Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis

Autores
Rudzinski, Marcelo Nicolas; Argüelles, Carina; Couto, Cristóbal; Oubiña, Jose Raul; Reina, Silvia Lorena
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: The purpose of this article is to analyze possible associations between systemic and ocular cytokine levels and specific clinical ophthalmologic signs from patients with a reactivation of toxoplasmic retinochoroiditis (RTR). Methods: A total of 18 patients with an active RTR episode, 8 patients with inactive scars, and 14 control patients were included in the study. Serum samples and aqueous humor (AH) samples were analyzed for IFN (interferon)-ã, interleukin (IL)-10, and IL-6 levels by ELISA. Inflammation grade, location, and size of the retinochoroidal active lesion, sampling time, and time to resolution were recorded. Results: A significantly negative correlation between AH and serum levels of IFN-ã was detected (p < 0.05). Patients with an AH IFN-ã/IL-10 ratio lower than 1 were associated with the longest time to resolution and/or severe complications. Conclusion: Serum IFN-ã levels may be used as a prognostic marker for both time to resolution and the development of possible severe complications during a given RTR episode.
Fil: Rudzinski, Marcelo Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Las Misiones; Argentina
Fil: Argüelles, Carina. Universidad Catolica de Las Misiones; Argentina
Fil: Couto, Cristóbal. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Oubiña, Jose Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Las Misiones; Argentina
Materia
ARGENTINA
IMMUNE RESPONSE
RETINOCHOROIDITIS
TOXOPLASMOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/156779
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic RetinochoroiditisRudzinski, Marcelo NicolasArgüelles, CarinaCouto, CristóbalOubiña, Jose RaulReina, Silvia LorenaARGENTINAIMMUNE RESPONSERETINOCHOROIDITISTOXOPLASMOSIShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Purpose: The purpose of this article is to analyze possible associations between systemic and ocular cytokine levels and specific clinical ophthalmologic signs from patients with a reactivation of toxoplasmic retinochoroiditis (RTR). Methods: A total of 18 patients with an active RTR episode, 8 patients with inactive scars, and 14 control patients were included in the study. Serum samples and aqueous humor (AH) samples were analyzed for IFN (interferon)-ã, interleukin (IL)-10, and IL-6 levels by ELISA. Inflammation grade, location, and size of the retinochoroidal active lesion, sampling time, and time to resolution were recorded. Results: A significantly negative correlation between AH and serum levels of IFN-ã was detected (p < 0.05). Patients with an AH IFN-ã/IL-10 ratio lower than 1 were associated with the longest time to resolution and/or severe complications. Conclusion: Serum IFN-ã levels may be used as a prognostic marker for both time to resolution and the development of possible severe complications during a given RTR episode.Fil: Rudzinski, Marcelo Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Las Misiones; ArgentinaFil: Argüelles, Carina. Universidad Catolica de Las Misiones; ArgentinaFil: Couto, Cristóbal. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Oubiña, Jose Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Las Misiones; ArgentinaTaylor & Francis Ltd2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/156779Rudzinski, Marcelo Nicolas; Argüelles, Carina; Couto, Cristóbal; Oubiña, Jose Raul; Reina, Silvia Lorena; Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis; Taylor & Francis Ltd; Ocular Immunology And Inflammation; 27; 6; 8-2018; 949-9570927-3948CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1499940info:eu-repo/semantics/altIdentifier/doi/10.1080/09273948.2018.1499940info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:40Zoai:ri.conicet.gov.ar:11336/156779instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:41.614CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis
title Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis
spellingShingle Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis
Rudzinski, Marcelo Nicolas
ARGENTINA
IMMUNE RESPONSE
RETINOCHOROIDITIS
TOXOPLASMOSIS
title_short Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis
