Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance

Autores
Talwar, G. P.; Rulli, Susana Beatriz; Vyas, Hemant; Purswani, Shilpi; Kabeer, Rafi Shiraz; Chopra, Prem; Singh, Priyanka; Atrey, Nishu; Nand, Kripa; Gupta, Jagdish C.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Reviewed is the work which led to the development of a unique vaccine that prevents pregnancy in sexually active women without impairment of ovulation and block of their making normally their sex steroid hormones. Being given that hCG is not expressed by non-pregnant females, immunization with the vaccine is devoid of any crossreaction with any tissue of the body. It is totally reversible and women regained fertility on decline of antibodies. A recombinant vaccine has been developed which is highly immunogenic in mice. It is undergoing extensive toxicology under GLP conditions in rodents and a primate species, the marmosets, before resumption of clinical trials. Ectopic expression of hCG or its subunits takes place in a variety of cancers, particularly at advanced stage with adverse survival and poor prognosis. Anti-hCG antibodies exercise therapeutic action against such cancers as indicated by in vitro culture and in vivo studies in nude mice. Transgenic hCG β mice put on weight and manifest insulin resistance. Immunization of these mice with the recombinant hCG β-LTB vaccine prevents obesity and insulin resistance.
Fil: Talwar, G. P.. Talwar Research Foundation; India
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Vyas, Hemant. Harvard Medical School; Estados Unidos
Fil: Purswani, Shilpi. Talwar Research Foundation; India
Fil: Kabeer, Rafi Shiraz. Talwar Research Foundation; India
Fil: Chopra, Prem. Sir Ganga Ram Hospital; India
Fil: Singh, Priyanka . Talwar Research Foundation; India
Fil: Atrey, Nishu. Talwar Research Foundation; India
Fil: Nand, Kripa. Talwar Research Foundation; India
Fil: Gupta, Jagdish C.. Talwar Research Foundation; India
Materia
HUMAN CHORIONIC GONADOTROPIN
FERTILITY CONTROL
POOR PROGNOSIS CANCERS
OBESITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6445
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6445
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistanceTalwar, G. P.Rulli, Susana Beatriz Vyas, HemantPurswani, ShilpiKabeer, Rafi ShirazChopra, PremSingh, Priyanka Atrey, NishuNand, Kripa Gupta, Jagdish C.HUMAN CHORIONIC GONADOTROPINFERTILITY CONTROLPOOR PROGNOSIS CANCERSOBESITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Reviewed is the work which led to the development of a unique vaccine that prevents pregnancy in sexually active women without impairment of ovulation and block of their making normally their sex steroid hormones. Being given that hCG is not expressed by non-pregnant females, immunization with the vaccine is devoid of any crossreaction with any tissue of the body. It is totally reversible and women regained fertility on decline of antibodies. A recombinant vaccine has been developed which is highly immunogenic in mice. It is undergoing extensive toxicology under GLP conditions in rodents and a primate species, the marmosets, before resumption of clinical trials. Ectopic expression of hCG or its subunits takes place in a variety of cancers, particularly at advanced stage with adverse survival and poor prognosis. Anti-hCG antibodies exercise therapeutic action against such cancers as indicated by in vitro culture and in vivo studies in nude mice. Transgenic hCG β mice put on weight and manifest insulin resistance. Immunization of these mice with the recombinant hCG β-LTB vaccine prevents obesity and insulin resistance.Fil: Talwar, G. P.. Talwar Research Foundation; IndiaFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Vyas, Hemant. Harvard Medical School; Estados UnidosFil: Purswani, Shilpi. Talwar Research Foundation; IndiaFil: Kabeer, Rafi Shiraz. Talwar Research Foundation; IndiaFil: Chopra, Prem. Sir Ganga Ram Hospital; IndiaFil: Singh, Priyanka . Talwar Research Foundation; IndiaFil: Atrey, Nishu. Talwar Research Foundation; IndiaFil: Nand, Kripa. Talwar Research Foundation; IndiaFil: Gupta, Jagdish C.. Talwar Research Foundation; IndiaOMICS Publishing Group2014-03-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6445Talwar, G. P.; Rulli, Susana Beatriz; Vyas, Hemant; Purswani, Shilpi; Kabeer, Rafi Shiraz; et al.; Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance; OMICS Publishing Group; Journal of Cell Science & Therapy; 5; 2; 28-3-2014; 1000159-10001592157-70132157-7013enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.4172/2157-7013.1000159info:eu-repo/semantics/altIdentifier/url/http://goo.gl/BmGLXZinfo:eu-repo/semantics/altIdentifier/url/http://file.scirp.org/Html/2-8902360_67326.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:23Zoai:ri.conicet.gov.ar:11336/6445instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:23.604CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance
title Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance
spellingShingle Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance
Talwar, G. P.
HUMAN CHORIONIC GONADOTROPIN
FERTILITY CONTROL
POOR PROGNOSIS CANCERS
OBESITY
title_short Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance
title_full Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance
title_fullStr Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance
title_full_unstemmed Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance
title_sort Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance
dc.creator.none.fl_str_mv Talwar, G. P.
