A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage
- Autores
- Singh Tomar, Ankit; Finger, Paul T.; Gallie, Brenda; Mallipatna, Ashwin; Kivelä, Tero T.; Zhang, Chengyue; Zhao, Junyang; Wilson, Matthew W.; Brenna, Rachel C.; Burges, Michala; Kim, Jonathan; Khetan, Vikas; Ganesan, Suganeswari; Yarovoy, Andrey; Yarovaya, Vera; Kotova, Elena; Yousef, Yacoub A.; Nummi, Kalle; Ushakova, Tatiana L.; Yugay, Olga V.; Polyakov, Vladimir G.; Ramirez Ortiz, Marco A.; Esparza Aguiar, Elizabeth; Chantada, Guillermo Luis; Schaiquevich, Paula Susana; Fandino, Adriana; Yam, Jason C.; Lau, Winnie W.; Lam, Carol P.; Sharwood, Phillipa; Moorthy, Sonia; Long, Quah Boon; Essuman, Vera Adobea; Renner, Lorna A.; Semenova, Ekaterina; Català, Jaume; Correa Llano, Genoveva; Carreras, Elisa
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Purpose: To evaluate the ability of the 8th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual to estimate metastatic and mortality rates for children with retinoblastoma(RB).Design: International, multicenter, registry-based retrospective case series PARTICIPANTS: 2190 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents.Methods: Patient-specific data fields for RB were designed by participating eye cancer specialists. All RB patients with adequate records to allow tumor staging by the AJCC criteria and follow-up for metastatic disease were studied.Main outcome measures: Metastasis-related 5- and 10-year survival data after initial tumor staging were estimated with the Kaplan-Meier method depending on AJCC clinical (cTNM) and pathological (pTNM) tumor, node, metastasis category and age, tumor laterality, and presence of heritable trait.Results: Of the 2190 patients, the records of 2085 patients(95.2%) with 2905 eyes were complete. The median age at diagnosis was 17.0 months. 1260 (65.4%) had unilateral RB. Amongst the 2085 patients, tumor categories were cT1a in 55 (2.6%), cT1b 168 (8.1%), cT2a 197 (9.4%), cT2b 812 (38.9%), cT3 835 (40.0%) and cT4 in 18 (0.9%) patients. Of these, 1397 eyes in 1353 patients(48.1%) were treated with enucleation. One hundred and nine patients (5.2%) developed metastases and died. The median time(n=92) from diagnosis to metastasis was 9.50 months. The 5- year Kaplan-Meier cumulative survival estimates by clinical tumor categories were 100% for category cT1a, 98% (95% confidence interval[CI], 97-99) for cT1b and cT2a, 96% (95% CI, 95-97) for cT2b, 89%(95% CI, 88-90) for cT3 tumors, and 45%(95% CI, 31-59) for cT4 tumors, respectively. Risk of metastasis increased with increasing cT (and pT) category(p < .001). Cox proportional hazards regression analysis confirmed a higher risk of metastasis in category cT3 (hazard rate [HR], 8.09; 95% CI, 2.55-25.70; p<0.001) and cT4 (HR, 48.55; 95% CI, 12.86-183.27; p< 0.001) compared to category cT1. Age, tumor laterality and presence of heritable trait did not influence the incidence of metastatic disease.Conclusion: Multicenter, international, internet-based data sharing facilitated analysis of the 8th edition AJCC RB Staging System for metastasis-related mortality and offered a proof of concept yielding quantitative, predictive estimates per category in a large, real life, heterogenous RB patient population.
