Global Retinoblastoma Treatment Outcomes: Association with National Income Level

• Autores: Tomar, Ankit Singh; Finger, Paul T.; Gallie, Brenda; Kivelä, Tero T.; Mallipatna, Ashwin; Zhang, Chengyue; Zhao, Junyang; Wilson, Matthew W.; Brenna, Rachel C.; Burges, Michala; Kim, Jonathan; Khetan, Vikas; Ganesan, Suganeswari; Yarovoy, Andrey; Yarovaya, Vera; Kotova, Elena; Yousef, Yacoub A.; Nummi, Kalle; Ushakova, Tatiana L.; Yugay, Olga V.; Polyakov, Vladimir G.; Ramirez Ortiz, Marco A.; Esparza Aguiar, Elizabeth; Chantada, Guillermo Luis; Schaiquevich, Paula Susana; Fandino, Adriana; Yam, Jason C.; Lau, Winnie W.; Lam, Carol P.; Sharwood, Phillipa
• Año de publicación: 2021
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: COUNTRY; GLOBAL; INCOME; OUTCOMES; RETINOBLASTOMA
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Purpose: To compare metastasis-related mortality, local treatment failure, and globe salvage after retinoblastoma in countries with different national income levels.Design: International, multicenter, registry-based retrospective case series.Participants: Two thousand one hundred ninety patients, 18 ophthalmic oncology centers, and 13 countries on 6 continents.Methods: Multicenter registry-based data were pooled from retinoblastoma patients enrolled between January 2001 and December 2013. Adequate data to allow American Joint Committee on Cancer staging, eighth edition, and analysis for the main outcome measures were available for 2085 patients. Each country was classified by national income level, as defined by the 2017 United Nations World Population Prospects, and included high-income countries (HICs), upper middle-income countries (UMICs), and lower middle-income countries (LMICs). Patient survival was estimated with the Kaplan-Meier method. Logistic and Cox proportional hazards regression models were used to determine associations between national income and treatment outcomes.Main outcome measures: Metastasis-related mortality and local treatment failure (defined as use of secondary enucleation or external beam radiation therapy).Results: Most (60%) study patients resided in UMICs and LMICs. The global median age at diagnosis was 17.0 months and higher in UMICs (20.0 months) and LMICs (20.0 months) than HICs (14.0 months; P < 0.001). Patients in UMICs and LMICs reported higher rates of disease-specific metastasis-related mortality and local treatment failure. As compared with HICs, metastasis-related mortality was 10.3-fold higher for UMICs and 9.3-fold higher for LMICs, and the risk for local treatment failure was 2.2-fold and 1.6-fold higher, respectively (all P < 0.001).Conclusions: This international, multicenter, registry-based analysis of retinoblastoma management revealed that lower national income levels were associated with significantly higher rates of metastasis-related mortality, local treatment failure, and lower globe salvage.
Fil: Tomar, Ankit Singh. New York Eye Cancer Center; Estados Unidos
Fil: Finger, Paul T.. New York Eye Cancer Center; Estados Unidos
Fil: Gallie, Brenda. University of Toronto; Canadá
Fil: Kivelä, Tero T.. Helsinki University Hospital; Finlandia. University of Helsinki; Finlandia
Fil: Mallipatna, Ashwin. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Zhang, Chengyue. Beijing Children’s Hospital; China
Fil: Zhao, Junyang. Beijing Children’s Hospital; China
Fil: Wilson, Matthew W.. University of Tennessee; Estados Unidos
Fil: Brenna, Rachel C.. University of Tennessee; Estados Unidos
Fil: Burges, Michala. University of Tennessee; Estados Unidos
Fil: Kim, Jonathan. Keck Medical School of the University of Southern California; Estados Unidos
Fil: Khetan, Vikas. Sankara Nethralaya; India
Fil: Ganesan, Suganeswari. Sankara Nethralaya; India
Fil: Yarovoy, Andrey. The S. N. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Yarovaya, Vera. The S. N. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Kotova, Elena. The S. N. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Yousef, Yacoub A.. King Hussein Cancer Center; Jordania
Fil: Nummi, Kalle. Helsinki University Hospital; Finlandia. University of Helsinki; Finlandia
Fil: Ushakova, Tatiana L.. N. N. Blokhin National Medical Research Center Oncology of Russian Federation; Alemania. Medical Academy of Postgraduate Education; Alemania
Fil: Yugay, Olga V.. N. N. Blokhin National Medical Research Center Oncology of Russian Federation; Alemania
Fil: Polyakov, Vladimir G.. N. N. Blokhin National Medical Research Center Oncology of Russian Federation; Alemania
Fil: Ramirez Ortiz, Marco A.. Hospital Infantil de Mexico Federico Gomez; México
Fil: Esparza Aguiar, Elizabeth. Hospital Infantil de Mexico Federico Gomez; México
Fil: Chantada, Guillermo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Schaiquevich, Paula Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Fandino, Adriana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Yam, Jason C.. Chinese University Of Hong Kong; Hong Kong
Fil: Lau, Winnie W.. Chinese University Of Hong Kong; Hong Kong
Fil: Lam, Carol P.. Chinese University Of Hong Kong; Hong Kong
Fil: Sharwood, Phillipa. University of Sydney; Australia