Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction

Autores
Martín, Pedro; Rebolledo, Alejandro; Roldán Palomo, Ana Rocío; Moncada, Melisa; Piccinini, Luciano; Milesi, María Verónica
Año de publicación
2014
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Through their control of cell membrane potential, potassium (K+) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K+ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca2+-sensitive K+ channel and voltage-dependent K+ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca2+-sensitive K+ channels, 2-pore domains K+ channels and inward rectifier K+ channels also appear to be present in HUASMCs, while intermediate conductance Ca2+-sensitive K+ channels and ATP-sensitive K+ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K+ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.
Grupo de Investigación en Fisiología Vascular
Materia
Biología
Human umbilical artery
K+ channels
Patch-clamp
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/107645
Acceder
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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contractionMartín, PedroRebolledo, AlejandroRoldán Palomo, Ana RocíoMoncada, MelisaPiccinini, LucianoMilesi, María VerónicaBiologíaHuman umbilical arteryK+ channelsPatch-clampThrough their control of cell membrane potential, potassium (K+) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K+ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca2+-sensitive K+ channel and voltage-dependent K+ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca2+-sensitive K+ channels, 2-pore domains K+ channels and inward rectifier K+ channels also appear to be present in HUASMCs, while intermediate conductance Ca2+-sensitive K+ channels and ATP-sensitive K+ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K+ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.Grupo de Investigación en Fisiología Vascular2014info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf432-441http://sedici.unlp.edu.ar/handle/10915/107645enginfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3960844&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/issn/1933-7205info:eu-repo/semantics/altIdentifier/pmid/24084522info:eu-repo/semantics/altIdentifier/doi/10.1177/1933719113504468info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:23:52Zoai:sedici.unlp.edu.ar:10915/107645Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:23:53.069SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
spellingShingle Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
Martín, Pedro
Biología
Human umbilical artery
K+ channels
Patch-clamp
title_short Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title_full Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title_fullStr Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title_full_unstemmed Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title_sort Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
dc.creator.none.fl_str_mv Martín, Pedro
Rebolledo, Alejandro
Roldán Palomo, Ana Rocío
Moncada, Melisa
Piccinini, Luciano
Milesi, María Verónica
author Martín, Pedro
author_facet Martín, Pedro
Rebolledo, Alejandro
Roldán Palomo, Ana Rocío
Moncada, Melisa
Piccinini, Luciano
Milesi, María Verónica
author_role author
author2 Rebolledo, Alejandro
Roldán Palomo, Ana Rocío
Moncada, Melisa
Piccinini, Luciano
Milesi, María Verónica
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Human umbilical artery
K+ channels
Patch-clamp
topic Biología
Human umbilical artery
K+ channels
Patch-clamp
dc.description.none.fl_txt_mv Through their control of cell membrane potential, potassium (K+) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K+ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca2+-sensitive K+ channel and voltage-dependent K+ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca2+-sensitive K+ channels, 2-pore domains K+ channels and inward rectifier K+ channels also appear to be present in HUASMCs, while intermediate conductance Ca2+-sensitive K+ channels and ATP-sensitive K+ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K+ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.
Grupo de Investigación en Fisiología Vascular
description Through their control of cell membrane potential, potassium (K+) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K+ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca2+-sensitive K+ channel and voltage-dependent K+ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca2+-sensitive K+ channels, 2-pore domains K+ channels and inward rectifier K+ channels also appear to be present in HUASMCs, while intermediate conductance Ca2+-sensitive K+ channels and ATP-sensitive K+ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K+ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/review
info:eu-repo/semantics/publishedVersion
Revision
http://purl.org/coar/resource_type/c_dcae04bc
info:ar-repo/semantics/resenaArticulo
format review
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/107645
url http://sedici.unlp.edu.ar/handle/10915/107645
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3960844&blobtype=pdf
info:eu-repo/semantics/altIdentifier/issn/1933-7205
info:eu-repo/semantics/altIdentifier/pmid/24084522
info:eu-repo/semantics/altIdentifier/doi/10.1177/1933719113504468
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
432-441
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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