Phenotypic characterisation of mice with exaggerated and missing LH/hCG action

Autores
Ahtiainen, Petteri; Rulli, Susana Beatriz; Pakarainen, Tomi; Zhang, Fu-Ping; Poutanen, Matti; Huhtaniemi, Ilpo
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) alpha and beta subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus. The purpose of this review is to summarise the key findings on these two genetically modified mouse models.
Fil: Ahtiainen, Petteri. University of Turku; Finlandia
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Pakarainen, Tomi. University of Turku; Finlandia
Fil: Zhang, Fu-Ping. University of Helsinki; Finlandia
Fil: Poutanen, Matti. University of Turku; Finlandia
Fil: Huhtaniemi, Ilpo. University of Turku; Finlandia. Imperial College London; Reino Unido
Materia
Human Chorionic Gonadotropin
Luteninzing Hormone Receptor
Phenotype
Gene Expression
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27510
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/27510
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Phenotypic characterisation of mice with exaggerated and missing LH/hCG actionAhtiainen, PetteriRulli, Susana BeatrizPakarainen, TomiZhang, Fu-PingPoutanen, MattiHuhtaniemi, IlpoHuman Chorionic GonadotropinLuteninzing Hormone ReceptorPhenotypeGene Expressionhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) alpha and beta subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus. The purpose of this review is to summarise the key findings on these two genetically modified mouse models.Fil: Ahtiainen, Petteri. University of Turku; FinlandiaFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Pakarainen, Tomi. University of Turku; FinlandiaFil: Zhang, Fu-Ping. University of Helsinki; FinlandiaFil: Poutanen, Matti. University of Turku; FinlandiaFil: Huhtaniemi, Ilpo. University of Turku; Finlandia. Imperial College London; Reino UnidoElsevier Ireland2007-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/27510Ahtiainen, Petteri; Rulli, Susana Beatriz; Pakarainen, Tomi; Zhang, Fu-Ping; Poutanen, Matti; et al.; Phenotypic characterisation of mice with exaggerated and missing LH/hCG action; Elsevier Ireland; Molecular and Cellular Endocrinology; 260-262; 1-2007; 255-2630303-72071872-8057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720706004357?via%3Dihub#!info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2005.11.047info:eu-repo/semantics/altIdentifier/pmid/17029767info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:04Zoai:ri.conicet.gov.ar:11336/27510instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:04.402CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
spellingShingle Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
Ahtiainen, Petteri
Human Chorionic Gonadotropin
Luteninzing Hormone Receptor
Phenotype
Gene Expression
title_short Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title_full Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title_fullStr Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title_full_unstemmed Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
title_sort Phenotypic characterisation of mice with exaggerated and missing LH/hCG action
dc.creator.none.fl_str_mv Ahtiainen, Petteri
Rulli, Susana Beatriz
Pakarainen, Tomi
Zhang, Fu-Ping
Poutanen, Matti
Huhtaniemi, Ilpo
author Ahtiainen, Petteri
author_facet Ahtiainen, Petteri
Rulli, Susana Beatriz
Pakarainen, Tomi
Zhang, Fu-Ping
Poutanen, Matti
Huhtaniemi, Ilpo
author_role author
author2 Rulli, Susana Beatriz
Pakarainen, Tomi
Zhang, Fu-Ping
Poutanen, Matti
Huhtaniemi, Ilpo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Human Chorionic Gonadotropin
Luteninzing Hormone Receptor
Phenotype
Gene Expression
topic Human Chorionic Gonadotropin
Luteninzing Hormone Receptor
Phenotype
Gene Expression
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) alpha and beta subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus. The purpose of this review is to summarise the key findings on these two genetically modified mouse models.
Fil: Ahtiainen, Petteri. University of Turku; Finlandia
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Pakarainen, Tomi. University of Turku; Finlandia
Fil: Zhang, Fu-Ping. University of Helsinki; Finlandia
Fil: Poutanen, Matti. University of Turku; Finlandia
Fil: Huhtaniemi, Ilpo. University of Turku; Finlandia. Imperial College London; Reino Unido
description In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) alpha and beta subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus. The purpose of this review is to summarise the key findings on these two genetically modified mouse models.
publishDate 2007
dc.date.none.fl_str_mv 2007-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27510
Ahtiainen, Petteri; Rulli, Susana Beatriz; Pakarainen, Tomi; Zhang, Fu-Ping; Poutanen, Matti; et al.; Phenotypic characterisation of mice with exaggerated and missing LH/hCG action; Elsevier Ireland; Molecular and Cellular Endocrinology; 260-262; 1-2007; 255-263
0303-7207
1872-8057
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27510
identifier_str_mv Ahtiainen, Petteri; Rulli, Susana Beatriz; Pakarainen, Tomi; Zhang, Fu-Ping; Poutanen, Matti; et al.; Phenotypic characterisation of mice with exaggerated and missing LH/hCG action; Elsevier Ireland; Molecular and Cellular Endocrinology; 260-262; 1-2007; 255-263
0303-7207
1872-8057
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720706004357?via%3Dihub#!
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2005.11.047
info:eu-repo/semantics/altIdentifier/pmid/17029767
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269940742094848
score 13.13397

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