Immunomodulatory role of histamine H4 receptor in breast cancer

Autores
Sterle, Helena Andrea; Nicoud, Melisa Beatriz; Massari, Noelia Andrea; Táquez Delgado, Mónica Alejandra; Herrero Ducloux, María Verónica; Cremaschi, Graciela Alicia; Medina, Vanina Araceli
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of H4R in antitumour immunity in a model of triple-negative breast cancer. Methods: We evaluated growth parameters, histological characteristics and the composition of tumour, splenic and tumour draining lymph node (TDLN) immune subsets, in a syngeneic model, developed orthotopically with 4T1 cells in H4R knockout (H4R-KO) and wild-type mice. Results: Mice lacking H4R show reduced tumour size and weight, decreased number of lung metastases and percentage of CD4 + tumour-infiltrating T cells, while exhibiting increased infiltration of NK cells and CD19 + lymphocytes. Likewise, TDLN of H4R-KO mice show decreased CD4 + T cells and T regulatory cells (CD4 + CD25 + FoxP3 + ), and increased percentages of NK cells. Finally, H4R-deficient mice show decreased Tregs in spleens and non-draining lymph nodes, and a negative correlation between tumour weight and the percentages of CD4 + , CD19 + and NK splenic cells, suggesting that H4R also regulates antitumour immunity at a systemic level. Conclusions: This is the first report that demonstrates the participation of H4R in antitumour immunity, suggesting that H4R could be a target for cancer treatment.
Fil: Sterle, Helena Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Nicoud, Melisa Beatriz. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Massari, Noelia Andrea. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro; Argentina
Fil: Táquez Delgado, Mónica Alejandra. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Herrero Ducloux, María Verónica. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro; Argentina
Fil: Cremaschi, Graciela Alicia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Materia
Histamine H4 receptor
Breast Cancer
antitumor immunity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120495
Acceder
id CONICETDig_23d2f5d7b77bfc02e6b0668904c11371
oai_identifier_str oai:ri.conicet.gov.ar:11336/120495
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immunomodulatory role of histamine H4 receptor in breast cancerSterle, Helena AndreaNicoud, Melisa BeatrizMassari, Noelia AndreaTáquez Delgado, Mónica AlejandraHerrero Ducloux, María VerónicaCremaschi, Graciela AliciaMedina, Vanina AraceliHistamine H4 receptorBreast Cancerantitumor immunityhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of H4R in antitumour immunity in a model of triple-negative breast cancer. Methods: We evaluated growth parameters, histological characteristics and the composition of tumour, splenic and tumour draining lymph node (TDLN) immune subsets, in a syngeneic model, developed orthotopically with 4T1 cells in H4R knockout (H4R-KO) and wild-type mice. Results: Mice lacking H4R show reduced tumour size and weight, decreased number of lung metastases and percentage of CD4 + tumour-infiltrating T cells, while exhibiting increased infiltration of NK cells and CD19 + lymphocytes. Likewise, TDLN of H4R-KO mice show decreased CD4 + T cells and T regulatory cells (CD4 + CD25 + FoxP3 + ), and increased percentages of NK cells. Finally, H4R-deficient mice show decreased Tregs in spleens and non-draining lymph nodes, and a negative correlation between tumour weight and the percentages of CD4 + , CD19 + and NK splenic cells, suggesting that H4R also regulates antitumour immunity at a systemic level. Conclusions: This is the first report that demonstrates the participation of H4R in antitumour immunity, suggesting that H4R could be a target for cancer treatment.Fil: Sterle, Helena Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Nicoud, Melisa Beatriz. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Massari, Noelia Andrea. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro; ArgentinaFil: Táquez Delgado, Mónica Alejandra. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Herrero Ducloux, María Verónica. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro; ArgentinaFil: Cremaschi, Graciela Alicia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaNature Publishing Group2019-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120495Sterle, Helena Andrea; Nicoud, Melisa Beatriz; Massari, Noelia Andrea; Táquez Delgado, Mónica Alejandra; Herrero Ducloux, María Verónica; et al.; Immunomodulatory role of histamine H4 receptor in breast cancer; Nature Publishing Group; British Journal Of Cancer; 120; 1; 1-2019; 128-1380007-0920CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41416-018-0173-zinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41416-018-0173-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:52:31Zoai:ri.conicet.gov.ar:11336/120495instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:52:31.65CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immunomodulatory role of histamine H4 receptor in breast cancer
title Immunomodulatory role of histamine H4 receptor in breast cancer
spellingShingle Immunomodulatory role of histamine H4 receptor in breast cancer
Sterle, Helena Andrea
Histamine H4 receptor
Breast Cancer
