Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance
- Autores
- Alvarez, Gonzalo Agustin; Shemesh, Noam; Frydman, Lucio
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Nuclear magnetic resonance is a powerful tool for probing the structures of chemical and biological systems. Combined with field gradients it leads to NMR imaging (MRI), a widespread tool in non-invasive examinations. Sensitivity usually limits MRI's spatial resolution to tens of micrometers, but other sources of information like those delivered by constrained diffusion processes, enable one extract morphological information down to micron and sub-micron scales. We report here on a new method that also exploits diffusion-isotropic or anisotropic-to sense morphological parameters in the nm-mm range, based on distributions of susceptibility-induced magnetic field gradients. A theoretical framework is developed to define this source of information, leading to the proposition of internal gradient-distribution tensors. Gradient-based spin-echo sequences are designed to measure these new observables. These methods can be used to map orientations even when dealing with unconstrained diffusion, as is here demonstrated with studies of structured systems, including tissues.
Fil: Alvarez, Gonzalo Agustin. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Weizmann Institute Of Science Israel; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina
Fil: Shemesh, Noam. Champalimaud Neuroscience Programme At The Champalimaud Centre For The Unknown; Portugal. Weizmann Institute Of Science Israel; Israel
Fil: Frydman, Lucio. Weizmann Institute Of Science Israel; Israel - Materia
-
NMR
MRI
Tissue microstructure
Diffusion weighted imaging - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/68159
Ver los metadatos del registro completo
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Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonanceAlvarez, Gonzalo AgustinShemesh, NoamFrydman, LucioNMRMRITissue microstructureDiffusion weighted imaginghttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Nuclear magnetic resonance is a powerful tool for probing the structures of chemical and biological systems. Combined with field gradients it leads to NMR imaging (MRI), a widespread tool in non-invasive examinations. Sensitivity usually limits MRI's spatial resolution to tens of micrometers, but other sources of information like those delivered by constrained diffusion processes, enable one extract morphological information down to micron and sub-micron scales. We report here on a new method that also exploits diffusion-isotropic or anisotropic-to sense morphological parameters in the nm-mm range, based on distributions of susceptibility-induced magnetic field gradients. A theoretical framework is developed to define this source of information, leading to the proposition of internal gradient-distribution tensors. Gradient-based spin-echo sequences are designed to measure these new observables. These methods can be used to map orientations even when dealing with unconstrained diffusion, as is here demonstrated with studies of structured systems, including tissues.Fil: Alvarez, Gonzalo Agustin. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Weizmann Institute Of Science Israel; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Shemesh, Noam. Champalimaud Neuroscience Programme At The Champalimaud Centre For The Unknown; Portugal. Weizmann Institute Of Science Israel; IsraelFil: Frydman, Lucio. Weizmann Institute Of Science Israel; IsraelNature Publishing Group2017-12-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/68159Alvarez, Gonzalo Agustin; Shemesh, Noam; Frydman, Lucio; Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance; Nature Publishing Group; Scientific Reports; 7; 3311; 12-12-2017; 1-102045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-017-03277-9info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-03277-9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:02Zoai:ri.conicet.gov.ar:11336/68159instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:03.143CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance |
title |
Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance |
spellingShingle |
Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance Alvarez, Gonzalo Agustin NMR MRI Tissue microstructure Diffusion weighted imaging |
title_short |
Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance |
title_full |
Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance |
title_fullStr |
Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance |
title_full_unstemmed |
Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance |
title_sort |
Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance |
dc.creator.none.fl_str_mv |
Alvarez, Gonzalo Agustin Shemesh, Noam Frydman, Lucio |
author |
Alvarez, Gonzalo Agustin |
author_facet |
Alvarez, Gonzalo Agustin Shemesh, Noam Frydman, Lucio |
author_role |
author |
author2 |
Shemesh, Noam Frydman, Lucio |
author2_role |
author author |
dc.subject.none.fl_str_mv |
NMR MRI Tissue microstructure Diffusion weighted imaging |
topic |
NMR MRI Tissue microstructure Diffusion weighted imaging |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.3 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Nuclear magnetic resonance is a powerful tool for probing the structures of chemical and biological systems. Combined with field gradients it leads to NMR imaging (MRI), a widespread tool in non-invasive examinations. Sensitivity usually limits MRI's spatial resolution to tens of micrometers, but other sources of information like those delivered by constrained diffusion processes, enable one extract morphological information down to micron and sub-micron scales. We report here on a new method that also exploits diffusion-isotropic or anisotropic-to sense morphological parameters in the nm-mm range, based on distributions of susceptibility-induced magnetic field gradients. A theoretical framework is developed to define this source of information, leading to the proposition of internal gradient-distribution tensors. Gradient-based spin-echo sequences are designed to measure these new observables. These methods can be used to map orientations even when dealing with unconstrained diffusion, as is here demonstrated with studies of structured systems, including tissues. Fil: Alvarez, Gonzalo Agustin. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Weizmann Institute Of Science Israel; Israel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina Fil: Shemesh, Noam. Champalimaud Neuroscience Programme At The Champalimaud Centre For The Unknown; Portugal. Weizmann Institute Of Science Israel; Israel Fil: Frydman, Lucio. Weizmann Institute Of Science Israel; Israel |
description |
Nuclear magnetic resonance is a powerful tool for probing the structures of chemical and biological systems. Combined with field gradients it leads to NMR imaging (MRI), a widespread tool in non-invasive examinations. Sensitivity usually limits MRI's spatial resolution to tens of micrometers, but other sources of information like those delivered by constrained diffusion processes, enable one extract morphological information down to micron and sub-micron scales. We report here on a new method that also exploits diffusion-isotropic or anisotropic-to sense morphological parameters in the nm-mm range, based on distributions of susceptibility-induced magnetic field gradients. A theoretical framework is developed to define this source of information, leading to the proposition of internal gradient-distribution tensors. Gradient-based spin-echo sequences are designed to measure these new observables. These methods can be used to map orientations even when dealing with unconstrained diffusion, as is here demonstrated with studies of structured systems, including tissues. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/68159 Alvarez, Gonzalo Agustin; Shemesh, Noam; Frydman, Lucio; Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance; Nature Publishing Group; Scientific Reports; 7; 3311; 12-12-2017; 1-10 2045-2322 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/68159 |
identifier_str_mv |
Alvarez, Gonzalo Agustin; Shemesh, Noam; Frydman, Lucio; Internal gradient distributions: A susceptibility-derived tensor delivering morphologies by magnetic resonance; Nature Publishing Group; Scientific Reports; 7; 3311; 12-12-2017; 1-10 2045-2322 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-017-03277-9 info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-017-03277-9 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |