The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats

Autores
Laconi, Myriam Raquel; Casteller, Guillermo; Gargiulo, Pascual Angel; Bregonzio Diaz, Claudia; Cabrera Kreiker, Ricardo Jorge
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The behavioural display in the plus-maze, an established experimental model of anxiety, was studied in rats injected into the lateral brain ventricle (i.c.v.) with the neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone). Female rats under different gonadal hormonal status were chosen. Allopregnanolone enhanced exploration of the open arms in both estrous rats and ovariectomized estrogen and progesterone primed rats. No effect was observed in diestrous 1 and ovariectomized not-primed rats. In all cases, the plus-maze locomotor-exploratory behaviour was not affected by allopregnanolone. The GABAA receptor antagonist, bicuculline (9.8 μM i.c.v.) reversed the allopregnanolone action in the ovariectomized primed rats. When bicuculline was injected i.c.v. in conjunction with allopregnanolone, the anxiogenic effect of bicuculline was reversed by the highest dose (25 μM) of allopregnanolone only. These results suggest that allopregnanolone exerts an anxiolytic action interacting with the GABAA receptor in an estrogen-dependent manner. © 2001 Elsevier Science B.V.
Fil: Laconi, Myriam Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Casteller, Guillermo. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; Argentina
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; Argentina
Fil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; Argentina
Materia
ALLOPREGNANOLONE
ANXIETY
ESTROUS CYCLE
GABAA RECEPTOR
NEUROSTEROID
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/171955
Acceder
id CONICETDig_d81b72620d53b088b363eabd37e3196a
oai_identifier_str oai:ri.conicet.gov.ar:11336/171955
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female ratsLaconi, Myriam RaquelCasteller, GuillermoGargiulo, Pascual AngelBregonzio Diaz, ClaudiaCabrera Kreiker, Ricardo JorgeALLOPREGNANOLONEANXIETYESTROUS CYCLEGABAA RECEPTORNEUROSTEROIDhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The behavioural display in the plus-maze, an established experimental model of anxiety, was studied in rats injected into the lateral brain ventricle (i.c.v.) with the neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone). Female rats under different gonadal hormonal status were chosen. Allopregnanolone enhanced exploration of the open arms in both estrous rats and ovariectomized estrogen and progesterone primed rats. No effect was observed in diestrous 1 and ovariectomized not-primed rats. In all cases, the plus-maze locomotor-exploratory behaviour was not affected by allopregnanolone. The GABAA receptor antagonist, bicuculline (9.8 μM i.c.v.) reversed the allopregnanolone action in the ovariectomized primed rats. When bicuculline was injected i.c.v. in conjunction with allopregnanolone, the anxiogenic effect of bicuculline was reversed by the highest dose (25 μM) of allopregnanolone only. These results suggest that allopregnanolone exerts an anxiolytic action interacting with the GABAA receptor in an estrogen-dependent manner. © 2001 Elsevier Science B.V.Fil: Laconi, Myriam Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Casteller, Guillermo. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; ArgentinaFil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; ArgentinaFil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; ArgentinaFil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; ArgentinaElsevier Science2001-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/171955Laconi, Myriam Raquel; Casteller, Guillermo; Gargiulo, Pascual Angel; Bregonzio Diaz, Claudia; Cabrera Kreiker, Ricardo Jorge; The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats; Elsevier Science; European Journal of Pharmacology; 417; 1-2; 4-2001; 111-1160014-2999CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014299901008652info:eu-repo/semantics/altIdentifier/doi/10.1016/S0014-2999(01)00865-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:01Zoai:ri.conicet.gov.ar:11336/171955instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:01.658CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
title The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
spellingShingle The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
Laconi, Myriam Raquel
ALLOPREGNANOLONE
ANXIETY
ESTROUS CYCLE
GABAA RECEPTOR
NEUROSTEROID
title_short The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
title_full The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
title_fullStr The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
title_full_unstemmed The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
title_sort The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats
dc.creator.none.fl_str_mv Laconi, Myriam Raquel
Casteller, Guillermo
Gargiulo, Pascual Angel
Bregonzio Diaz, Claudia
Cabrera Kreiker, Ricardo Jorge
author Laconi, Myriam Raquel
author_facet Laconi, Myriam Raquel
Casteller, Guillermo
Gargiulo, Pascual Angel
Bregonzio Diaz, Claudia
Cabrera Kreiker, Ricardo Jorge
author_role author
author2 Casteller, Guillermo
Gargiulo, Pascual Angel
Bregonzio Diaz, Claudia
Cabrera Kreiker, Ricardo Jorge
author2_role author
author
author
author
dc.subject.none.fl_str_mv ALLOPREGNANOLONE
ANXIETY
ESTROUS CYCLE
GABAA RECEPTOR
NEUROSTEROID
topic ALLOPREGNANOLONE
ANXIETY
ESTROUS CYCLE
GABAA RECEPTOR
NEUROSTEROID
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The behavioural display in the plus-maze, an established experimental model of anxiety, was studied in rats injected into the lateral brain ventricle (i.c.v.) with the neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone). Female rats under different gonadal hormonal status were chosen. Allopregnanolone enhanced exploration of the open arms in both estrous rats and ovariectomized estrogen and progesterone primed rats. No effect was observed in diestrous 1 and ovariectomized not-primed rats. In all cases, the plus-maze locomotor-exploratory behaviour was not affected by allopregnanolone. The GABAA receptor antagonist, bicuculline (9.8 μM i.c.v.) reversed the allopregnanolone action in the ovariectomized primed rats. When bicuculline was injected i.c.v. in conjunction with allopregnanolone, the anxiogenic effect of bicuculline was reversed by the highest dose (25 μM) of allopregnanolone only. These results suggest that allopregnanolone exerts an anxiolytic action interacting with the GABAA receptor in an estrogen-dependent manner. © 2001 Elsevier Science B.V.
Fil: Laconi, Myriam Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Casteller, Guillermo. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; Argentina
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; Argentina
Fil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas. Departamento de Neurociencias; Argentina
description The behavioural display in the plus-maze, an established experimental model of anxiety, was studied in rats injected into the lateral brain ventricle (i.c.v.) with the neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone). Female rats under different gonadal hormonal status were chosen. Allopregnanolone enhanced exploration of the open arms in both estrous rats and ovariectomized estrogen and progesterone primed rats. No effect was observed in diestrous 1 and ovariectomized not-primed rats. In all cases, the plus-maze locomotor-exploratory behaviour was not affected by allopregnanolone. The GABAA receptor antagonist, bicuculline (9.8 μM i.c.v.) reversed the allopregnanolone action in the ovariectomized primed rats. When bicuculline was injected i.c.v. in conjunction with allopregnanolone, the anxiogenic effect of bicuculline was reversed by the highest dose (25 μM) of allopregnanolone only. These results suggest that allopregnanolone exerts an anxiolytic action interacting with the GABAA receptor in an estrogen-dependent manner. © 2001 Elsevier Science B.V.
publishDate 2001
dc.date.none.fl_str_mv 2001-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/171955
Laconi, Myriam Raquel; Casteller, Guillermo; Gargiulo, Pascual Angel; Bregonzio Diaz, Claudia; Cabrera Kreiker, Ricardo Jorge; The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats; Elsevier Science; European Journal of Pharmacology; 417; 1-2; 4-2001; 111-116
0014-2999
CONICET Digital
CONICET
url http://hdl.handle.net/11336/171955
identifier_str_mv Laconi, Myriam Raquel; Casteller, Guillermo; Gargiulo, Pascual Angel; Bregonzio Diaz, Claudia; Cabrera Kreiker, Ricardo Jorge; The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats; Elsevier Science; European Journal of Pharmacology; 417; 1-2; 4-2001; 111-116
0014-2999
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0014299901008652
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0014-2999(01)00865-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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