Myelodysplastic syndromes in South America: A multinational study of 1080 patients

Autores
Belli, Carolina Bárbara; Pinheiro, Ronald Feitosa; Bestach, Yesica Soledad; Larripa, Irene Beatriz; da Silva Tanizawa, Roberta Sandra; Alfonso, Graciela; Gonzalez, Jacqueline; Rosenhain, Mariana; Watman, Nora; Cavalcante de Andrade Silva, Marcela; Negri Aranguren, Pedro; Garcia Rivello, Hernan Jorge; Magalhaes, Silvia M. M.; Valladares, Ximena; Undurraga, María S.; Velloso, Elvira R. P.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There are previously reported data describing differences between Asian and European patients with Myelodysplastic Syndromes (MDS), few direct comparisons based on cancer registration characteristics or using cohorts to validate scoring systems. This is the first study from South-America, which attempts to describe demographic, clinical features, and outcome of MDS patients. We retrospectively analyzed 1,080 patients with de novo MDS from Argentina (635), Brazil (345), and Chile (100). Chilean patients were younger (P=0.001) with female preponderance (P=0.071). Brazilian series showed a higher predominance of RARS subtype regarding FAB and WHO classifications (P<0.001). Hemoglobin levels were significantly lower in Brazilian and Chilean series (P<0.001), and Chilean series also showed a lower platelet count (P=0.028), with no differences concerning the neutrophil count, % BM blast, and the distribution of cytogenetic risk groups (P>0.05). Chilean series depicted a lower overall survival (OS; 35 months vs. 56 months-Argentine; 55 months-Brazil, P=0.030), which was consistent with a higher predominance of the high-risk group according both to the IPSS and IPSS-R (P=0.046 and P<0.001). The IPSS-R system and its variables showed a good reproducibility to predict clinical outcome for the whole South-American population. Epidemiological and clinical characteristics, distribution among prognostic subgroups, the OS, and the access to disease modifying therapies were more similar between Argentinean and Brazilian compared with Chilean MDS series. This will need further analysis in a larger group of patients. Descriptive and comparative studies are necessary to establish epidemiological features useful for public health attitudes to generate suitable therapeutic schemes.
Fil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Pinheiro, Ronald Feitosa. Universidade Estadual do Ceará; Brasil
Fil: Bestach, Yesica Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: da Silva Tanizawa, Roberta Sandra. Universidade de Sao Paulo; Brasil
Fil: Alfonso, Graciela. Hospital General de Agudos “A. J. Posadas”; Argentina
Fil: Gonzalez, Jacqueline. Hospital General de Agudos “C Durand"; Argentina
Fil: Rosenhain, Mariana. Hospital General de Agudos “Tornu"; Argentina
Fil: Watman, Nora. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Cavalcante de Andrade Silva, Marcela. Universidade de Sao Paulo; Brasil
Fil: Negri Aranguren, Pedro. Instituto Privado de Hematologia y Hemoterapia; Argentina
Fil: Garcia Rivello, Hernan Jorge. Hospital Italiano; Argentina
Fil: Magalhaes, Silvia M. M.. Federal University of Ceara; Brasil
Fil: Valladares, Ximena. Hospital Del Salvador; Chile
Fil: Undurraga, María S.. Hospital Del Salvador; Chile
Fil: Velloso, Elvira R. P.. Universidade de Sao Paulo; Brasil
Materia
Smd
Pronóstico
Citogenética
Ipss
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85223
Acceder
id CONICETDig_3244a6a20116bffdb4271c480fb700bd
oai_identifier_str oai:ri.conicet.gov.ar:11336/85223
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Myelodysplastic syndromes in South America: A multinational study of 1080 patientsBelli, Carolina BárbaraPinheiro, Ronald FeitosaBestach, Yesica SoledadLarripa, Irene Beatrizda Silva Tanizawa, Roberta SandraAlfonso, GracielaGonzalez, JacquelineRosenhain, MarianaWatman, NoraCavalcante de Andrade Silva, MarcelaNegri Aranguren, PedroGarcia Rivello, Hernan JorgeMagalhaes, Silvia M. M.Valladares, XimenaUndurraga, María S.Velloso, Elvira R. P.SmdPronósticoCitogenéticaIpsshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3There are previously reported data describing differences between Asian and European patients with Myelodysplastic Syndromes (MDS), few direct comparisons based on cancer registration characteristics or using cohorts to validate scoring systems. This is the first study from South-America, which attempts to describe demographic, clinical features, and outcome of MDS patients. We retrospectively analyzed 1,080 patients with de novo MDS from Argentina (635), Brazil (345), and Chile (100). Chilean patients were younger (P=0.001) with female preponderance (P=0.071). Brazilian series showed a higher predominance of RARS subtype regarding FAB and WHO classifications (P<0.001). Hemoglobin levels were significantly