Retinoblastoma seeds: Impact on American Joint Committee on Cancer clinical staging

• Autores: Tomar, Ankit Singh; Finger, Paul T.; Gallie, Brenda; Kivelä, Tero; Mallipatna, Ashwin; Zhang, Chengyue; Zhao, Junyang; Wilson, Matthew; Brennan, Rachel; Burges, Michala; Kim, Jonathan; Berry, Jesse L.; Jubran, Rima; Khetan, Vikas; Ganeshan, Suganeswari; Yarovoy, Andrey; Yarovaya, Vera; Kotova, Elena; Volodin, Denis; Yousef, Yacoub; Nummi, Kalle; Ushakova, Tatiana L.; Yugay, Olga V.; Polyakov, Vladimir G; Ramirez Ortiz, Marco Antonio; Esparza Aguiar, Elizabeth; Chantada, Guillermo Luis; Schaiquevich, Paula Susana; Fandiño, Adriana Cristina; Yam, Jason C.
• Año de publicación: 2021
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: retinoblastoma; vitreous seeds; treatment; AJCC
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Aim To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. Methods Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 and December 2013. 1054 RB eyes with vitreous or subretinal seeds from 18 ophthalmic oncology centres, in 13 countries within six continents were analysed. Local treatment failure was defined as the use of secondary enucleation or external beam radiation therapy (EBRT) and was estimated with the Kaplan-Meier method. Results Clinical category cT2b included 1054 eyes. Median age at presentation was 16.0 months. Of these, 428 (40.6%) eyes were salvaged, and 430 (40.8%) were treated with primary and 196 (18.6%) with secondary enucleation. Of the 592 eyes that had complete data for globe salvage analysis, the distribution of seeds was focal in 143 (24.2%) and diffuse in 449 (75.8%). The 5-year Kaplan-Meier cumulative globe-salvage (without EBRT) was 78% and 49% for eyes with focal and diffuse RB seeding, respectively. Cox proportional hazards regression analysis confirmed a higher local treatment failure risk with diffuse seeds as compared with focal seeds (hazard rate: 2.8; p<0.001). There was insufficient evidence to prove or disprove an association between vitreous seed type and local treatment failure risk(p=0.06). Conclusion This international, multicentre, registry-based analysis of RB eyes affirmed that eyes with diffuse intraocular distribution of RB seeds at diagnosis had a higher risk of local treatment failure when compared with focal seeds. Subclassification of AJCC RB category cT2b into focal vs diffuse seeds will improve prognostication for eye salvage.
Fil: Tomar, Ankit Singh. New York Eye Cancer Center; Estados Unidos
Fil: Finger, Paul T.. New York Eye Cancer Center; Estados Unidos
Fil: Gallie, Brenda. University Of Toronto. Hospital For Sick Children; Canadá
Fil: Kivelä, Tero. University of Helsinki; Finlandia. Helsinki University Hospital; Finlandia
Fil: Mallipatna, Ashwin. University Of Toronto. Hospital For Sick Children; Canadá. Narayana Nethralaya; India
Fil: Zhang, Chengyue. Beijing Children's Hospital; China
Fil: Zhao, Junyang. Beijing Children's Hospital; China
Fil: Wilson, Matthew. University of Tennessee; Estados Unidos
Fil: Brennan, Rachel. St Jude Children's Research Hospital; Estados Unidos
Fil: Burges, Michala. University of Tennessee; Estados Unidos
Fil: Kim, Jonathan. Keck Medical School of the University of Southern California; Estados Unidos
Fil: Berry, Jesse L.. Children's Hospital Los Angeles; Estados Unidos
Fil: Jubran, Rima. Childrens Hospital Society of Los Angeles; Estados Unidos
Fil: Khetan, Vikas. Vitreo Retinal Services; India
Fil: Ganeshan, Suganeswari. Vitreo Retinal Services; India
Fil: Yarovoy, Andrey. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Yarovaya, Vera. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Kotova, Elena. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Volodin, Denis. Fyodorov Eye Microsurgery Federal State Institution; Rusia
Fil: Yousef, Yacoub. King Hussein Cancer Center; Jordania
Fil: Nummi, Kalle. University of Helsinki; Finlandia. Helsinki University Hospital; Finlandia
Fil: Ushakova, Tatiana L.. N.N. Blokhin Russian Cancer Research Center; Rusia. Russian Academy of Postgraduate Medical Education; Rusia
Fil: Yugay, Olga V.. N.N. Blokhin Russian Cancer Research Center; Rusia
Fil: Polyakov, Vladimir G. N.N. Blokhin Russian Cancer Research Center; Rusia. Russian Academy of Sciences; Rusia
Fil: Ramirez Ortiz, Marco Antonio. Hospital Infantil de Mexico Federico Gomez; México
Fil: Esparza Aguiar, Elizabeth. Hospital Infantil de Mexico Federico Gomez; México
Fil: Chantada, Guillermo Luis. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fandiño, Adriana Cristina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Yam, Jason C.. The Chinese University of Hong Kong Faculty of Medicine; Hong Kong