Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)

Autores
Portas, Mercedes; Dubner, Diana; Taja, María Emilia; Gallegos, Cristina Eugenia; Michelin, Severino
Año de publicación
2013
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Late effects of radiation are generally irreversible and can have devastating effects on quality of life of people exposed either accidentally or during therapeutic radiation treatments. Although many etiologies have been suggested regarding these late toxicities, inflammatory parameters involved during the late phase are less known. Objective: The aim of this study was to analyze the response of the immune system in the inflammatory reactions in patients with late skin injuries after radiotherapy or interventional fluoroscopy procedures. Methods: The follow up of twenty five patients, out of 160 referred to Burn Hospital from 1997, that showed late cutaneous reactions graded according to the RTOG / EORTC system is reported here.The expression of adhesion molecules ICAM1 and β1-integrin on granulocytes and lymphocytes, as well as changes in subpopulations of T lymphocytes were evaluated by flow cytometry and the level of C-reactive protein, a well-studied inflammatory marker was quantified by an immunoturbidimetric assay. Results: The analysis of adhesion molecules expression revealed a higher expression of β1 Integrin on lymphocytes of Grade IV patients compared to non-exposed controls. It was also noted a decrease in its expression values in the follow up of patients with good response to therapeutic treatment. This was paralleled by a tendency to a decrease in the T(CD4+) / T(CD8+) ratio of G4 patients with bad evolution compared to G4 patients with good evolution.The level of C Reactive Protein (CRP) showed higher values in patients in acute phase and patients with late toxicity but in exacerbation crisis. Conclusions: The parameters analyzed, which require confirmation in a larger study, in combination with other inflammatory indicators, could be used as potential follow-up markers of the chronic radio-induced inflammation process just as its response to therapeutic treatments.
Fil: Portas, Mercedes. Universidad de Buenos Aires; Argentina
Fil: Dubner, Diana. Laboratorio de Radiopatología en Autoridad regulatoria Nuclear; Argentina
Fil: Taja, María Emilia. Universidad de Buenos Aires; Argentina
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Michelin, Severino. Universidad de Buenos Aires; Argentina
VIII Congresso Brasileiro de Queimaduras
Florianopolis
Brasil
Sociedad Brasileña de Quemaduras
Materia
IMMUNE SYSTEM
INFLAMMATION
RADIATION
CELL ADHESION MOLECULES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/236071
Acceder
id CONICETDig_94159b4790fca536735fcbac70081e51
oai_identifier_str oai:ri.conicet.gov.ar:11336/236071
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)Biomarcadores de reação inflamatória crônica em pacientes com queimaduras radiológicas (síndrome cutânea da radiação)Portas, MercedesDubner, DianaTaja, María EmiliaGallegos, Cristina EugeniaMichelin, SeverinoIMMUNE SYSTEMINFLAMMATIONRADIATIONCELL ADHESION MOLECULEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Late effects of radiation are generally irreversible and can have devastating effects on quality of life of people exposed either accidentally or during therapeutic radiation treatments. Although many etiologies have been suggested regarding these late toxicities, inflammatory parameters involved during the late phase are less known. Objective: The aim of this study was to analyze the response of the immune system in the inflammatory reactions in patients with late skin injuries after radiotherapy or interventional fluoroscopy procedures. Methods: The follow up of twenty five patients, out of 160 referred to Burn Hospital from 1997, that showed late cutaneous reactions graded according to the RTOG / EORTC system is reported here.The expression of adhesion molecules ICAM1 and β1-integrin on granulocytes and lymphocytes, as well as changes in subpopulations of T lymphocytes were evaluated by flow cytometry and the level of C-reactive protein, a well-studied inflammatory marker was quantified by an immunoturbidimetric assay. Results: The analysis of adhesion molecules expression revealed a higher expression of β1 Integrin on lymphocytes of Grade IV patients compared to non-exposed controls. It was also noted a decrease in its expression values in the follow up of patients with good response to therapeutic treatment. This was paralleled by a tendency to a decrease in the T(CD4+) / T(CD8+) ratio of G4 patients with bad evolution compared to G4 patients with good evolution.The level of C Reactive Protein (CRP) showed higher values in patients in acute phase and patients with late toxicity but in exacerbation crisis. Conclusions: The parameters analyzed, which require confirmation in a larger study, in combination with other inflammatory indicators, could be used as potential follow-up markers of the chronic radio-induced inflammation process just as its response to therapeutic treatments.Fil: Portas, Mercedes. Universidad de Buenos Aires; ArgentinaFil: Dubner, Diana. Laboratorio de Radiopatología en Autoridad regulatoria Nuclear; ArgentinaFil: Taja, María Emilia. Universidad de Buenos Aires; ArgentinaFil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Michelin, Severino. Universidad de Buenos Aires; ArgentinaVIII Congresso Brasileiro de QueimadurasFlorianopolisBrasilSociedad Brasileña de QuemadurasÓrgão Oficial da Sociedade Brasileira de QueimadurasLopes Pereima, Mauricio José2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/236071Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome); VIII Congresso Brasileiro de Queimaduras; Florianopolis; Brasil; 2012; 6-10CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.acm.org.br/viii-congresso-brasileiro-de-queimaduras-reune-em-florianopolis-os-maiores-nomes-da-especialidade/info:eu-repo/semantics/altIdentifier/url/https://www.rbqueimaduras.com.br/summary/18Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:52:27Zoai:ri.conicet.gov.ar:11336/236071instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:52:27.871CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)
Biomarcadores de reação inflamatória crônica em pacientes com queimaduras radiológicas (síndrome cutânea da radiação)
title Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)
