy loss. Pregnancy failure in these mice was associated with an unbalanced production of anti-angiogenic signals and most notably, with increased expression of genes related to inflammation and immunogenic activation of DC. Thus, NK cells appear to play an important role counteracting potential anomalies raised by DC expansion and overactivity in the decidua, becoming critical for normal pregnancy progression.Fil: Tirado González, Irene. Humboldt-Universität zu Berlin; AlemaniaFil: Barrientos, Gabriela Laura. Humboldt-Universität zu Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; ArgentinaFil: Freitag, Nancy. Humboldt-Universität zu Berlin; AlemaniaFil: Otto, Teresa. Universitat Essen; AlemaniaFil: Thijssen, Victor L. J. L.. Humboldt-Universität zu Berlin; AlemaniaFil: Moschansky, Petra. Humboldt-Universität zu Berlin; AlemaniaFil: von Kwiatkowski, Petra. Humboldt-Universität zu Berlin; AlemaniaFil: Klapp, Burghard F.. Humboldt-Universität zu Berlin; AlemaniaFil: Winterhager, Elke. Universitat Essen; AlemaniaFil: Bauersachs, Stefan. Ludwig Maximilians Universitat; AlemaniaFil: Blois, Sandra M.. Humboldt-Universität zu Berlin; AlemaniaPublic Library of Science2012-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/197534Tirado González, Irene; Barrientos, Gabriela Laura; Freitag, Nancy; Otto, Teresa; Thijssen, Victor L. J. L.; et al.; Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression; Public Library of Science; Plos One; 7; 10; 10-2012; 467551-46755101932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046755info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0046755info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T12:59:40Zoai:ri.conicet.gov.ar:11336/197534instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 12:59:40.784CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression
title Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression
spellingShingle Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression
Tirado González, Irene
natural killer cells
dendritic cells
mouse pregnancy
title_short Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression
title_full Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression
title_fullStr Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression
title_full_unstemmed Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression
title_sort Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression
dc.creator.none.fl_str_mv Tirado González, Irene
Barrientos, Gabriela Laura
Freitag, Nancy
Otto, Teresa
Thijssen, Victor L. J. L.
Moschansky, Petra
von Kwiatkowski, Petra
Klapp, Burghard F.
Winterhager, Elke
Bauersachs, Stefan
Blois, Sandra M.
author Tirado González, Irene
author_facet Tirado González, Irene
Barrientos, Gabriela Laura
Freitag, Nancy
Otto, Teresa
Thijssen, Victor L. J. L.
Moschansky, Petra
von Kwiatkowski, Petra
Klapp, Burghard F.
Winterhager, Elke
Bauersachs, Stefan
Blois, Sandra M.
author_role author
author2 Barrientos, Gabriela Laura
Freitag, Nancy
Otto, Teresa
Thijssen, Victor L. J. L.
Moschansky, Petra
von Kwiatkowski, Petra
Klapp, Burghard F.
Winterhager, Elke
Bauersachs, Stefan
Blois, Sandra M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv natural killer cells
dendritic cells
mouse pregnancy
topic natural killer cells
dendritic cells
mouse pregnancy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive. Using two different strategies to manipulate the frequency of NK cells and DC during gestation, we investigated their relative impact on the decidualization process and on angiogenic responses that characterize murine implantation. Manipulation of the frequency of NK cells, DC or both lead to a defective decidual response characterized by decreased proliferation and differentiation of stromal cells. Whereas no detrimental effects were evident upon expansion of DC, NK cell ablation in such expanded DC mice severely compromised decidual development and led to early pregnancy loss. Pregnancy failure in these mice was associated with an unbalanced production of anti-angiogenic signals and most notably, with increased expression of genes related to inflammation and immunogenic activation of DC. Thus, NK cells appear to play an important role counteracting potential anomalies raised by DC expansion and overactivity in the decidua, becoming critical for normal pregnancy progression.
Fil: Tirado González, Irene. Humboldt-Universität zu Berlin; Alemania
Fil: Barrientos, Gabriela Laura. Humboldt-Universität zu Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Freitag, Nancy. Humboldt-Universität zu Berlin; Alemania
Fil: Otto, Teresa. Universitat Essen; Alemania
Fil: Thijssen, Victor L. J. L.. Humboldt-Universität zu Berlin; Alemania
Fil: Moschansky, Petra. Humboldt-Universität zu Berlin; Alemania
Fil: von Kwiatkowski, Petra. Humboldt-Universität zu Berlin; Alemania
Fil: Klapp, Burghard F.. Humboldt-Universität zu Berlin; Alemania
Fil: Winterhager, Elke. Universitat Essen; Alemania
Fil: Bauersachs, Stefan. Ludwig Maximilians Universitat; Alemania
Fil: Blois, Sandra M.. Humboldt-Universität zu Berlin; Alemania
description Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive. Using two different strategies to manipulate the frequency of NK cells and DC during gestation, we investigated their relative impact on the decidualization process and on angiogenic responses that characterize murine implantation. Manipulation of the frequency of NK cells, DC or both lead to a defective decidual response characterized by decreased proliferation and differentiation of stromal cells. Whereas no detrimental effects were evident upon expansion of DC, NK cell ablation in such expanded DC mice severely compromised decidual development and led to early pregnancy loss. Pregnancy failure in these mice was associated with an unbalanced production of anti-angiogenic signals and most notably, with increased expression of genes related to inflammation and immunogenic activation of DC. Thus, NK cells appear to play an important role counteracting potential anomalies raised by DC expansion and overactivity in the decidua, becoming critical for normal pregnancy progression.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/197534
Tirado González, Irene; Barrientos, Gabriela Laura; Freitag, Nancy; Otto, Teresa; Thijssen, Victor L. J. L.; et al.; Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression; Public Library of Science; Plos One; 7; 10; 10-2012; 467551-4675510
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/197534
identifier_str_mv Tirado González, Irene; Barrientos, Gabriela Laura; Freitag, Nancy; Otto, Teresa; Thijssen, Victor L. J. L.; et al.; Uterine NK Cells Are Critical in Shaping DC Immunogenic Functions Compatible with Pregnancy Progression; Public Library of Science; Plos One; 7; 10; 10-2012; 467551-4675510
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046755
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0046755
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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