Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction

Autores
Martín, Pedro; Rebolledo, Alejandro; Roldan Palomo, Ana Rocio; Moncada, Melisa; Piccinini, Luciano; Milesi, Verónica
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Through their control of cell membrane potential, potassium (K(+)) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K(+) channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca(2+)-sensitive K(+) channel and voltage-dependent K(+) channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca(2+)-sensitive K(+) channels, 2-pore domains K(+) channels and inward rectifier K(+) channels also appear to be present in HUASMCs, while intermediate conductance Ca(2+)-sensitive K(+) channels and ATP-sensitive K(+) channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K(+) channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.
Fil: Martín, Pedro. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Rebolledo, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Roldan Palomo, Ana Rocio. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Moncada, Melisa. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Piccinini, Luciano. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Milesi, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Materia
K+ Channels
Human Umbilical Artery
Patch-Clamp
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32503
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery ContractionMartín, PedroRebolledo, AlejandroRoldan Palomo, Ana RocioMoncada, MelisaPiccinini, LucianoMilesi, VerónicaK+ ChannelsHuman Umbilical ArteryPatch-Clamphttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Through their control of cell membrane potential, potassium (K(+)) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K(+) channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca(2+)-sensitive K(+) channel and voltage-dependent K(+) channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca(2+)-sensitive K(+) channels, 2-pore domains K(+) channels and inward rectifier K(+) channels also appear to be present in HUASMCs, while intermediate conductance Ca(2+)-sensitive K(+) channels and ATP-sensitive K(+) channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K(+) channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.Fil: Martín, Pedro. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; ArgentinaFil: Rebolledo, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; ArgentinaFil: Roldan Palomo, Ana Rocio. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; ArgentinaFil: Moncada, Melisa. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; ArgentinaFil: Piccinini, Luciano. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; ArgentinaFil: Milesi, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; ArgentinaSage Publications2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32503Martín, Pedro; Rebolledo, Alejandro; Roldan Palomo, Ana Rocio; Moncada, Melisa; Piccinini, Luciano; et al.; Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction; Sage Publications; Reproductive Sciences; 21; 4; 4-2014; 432-4411933-7191CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1177/1933719113504468info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1933719113504468info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:06Zoai:ri.conicet.gov.ar:11336/32503instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:07.196CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction
title Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction
spellingShingle Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction
Martín, Pedro
K+ Channels
Human Umbilical Artery
Patch-Clamp
title_short Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction
title_full Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction
title_fullStr Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction
title_full_unstemmed Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction
title_sort Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction
dc.creator.none.fl_str_mv Martín, Pedro
Rebolledo, Alejandro
Roldan Palomo, Ana Rocio
Moncada, Melisa
Piccinini, Luciano
Milesi, Verónica
author Martín, Pedro
author_facet Martín, Pedro
Rebolledo, Alejandro
Roldan Palomo, Ana Rocio
Moncada, Melisa
Piccinini, Luciano
Milesi, Verónica
author_role author
author2 Rebolledo, Alejandro
Roldan Palomo, Ana Rocio
Moncada, Melisa
Piccinini, Luciano
Milesi, Verónica
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv K+ Channels
Human Umbilical Artery
Patch-Clamp
topic K+ Channels
Human Umbilical Artery
Patch-Clamp
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Through their control of cell membrane potential, potassium (K(+)) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K(+) channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca(2+)-sensitive K(+) channel and voltage-dependent K(+) channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca(2+)-sensitive K(+) channels, 2-pore domains K(+) channels and inward rectifier K(+) channels also appear to be present in HUASMCs, while intermediate conductance Ca(2+)-sensitive K(+) channels and ATP-sensitive K(+) channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K(+) channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.
Fil: Martín, Pedro. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Rebolledo, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Roldan Palomo, Ana Rocio. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Moncada, Melisa. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Piccinini, Luciano. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
Fil: Milesi, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Grupo de Investigación en Fisiología Vascular; Argentina
description Through their control of cell membrane potential, potassium (K(+)) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K(+) channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca(2+)-sensitive K(+) channel and voltage-dependent K(+) channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca(2+)-sensitive K(+) channels, 2-pore domains K(+) channels and inward rectifier K(+) channels also appear to be present in HUASMCs, while intermediate conductance Ca(2+)-sensitive K(+) channels and ATP-sensitive K(+) channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K(+) channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32503
Martín, Pedro; Rebolledo, Alejandro; Roldan Palomo, Ana Rocio; Moncada, Melisa; Piccinini, Luciano; et al.; Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction; Sage Publications; Reproductive Sciences; 21; 4; 4-2014; 432-441
1933-7191
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32503
identifier_str_mv Martín, Pedro; Rebolledo, Alejandro; Roldan Palomo, Ana Rocio; Moncada, Melisa; Piccinini, Luciano; et al.; Diversity of Potassium Channels in Human Umbilical Artery Smooth Muscle Cells: A Review of Their Roles in Human Umbilical Artery Contraction; Sage Publications; Reproductive Sciences; 21; 4; 4-2014; 432-441
1933-7191
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1177/1933719113504468
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/1933719113504468
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sage Publications
publisher.none.fl_str_mv Sage Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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