lower in Brazilian and Chilean series (P<0.001), and Chilean series also showed a lower platelet count (P=0.028), with no differences concerning the neutrophil count, % BM blast, and the distribution of cytogenetic risk groups (P>0.05). Chilean series depicted a lower overall survival (OS; 35 months vs. 56 months-Argentine; 55 months-Brazil, P=0.030), which was consistent with a higher predominance of the high-risk group according both to the IPSS and IPSS-R (P=0.046 and P<0.001). The IPSS-R system and its variables showed a good reproducibility to predict clinical outcome for the whole South-American population. Epidemiological and clinical characteristics, distribution among prognostic subgroups, the OS, and the access to disease modifying therapies were more similar between Argentinean and Brazilian compared with Chilean MDS series. This will need further analysis in a larger group of patients. Descriptive and comparative studies are necessary to establish epidemiological features useful for public health attitudes to generate suitable therapeutic schemes.Fil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Pinheiro, Ronald Feitosa. Universidade Estadual do Ceará; BrasilFil: Bestach, Yesica Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: da Silva Tanizawa, Roberta Sandra. Universidade de Sao Paulo; BrasilFil: Alfonso, Graciela. Hospital General de Agudos “A. J. Posadas”; ArgentinaFil: Gonzalez, Jacqueline. Hospital General de Agudos “C Durand"; ArgentinaFil: Rosenhain, Mariana. Hospital General de Agudos “Tornu"; ArgentinaFil: Watman, Nora. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Cavalcante de Andrade Silva, Marcela. Universidade de Sao Paulo; BrasilFil: Negri Aranguren, Pedro. Instituto Privado de Hematologia y Hemoterapia; ArgentinaFil: Garcia Rivello, Hernan Jorge. Hospital Italiano; ArgentinaFil: Magalhaes, Silvia M. M.. Federal University of Ceara; BrasilFil: Valladares, Ximena. Hospital Del Salvador; ChileFil: Undurraga, María S.. Hospital Del Salvador; ChileFil: Velloso, Elvira R. P.. Universidade de Sao Paulo; BrasilWiley-liss, Div John Wiley & Sons Inc2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85223Belli, Carolina Bárbara; Pinheiro, Ronald Feitosa; Bestach, Yesica Soledad; Larripa, Irene Beatriz; da Silva Tanizawa, Roberta Sandra; et al.; Myelodysplastic syndromes in South America: A multinational study of 1080 patients; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Hematology; 90; 10; 10-2015; 851-8580361-8609CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/ajh.24097info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.24097info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:58:25Zoai:ri.conicet.gov.ar:11336/85223instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:58:26.037CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Myelodysplastic syndromes in South America: A multinational study of 1080 patients
title Myelodysplastic syndromes in South America: A multinational study of 1080 patients
spellingShingle Myelodysplastic syndromes in South America: A multinational study of 1080 patients
Belli, Carolina Bárbara
Smd
Pronóstico
Citogenética
Ipss
title_short Myelodysplastic syndromes in South America: A multinational study of 1080 patients
title_full Myelodysplastic syndromes in South America: A multinational study of 1080 patients
title_fullStr Myelodysplastic syndromes in South America: A multinational study of 1080 patients
title_full_unstemmed Myelodysplastic syndromes in South America: A multinational study of 1080 patients
title_sort Myelodysplastic syndromes in South America: A multinational study of 1080 patients
dc.creator.none.fl_str_mv Belli, Carolina Bárbara
Pinheiro, Ronald Feitosa
Bestach, Yesica Soledad
Larripa, Irene Beatriz
da Silva Tanizawa, Roberta Sandra
Alfonso, Graciela
Gonzalez, Jacqueline
Rosenhain, Mariana
Watman, Nora
Cavalcante de Andrade Silva, Marcela
Negri Aranguren, Pedro
Garcia Rivello, Hernan Jorge
Magalhaes, Silvia M. M.
Valladares, Ximena
Undurraga, María S.
Velloso, Elvira R. P.
author Belli, Carolina Bárbara
author_facet Belli, Carolina Bárbara
Pinheiro, Ronald Feitosa
Bestach, Yesica Soledad
Larripa, Irene Beatriz
da Silva Tanizawa, Roberta Sandra
Alfonso, Graciela
Gonzalez, Jacqueline
Rosenhain, Mariana
Watman, Nora
Cavalcante de Andrade Silva, Marcela
Negri Aranguren, Pedro
Garcia Rivello, Hernan Jorge
Magalhaes, Silvia M. M.
Valladares, Ximena
Undurraga, María S.
Velloso, Elvira R. P.
author_role author
author2 Pinheiro, Ronald Feitosa
Bestach, Yesica Soledad
Larripa, Irene Beatriz
da Silva Tanizawa, Roberta Sandra
Alfonso, Graciela
Gonzalez, Jacqueline
Rosenhain, Mariana
Watman, Nora
Cavalcante de Andrade Silva, Marcela
Negri Aranguren, Pedro
Garcia Rivello, Hernan Jorge
Magalhaes, Silvia M. M.
Valladares, Ximena
Undurraga, María S.