Fil: Singh Tomar, Ankit. The New York Eye Cancer Center; Estados Unidos
Fil: Finger, Paul T.. The New York Eye Cancer Center; Estados Unidos
Fil: Gallie, Brenda. Princess Margaret Cancer Centre; Canadá
Fil: Mallipatna, Ashwin. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Kivelä, Tero T.. University of Helsinki; Finlandia
Fil: Zhang, Chengyue. Beijing Children's Hospital; China
Fil: Zhao, Junyang. Beijing Children's Hospital; China
Fil: Wilson, Matthew W.. University of Tennessee; Estados Unidos
Fil: Brenna, Rachel C.. University of Tennessee; Estados Unidos
Fil: Burges, Michala. University of Tennessee; Estados Unidos
Fil: Kim, Jonathan. The Vision Center at Children's Hospital Los Angeles; Estados Unidos
Fil: Khetan, Vikas. Sankara Nethralaya; India
Fil: Ganesan, Suganeswari. Sankara Nethralaya; India
Fil: Yarovoy, Andrey. The S.N. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Yarovaya, Vera. The S.N. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Kotova, Elena. The S.N. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Yousef, Yacoub A.. King Hussein Cancer Center; Jordania
Fil: Nummi, Kalle. University of Helsinki; Finlandia
Fil: Ushakova, Tatiana L.. N.N. Blokhin National Medical Research Center Oncology of Russian Federation; Rusia
Fil: Yugay, Olga V.. N.N. Blokhin National Medical Research Center Oncology of Russian Federation; Rusia
Fil: Polyakov, Vladimir G.. N.N. Blokhin National Medical Research Center Oncology of Russian Federation; Rusia
Fil: Ramirez Ortiz, Marco A.. Hospital Infantil de México Federico Gómez; México
Fil: Esparza Aguiar, Elizabeth. Hospital Infantil de México Federico Gómez; México
Fil: Chantada, Guillermo Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fandino, Adriana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Yam, Jason C.. The Chinese University of Hong Kong; Hong Kong
Fil: Lau, Winnie W.. The Chinese University of Hong Kong; Hong Kong
Fil: Lam, Carol P.. The Chinese University of Hong Kong; Hong Kong
Fil: Sharwood, Phillipa. University of Sydney; Australia
Fil: Moorthy, Sonia. KK Women’s and Children’s Hospital; Singapur
Fil: Long, Quah Boon. KK Women’s and Children’s Hospital; Singapur
Fil: Essuman, Vera Adobea. University of Ghana; Ghana
Fil: Renner, Lorna A.. University of Ghana; Ghana
Fil: Semenova, Ekaterina. The New York Eye Cancer Center; Estados Unidos
Fil: Català, Jaume. Hospital Sant Joan de Déu; España
Fil: Correa Llano, Genoveva. Hospital Sant Joan de Déu; España
Fil: Carreras, Elisa. Hospital Sant Joan de Déu; España - Materia
-
STAGING SYSTEM
METASTATIC
RETINOBLASTOMA
ONCOLOGY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/156521
Ver los metadatos del registro completo
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A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe SalvageSingh Tomar, AnkitFinger, Paul T.Gallie, BrendaMallipatna, AshwinKivelä, Tero T.Zhang, ChengyueZhao, JunyangWilson, Matthew W.Brenna, Rachel C.Burges, MichalaKim, JonathanKhetan, VikasGanesan, SuganeswariYarovoy, AndreyYarovaya, VeraKotova, ElenaYousef, Yacoub A.Nummi, KalleUshakova, Tatiana L.Yugay, Olga V.Polyakov, Vladimir G.Ramirez Ortiz, Marco A.Esparza Aguiar, ElizabethChantada, Guillermo LuisSchaiquevich, Paula SusanaFandino, AdrianaYam, Jason C.Lau, Winnie W.Lam, Carol P.Sharwood, PhillipaMoorthy, SoniaLong, Quah BoonEssuman, Vera AdobeaRenner, Lorna A.Semenova, EkaterinaCatalà, JaumeCorrea Llano, GenovevaCarreras, ElisaSTAGING SYSTEMMETASTATICRETINOBLASTOMAONCOLOGYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Purpose: To evaluate the ability of the 8th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual to estimate metastatic and mortality rates for children with retinoblastoma(RB).Design: International, multicenter, registry-based retrospective case series PARTICIPANTS: 2190 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents.Methods: Patient-specific data fields for RB were designed by participating eye cancer specialists. All RB patients with adequate records to allow tumor staging by the AJCC criteria and follow-up for metastatic disease were studied.Main outcome measures: Metastasis-related 5- and 10-year survival data after initial tumor staging were estimated with the Kaplan-Meier method depending on AJCC clinical (cTNM) and pathological (pTNM) tumor, node, metastasis category and age, tumor laterality, and presence of heritable trait.Results: Of the 2190 patients, the records of 2085 patients(95.2%) with 2905 eyes were complete. The median age at diagnosis was 17.0 months. 