Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes
- Autores
- Belli, Carolina Bárbara; Bestach, Yesica Soledad; Kornblihtt, Laura Inés; Larripa, Irene Beatriz
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Myelodysplastic Syndromes (MDS) are a heterogeneous group of hematological diseases characterized by refractory cytopenia(s) and variable risk of leukemic progression. Cytogenetic analysis is important in day-to-day clinical practice helping to define subgroups of MDS patients who share similarities in the course of the disease. There are recurring aberrations affecting chromosomes 5, 7, 8, and 20. While all of them do not suggest a therapeutic approach, their presence has been considered as a risk indicator since the original international prognostic scoring system (IPSS) was published. The most recent cytogenetic stratifications tried to find the prognostic significance of less frequent alterations which have been longer included in the intermediate group. Moreover, monitoring of karyotype changes is suggested to evaluate cytogenetic response to treatments and the acquisition of new aberrations associated to an unfavorable outcome. This review focuses on different cytogenetic risk stratifications that have been published during the past twenty years and the molecular background of the most relevant chromosomal findings.
Fil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Bestach, Yesica Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Kornblihtt, Laura Inés. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; Argentina
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina - Materia
-
Síndromes Mielodiasplasicos
Citogenética
Pronostico
Cariotipo - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/78643
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Prognostic Implications of Cytogenetic Features in Myelodysplastic SyndromesBelli, Carolina BárbaraBestach, Yesica SoledadKornblihtt, Laura InésLarripa, Irene BeatrizSíndromes MielodiasplasicosCitogenéticaPronosticoCariotipohttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Myelodysplastic Syndromes (MDS) are a heterogeneous group of hematological diseases characterized by refractory cytopenia(s) and variable risk of leukemic progression. Cytogenetic analysis is important in day-to-day clinical practice helping to define subgroups of MDS patients who share similarities in the course of the disease. There are recurring aberrations affecting chromosomes 5, 7, 8, and 20. While all of them do not suggest a therapeutic approach, their presence has been considered as a risk indicator since the original international prognostic scoring system (IPSS) was published. The most recent cytogenetic stratifications tried to find the prognostic significance of less frequent alterations which have been longer included in the intermediate group. Moreover, monitoring of karyotype changes is suggested to evaluate cytogenetic response to treatments and the acquisition of new aberrations associated to an unfavorable outcome. This review focuses on different cytogenetic risk stratifications that have been published during the past twenty years and the molecular background of the most relevant chromosomal findings.Fil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Bestach, Yesica Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Kornblihtt, Laura Inés. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; ArgentinaFil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaLondon Touch Briefing2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/78643Belli, Carolina Bárbara; Bestach, Yesica Soledad; Kornblihtt, Laura Inés; Larripa, Irene Beatriz; Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes; London Touch Briefing; Oncology & Hematology Review (US); 9; 1; 1-2013; 60-672052-3815CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.17925/OHR.2013.09.1.60info:eu-repo/semantics/altIdentifier/url/https://touchoncology.com/prognostic-implications-of-cytogenetic-features-in-myelodysplastic-syndromes/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:39:22Zoai:ri.conicet.gov.ar:11336/78643instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:39:22.672CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes |
title |
Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes |
spellingShingle |
Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes Belli, Carolina Bárbara Síndromes Mielodiasplasicos Citogenética Pronostico Cariotipo |
title_short |
Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes |
title_full |
Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes |
title_fullStr |
Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes |
title_full_unstemmed |
Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes |
title_sort |
Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes |
dc.creator.none.fl_str_mv |
Belli, Carolina Bárbara Bestach, Yesica Soledad Kornblihtt, Laura Inés Larripa, Irene Beatriz |
author |
Belli, Carolina Bárbara |
author_facet |
Belli, Carolina Bárbara Bestach, Yesica Soledad Kornblihtt, Laura Inés Larripa, Irene Beatriz |
author_role |
author |
author2 |
Bestach, Yesica Soledad Kornblihtt, Laura Inés Larripa, Irene Beatriz |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Síndromes Mielodiasplasicos Citogenética Pronostico Cariotipo |
topic |
Síndromes Mielodiasplasicos Citogenética Pronostico Cariotipo |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Myelodysplastic Syndromes (MDS) are a heterogeneous group of hematological diseases characterized by refractory cytopenia(s) and variable risk of leukemic progression. Cytogenetic analysis is important in day-to-day clinical practice helping to define subgroups of MDS patients who share similarities in the course of the disease. There are recurring aberrations affecting chromosomes 5, 7, 8, and 20. While all of them do not suggest a therapeutic approach, their presence has been considered as a risk indicator since the original international prognostic scoring system (IPSS) was published. The most recent cytogenetic stratifications tried to find the prognostic significance of less frequent alterations which have been longer included in the intermediate group. Moreover, monitoring of karyotype changes is suggested to evaluate cytogenetic response to treatments and the acquisition of new aberrations associated to an unfavorable outcome. This review focuses on different cytogenetic risk stratifications that have been published during the past twenty years and the molecular background of the most relevant chromosomal findings. Fil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Bestach, Yesica Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Kornblihtt, Laura Inés. Provincia de Buenos Aires. Hospital Interzonal General de Agudos Gral. San Martin; Argentina Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina |
description |
Myelodysplastic Syndromes (MDS) are a heterogeneous group of hematological diseases characterized by refractory cytopenia(s) and variable risk of leukemic progression. Cytogenetic analysis is important in day-to-day clinical practice helping to define subgroups of MDS patients who share similarities in the course of the disease. There are recurring aberrations affecting chromosomes 5, 7, 8, and 20. While all of them do not suggest a therapeutic approach, their presence has been considered as a risk indicator since the original international prognostic scoring system (IPSS) was published. The most recent cytogenetic stratifications tried to find the prognostic significance of less frequent alterations which have been longer included in the intermediate group. Moreover, monitoring of karyotype changes is suggested to evaluate cytogenetic response to treatments and the acquisition of new aberrations associated to an unfavorable outcome. This review focuses on different cytogenetic risk stratifications that have been published during the past twenty years and the molecular background of the most relevant chromosomal findings. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/78643 Belli, Carolina Bárbara; Bestach, Yesica Soledad; Kornblihtt, Laura Inés; Larripa, Irene Beatriz; Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes; London Touch Briefing; Oncology & Hematology Review (US); 9; 1; 1-2013; 60-67 2052-3815 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/78643 |
identifier_str_mv |
Belli, Carolina Bárbara; Bestach, Yesica Soledad; Kornblihtt, Laura Inés; Larripa, Irene Beatriz; Prognostic Implications of Cytogenetic Features in Myelodysplastic Syndromes; London Touch Briefing; Oncology & Hematology Review (US); 9; 1; 1-2013; 60-67 2052-3815 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.17925/OHR.2013.09.1.60 info:eu-repo/semantics/altIdentifier/url/https://touchoncology.com/prognostic-implications-of-cytogenetic-features-in-myelodysplastic-syndromes/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
London Touch Briefing |
publisher.none.fl_str_mv |
London Touch Briefing |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.22299 |