Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training

Autores
González Franco, Diego A.; Ramirez Amaya, Victor; Joseph Bravo, Patricia; Prado Alcalá, Roberto A.; Quirarte, Gina L.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Intense training refers to training mediated by emotionally arousing experiences, such as aversive conditioning motivated by relatively high intensities of foot-shock, which produces a strong memory that is highly resistant to extinction. Intense training protects memory consolidation against the amnestic effects of a wide variety of treatments, administered systemically or directly into brain structures. The mechanisms of this protective effect are unknown. To determine a potential neurobiological correlate of the protective effect of intense training, rats were trained in a one-trial step-through inhibitory avoidance task using different intensities of foot-shock (0.0, 0.5, 1.0, and 2.0 mA). Some rats from each group were sacrificed 45 min after training for immunohistochemical Arc protein detection in dorsal and ventral striatum; other rats were tested for extinction during six consecutive days, starting 48 h after training. The results showed that training with 1.0 and 2.0 mA produced optimal retention scores, which were significantly higher than those of the 0.5 and 0.0 mA groups. Also, a higher resistance to extinction was obtained with 2.0 mA than with the other intensities. A high number of neurons expressed Arc in ventral, but not in dorsal striatum in both the 1.0 and 2.0 mA groups, with a larger area of Arc signal in the latter group. We conclude that an increased Arc expression may be related to enhanced synaptic plasticity in the ventral striatum, suggesting that it may be one of the physiological substrates of enhanced learning.
Fil: González Franco, Diego A.. Universidad Nacional Autónoma de México; México
Fil: Ramirez Amaya, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Autónoma de Querétaro; México
Fil: Joseph Bravo, Patricia. Universidad Nacional Autónoma de México; México
Fil: Prado Alcalá, Roberto A.. Universidad Nacional Autónoma de México; México
Fil: Quirarte, Gina L.. Universidad Nacional Autónoma de México; México
Materia
Corticosterone
Immediate-Early Genes
Learning And Memory
Over-Training
Striatum
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/63999
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/63999
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance trainingGonzález Franco, Diego A.Ramirez Amaya, VictorJoseph Bravo, PatriciaPrado Alcalá, Roberto A.Quirarte, Gina L.CorticosteroneImmediate-Early GenesLearning And MemoryOver-TrainingStriatumhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Intense training refers to training mediated by emotionally arousing experiences, such as aversive conditioning motivated by relatively high intensities of foot-shock, which produces a strong memory that is highly resistant to extinction. Intense training protects memory consolidation against the amnestic effects of a wide variety of treatments, administered systemically or directly into brain structures. The mechanisms of this protective effect are unknown. To determine a potential neurobiological correlate of the protective effect of intense training, rats were trained in a one-trial step-through inhibitory avoidance task using different intensities of foot-shock (0.0, 0.5, 1.0, and 2.0 mA). Some rats from each group were sacrificed 45 min after training for immunohistochemical Arc protein detection in dorsal and ventral striatum; other rats were tested for extinction during six consecutive days, starting 48 h after training. The results showed that training with 1.0 and 2.0 mA produced optimal retention scores, which were significantly higher than those of the 0.5 and 0.0 mA groups. Also, a higher resistance to extinction was obtained with 2.0 mA than with the other intensities. A high number of neurons expressed Arc in ventral, but not in dorsal striatum in both the 1.0 and 2.0 mA groups, with a larger area of Arc signal in the latter group. We conclude that an increased Arc expression may be related to enhanced synaptic plasticity in the ventral striatum, suggesting that it may be one of the physiological substrates of enhanced learning.Fil: González Franco, Diego A.. Universidad Nacional Autónoma de México; MéxicoFil: Ramirez Amaya, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Autónoma de Querétaro; MéxicoFil: Joseph Bravo, Patricia. Universidad Nacional Autónoma de México; MéxicoFil: Prado Alcalá, Roberto A.. Universidad Nacional Autónoma de México; MéxicoFil: Quirarte, Gina L.. Universidad Nacional Autónoma de México; MéxicoAcademic Press Inc Elsevier Science2017-04-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/63999González Franco, Diego A.; Ramirez Amaya, Victor; Joseph Bravo, Patricia; Prado Alcalá, Roberto A.; Quirarte, Gina L.; Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 140; 6-4-2017; 17-261074-74271095-9564CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1074742716302143info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2017.02.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:00:43Zoai:ri.conicet.gov.ar:11336/63999instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:00:43.955CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training
title Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training
spellingShingle Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training
González Franco, Diego A.