title_full Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis
title_fullStr Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis
title_full_unstemmed Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis
title_sort Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis
dc.creator.none.fl_str_mv Rudzinski, Marcelo Nicolas
Argüelles, Carina
Couto, Cristóbal
Oubiña, Jose Raul
Reina, Silvia Lorena
author Rudzinski, Marcelo Nicolas
author_facet Rudzinski, Marcelo Nicolas
Argüelles, Carina
Couto, Cristóbal
Oubiña, Jose Raul
Reina, Silvia Lorena
author_role author
author2 Argüelles, Carina
Couto, Cristóbal
Oubiña, Jose Raul
Reina, Silvia Lorena
author2_role author
author
author
author
dc.subject.none.fl_str_mv ARGENTINA
IMMUNE RESPONSE
RETINOCHOROIDITIS
TOXOPLASMOSIS
topic ARGENTINA
IMMUNE RESPONSE
RETINOCHOROIDITIS
TOXOPLASMOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Purpose: The purpose of this article is to analyze possible associations between systemic and ocular cytokine levels and specific clinical ophthalmologic signs from patients with a reactivation of toxoplasmic retinochoroiditis (RTR). Methods: A total of 18 patients with an active RTR episode, 8 patients with inactive scars, and 14 control patients were included in the study. Serum samples and aqueous humor (AH) samples were analyzed for IFN (interferon)-ã, interleukin (IL)-10, and IL-6 levels by ELISA. Inflammation grade, location, and size of the retinochoroidal active lesion, sampling time, and time to resolution were recorded. Results: A significantly negative correlation between AH and serum levels of IFN-ã was detected (p < 0.05). Patients with an AH IFN-ã/IL-10 ratio lower than 1 were associated with the longest time to resolution and/or severe complications. Conclusion: Serum IFN-ã levels may be used as a prognostic marker for both time to resolution and the development of possible severe complications during a given RTR episode.
Fil: Rudzinski, Marcelo Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Las Misiones; Argentina
Fil: Argüelles, Carina. Universidad Catolica de Las Misiones; Argentina
Fil: Couto, Cristóbal. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Oubiña, Jose Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Reina, Silvia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Las Misiones; Argentina
description Purpose: The purpose of this article is to analyze possible associations between systemic and ocular cytokine levels and specific clinical ophthalmologic signs from patients with a reactivation of toxoplasmic retinochoroiditis (RTR). Methods: A total of 18 patients with an active RTR episode, 8 patients with inactive scars, and 14 control patients were included in the study. Serum samples and aqueous humor (AH) samples were analyzed for IFN (interferon)-ã, interleukin (IL)-10, and IL-6 levels by ELISA. Inflammation grade, location, and size of the retinochoroidal active lesion, sampling time, and time to resolution were recorded. Results: A significantly negative correlation between AH and serum levels of IFN-ã was detected (p < 0.05). Patients with an AH IFN-ã/IL-10 ratio lower than 1 were associated with the longest time to resolution and/or severe complications. Conclusion: Serum IFN-ã levels may be used as a prognostic marker for both time to resolution and the development of possible severe complications during a given RTR episode.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/156779
Rudzinski, Marcelo Nicolas; Argüelles, Carina; Couto, Cristóbal; Oubiña, Jose Raul; Reina, Silvia Lorena; Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis; Taylor & Francis Ltd; Ocular Immunology And Inflammation; 27; 6; 8-2018; 949-957
0927-3948
CONICET Digital
CONICET
url http://hdl.handle.net/11336/156779
identifier_str_mv Rudzinski, Marcelo Nicolas; Argüelles, Carina; Couto, Cristóbal; Oubiña, Jose Raul; Reina, Silvia Lorena; Immune Mediators against Toxoplasma Gondii during Reactivation of Toxoplasmic Retinochoroiditis; Taylor & Francis Ltd; Ocular Immunology And Inflammation; 27; 6; 8-2018; 949-957
0927-3948
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1499940
info:eu-repo/semantics/altIdentifier/doi/10.1080/09273948.2018.1499940
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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