Velloso, Elvira R. P.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Smd
Pronóstico
Citogenética
Ipss
topic Smd
Pronóstico
Citogenética
Ipss
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv There are previously reported data describing differences between Asian and European patients with Myelodysplastic Syndromes (MDS), few direct comparisons based on cancer registration characteristics or using cohorts to validate scoring systems. This is the first study from South-America, which attempts to describe demographic, clinical features, and outcome of MDS patients. We retrospectively analyzed 1,080 patients with de novo MDS from Argentina (635), Brazil (345), and Chile (100). Chilean patients were younger (P=0.001) with female preponderance (P=0.071). Brazilian series showed a higher predominance of RARS subtype regarding FAB and WHO classifications (P<0.001). Hemoglobin levels were significantly lower in Brazilian and Chilean series (P<0.001), and Chilean series also showed a lower platelet count (P=0.028), with no differences concerning the neutrophil count, % BM blast, and the distribution of cytogenetic risk groups (P>0.05). Chilean series depicted a lower overall survival (OS; 35 months vs. 56 months-Argentine; 55 months-Brazil, P=0.030), which was consistent with a higher predominance of the high-risk group according both to the IPSS and IPSS-R (P=0.046 and P<0.001). The IPSS-R system and its variables showed a good reproducibility to predict clinical outcome for the whole South-American population. Epidemiological and clinical characteristics, distribution among prognostic subgroups, the OS, and the access to disease modifying therapies were more similar between Argentinean and Brazilian compared with Chilean MDS series. This will need further analysis in a larger group of patients. Descriptive and comparative studies are necessary to establish epidemiological features useful for public health attitudes to generate suitable therapeutic schemes.
Fil: Belli, Carolina Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Pinheiro, Ronald Feitosa. Universidade Estadual do Ceará; Brasil
Fil: Bestach, Yesica Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: da Silva Tanizawa, Roberta Sandra. Universidade de Sao Paulo; Brasil
Fil: Alfonso, Graciela. Hospital General de Agudos “A. J. Posadas”; Argentina
Fil: Gonzalez, Jacqueline. Hospital General de Agudos “C Durand"; Argentina
Fil: Rosenhain, Mariana. Hospital General de Agudos “Tornu"; Argentina
Fil: Watman, Nora. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Cavalcante de Andrade Silva, Marcela. Universidade de Sao Paulo; Brasil
Fil: Negri Aranguren, Pedro. Instituto Privado de Hematologia y Hemoterapia; Argentina
Fil: Garcia Rivello, Hernan Jorge. Hospital Italiano; Argentina
Fil: Magalhaes, Silvia M. M.. Federal University of Ceara; Brasil
Fil: Valladares, Ximena. Hospital Del Salvador; Chile
Fil: Undurraga, María S.. Hospital Del Salvador; Chile
Fil: Velloso, Elvira R. P.. Universidade de Sao Paulo; Brasil
description There are previously reported data describing differences between Asian and European patients with Myelodysplastic Syndromes (MDS), few direct comparisons based on cancer registration characteristics or using cohorts to validate scoring systems. This is the first study from South-America, which attempts to describe demographic, clinical features, and outcome of MDS patients. We retrospectively analyzed 1,080 patients with de novo MDS from Argentina (635), Brazil (345), and Chile (100). Chilean patients were younger (P=0.001) with female preponderance (P=0.071). Brazilian series showed a higher predominance of RARS subtype regarding FAB and WHO classifications (P<0.001). Hemoglobin levels were significantly lower in Brazilian and Chilean series (P<0.001), and Chilean series also showed a lower platelet count (P=0.028), with no differences concerning the neutrophil count, % BM blast, and the distribution of cytogenetic risk groups (P>0.05). Chilean series depicted a lower overall survival (OS; 35 months vs. 56 months-Argentine; 55 months-Brazil, P=0.030), which was consistent with a higher predominance of the high-risk group according both to the IPSS and IPSS-R (P=0.046 and P<0.001). The IPSS-R system and its variables showed a good reproducibility to predict clinical outcome for the whole South-American population. Epidemiological and clinical characteristics, distribution among prognostic subgroups, the OS, and the access to disease modifying therapies were more similar between Argentinean and Brazilian compared with Chilean MDS series. This will need further analysis in a larger group of patients. Descriptive and comparative studies are necessary to establish epidemiological features useful for public health attitudes to generate suitable therapeutic schemes.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85223
Belli, Carolina Bárbara; Pinheiro, Ronald Feitosa; Bestach, Yesica Soledad; Larripa, Irene Beatriz; da Silva Tanizawa, Roberta Sandra; et al.; Myelodysplastic syndromes in South America: A multinational study of 1080 patients; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Hematology; 90; 10; 10-2015; 851-858
0361-8609
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85223
identifier_str_mv Belli, Carolina Bárbara; Pinheiro, Ronald Feitosa; Bestach, Yesica Soledad; Larripa, Irene Beatriz; da Silva Tanizawa, Roberta Sandra; et al.; Myelodysplastic syndromes in South America: A multinational study of 1080 patients; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Hematology; 90; 10; 10-2015; 851-858
0361-8609
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/ajh.24097
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.24097
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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