1260 (65.4%) had unilateral RB. Amongst the 2085 patients, tumor categories were cT1a in 55 (2.6%), cT1b 168 (8.1%), cT2a 197 (9.4%), cT2b 812 (38.9%), cT3 835 (40.0%) and cT4 in 18 (0.9%) patients. Of these, 1397 eyes in 1353 patients(48.1%) were treated with enucleation. One hundred and nine patients (5.2%) developed metastases and died. The median time(n=92) from diagnosis to metastasis was 9.50 months. The 5- year Kaplan-Meier cumulative survival estimates by clinical tumor categories were 100% for category cT1a, 98% (95% confidence interval[CI], 97-99) for cT1b and cT2a, 96% (95% CI, 95-97) for cT2b, 89%(95% CI, 88-90) for cT3 tumors, and 45%(95% CI, 31-59) for cT4 tumors, respectively. Risk of metastasis increased with increasing cT (and pT) category(p < .001). Cox proportional hazards regression analysis confirmed a higher risk of metastasis in category cT3 (hazard rate [HR], 8.09; 95% CI, 2.55-25.70; p<0.001) and cT4 (HR, 48.55; 95% CI, 12.86-183.27; p< 0.001) compared to category cT1. Age, tumor laterality and presence of heritable trait did not influence the incidence of metastatic disease.Conclusion: Multicenter, international, internet-based data sharing facilitated analysis of the 8th edition AJCC RB Staging System for metastasis-related mortality and offered a proof of concept yielding quantitative, predictive estimates per category in a large, real life, heterogenous RB patient population.Fil: Singh Tomar, Ankit. The New York Eye Cancer Center; Estados UnidosFil: Finger, Paul T.. The New York Eye Cancer Center; Estados UnidosFil: Gallie, Brenda. Princess Margaret Cancer Centre; CanadáFil: Mallipatna, Ashwin. University Of Toronto. Hospital For Sick Children; CanadáFil: Kivelä, Tero T.. University of Helsinki; FinlandiaFil: Zhang, Chengyue. Beijing Children's Hospital; ChinaFil: Zhao, Junyang. Beijing Children's Hospital; ChinaFil: Wilson, Matthew W.. University of Tennessee; Estados UnidosFil: Brenna, Rachel C.. University of Tennessee; Estados UnidosFil: Burges, Michala. University of Tennessee; Estados UnidosFil: Kim, Jonathan. The Vision Center at Children's Hospital Los Angeles; Estados UnidosFil: Khetan, Vikas. Sankara Nethralaya; IndiaFil: Ganesan, Suganeswari. Sankara Nethralaya; IndiaFil: Yarovoy, Andrey. The S.N. Fyodorov Eye Microsurgery Federal State Institution; RusiaFil: Yarovaya, Vera. The S.N. Fyodorov Eye Microsurgery Federal State Institution; RusiaFil: Kotova, Elena. The S.N. Fyodorov Eye Microsurgery Federal State Institution; RusiaFil: Yousef, Yacoub A.. King Hussein Cancer Center; JordaniaFil: Nummi, Kalle. University of Helsinki; FinlandiaFil: Ushakova, Tatiana L.. N.N. Blokhin National Medical Research Center Oncology of Russian Federation; RusiaFil: Yugay, Olga V.. N.N. Blokhin National Medical Research Center Oncology of Russian Federation; RusiaFil: Polyakov, Vladimir G.. N.N. Blokhin National Medical Research Center Oncology of Russian Federation; RusiaFil: Ramirez Ortiz, Marco A.. Hospital Infantil de México Federico Gómez; MéxicoFil: Esparza Aguiar, Elizabeth. Hospital Infantil de México Federico Gómez; MéxicoFil: Chantada, Guillermo Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fandino, Adriana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Yam, Jason C.. The Chinese University of Hong Kong; Hong KongFil: Lau, Winnie W.. The Chinese University of Hong Kong; Hong KongFil: Lam, Carol P.. The Chinese University of Hong Kong; Hong KongFil: Sharwood, Phillipa. University of Sydney; AustraliaFil: Moorthy, Sonia. KK Women’s and Children’s Hospital; SingapurFil: Long, Quah Boon. KK Women’s and Children’s Hospital; SingapurFil: Essuman, Vera Adobea. University of Ghana; GhanaFil: Renner, Lorna A.. University of Ghana; GhanaFil: Semenova, Ekaterina. The