Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits

Autores
Defagó, Víctor Hugo; Moyano, María Jimena; Bernhardt, Celina; Sambuelli, Gabriela; Cuestas, Eduardo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background The ingestion of caustic substances remains an important public health issue worldwide. Children represent 80% of the ingestion injury population globally. Accidental alkaline material accounts for most caustic ingestions. There is no conclusive evidence of tissue damage and stricture protection of a nasogastric-tube with a solid dilator in the literature, therefore it was hypothesized that early intraesophageal tube placement does not cause additional histopathologic damage and prevents strictures. Methods An exploratory study on experimental caustic esophageal burns in a rabbit model was designed. In the treated group a silicone tube was placed immediately after causing the burns, while the untreated group followed the natural course of the burn. On the twenty-second day, an esophagectomy was performed on all animals for microscopic (Histopathologic Damage Score and Stenosis Index) and macroscopic analysis. Results Forty animals were randomly divided into two groups. The Histopathologic Damage Score was 3.7 ± 1.1 in the treated group versus 3.9 ± 1.2 in the untreated group (p =.9690). The Stenosis Index was 0.6 ± 0.1 in treated rabbits versus 2.3 ± 0.2 in untreated (p <.0001). Conclusion The early placement of an intraesophageal tube with solid dilator prevents stenosis formation and does not produce greater tissue damage.
Fil: Defagó, Víctor Hugo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
Fil: Moyano, María Jimena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
Fil: Bernhardt, Celina. Universidad Catolica de Córdoba. Facultad de Medicina; Argentina
Fil: Sambuelli, Gabriela. Universidad Catolica de Córdoba. Facultad de Medicina; Argentina
Fil: Cuestas, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
BURNS
CAUSTIC
ESOPHAGUS
NASOGASTRIC-TUBE
PATHOLOGY
RABBIT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37924
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/37924
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbitsDefagó, Víctor HugoMoyano, María JimenaBernhardt, CelinaSambuelli, GabrielaCuestas, EduardoBURNSCAUSTICESOPHAGUSNASOGASTRIC-TUBEPATHOLOGYRABBIThttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background The ingestion of caustic substances remains an important public health issue worldwide. Children represent 80% of the ingestion injury population globally. Accidental alkaline material accounts for most caustic ingestions. There is no conclusive evidence of tissue damage and stricture protection of a nasogastric-tube with a solid dilator in the literature, therefore it was hypothesized that early intraesophageal tube placement does not cause additional histopathologic damage and prevents strictures. Methods An exploratory study on experimental caustic esophageal burns in a rabbit model was designed. In the treated group a silicone tube was placed immediately after causing the burns, while the untreated group followed the natural course of the burn. On the twenty-second day, an esophagectomy was performed on all animals for microscopic (Histopathologic Damage Score and Stenosis Index) and macroscopic analysis. Results Forty animals were randomly divided into two groups. The Histopathologic Damage Score was 3.7 ± 1.1 in the treated group versus 3.9 ± 1.2 in the untreated group (p =.9690). The Stenosis Index was 0.6 ± 0.1 in treated rabbits versus 2.3 ± 0.2 in untreated (p <.0001). Conclusion The early placement of an intraesophageal tube with solid dilator prevents stenosis formation and does not produce greater tissue damage.Fil: Defagó, Víctor Hugo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; ArgentinaFil: Moyano, María Jimena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; ArgentinaFil: Bernhardt, Celina. Universidad Catolica de Córdoba. Facultad de Medicina; ArgentinaFil: Sambuelli, Gabriela. Universidad Catolica de Córdoba. Facultad de Medicina; ArgentinaFil: Cuestas, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaW B Saunders Co-Elsevier Inc2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37924Defagó, Víctor Hugo; Moyano, María Jimena; Bernhardt, Celina; Sambuelli, Gabriela; Cuestas, Eduardo; Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits; W B Saunders Co-Elsevier Inc; Journal Of Pediatric Surgery; 50; 8; 8-2015; 1264-12680022-3468CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpedsurg.2014.11.040info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022346814007866info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:48:20Zoai:ri.conicet.gov.ar:11336/37924instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:48:20.991CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits
title Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits
spellingShingle Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits
Defagó, Víctor Hugo
BURNS
CAUSTIC
ESOPHAGUS
NASOGASTRIC-TUBE
PATHOLOGY
RABBIT
title_short Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits
title_full Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits
title_fullStr Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits
title_full_unstemmed Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits
title_sort Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits
dc.creator.none.fl_str_mv Defagó, Víctor Hugo
Moyano, María Jimena
Bernhardt, Celina
Sambuelli, Gabriela
Cuestas, Eduardo
author Defagó, Víctor Hugo
author_facet Defagó, Víctor Hugo
Moyano, María Jimena
Bernhardt, Celina
Sambuelli, Gabriela
Cuestas, Eduardo
author_role author
author2 Moyano, María Jimena
Bernhardt, Celina
Sambuelli, Gabriela
Cuestas, Eduardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv BURNS
CAUSTIC
ESOPHAGUS
NASOGASTRIC-TUBE
PATHOLOGY
RABBIT
topic BURNS
CAUSTIC
ESOPHAGUS
NASOGASTRIC-TUBE
PATHOLOGY
RABBIT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background The ingestion of caustic substances remains an important public health issue worldwide. Children represent 80% of the ingestion injury population globally. Accidental alkaline material accounts for most caustic ingestions. There is no conclusive evidence of tissue damage and stricture protection of a nasogastric-tube with a solid dilator in the literature, therefore it was hypothesized that early intraesophageal tube placement does not cause additional histopathologic damage and prevents strictures. Methods An exploratory study on experimental caustic esophageal burns in a rabbit model was designed. In the treated group a silicone tube was placed immediately after causing the burns, while the untreated group followed the natural course of the burn. On the twenty-second day, an esophagectomy was performed on all animals for microscopic (Histopathologic Damage Score and Stenosis Index) and macroscopic analysis. Results Forty animals were randomly divided into two groups. The Histopathologic Damage Score was 3.7 ± 1.1 in the treated group versus 3.9 ± 1.2 in the untreated group (p =.9690). The Stenosis Index was 0.6 ± 0.1 in treated rabbits versus 2.3 ± 0.2 in untreated (p <.0001). Conclusion The early placement of an intraesophageal tube with solid dilator prevents stenosis formation and does not produce greater tissue damage.
Fil: Defagó, Víctor Hugo. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
Fil: Moyano, María Jimena. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas; Argentina
Fil: Bernhardt, Celina. Universidad Catolica de Córdoba. Facultad de Medicina; Argentina
Fil: Sambuelli, Gabriela. Universidad Catolica de Córdoba. Facultad de Medicina; Argentina
Fil: Cuestas, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description Background The ingestion of caustic substances remains an important public health issue worldwide. Children represent 80% of the ingestion injury population globally. Accidental alkaline material accounts for most caustic ingestions. There is no conclusive evidence of tissue damage and stricture protection of a nasogastric-tube with a solid dilator in the literature, therefore it was hypothesized that early intraesophageal tube placement does not cause additional histopathologic damage and prevents strictures. Methods An exploratory study on experimental caustic esophageal burns in a rabbit model was designed. In the treated group a silicone tube was placed immediately after causing the burns, while the untreated group followed the natural course of the burn. On the twenty-second day, an esophagectomy was performed on all animals for microscopic (Histopathologic Damage Score and Stenosis Index) and macroscopic analysis. Results Forty animals were randomly divided into two groups. The Histopathologic Damage Score was 3.7 ± 1.1 in the treated group versus 3.9 ± 1.2 in the untreated group (p =.9690). The Stenosis Index was 0.6 ± 0.1 in treated rabbits versus 2.3 ± 0.2 in untreated (p <.0001). Conclusion The early placement of an intraesophageal tube with solid dilator prevents stenosis formation and does not produce greater tissue damage.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37924
Defagó, Víctor Hugo; Moyano, María Jimena; Bernhardt, Celina; Sambuelli, Gabriela; Cuestas, Eduardo; Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits; W B Saunders Co-Elsevier Inc; Journal Of Pediatric Surgery; 50; 8; 8-2015; 1264-1268
0022-3468
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37924
identifier_str_mv Defagó, Víctor Hugo; Moyano, María Jimena; Bernhardt, Celina; Sambuelli, Gabriela; Cuestas, Eduardo; Protective effect of early placement of nasogastric tube with solid dilator on tissue damage and stricture formation after caustic esophageal burns in rabbits; W B Saunders Co-Elsevier Inc; Journal Of Pediatric Surgery; 50; 8; 8-2015; 1264-1268
0022-3468
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpedsurg.2014.11.040
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022346814007866
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv W B Saunders Co-Elsevier Inc
publisher.none.fl_str_mv W B Saunders Co-Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1849872655746859008
score 13.011256

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