Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies

Autores
Gargiulo, Ernesto; Morande, Pablo Elías; Largeot, Anne; Moussay, Etienne; Paggetti, Jérôme
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Extracellular vesicles (EV), comprising microvesicles and exosomes, are particles released by every cell of an organism, found in all biological fluids, and commonly involved in cell-to-cell communication through the transfer of cargo materials such as miRNA, proteins, and immune-related ligands (e.g., FasL and PD-L1). An important characteristic of EV is that their composition, abundance, and roles are tightly related to the parental cells. This translates into a higher release of characteristic pro-tumor EV by cancer cells that leads to harming signals toward healthy microenvironment cells. In line with this, the key role of tumor-derived EV in cancer progression was demonstrated in multiple studies and is considered a hot topic in the field of oncology. Given their characteristics, tumor-derived EV carry important information concerning the state of tumor cells. This can be used to follow the outset, development, and progression of the neoplasia and to evaluate the design of appropriate therapeutic strategies. In keeping with this, the present brief review will focus on B-cell malignancies and how EV can be used as potential biomarkers to follow disease progression and stage. Furthermore, we will explore several proposed strategies aimed at using biologically engineered EV for treatment (e.g., drug delivery mechanisms) as well as for impairing the biogenesis, release, and internalization of cancer-derived EV, with the final objective to disrupt tumor–microenvironment communication.
Fil: Gargiulo, Ernesto. Luxembourg Institute of Health; Luxemburgo
Fil: Morande, Pablo Elías. Luxembourg Institute of Health; Luxemburgo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Largeot, Anne. Luxembourg Institute of Health; Luxemburgo
Fil: Moussay, Etienne. Luxembourg Institute of Health; Luxemburgo
Fil: Paggetti, Jérôme. Luxembourg Institute of Health; Luxemburgo
Materia
CLL
EV-BASED THERAPY
EXOSOME
EXTRACELLULAR VESICLES
LEUKEMIA
LYMPHOMA
MYELOMA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146448
Acceder
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spelling Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell MalignanciesGargiulo, ErnestoMorande, Pablo ElíasLargeot, AnneMoussay, EtiennePaggetti, JérômeCLLEV-BASED THERAPYEXOSOMEEXTRACELLULAR VESICLESLEUKEMIALYMPHOMAMYELOMAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Extracellular vesicles (EV), comprising microvesicles and exosomes, are particles released by every cell of an organism, found in all biological fluids, and commonly involved in cell-to-cell communication through the transfer of cargo materials such as miRNA, proteins, and immune-related ligands (e.g., FasL and PD-L1). An important characteristic of EV is that their composition, abundance, and roles are tightly related to the parental cells. This translates into a higher release of characteristic pro-tumor EV by cancer cells that leads to harming signals toward healthy microenvironment cells. In line with this, the key role of tumor-derived EV in cancer progression was demonstrated in multiple studies and is considered a hot topic in the field of oncology. Given their characteristics, tumor-derived EV carry important information concerning the state of tumor cells. This can be used to follow the outset, development, and progression of the neoplasia and to evaluate the design of appropriate therapeutic strategies. In keeping with this, the present brief review will focus on B-cell malignancies and how EV can be used as potential biomarkers to follow disease progression and stage. Furthermore, we will explore several proposed strategies aimed at using biologically engineered EV for treatment (e.g., drug delivery mechanisms) as well as for impairing the biogenesis, release, and internalization of cancer-derived EV, with the final objective to disrupt tumor–microenvironment communication.Fil: Gargiulo, Ernesto. Luxembourg Institute of Health; LuxemburgoFil: Morande, Pablo Elías. Luxembourg Institute of Health; Luxemburgo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Largeot, Anne. Luxembourg Institute of Health; LuxemburgoFil: Moussay, Etienne. Luxembourg Institute of Health; LuxemburgoFil: Paggetti, Jérôme. Luxembourg Institute of Health; LuxemburgoFrontiers Media2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146448Gargiulo, Ernesto; Morande, Pablo Elías; Largeot, Anne; Moussay, Etienne; Paggetti, Jérôme; Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies; Frontiers Media; Frontiers in Oncology; 10; 580874; 9-2020; 1-92234-943X2234-943XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550802/info:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2020.580874info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fonc.2020.580874/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:11Zoai:ri.conicet.gov.ar:11336/146448instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:11.743CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies
title Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies
spellingShingle Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies
Gargiulo, Ernesto
CLL
EV-BASED THERAPY
EXOSOME
EXTRACELLULAR VESICLES
LEUKEMIA
LYMPHOMA
MYELOMA
title_short Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies
title_full Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies
title_fullStr Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies
title_full_unstemmed Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies
title_sort Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies
dc.creator.none.fl_str_mv Gargiulo, Ernesto
Morande, Pablo Elías
Largeot, Anne
Moussay, Etienne
Paggetti, Jérôme
author Gargiulo, Ernesto
author_facet Gargiulo, Ernesto
Morande, Pablo Elías
Largeot, Anne
Moussay, Etienne
Paggetti, Jérôme
author_role author
author2 Morande, Pablo Elías
Largeot, Anne
Moussay, Etienne
Paggetti, Jérôme
author2_role author
author
author
author
dc.subject.none.fl_str_mv CLL
EV-BASED THERAPY
EXOSOME
EXTRACELLULAR VESICLES
LEUKEMIA
LYMPHOMA
MYELOMA
topic CLL
EV-BASED THERAPY
EXOSOME
EXTRACELLULAR VESICLES
LEUKEMIA
LYMPHOMA
MYELOMA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Extracellular vesicles (EV), comprising microvesicles and exosomes, are particles released by every cell of an organism, found in all biological fluids, and commonly involved in cell-to-cell communication through the transfer of cargo materials such as miRNA, proteins, and immune-related ligands (e.g., FasL and PD-L1). An important characteristic of EV is that their composition, abundance, and roles are tightly related to the parental cells. This translates into a higher release of characteristic pro-tumor EV by cancer cells that leads to harming signals toward healthy microenvironment cells. In line with this, the key role of tumor-derived EV in cancer progression was demonstrated in multiple studies and is considered a hot topic in the field of oncology. Given their characteristics, tumor-derived EV carry important information concerning the state of tumor cells. This can be used to follow the outset, development, and progression of the neoplasia and to evaluate the design of appropriate therapeutic strategies. In keeping with this, the present brief review will focus on B-cell malignancies and how EV can be used as potential biomarkers to follow disease progression and stage. Furthermore, we will explore several proposed strategies aimed at using biologically engineered EV for treatment (e.g., drug delivery mechanisms) as well as for impairing the biogenesis, release, and internalization of cancer-derived EV, with the final objective to disrupt tumor–microenvironment communication.
Fil: Gargiulo, Ernesto. Luxembourg Institute of Health; Luxemburgo
Fil: Morande, Pablo Elías. Luxembourg Institute of Health; Luxemburgo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Largeot, Anne. Luxembourg Institute of Health; Luxemburgo
Fil: Moussay, Etienne. Luxembourg Institute of Health; Luxemburgo
Fil: Paggetti, Jérôme. Luxembourg Institute of Health; Luxemburgo
description Extracellular vesicles (EV), comprising microvesicles and exosomes, are particles released by every cell of an organism, found in all biological fluids, and commonly involved in cell-to-cell communication through the transfer of cargo materials such as miRNA, proteins, and immune-related ligands (e.g., FasL and PD-L1). An important characteristic of EV is that their composition, abundance, and roles are tightly related to the parental cells. This translates into a higher release of characteristic pro-tumor EV by cancer cells that leads to harming signals toward healthy microenvironment cells. In line with this, the key role of tumor-derived EV in cancer progression was demonstrated in multiple studies and is considered a hot topic in the field of oncology. Given their characteristics, tumor-derived EV carry important information concerning the state of tumor cells. This can be used to follow the outset, development, and progression of the neoplasia and to evaluate the design of appropriate therapeutic strategies. In keeping with this, the present brief review will focus on B-cell malignancies and how EV can be used as potential biomarkers to follow disease progression and stage. Furthermore, we will explore several proposed strategies aimed at using biologically engineered EV for treatment (e.g., drug delivery mechanisms) as well as for impairing the biogenesis, release, and internalization of cancer-derived EV, with the final objective to disrupt tumor–microenvironment communication.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146448
Gargiulo, Ernesto; Morande, Pablo Elías; Largeot, Anne; Moussay, Etienne; Paggetti, Jérôme; Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies; Frontiers Media; Frontiers in Oncology; 10; 580874; 9-2020; 1-9
2234-943X
2234-943X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146448
identifier_str_mv Gargiulo, Ernesto; Morande, Pablo Elías; Largeot, Anne; Moussay, Etienne; Paggetti, Jérôme; Diagnostic and Therapeutic Potential of Extracellular Vesicles in B-Cell Malignancies; Frontiers Media; Frontiers in Oncology; 10; 580874; 9-2020; 1-9
2234-943X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550802/
info:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2020.580874
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fonc.2020.580874/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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