Histamine receptors and cancer pharmacology

Autores
Medina, Vanina Araceli; Rivera, Elena S.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Considerable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells. High histamine biosynthesis and content together with histamine receptors have been reported in different human neoplasias including melanoma, colon and breast cancer, as well as in experimental tumours in which histamine has been postulated to behave as an important paracrine and autocrine regulator of proliferation. The discovery of the human histamine H(4) receptor in different tissues has contributed to our understanding of histamine role in numerous physiological and pathological conditions revealing novel functions for histamine and opening new perspectives in histamine pharmacology research. In the present review we aimed to briefly summarize current knowledge on histamine and histamine receptor involvement in cancer before focusing on some recent evidence supporting the novel role of histamine H(4) receptor in cancer progression representing a promising molecular target and avenue for cancer drug development.
Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rivera, Elena S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Materia
Histamine
Histamine H4 Receptor
Cancer Pharmacology
Breast Cancer
Melanoma
Colon Cancer
Histamine H4 Receptor Ligands
Anticancer Drugs
Cell Proliferation
Malignancy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14251
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/14251
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Histamine receptors and cancer pharmacologyMedina, Vanina AraceliRivera, Elena S.HistamineHistamine H4 ReceptorCancer PharmacologyBreast CancerMelanomaColon CancerHistamine H4 Receptor LigandsAnticancer DrugsCell ProliferationMalignancyhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Considerable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells. High histamine biosynthesis and content together with histamine receptors have been reported in different human neoplasias including melanoma, colon and breast cancer, as well as in experimental tumours in which histamine has been postulated to behave as an important paracrine and autocrine regulator of proliferation. The discovery of the human histamine H(4) receptor in different tissues has contributed to our understanding of histamine role in numerous physiological and pathological conditions revealing novel functions for histamine and opening new perspectives in histamine pharmacology research. In the present review we aimed to briefly summarize current knowledge on histamine and histamine receptor involvement in cancer before focusing on some recent evidence supporting the novel role of histamine H(4) receptor in cancer progression representing a promising molecular target and avenue for cancer drug development.Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Rivera, Elena S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaWiley2010-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14251Medina, Vanina Araceli; Rivera, Elena S.; Histamine receptors and cancer pharmacology; Wiley; British Journal of Pharmacology; 161; 4; 10-2010; 755-7670007-1188enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2010.00961.x/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1476-5381.2010.00961.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:42:12Zoai:ri.conicet.gov.ar:11336/14251instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:42:12.736CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Histamine receptors and cancer pharmacology
title Histamine receptors and cancer pharmacology
spellingShingle Histamine receptors and cancer pharmacology
Medina, Vanina Araceli
Histamine
Histamine H4 Receptor
Cancer Pharmacology
Breast Cancer
Melanoma
Colon Cancer
Histamine H4 Receptor Ligands
Anticancer Drugs
Cell Proliferation
Malignancy
title_short Histamine receptors and cancer pharmacology
title_full Histamine receptors and cancer pharmacology
title_fullStr Histamine receptors and cancer pharmacology
title_full_unstemmed Histamine receptors and cancer pharmacology
title_sort Histamine receptors and cancer pharmacology
dc.creator.none.fl_str_mv Medina, Vanina Araceli
Rivera, Elena S.
author Medina, Vanina Araceli
author_facet Medina, Vanina Araceli
Rivera, Elena S.
author_role author
author2 Rivera, Elena S.
author2_role author
dc.subject.none.fl_str_mv Histamine
Histamine H4 Receptor
Cancer Pharmacology
Breast Cancer
Melanoma
Colon Cancer
Histamine H4 Receptor Ligands
Anticancer Drugs
Cell Proliferation
Malignancy
topic Histamine
Histamine H4 Receptor
Cancer Pharmacology
Breast Cancer
Melanoma
Colon Cancer
Histamine H4 Receptor Ligands
Anticancer Drugs
Cell Proliferation
Malignancy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Considerable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells. High histamine biosynthesis and content together with histamine receptors have been reported in different human neoplasias including melanoma, colon and breast cancer, as well as in experimental tumours in which histamine has been postulated to behave as an important paracrine and autocrine regulator of proliferation. The discovery of the human histamine H(4) receptor in different tissues has contributed to our understanding of histamine role in numerous physiological and pathological conditions revealing novel functions for histamine and opening new perspectives in histamine pharmacology research. In the present review we aimed to briefly summarize current knowledge on histamine and histamine receptor involvement in cancer before focusing on some recent evidence supporting the novel role of histamine H(4) receptor in cancer progression representing a promising molecular target and avenue for cancer drug development.
Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rivera, Elena S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
description Considerable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells. High histamine biosynthesis and content together with histamine receptors have been reported in different human neoplasias including melanoma, colon and breast cancer, as well as in experimental tumours in which histamine has been postulated to behave as an important paracrine and autocrine regulator of proliferation. The discovery of the human histamine H(4) receptor in different tissues has contributed to our understanding of histamine role in numerous physiological and pathological conditions revealing novel functions for histamine and opening new perspectives in histamine pharmacology research. In the present review we aimed to briefly summarize current knowledge on histamine and histamine receptor involvement in cancer before focusing on some recent evidence supporting the novel role of histamine H(4) receptor in cancer progression representing a promising molecular target and avenue for cancer drug development.
publishDate 2010
dc.date.none.fl_str_mv 2010-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14251
Medina, Vanina Araceli; Rivera, Elena S.; Histamine receptors and cancer pharmacology; Wiley; British Journal of Pharmacology; 161; 4; 10-2010; 755-767
0007-1188
url http://hdl.handle.net/11336/14251
identifier_str_mv Medina, Vanina Araceli; Rivera, Elena S.; Histamine receptors and cancer pharmacology; Wiley; British Journal of Pharmacology; 161; 4; 10-2010; 755-767
0007-1188
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2010.00961.x/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1476-5381.2010.00961.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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