New York Eye Cancer Center; Estados UnidosFil: Català, Jaume. Hospital Sant Joan de Déu; EspañaFil: Correa Llano, Genoveva. Hospital Sant Joan de Déu; EspañaFil: Carreras, Elisa. Hospital Sant Joan de Déu; EspañaElsevier Science Inc.2020-06-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/156521Singh Tomar, Ankit; Finger, Paul T.; Gallie, Brenda; Mallipatna, Ashwin; Kivelä, Tero T.; et al.; A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage; Elsevier Science Inc.; Ophthalmology; 127; 12; 8-6-2020; 1733-17460161-64201549-4713CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.aaojournal.org/article/S0161-6420(20)30524-8/fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ophtha.2020.05.051info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:30Zoai:ri.conicet.gov.ar:11336/156521instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:30.37CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage |
| title |
A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage |
| spellingShingle |
A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage Singh Tomar, Ankit STAGING SYSTEM METASTATIC RETINOBLASTOMA ONCOLOGY |
| title_short |
A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage |
| title_full |
A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage |
| title_fullStr |
A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage |
| title_full_unstemmed |
A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage |
| title_sort |
A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage |
| dc.creator.none.fl_str_mv |
Singh Tomar, Ankit Finger, Paul T. Gallie, Brenda Mallipatna, Ashwin Kivelä, Tero T. Zhang, Chengyue Zhao, Junyang Wilson, Matthew W. Brenna, Rachel C. Burges, Michala Kim, Jonathan Khetan, Vikas Ganesan, Suganeswari Yarovoy, Andrey Yarovaya, Vera Kotova, Elena Yousef, Yacoub A. Nummi, Kalle Ushakova, Tatiana L. Yugay, Olga V. Polyakov, Vladimir G. Ramirez Ortiz, Marco A. Esparza Aguiar, Elizabeth Chantada, Guillermo Luis Schaiquevich, Paula Susana Fandino, Adriana Yam, Jason C. Lau, Winnie W. Lam, Carol P. Sharwood, Phillipa Moorthy, Sonia Long, Quah Boon Essuman, Vera Adobea Renner, Lorna A. Semenova, Ekaterina Català, Jaume Correa Llano, Genoveva Carreras, Elisa |
| author |
Singh Tomar, Ankit |
| author_facet |
Singh Tomar, Ankit Finger, Paul T. Gallie, Brenda Mallipatna, Ashwin Kivelä, Tero T. Zhang, Chengyue Zhao, Junyang Wilson, Matthew W. Brenna, Rachel C. Burges, Michala Kim, Jonathan Khetan, Vikas Ganesan, Suganeswari Yarovoy, Andrey Yarovaya, Vera Kotova, Elena Yousef, Yacoub A. Nummi, Kalle Ushakova, Tatiana L. Yugay, Olga V. Polyakov, Vladimir G. Ramirez Ortiz, Marco A. Esparza Aguiar, Elizabeth Chantada, Guillermo Luis Schaiquevich, Paula Susana Fandino, Adriana Yam, Jason C. Lau, Winnie W. Lam, Carol P. Sharwood, Phillipa Moorthy, Sonia Long, Quah Boon Essuman, Vera Adobea Renner, Lorna A. Semenova, Ekaterina Català, Jaume Correa Llano, Genoveva Carreras, Elisa |
| author_role |
author |
| author2 |
Finger, Paul T. Gallie, Brenda Mallipatna, Ashwin Kivelä, Tero T. Zhang, Chengyue Zhao, Junyang Wilson, Matthew W. Brenna, Rachel C. Burges, Michala Kim, Jonathan Khetan, Vikas Ganesan, Suganeswari Yarovoy, Andrey Yarovaya, Vera Kotova, Elena Yousef, Yacoub A. Nummi, Kalle Ushakova, Tatiana L. Yugay, Olga V. Polyakov, Vladimir G. Ramirez Ortiz, Marco A. Esparza Aguiar, Elizabeth Chantada, Guillermo Luis Schaiquevich, Paula Susana Fandino, Adriana Yam, Jason C. Lau, Winnie W. Lam, Carol P. Sharwood, Phillipa Moorthy, Sonia Long, Quah Boon Essuman, Vera Adobea Renner, Lorna A. Semenova, Ekaterina Català, Jaume Correa Llano, Genoveva Carreras, Elisa |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
STAGING SYSTEM METASTATIC RETINOBLASTOMA ONCOLOGY |
| topic |
