Immune system effectors as biomarkers of prognosis after acute burns in a case-control study

Autores
Ferrari, Alejandro; Di Croce, Lorena; Saavedra, Sabrina; Hartwig, Marisel; Perrone, Omar; Guzmán, María Alejandra
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Burns are a global health problem due to frequent complications, which lead to systemic inflammation, acute respiratory distresssyndrome, multiorgan dysfunction, and death. Following the initial injury, it has been demonstrated that the immune system plays akey role in early inflammation, tissue regeneration, and the response against pathogens. In this study, the performance of laboratorydeterminations as biomarkers of prognosis in acute burned patients was evaluated in a retrospective case-control protocol.Laboratory determinations were immunoglobulin G (IgG), immunoglobulin M (IgM), C-reactive protein (CRP), complement C4protein (C4), total serum protein (TP), albumin, prealbumin, cholesterol (CHOL), pseudocholinesterase activity (CHE), andtransferrin. Patients in the deceased group (DG) showed lower initial IgG levels (p < 0.05) than patients in the survivor group (SG),with a negative predictive value (NPV) of 0.86, and this difference persisted during the hospitalization period. Furthermore, DGpatients showed a decrease in CHOL and CHE during the hospitalization period (NPV of 0.86), a tendency that was not observed forthe SG. Albumin, TP, C4, and transferrin showed lower initial values in DG than the SG, with a strong correlation with the totalburned surface area (TBSA). These results indicate that IgG, CHOL, and CHE measurement might provide useful information formedical intervention independently of the TBSA and suggest that the measurement of TBSA-linked parameters might help toestimate the severity of burns more objectively. In this paper, the causes and implications of the alteration of effector molecules ofthe immune system are discussed.
Fil: Ferrari, Alejandro. Instituto Nacional del Agua. Gerencia de Programas y Proyectos. Centro de la Region Semiarida.; Argentina. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Croce, Lorena. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
Fil: Saavedra, Sabrina. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
Fil: Hartwig, Marisel. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
Fil: Perrone, Omar. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
Fil: Guzmán, María Alejandra. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
Materia
severe burns
biomarkers
immune system
igg
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/246821
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immune system effectors as biomarkers of prognosis after acute burns in a case-control studyFerrari, AlejandroDi Croce, LorenaSaavedra, SabrinaHartwig, MariselPerrone, OmarGuzmán, María Alejandrasevere burnsbiomarkersimmune systemigghttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Burns are a global health problem due to frequent complications, which lead to systemic inflammation, acute respiratory distresssyndrome, multiorgan dysfunction, and death. Following the initial injury, it has been demonstrated that the immune system plays akey role in early inflammation, tissue regeneration, and the response against pathogens. In this study, the performance of laboratorydeterminations as biomarkers of prognosis in acute burned patients was evaluated in a retrospective case-control protocol.Laboratory determinations were immunoglobulin G (IgG), immunoglobulin M (IgM), C-reactive protein (CRP), complement C4protein (C4), total serum protein (TP), albumin, prealbumin, cholesterol (CHOL), pseudocholinesterase activity (CHE), andtransferrin. Patients in the deceased group (DG) showed lower initial IgG levels (p < 0.05) than patients in the survivor group (SG),with a negative predictive value (NPV) of 0.86, and this difference persisted during the hospitalization period. Furthermore, DGpatients showed a decrease in CHOL and CHE during the hospitalization period (NPV of 0.86), a tendency that was not observed forthe SG. Albumin, TP, C4, and transferrin showed lower initial values in DG than the SG, with a strong correlation with the totalburned surface area (TBSA). These results indicate that IgG, CHOL, and CHE measurement might provide useful information formedical intervention independently of the TBSA and suggest that the measurement of TBSA-linked parameters might help toestimate the severity of burns more objectively. In this paper, the causes and implications of the alteration of effector molecules ofthe immune system are discussed.Fil: Ferrari, Alejandro. Instituto Nacional del Agua. Gerencia de Programas y Proyectos. Centro de la Region Semiarida.; Argentina. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Di Croce, Lorena. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; ArgentinaFil: Saavedra, Sabrina. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; ArgentinaFil: Hartwig, Marisel. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; ArgentinaFil: Perrone, Omar. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; ArgentinaFil: Guzmán, María Alejandra. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; ArgentinaAcademia.edu2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/246821Ferrari, Alejandro; Di Croce, Lorena; Saavedra, Sabrina; Hartwig, Marisel; Perrone, Omar; et al.; Immune system effectors as biomarkers of prognosis after acute burns in a case-control study; Academia.edu; Academia Biology; 2; 2; 6-2024; 1-92837-4010CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.20935/AcadBiol6243info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T09:12:27Zoai:ri.conicet.gov.ar:11336/246821instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 09:12:27.471CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
title Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
spellingShingle Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
Ferrari, Alejandro
severe burns
biomarkers
immune system
igg
title_short Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
title_full Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
title_fullStr Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
title_full_unstemmed Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
title_sort Immune system effectors as biomarkers of prognosis after acute burns in a case-control study
dc.creator.none.fl_str_mv Ferrari, Alejandro
Di Croce, Lorena
Saavedra, Sabrina
Hartwig, Marisel
Perrone, Omar
Guzmán, María Alejandra
author Ferrari, Alejandro
author_facet Ferrari, Alejandro
Di Croce, Lorena
Saavedra, Sabrina
Hartwig, Marisel
Perrone, Omar
Guzmán, María Alejandra
author_role author
author2 Di Croce, Lorena
Saavedra, Sabrina
Hartwig, Marisel
Perrone, Omar
Guzmán, María Alejandra
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv severe burns
biomarkers
immune system
igg
topic severe burns
biomarkers
immune system
igg
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Burns are a global health problem due to frequent complications, which lead to systemic inflammation, acute respiratory distresssyndrome, multiorgan dysfunction, and death. Following the initial injury, it has been demonstrated that the immune system plays akey role in early inflammation, tissue regeneration, and the response against pathogens. In this study, the performance of laboratorydeterminations as biomarkers of prognosis in acute burned patients was evaluated in a retrospective case-control protocol.Laboratory determinations were immunoglobulin G (IgG), immunoglobulin M (IgM), C-reactive protein (CRP), complement C4protein (C4), total serum protein (TP), albumin, prealbumin, cholesterol (CHOL), pseudocholinesterase activity (CHE), andtransferrin. Patients in the deceased group (DG) showed lower initial IgG levels (p < 0.05) than patients in the survivor group (SG),with a negative predictive value (NPV) of 0.86, and this difference persisted during the hospitalization period. Furthermore, DGpatients showed a decrease in CHOL and CHE during the hospitalization period (NPV of 0.86), a tendency that was not observed forthe SG. Albumin, TP, C4, and transferrin showed lower initial values in DG than the SG, with a strong correlation with the totalburned surface area (TBSA). These results indicate that IgG, CHOL, and CHE measurement might provide useful information formedical intervention independently of the TBSA and suggest that the measurement of TBSA-linked parameters might help toestimate the severity of burns more objectively. In this paper, the causes and implications of the alteration of effector molecules ofthe immune system are discussed.
Fil: Ferrari, Alejandro. Instituto Nacional del Agua. Gerencia de Programas y Proyectos. Centro de la Region Semiarida.; Argentina. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Di Croce, Lorena. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
Fil: Saavedra, Sabrina. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
Fil: Hartwig, Marisel. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
Fil: Perrone, Omar. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
Fil: Guzmán, María Alejandra. Hospital Municipal de Quemados Dr. Arturo Umberto Illia; Argentina
description Burns are a global health problem due to frequent complications, which lead to systemic inflammation, acute respiratory distresssyndrome, multiorgan dysfunction, and death. Following the initial injury, it has been demonstrated that the immune system plays akey role in early inflammation, tissue regeneration, and the response against pathogens. In this study, the performance of laboratorydeterminations as biomarkers of prognosis in acute burned patients was evaluated in a retrospective case-control protocol.Laboratory determinations were immunoglobulin G (IgG), immunoglobulin M (IgM), C-reactive protein (CRP), complement C4protein (C4), total serum protein (TP), albumin, prealbumin, cholesterol (CHOL), pseudocholinesterase activity (CHE), andtransferrin. Patients in the deceased group (DG) showed lower initial IgG levels (p < 0.05) than patients in the survivor group (SG),with a negative predictive value (NPV) of 0.86, and this difference persisted during the hospitalization period. Furthermore, DGpatients showed a decrease in CHOL and CHE during the hospitalization period (NPV of 0.86), a tendency that was not observed forthe SG. Albumin, TP, C4, and transferrin showed lower initial values in DG than the SG, with a strong correlation with the totalburned surface area (TBSA). These results indicate that IgG, CHOL, and CHE measurement might provide useful information formedical intervention independently of the TBSA and suggest that the measurement of TBSA-linked parameters might help toestimate the severity of burns more objectively. In this paper, the causes and implications of the alteration of effector molecules ofthe immune system are discussed.
publishDate 2024
dc.date.none.fl_str_mv 2024-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/246821
Ferrari, Alejandro; Di Croce, Lorena; Saavedra, Sabrina; Hartwig, Marisel; Perrone, Omar; et al.; Immune system effectors as biomarkers of prognosis after acute burns in a case-control study; Academia.edu; Academia Biology; 2; 2; 6-2024; 1-9
2837-4010
CONICET Digital
CONICET
url http://hdl.handle.net/11336/246821
identifier_str_mv Ferrari, Alejandro; Di Croce, Lorena; Saavedra, Sabrina; Hartwig, Marisel; Perrone, Omar; et al.; Immune system effectors as biomarkers of prognosis after acute burns in a case-control study; Academia.edu; Academia Biology; 2; 2; 6-2024; 1-9
2837-4010
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.20935/AcadBiol6243
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academia.edu
publisher.none.fl_str_mv Academia.edu
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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