Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats

Autores
Albarellos, Gabriela Alejandra; Montoya, Laura; Denamiel, G .; Velo, M.; Landoni, Maria Fabiana
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The pharmacokinetic properties and bone concentrations of lincomycin in cats after single intravenous and intramuscular administration at a dose rate of 10 mg/kg were investigated. Lincomycin minimum inhibitory concentration (MIC) for some gram-positive strains isolated from clinical cases was determined. Serum lincomycin disposition was best fitted to a bicompartmental and a monocompartmental open models with first-order elimination after intravenous and intramuscular dosing, respectively.  After intravenous administration, distribution was rapid (T½ (d) 0.22±0.09 h) and wide as reflected by the volume of distribution (V(d(ss))) of 1.24±0.08 L/kg. Plasma clearance was of 0.28±0.09 L/h.kg and elimination half-life (T½) of 3.56±0.62 h. Peak serum concentration (Cmax), Tmax and bioavailability for the intramuscular administration were 7.97±2.31 µg/mL, 0.12±0.05 h and 82.55±23.64% respectively. Thirty to 45 minutes after intravenous administration, lincomycin bone concentrations were 9.31±1.75 µg/mL. At the same time after intramuscular administration, bone concentrations were 3.53±0.28 µg/mL. The corresponding bone/serum ratios were 0.77±0.04 (intravenous) and 0.69±0.18 (intramuscular). Lincomycin MIC for Staphylococcus spp ranged from 0.25 to 16 µg/mL and for Streptococcus spp from 0.25 to 8 µg/mL.
Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Denamiel, G .. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Velo, M.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
LINCOMYCIN
CAT
PHARMACOKINETICS
PHARMACODYNAMICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/273033
Acceder
id CONICETDig_df4852ee746c83d48d084de7dc79222f
oai_identifier_str oai:ri.conicet.gov.ar:11336/273033
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to catsAlbarellos, Gabriela AlejandraMontoya, LauraDenamiel, G .Velo, M.Landoni, Maria FabianaLINCOMYCINCATPHARMACOKINETICSPHARMACODYNAMICShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The pharmacokinetic properties and bone concentrations of lincomycin in cats after single intravenous and intramuscular administration at a dose rate of 10 mg/kg were investigated. Lincomycin minimum inhibitory concentration (MIC) for some gram-positive strains isolated from clinical cases was determined. Serum lincomycin disposition was best fitted to a bicompartmental and a monocompartmental open models with first-order elimination after intravenous and intramuscular dosing, respectively.  After intravenous administration, distribution was rapid (T½ (d) 0.22±0.09 h) and wide as reflected by the volume of distribution (V(d(ss))) of 1.24±0.08 L/kg. Plasma clearance was of 0.28±0.09 L/h.kg and elimination half-life (T½) of 3.56±0.62 h. Peak serum concentration (Cmax), Tmax and bioavailability for the intramuscular administration were 7.97±2.31 µg/mL, 0.12±0.05 h and 82.55±23.64% respectively. Thirty to 45 minutes after intravenous administration, lincomycin bone concentrations were 9.31±1.75 µg/mL. At the same time after intramuscular administration, bone concentrations were 3.53±0.28 µg/mL. The corresponding bone/serum ratios were 0.77±0.04 (intravenous) and 0.69±0.18 (intramuscular). Lincomycin MIC for Staphylococcus spp ranged from 0.25 to 16 µg/mL and for Streptococcus spp from 0.25 to 8 µg/mL.Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Denamiel, G .. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Velo, M.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaWiley Blackwell Publishing, Inc2011-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/273033Albarellos, Gabriela Alejandra; Montoya, Laura; Denamiel, G .; Velo, M.; Landoni, Maria Fabiana; Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; 6; 12-2011; 534-5400140-7783CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2011.01355.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2011.01355.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:23:26Zoai:ri.conicet.gov.ar:11336/273033instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:23:26.962CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats
title Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats
spellingShingle Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats
Albarellos, Gabriela Alejandra
LINCOMYCIN
CAT
PHARMACOKINETICS
PHARMACODYNAMICS
title_short Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats
title_full Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats
title_fullStr Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats
title_full_unstemmed Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats
title_sort Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats
dc.creator.none.fl_str_mv Albarellos, Gabriela Alejandra
Montoya, Laura
Denamiel, G .
