Extragonadal LH/hCG action-Not yet time to rewrite textbooks

Autores
Pakarainen, Tomi; Ahtiainen, Petteri; Zhang, Fu Ping; Rulli, Susana Beatriz; Poutanen, Matti; Huhtaniemi, Ilpo
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gonadotropins are indispensable in both sexes in the regulation of gonadal sex steroid production and gametogenesis. In addition to their well-established classical actions, numerous recent publications have indicated the presence and function of luteinizing hormone/chorionic gonadotropin receptors (LH/hCG-R) in a variety of extragonadal tissues. However, the physiological significance of such effects has remained unclear. We have generated two genetically modified mouse models, one with excessive production of hCG and the other with targeted disruption of LH/hCG-R gene, and used them to address the functions of LH and hCG. Numerous gonadal and extragonadal phenotypes were found in the models with the two extremes of LH/hCG action. However, when the extragonadal effects were scrutinized in greater detail, they all appeared to arise through modification of gonadal function, either through enhanced or inhibited response to LH/hCG stimulation. Hence, further evidence is needed before the extragonadal LH/hCG-R expression can be considered functionally significant.
Fil: Pakarainen, Tomi. University of Turku; Finlandia
Fil: Ahtiainen, Petteri. University of Turku; Finlandia
Fil: Zhang, Fu Ping. University of Helsinki; Finlandia
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Poutanen, Matti. University of Turku; Finlandia
Fil: Huhtaniemi, Ilpo. University of Turku; Finlandia. IMperial College London; Reino Unido
Materia
HUMAN CHORIONIC GONADOTROPIN
LUTEINIZING HORMONE RECEPTOR
GONADOTROPINS
TRANSGENIC MOUSE
OVARY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27511
Acceder
id CONICETDig_e0e453c4baa744ab52b550c7f0994565
oai_identifier_str oai:ri.conicet.gov.ar:11336/27511
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Extragonadal LH/hCG action-Not yet time to rewrite textbooksPakarainen, TomiAhtiainen, PetteriZhang, Fu PingRulli, Susana BeatrizPoutanen, MattiHuhtaniemi, IlpoHUMAN CHORIONIC GONADOTROPINLUTEINIZING HORMONE RECEPTORGONADOTROPINSTRANSGENIC MOUSEOVARYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Gonadotropins are indispensable in both sexes in the regulation of gonadal sex steroid production and gametogenesis. In addition to their well-established classical actions, numerous recent publications have indicated the presence and function of luteinizing hormone/chorionic gonadotropin receptors (LH/hCG-R) in a variety of extragonadal tissues. However, the physiological significance of such effects has remained unclear. We have generated two genetically modified mouse models, one with excessive production of hCG and the other with targeted disruption of LH/hCG-R gene, and used them to address the functions of LH and hCG. Numerous gonadal and extragonadal phenotypes were found in the models with the two extremes of LH/hCG action. However, when the extragonadal effects were scrutinized in greater detail, they all appeared to arise through modification of gonadal function, either through enhanced or inhibited response to LH/hCG stimulation. Hence, further evidence is needed before the extragonadal LH/hCG-R expression can be considered functionally significant.Fil: Pakarainen, Tomi. University of Turku; FinlandiaFil: Ahtiainen, Petteri. University of Turku; FinlandiaFil: Zhang, Fu Ping. University of Helsinki; FinlandiaFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Poutanen, Matti. University of Turku; FinlandiaFil: Huhtaniemi, Ilpo. University of Turku; Finlandia. IMperial College London; Reino UnidoElsevier Ireland2007-04-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/27511Pakarainen, Tomi; Ahtiainen, Petteri; Zhang, Fu Ping; Rulli, Susana Beatriz; Poutanen, Matti; et al.; Extragonadal LH/hCG action-Not yet time to rewrite textbooks; Elsevier Ireland; Molecular and Cellular Endocrinology; 269; 1-2; 15-4-2007; 9-160303-72071872-8057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720707000391info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2006.10.019info:eu-repo/semantics/altIdentifier/pmid/17350753info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:26Zoai:ri.conicet.gov.ar:11336/27511instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:26.933CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Extragonadal LH/hCG action-Not yet time to rewrite textbooks
title Extragonadal LH/hCG action-Not yet time to rewrite textbooks
spellingShingle Extragonadal LH/hCG action-Not yet time to rewrite textbooks
Pakarainen, Tomi