antitumor immunity
title_short Immunomodulatory role of histamine H4 receptor in breast cancer
title_full Immunomodulatory role of histamine H4 receptor in breast cancer
title_fullStr Immunomodulatory role of histamine H4 receptor in breast cancer
title_full_unstemmed Immunomodulatory role of histamine H4 receptor in breast cancer
title_sort Immunomodulatory role of histamine H4 receptor in breast cancer
dc.creator.none.fl_str_mv Sterle, Helena Andrea
Nicoud, Melisa Beatriz
Massari, Noelia Andrea
Táquez Delgado, Mónica Alejandra
Herrero Ducloux, María Verónica
Cremaschi, Graciela Alicia
Medina, Vanina Araceli
author Sterle, Helena Andrea
author_facet Sterle, Helena Andrea
Nicoud, Melisa Beatriz
Massari, Noelia Andrea
Táquez Delgado, Mónica Alejandra
Herrero Ducloux, María Verónica
Cremaschi, Graciela Alicia
Medina, Vanina Araceli
author_role author
author2 Nicoud, Melisa Beatriz
Massari, Noelia Andrea
Táquez Delgado, Mónica Alejandra
Herrero Ducloux, María Verónica
Cremaschi, Graciela Alicia
Medina, Vanina Araceli
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Histamine H4 receptor
Breast Cancer
antitumor immunity
topic Histamine H4 receptor
Breast Cancer
antitumor immunity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of H4R in antitumour immunity in a model of triple-negative breast cancer. Methods: We evaluated growth parameters, histological characteristics and the composition of tumour, splenic and tumour draining lymph node (TDLN) immune subsets, in a syngeneic model, developed orthotopically with 4T1 cells in H4R knockout (H4R-KO) and wild-type mice. Results: Mice lacking H4R show reduced tumour size and weight, decreased number of lung metastases and percentage of CD4 + tumour-infiltrating T cells, while exhibiting increased infiltration of NK cells and CD19 + lymphocytes. Likewise, TDLN of H4R-KO mice show decreased CD4 + T cells and T regulatory cells (CD4 + CD25 + FoxP3 + ), and increased percentages of NK cells. Finally, H4R-deficient mice show decreased Tregs in spleens and non-draining lymph nodes, and a negative correlation between tumour weight and the percentages of CD4 + , CD19 + and NK splenic cells, suggesting that H4R also regulates antitumour immunity at a systemic level. Conclusions: This is the first report that demonstrates the participation of H4R in antitumour immunity, suggesting that H4R could be a target for cancer treatment.
Fil: Sterle, Helena Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Nicoud, Melisa Beatriz. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Massari, Noelia Andrea. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro; Argentina
Fil: Táquez Delgado, Mónica Alejandra. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Herrero Ducloux, María Verónica. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro; Argentina
Fil: Cremaschi, Graciela Alicia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
description Background: Although the role of histamine H4 receptor (H4R) in immune cells is being extensively investigated, its immunomodulatory function in cancer is completely unknown. This study aimed to investigate the role of H4R in antitumour immunity in a model of triple-negative breast cancer. Methods: We evaluated growth parameters, histological characteristics and the composition of tumour, splenic and tumour draining lymph node (TDLN) immune subsets, in a syngeneic model, developed orthotopically with 4T1 cells in H4R knockout (H4R-KO) and wild-type mice. Results: Mice lacking H4R show reduced tumour size and weight, decreased number of lung metastases and percentage of CD4 + tumour-infiltrating T cells, while exhibiting increased infiltration of NK cells and CD19 + lymphocytes. Likewise, TDLN of H4R-KO mice show decreased CD4 + T cells and T regulatory cells (CD4 + CD25 + FoxP3 + ), and increased percentages of NK cells. Finally, H4R-deficient mice show decreased Tregs in spleens and non-draining lymph nodes, and a negative correlation between tumour weight and the percentages of CD4 + , CD19 + and NK splenic cells, suggesting that H4R also regulates antitumour immunity at a systemic level. Conclusions: This is the first report that demonstrates the participation of H4R in antitumour immunity, suggesting that H4R could be a target for cancer treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120495
Sterle, Helena Andrea; Nicoud, Melisa Beatriz; Massari, Noelia Andrea; Táquez Delgado, Mónica Alejandra; Herrero Ducloux, María Verónica; et al.; Immunomodulatory role of histamine H4 receptor in breast cancer; Nature Publishing Group; British Journal Of Cancer; 120; 1; 1-2019; 128-138
0007-0920
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120495
identifier_str_mv Sterle, Helena Andrea; Nicoud, Melisa Beatriz; Massari, Noelia Andrea; Táquez Delgado, Mónica Alejandra; Herrero Ducloux, María Verónica; et al.; Immunomodulatory role of histamine H4 receptor in breast cancer; Nature Publishing Group; British Journal Of Cancer; 120; 1; 1-2019; 128-138
0007-0920
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41416-018-0173-z
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41416-018-0173-z
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.000565

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