Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity

Autores
Barta, Anita; Salusso, Agostina; Kúsz, Norbert; Berkecz, Róbert; Schlauer, Jan; Purger, Dragica; Hohmann, Judit; Carpinella, Maria Cecilia; Vasas, Andrea
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Continuing our search for bioactive compounds in species from the Juncaceae family, Juncus articulatus was investigated. Ten previously undescribed phenanthrenes articu-lins A−J (1−10) and ten known compounds juncuenin B, dehydrojuncuenin B, juncatrin B, ensifolins E, F, H, I, K, juncuenin D, and luzulin A (11−20) along with other compounds, have been isolated and identified. The isolated compounds were evaluated for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus (MSSA), and methicillin-resistant Staphylococcus aureus (MRSA). Compounds 12 and 14 exhibited the most potent activity against planktonic and sessile MSSA and MRSA with minimum inhibitory concentration (MIC) values of 15.1 μM (12 for both bacterial strains) and 15.3 μM (14 for both bacterial strains). Compounds 15, 17, and 18 also exhibited activity against both strains, although to a lower extent, with MIC values ranging from 30.0 to 56.8 μM. The inhibition of biofilm formation of these compounds was observed at 15.1−114.3 μM. This study elucidates the phenanthrene composition of J. articulatus and the antibacterial effect of these compounds
Fil: Barta, Anita. University of Szeged; Hungría
Fil: Salusso, Agostina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina
Fil: Kúsz, Norbert. University of Szeged; Hungría
Fil: Berkecz, Róbert. University of Szeged; Hungría
Fil: Schlauer, Jan. University of Tubingen; Alemania
Fil: Purger, Dragica. University of Pécs; Hungría
Fil: Hohmann, Judit. University of Szeged; Hungría
Fil: Carpinella, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina
Fil: Vasas, Andrea. University of Szeged; Hungría
Materia
PRODUCTOS NATURALES
ANTIBACTERIANOS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/257254
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/257254
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory ActivityBarta, AnitaSalusso, AgostinaKúsz, NorbertBerkecz, RóbertSchlauer, JanPurger, DragicaHohmann, JuditCarpinella, Maria CeciliaVasas, AndreaPRODUCTOS NATURALESANTIBACTERIANOShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Continuing our search for bioactive compounds in species from the Juncaceae family, Juncus articulatus was investigated. Ten previously undescribed phenanthrenes articu-lins A−J (1−10) and ten known compounds juncuenin B, dehydrojuncuenin B, juncatrin B, ensifolins E, F, H, I, K, juncuenin D, and luzulin A (11−20) along with other compounds, have been isolated and identified. The isolated compounds were evaluated for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus (MSSA), and methicillin-resistant Staphylococcus aureus (MRSA). Compounds 12 and 14 exhibited the most potent activity against planktonic and sessile MSSA and MRSA with minimum inhibitory concentration (MIC) values of 15.1 μM (12 for both bacterial strains) and 15.3 μM (14 for both bacterial strains). Compounds 15, 17, and 18 also exhibited activity against both strains, although to a lower extent, with MIC values ranging from 30.0 to 56.8 μM. The inhibition of biofilm formation of these compounds was observed at 15.1−114.3 μM. This study elucidates the phenanthrene composition of J. articulatus and the antibacterial effect of these compoundsFil: Barta, Anita. University of Szeged; HungríaFil: Salusso, Agostina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; ArgentinaFil: Kúsz, Norbert. University of Szeged; HungríaFil: Berkecz, Róbert. University of Szeged; HungríaFil: Schlauer, Jan. University of Tubingen; AlemaniaFil: Purger, Dragica. University of Pécs; HungríaFil: Hohmann, Judit. University of Szeged; HungríaFil: Carpinella, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; ArgentinaFil: Vasas, Andrea. University of Szeged; HungríaAmerican Chemical Society2024-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/257254Barta, Anita; Salusso, Agostina; Kúsz, Norbert; Berkecz, Róbert; Schlauer, Jan; et al.; Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity; American Chemical Society; Journal of Natural Products; 87; 8; 8-2024; 2068-20800163-3864CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.jnatprod.4c00577info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jnatprod.4c00577info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:44:12Zoai:ri.conicet.gov.ar:11336/257254instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:44:12.396CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
title Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
spellingShingle Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
