Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging

Autores
Zwick, Analía Elizabeth; Suter, Dieter; Kurizki, Gershon; Álvarez, Gonzalo Sebastián
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Characterization of microstructures in living tissues is one of the keys to diagnosing early stages of pathology and understanding disease mechanisms. However, the extraction of reliable information on biomarkers based on microstructure details is still a challenge, as the size of features that can be resolved with noninvasive magnetic resonance imaging (MRI) is orders of magnitude larger than the relevant structures. Here we derive from quantum information theory the ultimate precision limits for obtaining such details by MRI probing of water-molecule diffusion. We show that currently available MRI pulse sequences can be optimized to attain the ultimate precision limits by choosing control parameters that are uniquely determined by the expected size, the diffusion coefficient, and the spin relaxation time T2. By attaining the ultimate precision limit per measurement, the number of measurements and the total acquisition time may be drastically reduced compared to the present state of the art. These results are expected to open alternative avenues towards unraveling diagnostic information by quantitative MRI.
Fil: Zwick, Analía Elizabeth. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; Argentina
Fil: Suter, Dieter. Universität Dortmund; Alemania
Fil: Kurizki, Gershon. Weizmann Institute Of Science; Israel
Fil: Álvarez, Gonzalo Sebastián. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; Argentina
Materia
MRI
Quantum Sensors
NMR
microestructuras biologicas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123891
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/123891
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance ImagingZwick, Analía ElizabethSuter, DieterKurizki, GershonÁlvarez, Gonzalo SebastiánMRIQuantum SensorsNMRmicroestructuras biologicashttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Characterization of microstructures in living tissues is one of the keys to diagnosing early stages of pathology and understanding disease mechanisms. However, the extraction of reliable information on biomarkers based on microstructure details is still a challenge, as the size of features that can be resolved with noninvasive magnetic resonance imaging (MRI) is orders of magnitude larger than the relevant structures. Here we derive from quantum information theory the ultimate precision limits for obtaining such details by MRI probing of water-molecule diffusion. We show that currently available MRI pulse sequences can be optimized to attain the ultimate precision limits by choosing control parameters that are uniquely determined by the expected size, the diffusion coefficient, and the spin relaxation time T2. By attaining the ultimate precision limit per measurement, the number of measurements and the total acquisition time may be drastically reduced compared to the present state of the art. These results are expected to open alternative avenues towards unraveling diagnostic information by quantitative MRI.Fil: Zwick, Analía Elizabeth. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; ArgentinaFil: Suter, Dieter. Universität Dortmund; AlemaniaFil: Kurizki, Gershon. Weizmann Institute Of Science; IsraelFil: Álvarez, Gonzalo Sebastián. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; ArgentinaAmerican Physical Society2020-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123891Zwick, Analía Elizabeth; Suter, Dieter; Kurizki, Gershon; Álvarez, Gonzalo Sebastián; Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging; American Physical Society; Physical Review Applied; 14; 2; 8-2020; 1-72331-7019CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://arxiv.org/abs/1912.12239info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevApplied.14.024088info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:12:15Zoai:ri.conicet.gov.ar:11336/123891instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:12:16.034CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging
title Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging
spellingShingle Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging
Zwick, Analía Elizabeth
MRI
Quantum Sensors
NMR
microestructuras biologicas
title_short Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging
title_full Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging
title_fullStr Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging
title_full_unstemmed Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging
title_sort Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging
dc.creator.none.fl_str_mv Zwick, Analía Elizabeth
Suter, Dieter
Kurizki, Gershon
Álvarez, Gonzalo Sebastián
author Zwick, Analía Elizabeth
author_facet Zwick, Analía Elizabeth
Suter, Dieter
Kurizki, Gershon
Álvarez, Gonzalo Sebastián
author_role author
author2 Suter, Dieter
Kurizki, Gershon
Álvarez, Gonzalo Sebastián
author2_role author
author
author
dc.subject.none.fl_str_mv MRI
Quantum Sensors
NMR
microestructuras biologicas
topic MRI
Quantum Sensors
NMR
microestructuras biologicas
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Characterization of microstructures in living tissues is one of the keys to diagnosing early stages of pathology and understanding disease mechanisms. However, the extraction of reliable information on biomarkers based on microstructure details is still a challenge, as the size of features that can be resolved with noninvasive magnetic resonance imaging (MRI) is orders of magnitude larger than the relevant structures. Here we derive from quantum information theory the ultimate precision limits for obtaining such details by MRI probing of water-molecule diffusion. We show that currently available MRI pulse sequences can be optimized to attain the ultimate precision limits by choosing control parameters that are uniquely determined by the expected size, the diffusion coefficient, and the spin relaxation time T2. By attaining the ultimate precision limit per measurement, the number of measurements and the total acquisition time may be drastically reduced compared to the present state of the art. These results are expected to open alternative avenues towards unraveling diagnostic information by quantitative MRI.
Fil: Zwick, Analía Elizabeth. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; Argentina
Fil: Suter, Dieter. Universität Dortmund; Alemania
Fil: Kurizki, Gershon. Weizmann Institute Of Science; Israel
Fil: Álvarez, Gonzalo Sebastián. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; Argentina
description Characterization of microstructures in living tissues is one of the keys to diagnosing early stages of pathology and understanding disease mechanisms. However, the extraction of reliable information on biomarkers based on microstructure details is still a challenge, as the size of features that can be resolved with noninvasive magnetic resonance imaging (MRI) is orders of magnitude larger than the relevant structures. Here we derive from quantum information theory the ultimate precision limits for obtaining such details by MRI probing of water-molecule diffusion. We show that currently available MRI pulse sequences can be optimized to attain the ultimate precision limits by choosing control parameters that are uniquely determined by the expected size, the diffusion coefficient, and the spin relaxation time T2. By attaining the ultimate precision limit per measurement, the number of measurements and the total acquisition time may be drastically reduced compared to the present state of the art. These results are expected to open alternative avenues towards unraveling diagnostic information by quantitative MRI.
publishDate 2020
dc.date.none.fl_str_mv 2020-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123891
Zwick, Analía Elizabeth; Suter, Dieter; Kurizki, Gershon; Álvarez, Gonzalo Sebastián; Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging; American Physical Society; Physical Review Applied; 14; 2; 8-2020; 1-7
2331-7019
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123891
identifier_str_mv Zwick, Analía Elizabeth; Suter, Dieter; Kurizki, Gershon; Álvarez, Gonzalo Sebastián; Precision Limits of Tissue Microstructure Characterization by Magnetic Resonance Imaging; American Physical Society; Physical Review Applied; 14; 2; 8-2020; 1-7
2331-7019
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://arxiv.org/abs/1912.12239
info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevApplied.14.024088
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980637921771520
score 12.48226

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