Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia

Autores
Vazquez Blanco, Manuel; Ruda Vega, Hilda; Giuliano, Rodolfo; Grana, Daniel Rodolfo; Azzato, Francisco; Lerman, Jorge; Milei, Jose
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The authors hypothesized that preeclampsia may change the phenotype of umbilical cord vessels. Segments of umbilical cords were obtained from 29 pregnant women (20 healthy and 9 with preeclampsia), which were histomorphometrically assessed. Birth weight was 2928 ± 613 g for the control group vs 1749 ± 656 g for the preeclampsia group (P<.0001). A significantly shorter gestational period was noted in the preeclampsia group: 35 weeks vs 39 weeks in the healthy group. Measurements of the outer layer area (116.4 ± 55 ìm(2) vs 56.5±25 ìm(2) ; P=.0038), the inner layer area (63.1 ± 16 ìm(2) vs 28.6±8 ìm(2) ; P<.0001), the lumen area (8.4 ± 1 ìm(2) vs 3.4±2 ìm(2) ; P=.0003), and the wall/lumen ratio (20.3 ± 9 vs 3.1 ± 0.6; P<.0001) of arteries were significantly larger in the preeclampsia umbilical cords. Concerning veins, the wall/lumen ratio was higher in the preeclampsia group. In this study, the umbilical cord in preeclampsia showed significant changes in the structure of umbilical arteries, with increases in wall areas and wall/lumen ratios.
Fil: Vazquez Blanco, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Ruda Vega, Hilda. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Giuliano, Rodolfo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Grana, Daniel Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Azzato, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Lerman, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
PREECLAMPSIA
UMBILICAL ARTERY
UMBILICAL VEIN
PATHOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268242
Acceder
id CONICETDig_dd60545c3aa7b64b2ac4ca9b190dbe95
oai_identifier_str oai:ri.conicet.gov.ar:11336/268242
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Histomorphometry of Umbilical Cord Blood Vessels in PreeclampsiaVazquez Blanco, ManuelRuda Vega, HildaGiuliano, RodolfoGrana, Daniel RodolfoAzzato, FranciscoLerman, JorgeMilei, JosePREECLAMPSIAUMBILICAL ARTERYUMBILICAL VEINPATHOLOGYhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The authors hypothesized that preeclampsia may change the phenotype of umbilical cord vessels. Segments of umbilical cords were obtained from 29 pregnant women (20 healthy and 9 with preeclampsia), which were histomorphometrically assessed. Birth weight was 2928 ± 613 g for the control group vs 1749 ± 656 g for the preeclampsia group (P<.0001). A significantly shorter gestational period was noted in the preeclampsia group: 35 weeks vs 39 weeks in the healthy group. Measurements of the outer layer area (116.4 ± 55 ìm(2) vs 56.5±25 ìm(2) ; P=.0038), the inner layer area (63.1 ± 16 ìm(2) vs 28.6±8 ìm(2) ; P<.0001), the lumen area (8.4 ± 1 ìm(2) vs 3.4±2 ìm(2) ; P=.0003), and the wall/lumen ratio (20.3 ± 9 vs 3.1 ± 0.6; P<.0001) of arteries were significantly larger in the preeclampsia umbilical cords. Concerning veins, the wall/lumen ratio was higher in the preeclampsia group. In this study, the umbilical cord in preeclampsia showed significant changes in the structure of umbilical arteries, with increases in wall areas and wall/lumen ratios.Fil: Vazquez Blanco, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Ruda Vega, Hilda. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Giuliano, Rodolfo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Grana, Daniel Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Azzato, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Lerman, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaWiley Blackwell Publishing, Inc2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268242Vazquez Blanco, Manuel; Ruda Vega, Hilda; Giuliano, Rodolfo; Grana, Daniel Rodolfo; Azzato, Francisco; et al.; Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia; Wiley Blackwell Publishing, Inc; Journal Of Clinical Hypertension; 13; 1; 1-2011; 30-341524-6175CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1751-7176.2010.00384.xinfo:eu-repo/semantics/altIdentifier/doi/ 10.1111/j.1751-7176.2010.00384.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:27Zoai:ri.conicet.gov.ar:11336/268242instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:27.428CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia
title Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia
spellingShingle Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia
Vazquez Blanco, Manuel
PREECLAMPSIA
UMBILICAL ARTERY
UMBILICAL VEIN
PATHOLOGY
title_short Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia
title_full Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia
title_fullStr Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia
title_full_unstemmed Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia
title_sort Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia
dc.creator.none.fl_str_mv Vazquez Blanco, Manuel
Ruda Vega, Hilda
Giuliano, Rodolfo
Grana, Daniel Rodolfo
Azzato, Francisco
Lerman, Jorge
Milei, Jose
author Vazquez Blanco, Manuel
author_facet Vazquez Blanco, Manuel
Ruda Vega, Hilda
Giuliano, Rodolfo
Grana, Daniel Rodolfo
Azzato, Francisco
Lerman, Jorge
Milei, Jose
author_role author
author2 Ruda Vega, Hilda
Giuliano, Rodolfo
Grana, Daniel Rodolfo
Azzato, Francisco
Lerman, Jorge
Milei, Jose
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv PREECLAMPSIA
UMBILICAL ARTERY
UMBILICAL VEIN
PATHOLOGY
topic PREECLAMPSIA
UMBILICAL ARTERY
UMBILICAL VEIN
PATHOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The authors hypothesized that preeclampsia may change the phenotype of umbilical cord vessels. Segments of umbilical cords were obtained from 29 pregnant women (20 healthy and 9 with preeclampsia), which were histomorphometrically assessed. Birth weight was 2928 ± 613 g for the control group vs 1749 ± 656 g for the preeclampsia group (P<.0001). A significantly shorter gestational period was noted in the preeclampsia group: 35 weeks vs 39 weeks in the healthy group. Measurements of the outer layer area (116.4 ± 55 ìm(2) vs 56.5±25 ìm(2) ; P=.0038), the inner layer area (63.1 ± 16 ìm(2) vs 28.6±8 ìm(2) ; P<.0001), the lumen area (8.4 ± 1 ìm(2) vs 3.4±2 ìm(2) ; P=.0003), and the wall/lumen ratio (20.3 ± 9 vs 3.1 ± 0.6; P<.0001) of arteries were significantly larger in the preeclampsia umbilical cords. Concerning veins, the wall/lumen ratio was higher in the preeclampsia group. In this study, the umbilical cord in preeclampsia showed significant changes in the structure of umbilical arteries, with increases in wall areas and wall/lumen ratios.
Fil: Vazquez Blanco, Manuel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Ruda Vega, Hilda. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Giuliano, Rodolfo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Grana, Daniel Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Azzato, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Lerman, Jorge. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description The authors hypothesized that preeclampsia may change the phenotype of umbilical cord vessels. Segments of umbilical cords were obtained from 29 pregnant women (20 healthy and 9 with preeclampsia), which were histomorphometrically assessed. Birth weight was 2928 ± 613 g for the control group vs 1749 ± 656 g for the preeclampsia group (P<.0001). A significantly shorter gestational period was noted in the preeclampsia group: 35 weeks vs 39 weeks in the healthy group. Measurements of the outer layer area (116.4 ± 55 ìm(2) vs 56.5±25 ìm(2) ; P=.0038), the inner layer area (63.1 ± 16 ìm(2) vs 28.6±8 ìm(2) ; P<.0001), the lumen area (8.4 ± 1 ìm(2) vs 3.4±2 ìm(2) ; P=.0003), and the wall/lumen ratio (20.3 ± 9 vs 3.1 ± 0.6; P<.0001) of arteries were significantly larger in the preeclampsia umbilical cords. Concerning veins, the wall/lumen ratio was higher in the preeclampsia group. In this study, the umbilical cord in preeclampsia showed significant changes in the structure of umbilical arteries, with increases in wall areas and wall/lumen ratios.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268242
Vazquez Blanco, Manuel; Ruda Vega, Hilda; Giuliano, Rodolfo; Grana, Daniel Rodolfo; Azzato, Francisco; et al.; Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia; Wiley Blackwell Publishing, Inc; Journal Of Clinical Hypertension; 13; 1; 1-2011; 30-34
1524-6175
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268242
identifier_str_mv Vazquez Blanco, Manuel; Ruda Vega, Hilda; Giuliano, Rodolfo; Grana, Daniel Rodolfo; Azzato, Francisco; et al.; Histomorphometry of Umbilical Cord Blood Vessels in Preeclampsia; Wiley Blackwell Publishing, Inc; Journal Of Clinical Hypertension; 13; 1; 1-2011; 30-34
1524-6175
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/j.1751-7176.2010.00384.x
info:eu-repo/semantics/altIdentifier/doi/ 10.1111/j.1751-7176.2010.00384.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269581137149952
score 13.13397

Publicaciones similares