Velo, M.
Landoni, Maria Fabiana
author Albarellos, Gabriela Alejandra
author_facet Albarellos, Gabriela Alejandra
Montoya, Laura
Denamiel, G .
Velo, M.
Landoni, Maria Fabiana
author_role author
author2 Montoya, Laura
Denamiel, G .
Velo, M.
Landoni, Maria Fabiana
author2_role author
author
author
author
dc.subject.none.fl_str_mv LINCOMYCIN
CAT
PHARMACOKINETICS
PHARMACODYNAMICS
topic LINCOMYCIN
CAT
PHARMACOKINETICS
PHARMACODYNAMICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The pharmacokinetic properties and bone concentrations of lincomycin in cats after single intravenous and intramuscular administration at a dose rate of 10 mg/kg were investigated. Lincomycin minimum inhibitory concentration (MIC) for some gram-positive strains isolated from clinical cases was determined. Serum lincomycin disposition was best fitted to a bicompartmental and a monocompartmental open models with first-order elimination after intravenous and intramuscular dosing, respectively.  After intravenous administration, distribution was rapid (T½ (d) 0.22±0.09 h) and wide as reflected by the volume of distribution (V(d(ss))) of 1.24±0.08 L/kg. Plasma clearance was of 0.28±0.09 L/h.kg and elimination half-life (T½) of 3.56±0.62 h. Peak serum concentration (Cmax), Tmax and bioavailability for the intramuscular administration were 7.97±2.31 µg/mL, 0.12±0.05 h and 82.55±23.64% respectively. Thirty to 45 minutes after intravenous administration, lincomycin bone concentrations were 9.31±1.75 µg/mL. At the same time after intramuscular administration, bone concentrations were 3.53±0.28 µg/mL. The corresponding bone/serum ratios were 0.77±0.04 (intravenous) and 0.69±0.18 (intramuscular). Lincomycin MIC for Staphylococcus spp ranged from 0.25 to 16 µg/mL and for Streptococcus spp from 0.25 to 8 µg/mL.
Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Denamiel, G .. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Velo, M.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Landoni, Maria Fabiana. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description The pharmacokinetic properties and bone concentrations of lincomycin in cats after single intravenous and intramuscular administration at a dose rate of 10 mg/kg were investigated. Lincomycin minimum inhibitory concentration (MIC) for some gram-positive strains isolated from clinical cases was determined. Serum lincomycin disposition was best fitted to a bicompartmental and a monocompartmental open models with first-order elimination after intravenous and intramuscular dosing, respectively.  After intravenous administration, distribution was rapid (T½ (d) 0.22±0.09 h) and wide as reflected by the volume of distribution (V(d(ss))) of 1.24±0.08 L/kg. Plasma clearance was of 0.28±0.09 L/h.kg and elimination half-life (T½) of 3.56±0.62 h. Peak serum concentration (Cmax), Tmax and bioavailability for the intramuscular administration were 7.97±2.31 µg/mL, 0.12±0.05 h and 82.55±23.64% respectively. Thirty to 45 minutes after intravenous administration, lincomycin bone concentrations were 9.31±1.75 µg/mL. At the same time after intramuscular administration, bone concentrations were 3.53±0.28 µg/mL. The corresponding bone/serum ratios were 0.77±0.04 (intravenous) and 0.69±0.18 (intramuscular). Lincomycin MIC for Staphylococcus spp ranged from 0.25 to 16 µg/mL and for Streptococcus spp from 0.25 to 8 µg/mL.
publishDate 2011
dc.date.none.fl_str_mv 2011-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/273033
Albarellos, Gabriela Alejandra; Montoya, Laura; Denamiel, G .; Velo, M.; Landoni, Maria Fabiana; Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; 6; 12-2011; 534-540
0140-7783
CONICET Digital
CONICET
url http://hdl.handle.net/11336/273033
identifier_str_mv Albarellos, Gabriela Alejandra; Montoya, Laura; Denamiel, G .; Velo, M.; Landoni, Maria Fabiana; Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 35; 6; 12-2011; 534-540
0140-7783
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2885.2011.01355.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2885.2011.01355.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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