Rulli, Susana Beatriz
Vyas, Hemant
Purswani, Shilpi
Kabeer, Rafi Shiraz
Chopra, Prem
Singh, Priyanka
Atrey, Nishu
Nand, Kripa
Gupta, Jagdish C.
author Talwar, G. P.
author_facet Talwar, G. P.
Rulli, Susana Beatriz
Vyas, Hemant
Purswani, Shilpi
Kabeer, Rafi Shiraz
Chopra, Prem
Singh, Priyanka
Atrey, Nishu
Nand, Kripa
Gupta, Jagdish C.
author_role author
author2 Rulli, Susana Beatriz
Vyas, Hemant
Purswani, Shilpi
Kabeer, Rafi Shiraz
Chopra, Prem
Singh, Priyanka
Atrey, Nishu
Nand, Kripa
Gupta, Jagdish C.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HUMAN CHORIONIC GONADOTROPIN
FERTILITY CONTROL
POOR PROGNOSIS CANCERS
OBESITY
topic HUMAN CHORIONIC GONADOTROPIN
FERTILITY CONTROL
POOR PROGNOSIS CANCERS
OBESITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Reviewed is the work which led to the development of a unique vaccine that prevents pregnancy in sexually active women without impairment of ovulation and block of their making normally their sex steroid hormones. Being given that hCG is not expressed by non-pregnant females, immunization with the vaccine is devoid of any crossreaction with any tissue of the body. It is totally reversible and women regained fertility on decline of antibodies. A recombinant vaccine has been developed which is highly immunogenic in mice. It is undergoing extensive toxicology under GLP conditions in rodents and a primate species, the marmosets, before resumption of clinical trials. Ectopic expression of hCG or its subunits takes place in a variety of cancers, particularly at advanced stage with adverse survival and poor prognosis. Anti-hCG antibodies exercise therapeutic action against such cancers as indicated by in vitro culture and in vivo studies in nude mice. Transgenic hCG β mice put on weight and manifest insulin resistance. Immunization of these mice with the recombinant hCG β-LTB vaccine prevents obesity and insulin resistance.
Fil: Talwar, G. P.. Talwar Research Foundation; India
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Vyas, Hemant. Harvard Medical School; Estados Unidos
Fil: Purswani, Shilpi. Talwar Research Foundation; India
Fil: Kabeer, Rafi Shiraz. Talwar Research Foundation; India
Fil: Chopra, Prem. Sir Ganga Ram Hospital; India
Fil: Singh, Priyanka . Talwar Research Foundation; India
Fil: Atrey, Nishu. Talwar Research Foundation; India
Fil: Nand, Kripa. Talwar Research Foundation; India
Fil: Gupta, Jagdish C.. Talwar Research Foundation; India
description Reviewed is the work which led to the development of a unique vaccine that prevents pregnancy in sexually active women without impairment of ovulation and block of their making normally their sex steroid hormones. Being given that hCG is not expressed by non-pregnant females, immunization with the vaccine is devoid of any crossreaction with any tissue of the body. It is totally reversible and women regained fertility on decline of antibodies. A recombinant vaccine has been developed which is highly immunogenic in mice. It is undergoing extensive toxicology under GLP conditions in rodents and a primate species, the marmosets, before resumption of clinical trials. Ectopic expression of hCG or its subunits takes place in a variety of cancers, particularly at advanced stage with adverse survival and poor prognosis. Anti-hCG antibodies exercise therapeutic action against such cancers as indicated by in vitro culture and in vivo studies in nude mice. Transgenic hCG β mice put on weight and manifest insulin resistance. Immunization of these mice with the recombinant hCG β-LTB vaccine prevents obesity and insulin resistance.
publishDate 2014
dc.date.none.fl_str_mv 2014-03-28
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6445
Talwar, G. P.; Rulli, Susana Beatriz; Vyas, Hemant; Purswani, Shilpi; Kabeer, Rafi Shiraz; et al.; Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance; OMICS Publishing Group; Journal of Cell Science & Therapy; 5; 2; 28-3-2014; 1000159-1000159
2157-7013
2157-7013
url http://hdl.handle.net/11336/6445
identifier_str_mv Talwar, G. P.; Rulli, Susana Beatriz; Vyas, Hemant; Purswani, Shilpi; Kabeer, Rafi Shiraz; et al.; Making of a unique birth control vaccine against hCG with additional potential of therapy of advanced stage cancers and prevention of obesity and insulin resistance; OMICS Publishing Group; Journal of Cell Science & Therapy; 5; 2; 28-3-2014; 1000159-1000159
2157-7013
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.4172/2157-7013.1000159
info:eu-repo/semantics/altIdentifier/url/http://goo.gl/BmGLXZ
info:eu-repo/semantics/altIdentifier/url/http://file.scirp.org/Html/2-8902360_67326.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv OMICS Publishing Group
publisher.none.fl_str_mv OMICS Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269341303701504
score 13.13397

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