Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns

Autores
Mansilla, Eduardo; Marin, Gustavo Horacio; Berges, Mirta; Scafatti, Silvia; Rivas, Jaime; Núñez, Andrea; Menvielle, Martin; Lamonega, Roberto; Gardiner, Cecilia; Drago, Hugo; Sturla, Flavio; Portas, Mercedes; Bossi, Silvia; Castuma, Maria Victoria; Peña Luengas, Sandra; Roque, Gustavo; Martire, Karina; Taulamet, María José; Orlandi, Gabriel; Tarditti, Adrian
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: In January 2005, Rasulov et al. originally published ?First experience in the use of bone marrowmesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns. Here, we present the firstever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine.Methods: A young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns whileworking with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow ofa cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry ofHealth, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after earlyescharotomy.Results: So far, our preliminary experience and our early results have been very impressive showing an outstandingsafety data as well as some impressive good results in the use of CMSCs.Conclusions: Based on all this, we think that improvements in the use of stem cells for burns might be possible in thenear future and a lot of time as well as many lives could be saved by many other research teams all over the world.CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation.
Fil: Mansilla, Eduardo. No especifíca;
Fil: Marin, Gustavo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Berges, Mirta. Hospital San Martin; Argentina
Fil: Scafatti, Silvia. Hospital San Martin; Argentina
Fil: Rivas, Jaime. Hospital San Martin; Argentina
Fil: Núñez, Andrea. Hospital San Martin; Argentina
Fil: Menvielle, Martin. Hospital San Martin; Argentina
Fil: Lamonega, Roberto. Hospital San Martin; Argentina
Fil: Gardiner, Cecilia. Hospital San Martin; Argentina
Fil: Drago, Hugo. Hospital Burns; Argentina
Fil: Sturla, Flavio. Hospital Burns; Argentina
Fil: Portas, Mercedes. Hospital Burns; Argentina
Fil: Bossi, Silvia. Hospital Burns; Argentina
Fil: Castuma, Maria Victoria. No especifíca;
Fil: Peña Luengas, Sandra. Universidad de Puerto Rico; Puerto Rico
Fil: Roque, Gustavo. No especifíca;
Fil: Martire, Karina. No especifíca;
Fil: Taulamet, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Orlandi, Gabriel. No especifíca;
Fil: Tarditti, Adrian. No especifíca;
Materia
Mesenchymal
Burns
Cadaveric
Transplantation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/112630
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/112630
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burnsMansilla, EduardoMarin, Gustavo HoracioBerges, MirtaScafatti, SilviaRivas, JaimeNúñez, AndreaMenvielle, MartinLamonega, RobertoGardiner, CeciliaDrago, HugoSturla, FlavioPortas, MercedesBossi, SilviaCastuma, Maria VictoriaPeña Luengas, SandraRoque, GustavoMartire, KarinaTaulamet, María JoséOrlandi, GabrielTarditti, AdrianMesenchymalBurnsCadavericTransplantationhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2Background: In January 2005, Rasulov et al. originally published ?First experience in the use of bone marrowmesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns. Here, we present the firstever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine.Methods: A young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns whileworking with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow ofa cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry ofHealth, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after earlyescharotomy.Results: So far, our preliminary experience and our early results have been very impressive showing an outstandingsafety data as well as some impressive good results in the use of CMSCs.Conclusions: Based on all this, we think that improvements in the use of stem cells for burns might be possible in thenear future and a lot of time as well as many lives could be saved by many other research teams all over the world.CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation.Fil: Mansilla, Eduardo. No especifíca;Fil: Marin, Gustavo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Berges, Mirta. Hospital San Martin; ArgentinaFil: Scafatti, Silvia. Hospital San Martin; ArgentinaFil: Rivas, Jaime. Hospital San Martin; ArgentinaFil: Núñez, Andrea. Hospital San Martin; ArgentinaFil: Menvielle, Martin. Hospital San Martin; ArgentinaFil: Lamonega, Roberto. Hospital San Martin; ArgentinaFil: Gardiner, Cecilia. Hospital San Martin; ArgentinaFil: Drago, Hugo. Hospital Burns; ArgentinaFil: Sturla, Flavio. Hospital Burns; ArgentinaFil: Portas, Mercedes. Hospital Burns; ArgentinaFil: Bossi, Silvia. Hospital Burns; ArgentinaFil: Castuma, Maria Victoria. No especifíca;Fil: Peña Luengas, Sandra. Universidad de Puerto Rico; Puerto RicoFil: Roque, Gustavo. No especifíca;Fil: Martire, Karina. No especifíca;Fil: Taulamet, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Orlandi, Gabriel. No especifíca;Fil: Tarditti, Adrian. No especifíca;Springer2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/112630Mansilla, Eduardo; Marin, Gustavo Horacio; Berges, Mirta; Scafatti, Silvia; Rivas, Jaime; et al.; Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns; Springer; Burns & Trauma; 3; 17; 9-2015; 2-102321-38682321-3876CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s41038-015-0018-4info:eu-repo/semantics/altIdentifier/url/https://burnstrauma.biomedcentral.com/articles/10.1186/s41038-015-0018-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:02:05Zoai:ri.conicet.gov.ar:11336/112630instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:02:06.206CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
title Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
spellingShingle Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