HUMAN CHORIONIC GONADOTROPIN
LUTEINIZING HORMONE RECEPTOR
GONADOTROPINS
TRANSGENIC MOUSE
OVARY
title_short Extragonadal LH/hCG action-Not yet time to rewrite textbooks
title_full Extragonadal LH/hCG action-Not yet time to rewrite textbooks
title_fullStr Extragonadal LH/hCG action-Not yet time to rewrite textbooks
title_full_unstemmed Extragonadal LH/hCG action-Not yet time to rewrite textbooks
title_sort Extragonadal LH/hCG action-Not yet time to rewrite textbooks
dc.creator.none.fl_str_mv Pakarainen, Tomi
Ahtiainen, Petteri
Zhang, Fu Ping
Rulli, Susana Beatriz
Poutanen, Matti
Huhtaniemi, Ilpo
author Pakarainen, Tomi
author_facet Pakarainen, Tomi
Ahtiainen, Petteri
Zhang, Fu Ping
Rulli, Susana Beatriz
Poutanen, Matti
Huhtaniemi, Ilpo
author_role author
author2 Ahtiainen, Petteri
Zhang, Fu Ping
Rulli, Susana Beatriz
Poutanen, Matti
Huhtaniemi, Ilpo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HUMAN CHORIONIC GONADOTROPIN
LUTEINIZING HORMONE RECEPTOR
GONADOTROPINS
TRANSGENIC MOUSE
OVARY
topic HUMAN CHORIONIC GONADOTROPIN
LUTEINIZING HORMONE RECEPTOR
GONADOTROPINS
TRANSGENIC MOUSE
OVARY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Gonadotropins are indispensable in both sexes in the regulation of gonadal sex steroid production and gametogenesis. In addition to their well-established classical actions, numerous recent publications have indicated the presence and function of luteinizing hormone/chorionic gonadotropin receptors (LH/hCG-R) in a variety of extragonadal tissues. However, the physiological significance of such effects has remained unclear. We have generated two genetically modified mouse models, one with excessive production of hCG and the other with targeted disruption of LH/hCG-R gene, and used them to address the functions of LH and hCG. Numerous gonadal and extragonadal phenotypes were found in the models with the two extremes of LH/hCG action. However, when the extragonadal effects were scrutinized in greater detail, they all appeared to arise through modification of gonadal function, either through enhanced or inhibited response to LH/hCG stimulation. Hence, further evidence is needed before the extragonadal LH/hCG-R expression can be considered functionally significant.
Fil: Pakarainen, Tomi. University of Turku; Finlandia
Fil: Ahtiainen, Petteri. University of Turku; Finlandia
Fil: Zhang, Fu Ping. University of Helsinki; Finlandia
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Poutanen, Matti. University of Turku; Finlandia
Fil: Huhtaniemi, Ilpo. University of Turku; Finlandia. IMperial College London; Reino Unido
description Gonadotropins are indispensable in both sexes in the regulation of gonadal sex steroid production and gametogenesis. In addition to their well-established classical actions, numerous recent publications have indicated the presence and function of luteinizing hormone/chorionic gonadotropin receptors (LH/hCG-R) in a variety of extragonadal tissues. However, the physiological significance of such effects has remained unclear. We have generated two genetically modified mouse models, one with excessive production of hCG and the other with targeted disruption of LH/hCG-R gene, and used them to address the functions of LH and hCG. Numerous gonadal and extragonadal phenotypes were found in the models with the two extremes of LH/hCG action. However, when the extragonadal effects were scrutinized in greater detail, they all appeared to arise through modification of gonadal function, either through enhanced or inhibited response to LH/hCG stimulation. Hence, further evidence is needed before the extragonadal LH/hCG-R expression can be considered functionally significant.
publishDate 2007
dc.date.none.fl_str_mv 2007-04-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27511
Pakarainen, Tomi; Ahtiainen, Petteri; Zhang, Fu Ping; Rulli, Susana Beatriz; Poutanen, Matti; et al.; Extragonadal LH/hCG action-Not yet time to rewrite textbooks; Elsevier Ireland; Molecular and Cellular Endocrinology; 269; 1-2; 15-4-2007; 9-16
0303-7207
1872-8057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27511
identifier_str_mv Pakarainen, Tomi; Ahtiainen, Petteri; Zhang, Fu Ping; Rulli, Susana Beatriz; Poutanen, Matti; et al.; Extragonadal LH/hCG action-Not yet time to rewrite textbooks; Elsevier Ireland; Molecular and Cellular Endocrinology; 269; 1-2; 15-4-2007; 9-16
0303-7207
1872-8057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720707000391
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2006.10.019
info:eu-repo/semantics/altIdentifier/pmid/17350753
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269694685347840
score 13.13397

Publicaciones similares