STAGING SYSTEM METASTATIC RETINOBLASTOMA ONCOLOGY |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Purpose: To evaluate the ability of the 8th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual to estimate metastatic and mortality rates for children with retinoblastoma(RB).Design: International, multicenter, registry-based retrospective case series PARTICIPANTS: 2190 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents.Methods: Patient-specific data fields for RB were designed by participating eye cancer specialists. All RB patients with adequate records to allow tumor staging by the AJCC criteria and follow-up for metastatic disease were studied.Main outcome measures: Metastasis-related 5- and 10-year survival data after initial tumor staging were estimated with the Kaplan-Meier method depending on AJCC clinical (cTNM) and pathological (pTNM) tumor, node, metastasis category and age, tumor laterality, and presence of heritable trait.Results: Of the 2190 patients, the records of 2085 patients(95.2%) with 2905 eyes were complete. The median age at diagnosis was 17.0 months. 1260 (65.4%) had unilateral RB. Amongst the 2085 patients, tumor categories were cT1a in 55 (2.6%), cT1b 168 (8.1%), cT2a 197 (9.4%), cT2b 812 (38.9%), cT3 835 (40.0%) and cT4 in 18 (0.9%) patients. Of these, 1397 eyes in 1353 patients(48.1%) were treated with enucleation. One hundred and nine patients (5.2%) developed metastases and died. The median time(n=92) from diagnosis to metastasis was 9.50 months. The 5- year Kaplan-Meier cumulative survival estimates by clinical tumor categories were 100% for category cT1a, 98% (95% confidence interval[CI], 97-99) for cT1b and cT2a, 96% (95% CI, 95-97) for cT2b, 89%(95% CI, 88-90) for cT3 tumors, and 45%(95% CI, 31-59) for cT4 tumors, respectively. Risk of metastasis increased with increasing cT (and pT) category(p < .001). Cox proportional hazards regression analysis confirmed a higher risk of metastasis in category cT3 (hazard rate [HR], 8.09; 95% CI, 2.55-25.70; p<0.001) and cT4 (HR, 48.55; 95% CI, 12.86-183.27; p< 0.001) compared to category cT1. Age, tumor laterality and presence of heritable trait did not influence the incidence of metastatic disease.Conclusion: Multicenter, international, internet-based data sharing facilitated analysis of the 8th edition AJCC RB Staging System for metastasis-related mortality and offered a proof of concept yielding quantitative, predictive estimates per category in a large, real life, heterogenous RB patient population. Fil: Singh Tomar, Ankit. The New York Eye Cancer Center; Estados Unidos Fil: Finger, Paul T.. The New York Eye Cancer Center; Estados Unidos Fil: Gallie, Brenda. Princess Margaret Cancer Centre; Canadá Fil: Mallipatna, Ashwin. University Of Toronto. Hospital For Sick Children; Canadá Fil: Kivelä, Tero T.. University of Helsinki; Finlandia Fil: Zhang, Chengyue. Beijing Children's Hospital; China Fil: Zhao, Junyang. Beijing Children's Hospital; China Fil: Wilson, Matthew W.. University of Tennessee; Estados Unidos Fil: Brenna, Rachel C.. University of Tennessee; Estados Unidos Fil: Burges, Michala. University of Tennessee; Estados Unidos Fil: Kim, Jonathan. The Vision Center at Children's Hospital Los Angeles; Estados Unidos Fil: Khetan, Vikas. Sankara Nethralaya; India Fil: Ganesan, Suganeswari. Sankara Nethralaya; India Fil: Yarovoy, Andrey. The S.N. Fyodorov Eye Microsurgery Federal State Institution; Rusia Fil: Yarovaya, Vera. The S.N. Fyodorov Eye Microsurgery Federal State Institution; Rusia Fil: Kotova, Elena. The S.N. Fyodorov Eye Microsurgery Federal State Institution; Rusia Fil: Yousef, Yacoub A.. King Hussein Cancer Center; Jordania Fil: Nummi, Kalle. University of Helsinki; Finlandia Fil: Ushakova, Tatiana L.. N.N. Blokhin National Medical Research Center Oncology of Russian Federation; Rusia Fil: Yugay, Olga V.. N.N. Blokhin National Medical Research Center Oncology of Russian Federation; Rusia Fil: Polyakov, Vladimir G.. N.N. Blokhin National Medical Research Center Oncology of Russian Federation; Rusia Fil: Ramirez Ortiz, Marco A.. Hospital Infantil de México Federico Gómez; México Fil: Esparza Aguiar, Elizabeth. Hospital Infantil de México Federico Gómez; México Fil: Chantada, Guillermo Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Fandino, Adriana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Yam, Jason C.. The Chinese University of Hong Kong; Hong Kong Fil: Lau, Winnie W.. The Chinese University of Hong Kong; Hong Kong Fil: Lam, Carol P.. The Chinese University of Hong Kong; Hong Kong Fil: Sharwood, Phillipa. University of Sydney; Australia Fil: Moorthy, Sonia. KK Women’s and Children’s Hospital; Singapur Fil: Long, Quah Boon. KK Women’s and Children’s Hospital; Singapur Fil: Essuman, Vera Adobea. University of Ghana; Ghana Fil: Renner, Lorna A.. University of Ghana; Ghana Fil: Semenova, Ekaterina. The New York Eye Cancer Center; Estados Unidos Fil: Català, Jaume. Hospital Sant Joan de Déu; España Fil: Correa Llano, Genoveva. Hospital Sant Joan de Déu; España Fil: Carreras, Elisa. Hospital Sant Joan de Déu; España |