Mansilla, Eduardo
Mesenchymal
Burns
Cadaveric
Transplantation
title_short Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
title_full Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
title_fullStr Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
title_full_unstemmed Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
title_sort Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
dc.creator.none.fl_str_mv Mansilla, Eduardo
Marin, Gustavo Horacio
Berges, Mirta
Scafatti, Silvia
Rivas, Jaime
Núñez, Andrea
Menvielle, Martin
Lamonega, Roberto
Gardiner, Cecilia
Drago, Hugo
Sturla, Flavio
Portas, Mercedes
Bossi, Silvia
Castuma, Maria Victoria
Peña Luengas, Sandra
Roque, Gustavo
Martire, Karina
Taulamet, María José
Orlandi, Gabriel
Tarditti, Adrian
author Mansilla, Eduardo
author_facet Mansilla, Eduardo
Marin, Gustavo Horacio
Berges, Mirta
Scafatti, Silvia
Rivas, Jaime
Núñez, Andrea
Menvielle, Martin
Lamonega, Roberto
Gardiner, Cecilia
Drago, Hugo
Sturla, Flavio
Portas, Mercedes
Bossi, Silvia
Castuma, Maria Victoria
Peña Luengas, Sandra
Roque, Gustavo
Martire, Karina
Taulamet, María José
Orlandi, Gabriel
Tarditti, Adrian
author_role author
author2 Marin, Gustavo Horacio
Berges, Mirta
Scafatti, Silvia
Rivas, Jaime
Núñez, Andrea
Menvielle, Martin
Lamonega, Roberto
Gardiner, Cecilia
Drago, Hugo
Sturla, Flavio
Portas, Mercedes
Bossi, Silvia
Castuma, Maria Victoria
Peña Luengas, Sandra
Roque, Gustavo
Martire, Karina
Taulamet, María José
Orlandi, Gabriel
Tarditti, Adrian
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mesenchymal
Burns
Cadaveric
Transplantation
topic Mesenchymal
Burns
Cadaveric
Transplantation
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Background: In January 2005, Rasulov et al. originally published ?First experience in the use of bone marrowmesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns. Here, we present the firstever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine.Methods: A young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns whileworking with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow ofa cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry ofHealth, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after earlyescharotomy.Results: So far, our preliminary experience and our early results have been very impressive showing an outstandingsafety data as well as some impressive good results in the use of CMSCs.Conclusions: Based on all this, we think that improvements in the use of stem cells for burns might be possible in thenear future and a lot of time as well as many lives could be saved by many other research teams all over the world.CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation.
Fil: Mansilla, Eduardo. No especifíca;
Fil: Marin, Gustavo Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Berges, Mirta. Hospital San Martin; Argentina
Fil: Scafatti, Silvia. Hospital San Martin; Argentina
Fil: Rivas, Jaime. Hospital San Martin; Argentina
Fil: Núñez, Andrea. Hospital San Martin; Argentina
Fil: Menvielle, Martin. Hospital San Martin; Argentina
Fil: Lamonega, Roberto. Hospital San Martin; Argentina
Fil: Gardiner, Cecilia. Hospital San Martin; Argentina
Fil: Drago, Hugo. Hospital Burns; Argentina
Fil: Sturla, Flavio. Hospital Burns; Argentina
Fil: Portas, Mercedes. Hospital Burns; Argentina
Fil: Bossi, Silvia. Hospital Burns; Argentina
Fil: Castuma, Maria Victoria. No especifíca;
Fil: Peña Luengas, Sandra. Universidad de Puerto Rico; Puerto Rico
Fil: Roque, Gustavo. No especifíca;
Fil: Martire, Karina. No especifíca;
Fil: Taulamet, María José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Orlandi, Gabriel. No especifíca;
Fil: Tarditti, Adrian. No especifíca;
description Background: In January 2005, Rasulov et al. originally published ?First experience in the use of bone marrowmesenchymal stem cells (MSCs) for the treatment of a patient with deep skin burns. Here, we present the firstever treated patient with cadaveric bone marrow mesenchymal stem cells (CMSCs) in the history of Medicine.Methods: A young man, who severely burned 60 % of his total body surface with 30 % of full-thickness burns whileworking with a grass trimmer that exploded, was involved in the study. MSCs were obtained from the bone marrow ofa cadaver donor in a routine procurement procedure of CUCAIBA, the Province of Buenos Aires, Argentina, Ministry ofHealth, Transplantation Agency, cultured, expanded, and applied on the burned surfaces using a fibrin spray after earlyescharotomy.Results: So far, our preliminary experience and our early results have been very impressive showing an outstandingsafety data as well as some impressive good results in the use of CMSCs.Conclusions: Based on all this, we think that improvements in the use of stem cells for burns might be possible in thenear future and a lot of time as well as many lives could be saved by many other research teams all over the world.CMSCs will probably be a real scientific opportunity in Regenerative Medicine as well as in Transplantation.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/112630
Mansilla, Eduardo; Marin, Gustavo Horacio; Berges, Mirta; Scafatti, Silvia; Rivas, Jaime; et al.; Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns; Springer; Burns & Trauma; 3; 17; 9-2015; 2-10
2321-3868
2321-3876
CONICET Digital
CONICET
url http://hdl.handle.net/11336/112630
identifier_str_mv Mansilla, Eduardo; Marin, Gustavo Horacio; Berges, Mirta; Scafatti, Silvia; Rivas, Jaime; et al.; Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns; Springer; Burns & Trauma; 3; 17; 9-2015; 2-10
2321-3868
2321-3876
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s41038-015-0018-4
info:eu-repo/semantics/altIdentifier/url/https://burnstrauma.biomedcentral.com/articles/10.1186/s41038-015-0018-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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