spellingShingle Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)
Portas, Mercedes
IMMUNE SYSTEM
INFLAMMATION
RADIATION
CELL ADHESION MOLECULES
title_short Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)
title_full Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)
title_fullStr Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)
title_full_unstemmed Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)
title_sort Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome)
dc.creator.none.fl_str_mv Portas, Mercedes
Dubner, Diana
Taja, María Emilia
Gallegos, Cristina Eugenia
Michelin, Severino
author Portas, Mercedes
author_facet Portas, Mercedes
Dubner, Diana
Taja, María Emilia
Gallegos, Cristina Eugenia
Michelin, Severino
author_role author
author2 Dubner, Diana
Taja, María Emilia
Gallegos, Cristina Eugenia
Michelin, Severino
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Lopes Pereima, Mauricio José
dc.subject.none.fl_str_mv IMMUNE SYSTEM
INFLAMMATION
RADIATION
CELL ADHESION MOLECULES
topic IMMUNE SYSTEM
INFLAMMATION
RADIATION
CELL ADHESION MOLECULES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Late effects of radiation are generally irreversible and can have devastating effects on quality of life of people exposed either accidentally or during therapeutic radiation treatments. Although many etiologies have been suggested regarding these late toxicities, inflammatory parameters involved during the late phase are less known. Objective: The aim of this study was to analyze the response of the immune system in the inflammatory reactions in patients with late skin injuries after radiotherapy or interventional fluoroscopy procedures. Methods: The follow up of twenty five patients, out of 160 referred to Burn Hospital from 1997, that showed late cutaneous reactions graded according to the RTOG / EORTC system is reported here.The expression of adhesion molecules ICAM1 and β1-integrin on granulocytes and lymphocytes, as well as changes in subpopulations of T lymphocytes were evaluated by flow cytometry and the level of C-reactive protein, a well-studied inflammatory marker was quantified by an immunoturbidimetric assay. Results: The analysis of adhesion molecules expression revealed a higher expression of β1 Integrin on lymphocytes of Grade IV patients compared to non-exposed controls. It was also noted a decrease in its expression values in the follow up of patients with good response to therapeutic treatment. This was paralleled by a tendency to a decrease in the T(CD4+) / T(CD8+) ratio of G4 patients with bad evolution compared to G4 patients with good evolution.The level of C Reactive Protein (CRP) showed higher values in patients in acute phase and patients with late toxicity but in exacerbation crisis. Conclusions: The parameters analyzed, which require confirmation in a larger study, in combination with other inflammatory indicators, could be used as potential follow-up markers of the chronic radio-induced inflammation process just as its response to therapeutic treatments.
Fil: Portas, Mercedes. Universidad de Buenos Aires; Argentina
Fil: Dubner, Diana. Laboratorio de Radiopatología en Autoridad regulatoria Nuclear; Argentina
Fil: Taja, María Emilia. Universidad de Buenos Aires; Argentina
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Michelin, Severino. Universidad de Buenos Aires; Argentina
VIII Congresso Brasileiro de Queimaduras
Florianopolis
Brasil
Sociedad Brasileña de Quemaduras
description Late effects of radiation are generally irreversible and can have devastating effects on quality of life of people exposed either accidentally or during therapeutic radiation treatments. Although many etiologies have been suggested regarding these late toxicities, inflammatory parameters involved during the late phase are less known. Objective: The aim of this study was to analyze the response of the immune system in the inflammatory reactions in patients with late skin injuries after radiotherapy or interventional fluoroscopy procedures. Methods: The follow up of twenty five patients, out of 160 referred to Burn Hospital from 1997, that showed late cutaneous reactions graded according to the RTOG / EORTC system is reported here.The expression of adhesion molecules ICAM1 and β1-integrin on granulocytes and lymphocytes, as well as changes in subpopulations of T lymphocytes were evaluated by flow cytometry and the level of C-reactive protein, a well-studied inflammatory marker was quantified by an immunoturbidimetric assay. Results: The analysis of adhesion molecules expression revealed a higher expression of β1 Integrin on lymphocytes of Grade IV patients compared to non-exposed controls. It was also noted a decrease in its expression values in the follow up of patients with good response to therapeutic treatment. This was paralleled by a tendency to a decrease in the T(CD4+) / T(CD8+) ratio of G4 patients with bad evolution compared to G4 patients with good evolution.The level of C Reactive Protein (CRP) showed higher values in patients in acute phase and patients with late toxicity but in exacerbation crisis. Conclusions: The parameters analyzed, which require confirmation in a larger study, in combination with other inflammatory indicators, could be used as potential follow-up markers of the chronic radio-induced inflammation process just as its response to therapeutic treatments.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/236071
Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome); VIII Congresso Brasileiro de Queimaduras; Florianopolis; Brasil; 2012; 6-10
CONICET Digital
CONICET
url http://hdl.handle.net/11336/236071
identifier_str_mv Biomarkers of chronic inflammatory reaction in patients with radiological burns (cutaneous radiation syndrome); VIII Congresso Brasileiro de Queimaduras; Florianopolis; Brasil; 2012; 6-10
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.acm.org.br/viii-congresso-brasileiro-de-queimaduras-reune-em-florianopolis-os-maiores-nomes-da-especialidade/
info:eu-repo/semantics/altIdentifier/url/https://www.rbqueimaduras.com.br/summary/18
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Órgão Oficial da Sociedade Brasileira de Queimaduras
publisher.none.fl_str_mv Órgão Oficial da Sociedade Brasileira de Queimaduras
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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