| description |
Purpose: To evaluate the ability of the 8th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual to estimate metastatic and mortality rates for children with retinoblastoma(RB).Design: International, multicenter, registry-based retrospective case series PARTICIPANTS: 2190 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents.Methods: Patient-specific data fields for RB were designed by participating eye cancer specialists. All RB patients with adequate records to allow tumor staging by the AJCC criteria and follow-up for metastatic disease were studied.Main outcome measures: Metastasis-related 5- and 10-year survival data after initial tumor staging were estimated with the Kaplan-Meier method depending on AJCC clinical (cTNM) and pathological (pTNM) tumor, node, metastasis category and age, tumor laterality, and presence of heritable trait.Results: Of the 2190 patients, the records of 2085 patients(95.2%) with 2905 eyes were complete. The median age at diagnosis was 17.0 months. 1260 (65.4%) had unilateral RB. Amongst the 2085 patients, tumor categories were cT1a in 55 (2.6%), cT1b 168 (8.1%), cT2a 197 (9.4%), cT2b 812 (38.9%), cT3 835 (40.0%) and cT4 in 18 (0.9%) patients. Of these, 1397 eyes in 1353 patients(48.1%) were treated with enucleation. One hundred and nine patients (5.2%) developed metastases and died. The median time(n=92) from diagnosis to metastasis was 9.50 months. The 5- year Kaplan-Meier cumulative survival estimates by clinical tumor categories were 100% for category cT1a, 98% (95% confidence interval[CI], 97-99) for cT1b and cT2a, 96% (95% CI, 95-97) for cT2b, 89%(95% CI, 88-90) for cT3 tumors, and 45%(95% CI, 31-59) for cT4 tumors, respectively. Risk of metastasis increased with increasing cT (and pT) category(p < .001). Cox proportional hazards regression analysis confirmed a higher risk of metastasis in category cT3 (hazard rate [HR], 8.09; 95% CI, 2.55-25.70; p<0.001) and cT4 (HR, 48.55; 95% CI, 12.86-183.27; p< 0.001) compared to category cT1. Age, tumor laterality and presence of heritable trait did not influence the incidence of metastatic disease.Conclusion: Multicenter, international, internet-based data sharing facilitated analysis of the 8th edition AJCC RB Staging System for metastasis-related mortality and offered a proof of concept yielding quantitative, predictive estimates per category in a large, real life, heterogenous RB patient population. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-06-08 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/156521 Singh Tomar, Ankit; Finger, Paul T.; Gallie, Brenda; Mallipatna, Ashwin; Kivelä, Tero T.; et al.; A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage; Elsevier Science Inc.; Ophthalmology; 127; 12; 8-6-2020; 1733-1746 0161-6420 1549-4713 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/156521 |
| identifier_str_mv |
Singh Tomar, Ankit; Finger, Paul T.; Gallie, Brenda; Mallipatna, Ashwin; Kivelä, Tero T.; et al.; A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma. Part II: Treatment Success and Globe Salvage; Elsevier Science Inc.; Ophthalmology; 127; 12; 8-6-2020; 1733-1746 0161-6420 1549-4713 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.aaojournal.org/article/S0161-6420(20)30524-8/fulltext info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ophtha.2020.05.051 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier Science Inc. |
| publisher.none.fl_str_mv |
Elsevier Science Inc. |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269034800742400 |
| score |
13.13397 |