The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?

Autores
Marcial López, Carla Agustina; Ratner, Laura Daniela; Calandra, Ricardo Saul; Rulli, Susana Beatriz
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Transgenic female mice expressing human chorionic gonadotropin-ß (hCGß +) produce elevated levels of hCG, prolactin and progesterone, show precocious puberty, are infertile and develop pituitary tumors. We have previously demonstrated that a short-term treatment of juvenile hCGß + females with the dopamine agonist cabergoline normalizes the phenotypic changes of hCGß + females. Even more, the treatment prevented phenotypic alterations on the transgenic offspring. The aim of this study was to determine if the cabergoline treatment has its effect during pregnancy and/or lactation. Two groups of 2-month-old wild-type (WT) females were mated with hCGß + males: (1) Six-week-old WT females pretreated with cabergoline (500 µ g/kg, ip), every other day for one week (WT-CAB mothers); (2) WT females without treatment (WT- mothers).
Fil: Marcial López, Carla Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Ratner, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
International Symposium on Reproductive Health: overcoming barriers for research in reproduction
Buenos Aires
Argentina
ISRH2021 1 Scientific and Organizing Committee
CEFYBO-CONICET
Universidad de Buenos Aires. Facultad de Medicina
Materia
TRANSGENIC MICE
HUMAN CHORIONIC GONADOTROPIN
CABERGOLINE
OFFSPRING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/151537
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/151537
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?Marcial López, Carla AgustinaRatner, Laura DanielaCalandra, Ricardo SaulRulli, Susana BeatrizTRANSGENIC MICEHUMAN CHORIONIC GONADOTROPINCABERGOLINEOFFSPRINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Transgenic female mice expressing human chorionic gonadotropin-ß (hCGß +) produce elevated levels of hCG, prolactin and progesterone, show precocious puberty, are infertile and develop pituitary tumors. We have previously demonstrated that a short-term treatment of juvenile hCGß + females with the dopamine agonist cabergoline normalizes the phenotypic changes of hCGß + females. Even more, the treatment prevented phenotypic alterations on the transgenic offspring. The aim of this study was to determine if the cabergoline treatment has its effect during pregnancy and/or lactation. Two groups of 2-month-old wild-type (WT) females were mated with hCGß + males: (1) Six-week-old WT females pretreated with cabergoline (500 µ g/kg, ip), every other day for one week (WT-CAB mothers); (2) WT females without treatment (WT- mothers).Fil: Marcial López, Carla Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ratner, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaInternational Symposium on Reproductive Health: overcoming barriers for research in reproductionBuenos AiresArgentinaISRH2021 1 Scientific and Organizing CommitteeCEFYBO-CONICETUniversidad de Buenos Aires. Facultad de MedicinaIMR Press2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectVirtualJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/151537The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?; International Symposium on Reproductive Health: overcoming barriers for research in reproduction; Buenos Aires; Argentina; 2021; 1-10390-6663CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://imrpress.com/journal/CEOG/48/3/10.31083/j.ceog.2021.03.0511info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.31083/j.ceog.2021.03.0511Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:35Zoai:ri.conicet.gov.ar:11336/151537instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:35.763CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?
title The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?
spellingShingle The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?
Marcial López, Carla Agustina
TRANSGENIC MICE
HUMAN CHORIONIC GONADOTROPIN
CABERGOLINE
OFFSPRING
title_short The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?
title_full The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?
title_fullStr The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?
title_full_unstemmed The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?
title_sort The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?
dc.creator.none.fl_str_mv Marcial López, Carla Agustina
Ratner, Laura Daniela
Calandra, Ricardo Saul
Rulli, Susana Beatriz
author Marcial López, Carla Agustina
author_facet Marcial López, Carla Agustina
Ratner, Laura Daniela
Calandra, Ricardo Saul
Rulli, Susana Beatriz
author_role author
author2 Ratner, Laura Daniela
Calandra, Ricardo Saul
Rulli, Susana Beatriz
author2_role author
author
author
dc.subject.none.fl_str_mv TRANSGENIC MICE
HUMAN CHORIONIC GONADOTROPIN
CABERGOLINE
OFFSPRING
topic TRANSGENIC MICE
HUMAN CHORIONIC GONADOTROPIN
CABERGOLINE
OFFSPRING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Transgenic female mice expressing human chorionic gonadotropin-ß (hCGß +) produce elevated levels of hCG, prolactin and progesterone, show precocious puberty, are infertile and develop pituitary tumors. We have previously demonstrated that a short-term treatment of juvenile hCGß + females with the dopamine agonist cabergoline normalizes the phenotypic changes of hCGß + females. Even more, the treatment prevented phenotypic alterations on the transgenic offspring. The aim of this study was to determine if the cabergoline treatment has its effect during pregnancy and/or lactation. Two groups of 2-month-old wild-type (WT) females were mated with hCGß + males: (1) Six-week-old WT females pretreated with cabergoline (500 µ g/kg, ip), every other day for one week (WT-CAB mothers); (2) WT females without treatment (WT- mothers).
Fil: Marcial López, Carla Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Ratner, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
International Symposium on Reproductive Health: overcoming barriers for research in reproduction
Buenos Aires
Argentina
ISRH2021 1 Scientific and Organizing Committee
CEFYBO-CONICET
Universidad de Buenos Aires. Facultad de Medicina
description Transgenic female mice expressing human chorionic gonadotropin-ß (hCGß +) produce elevated levels of hCG, prolactin and progesterone, show precocious puberty, are infertile and develop pituitary tumors. We have previously demonstrated that a short-term treatment of juvenile hCGß + females with the dopamine agonist cabergoline normalizes the phenotypic changes of hCGß + females. Even more, the treatment prevented phenotypic alterations on the transgenic offspring. The aim of this study was to determine if the cabergoline treatment has its effect during pregnancy and/or lactation. Two groups of 2-month-old wild-type (WT) females were mated with hCGß + males: (1) Six-week-old WT females pretreated with cabergoline (500 µ g/kg, ip), every other day for one week (WT-CAB mothers); (2) WT females without treatment (WT- mothers).
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Virtual
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/151537
The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?; International Symposium on Reproductive Health: overcoming barriers for research in reproduction; Buenos Aires; Argentina; 2021; 1-1
0390-6663
CONICET Digital
CONICET
url http://hdl.handle.net/11336/151537
identifier_str_mv The influence of cabergoline on the offspring phenotype of human chorionic gonadotropin (hCG)- secreting female mice: does mother's milk make the difference?; International Symposium on Reproductive Health: overcoming barriers for research in reproduction; Buenos Aires; Argentina; 2021; 1-1
0390-6663
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://imrpress.com/journal/CEOG/48/3/10.31083/j.ceog.2021.03.0511
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.31083/j.ceog.2021.03.0511
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv IMR Press
publisher.none.fl_str_mv IMR Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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