Barta, Anita
PRODUCTOS NATURALES
ANTIBACTERIANOS
title_short Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
title_full Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
title_fullStr Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
title_full_unstemmed Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
title_sort Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
dc.creator.none.fl_str_mv Barta, Anita
Salusso, Agostina
Kúsz, Norbert
Berkecz, Róbert
Schlauer, Jan
Purger, Dragica
Hohmann, Judit
Carpinella, Maria Cecilia
Vasas, Andrea
author Barta, Anita
author_facet Barta, Anita
Salusso, Agostina
Kúsz, Norbert
Berkecz, Róbert
Schlauer, Jan
Purger, Dragica
Hohmann, Judit
Carpinella, Maria Cecilia
Vasas, Andrea
author_role author
author2 Salusso, Agostina
Kúsz, Norbert
Berkecz, Róbert
Schlauer, Jan
Purger, Dragica
Hohmann, Judit
Carpinella, Maria Cecilia
Vasas, Andrea
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PRODUCTOS NATURALES
ANTIBACTERIANOS
topic PRODUCTOS NATURALES
ANTIBACTERIANOS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Continuing our search for bioactive compounds in species from the Juncaceae family, Juncus articulatus was investigated. Ten previously undescribed phenanthrenes articu-lins A−J (1−10) and ten known compounds juncuenin B, dehydrojuncuenin B, juncatrin B, ensifolins E, F, H, I, K, juncuenin D, and luzulin A (11−20) along with other compounds, have been isolated and identified. The isolated compounds were evaluated for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus (MSSA), and methicillin-resistant Staphylococcus aureus (MRSA). Compounds 12 and 14 exhibited the most potent activity against planktonic and sessile MSSA and MRSA with minimum inhibitory concentration (MIC) values of 15.1 μM (12 for both bacterial strains) and 15.3 μM (14 for both bacterial strains). Compounds 15, 17, and 18 also exhibited activity against both strains, although to a lower extent, with MIC values ranging from 30.0 to 56.8 μM. The inhibition of biofilm formation of these compounds was observed at 15.1−114.3 μM. This study elucidates the phenanthrene composition of J. articulatus and the antibacterial effect of these compounds
Fil: Barta, Anita. University of Szeged; Hungría
Fil: Salusso, Agostina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina
Fil: Kúsz, Norbert. University of Szeged; Hungría
Fil: Berkecz, Róbert. University of Szeged; Hungría
Fil: Schlauer, Jan. University of Tubingen; Alemania
Fil: Purger, Dragica. University of Pécs; Hungría
Fil: Hohmann, Judit. University of Szeged; Hungría
Fil: Carpinella, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina
Fil: Vasas, Andrea. University of Szeged; Hungría
description Continuing our search for bioactive compounds in species from the Juncaceae family, Juncus articulatus was investigated. Ten previously undescribed phenanthrenes articu-lins A−J (1−10) and ten known compounds juncuenin B, dehydrojuncuenin B, juncatrin B, ensifolins E, F, H, I, K, juncuenin D, and luzulin A (11−20) along with other compounds, have been isolated and identified. The isolated compounds were evaluated for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus (MSSA), and methicillin-resistant Staphylococcus aureus (MRSA). Compounds 12 and 14 exhibited the most potent activity against planktonic and sessile MSSA and MRSA with minimum inhibitory concentration (MIC) values of 15.1 μM (12 for both bacterial strains) and 15.3 μM (14 for both bacterial strains). Compounds 15, 17, and 18 also exhibited activity against both strains, although to a lower extent, with MIC values ranging from 30.0 to 56.8 μM. The inhibition of biofilm formation of these compounds was observed at 15.1−114.3 μM. This study elucidates the phenanthrene composition of J. articulatus and the antibacterial effect of these compounds
publishDate 2024
dc.date.none.fl_str_mv 2024-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/257254
Barta, Anita; Salusso, Agostina; Kúsz, Norbert; Berkecz, Róbert; Schlauer, Jan; et al.; Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity; American Chemical Society; Journal of Natural Products; 87; 8; 8-2024; 2068-2080
0163-3864
CONICET Digital
CONICET
url http://hdl.handle.net/11336/257254
identifier_str_mv Barta, Anita; Salusso, Agostina; Kúsz, Norbert; Berkecz, Róbert; Schlauer, Jan; et al.; Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity; American Chemical Society; Journal of Natural Products; 87; 8; 8-2024; 2068-2080
0163-3864
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.jnatprod.4c00577
info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jnatprod.4c00577
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1847977046683156480
score 13.087074

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