Corticosterone
Immediate-Early Genes
Learning And Memory
Over-Training
Striatum
title_short Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training
title_full Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training
title_fullStr Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training
title_full_unstemmed Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training
title_sort Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training
dc.creator.none.fl_str_mv González Franco, Diego A.
Ramirez Amaya, Victor
Joseph Bravo, Patricia
Prado Alcalá, Roberto A.
Quirarte, Gina L.
author González Franco, Diego A.
author_facet González Franco, Diego A.
Ramirez Amaya, Victor
Joseph Bravo, Patricia
Prado Alcalá, Roberto A.
Quirarte, Gina L.
author_role author
author2 Ramirez Amaya, Victor
Joseph Bravo, Patricia
Prado Alcalá, Roberto A.
Quirarte, Gina L.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Corticosterone
Immediate-Early Genes
Learning And Memory
Over-Training
Striatum
topic Corticosterone
Immediate-Early Genes
Learning And Memory
Over-Training
Striatum
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Intense training refers to training mediated by emotionally arousing experiences, such as aversive conditioning motivated by relatively high intensities of foot-shock, which produces a strong memory that is highly resistant to extinction. Intense training protects memory consolidation against the amnestic effects of a wide variety of treatments, administered systemically or directly into brain structures. The mechanisms of this protective effect are unknown. To determine a potential neurobiological correlate of the protective effect of intense training, rats were trained in a one-trial step-through inhibitory avoidance task using different intensities of foot-shock (0.0, 0.5, 1.0, and 2.0 mA). Some rats from each group were sacrificed 45 min after training for immunohistochemical Arc protein detection in dorsal and ventral striatum; other rats were tested for extinction during six consecutive days, starting 48 h after training. The results showed that training with 1.0 and 2.0 mA produced optimal retention scores, which were significantly higher than those of the 0.5 and 0.0 mA groups. Also, a higher resistance to extinction was obtained with 2.0 mA than with the other intensities. A high number of neurons expressed Arc in ventral, but not in dorsal striatum in both the 1.0 and 2.0 mA groups, with a larger area of Arc signal in the latter group. We conclude that an increased Arc expression may be related to enhanced synaptic plasticity in the ventral striatum, suggesting that it may be one of the physiological substrates of enhanced learning.
Fil: González Franco, Diego A.. Universidad Nacional Autónoma de México; México
Fil: Ramirez Amaya, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Autónoma de Querétaro; México
Fil: Joseph Bravo, Patricia. Universidad Nacional Autónoma de México; México
Fil: Prado Alcalá, Roberto A.. Universidad Nacional Autónoma de México; México
Fil: Quirarte, Gina L.. Universidad Nacional Autónoma de México; México
description Intense training refers to training mediated by emotionally arousing experiences, such as aversive conditioning motivated by relatively high intensities of foot-shock, which produces a strong memory that is highly resistant to extinction. Intense training protects memory consolidation against the amnestic effects of a wide variety of treatments, administered systemically or directly into brain structures. The mechanisms of this protective effect are unknown. To determine a potential neurobiological correlate of the protective effect of intense training, rats were trained in a one-trial step-through inhibitory avoidance task using different intensities of foot-shock (0.0, 0.5, 1.0, and 2.0 mA). Some rats from each group were sacrificed 45 min after training for immunohistochemical Arc protein detection in dorsal and ventral striatum; other rats were tested for extinction during six consecutive days, starting 48 h after training. The results showed that training with 1.0 and 2.0 mA produced optimal retention scores, which were significantly higher than those of the 0.5 and 0.0 mA groups. Also, a higher resistance to extinction was obtained with 2.0 mA than with the other intensities. A high number of neurons expressed Arc in ventral, but not in dorsal striatum in both the 1.0 and 2.0 mA groups, with a larger area of Arc signal in the latter group. We conclude that an increased Arc expression may be related to enhanced synaptic plasticity in the ventral striatum, suggesting that it may be one of the physiological substrates of enhanced learning.
publishDate 2017
dc.date.none.fl_str_mv 2017-04-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/63999
González Franco, Diego A.; Ramirez Amaya, Victor; Joseph Bravo, Patricia; Prado Alcalá, Roberto A.; Quirarte, Gina L.; Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 140; 6-4-2017; 17-26
1074-7427
1095-9564
CONICET Digital
CONICET
url http://hdl.handle.net/11336/63999
identifier_str_mv González Franco, Diego A.; Ramirez Amaya, Victor; Joseph Bravo, Patricia; Prado Alcalá, Roberto A.; Quirarte, Gina L.; Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training; Academic Press Inc Elsevier Science; Neurobiology of Learning and Memory; 140; 6-4-2017; 17-26
1074-7427
1095-9564
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1074742716302143
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2017.02.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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