Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens

Autores
Marcott, Pamela F.; Gong, Sheng; Donthamsetti, Prashant; Grinnell, Steven G.; Nelson, Melissa N.; Newman, Amy H.; Birnbaumer, Lutz; Martemyanov, Kirill A.; Javitch, Jonathan A.; Ford, Christopher P.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (MSNs) across striatal subregions. Here we examined the activation of D2 receptors following the synaptic release of dopamine in the dorsal striatum (DStr) and nucleus accumbens (NAc) shell. We found that D2 receptor-mediated synaptic currents were slower in the NAc and this difference occurred at the level of D2-receptor signaling. As a result of preferential coupling to Gαo, we also found that D2 receptors in MSNs demonstrated higher sensitivity for dopamine in the NAc. The higher sensitivity in the NAc was eliminated following cocaine exposure. These results identify differences in the sensitivity and timing of D2-receptor signaling across the striatum that influence how nigrostriatal and mesolimbic signals are encoded across these circuits. Marcott et al. identify that D2 receptors on MSNs differ in their sensitivity and rate of activation between the dorsal striatum and nucleus accumbens. These regional differences in signaling shape how D2 receptors encode dopamine release events in nigrostriatal and mesolimbic circuits.
Fil: Marcott, Pamela F.. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
Fil: Gong, Sheng. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
Fil: Donthamsetti, Prashant. Columbia University; Estados Unidos. University of California; Estados Unidos
Fil: Grinnell, Steven G.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados Unidos
Fil: Nelson, Melissa N.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados Unidos
Fil: Newman, Amy H.. National Institute of Drug Abuse – Intramural Research Program; Estados Unidos
Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory, ; Estados Unidos. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Martemyanov, Kirill A.. The Scripps Research Institute; Estados Unidos
Fil: Javitch, Jonathan A.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados Unidos
Fil: Ford, Christopher P.. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
Materia
ADDICTION
BASAL GANGLIA
DOPAMINE
GPCR
METABOTROPIC
SCHIZOPHRENIA
SENSITIZATION
STRIATUM
SYNAPTIC TRANSMISSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/99341
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/99341
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus AccumbensMarcott, Pamela F.Gong, ShengDonthamsetti, PrashantGrinnell, Steven G.Nelson, Melissa N.Newman, Amy H.Birnbaumer, LutzMartemyanov, Kirill A.Javitch, Jonathan A.Ford, Christopher P.ADDICTIONBASAL GANGLIADOPAMINEGPCRMETABOTROPICSCHIZOPHRENIASENSITIZATIONSTRIATUMSYNAPTIC TRANSMISSIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (MSNs) across striatal subregions. Here we examined the activation of D2 receptors following the synaptic release of dopamine in the dorsal striatum (DStr) and nucleus accumbens (NAc) shell. We found that D2 receptor-mediated synaptic currents were slower in the NAc and this difference occurred at the level of D2-receptor signaling. As a result of preferential coupling to Gαo, we also found that D2 receptors in MSNs demonstrated higher sensitivity for dopamine in the NAc. The higher sensitivity in the NAc was eliminated following cocaine exposure. These results identify differences in the sensitivity and timing of D2-receptor signaling across the striatum that influence how nigrostriatal and mesolimbic signals are encoded across these circuits. Marcott et al. identify that D2 receptors on MSNs differ in their sensitivity and rate of activation between the dorsal striatum and nucleus accumbens. These regional differences in signaling shape how D2 receptors encode dopamine release events in nigrostriatal and mesolimbic circuits.Fil: Marcott, Pamela F.. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados UnidosFil: Gong, Sheng. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados UnidosFil: Donthamsetti, Prashant. Columbia University; Estados Unidos. University of California; Estados UnidosFil: Grinnell, Steven G.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados UnidosFil: Nelson, Melissa N.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados UnidosFil: Newman, Amy H.. National Institute of Drug Abuse – Intramural Research Program; Estados UnidosFil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory, ; Estados Unidos. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Martemyanov, Kirill A.. The Scripps Research Institute; Estados UnidosFil: Javitch, Jonathan A.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados UnidosFil: Ford, Christopher P.. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados UnidosCell Press2018-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/99341Marcott, Pamela F.; Gong, Sheng; Donthamsetti, Prashant; Grinnell, Steven G.; Nelson, Melissa N.; et al.; Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens; Cell Press; Neuron; 98; 3; 5-2018; 575-587; e40896-6273CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2018.03.038info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0896627318302447info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:10Zoai:ri.conicet.gov.ar:11336/99341instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:10.628CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
title Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
spellingShingle Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
Marcott, Pamela F.
ADDICTION
BASAL GANGLIA
DOPAMINE
GPCR
METABOTROPIC
SCHIZOPHRENIA
SENSITIZATION
STRIATUM
SYNAPTIC TRANSMISSION
title_short Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
title_full Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
title_fullStr Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
title_full_unstemmed Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
title_sort Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens
dc.creator.none.fl_str_mv Marcott, Pamela F.
Gong, Sheng
Donthamsetti, Prashant
Grinnell, Steven G.
Nelson, Melissa N.
Newman, Amy H.
Birnbaumer, Lutz
Martemyanov, Kirill A.
Javitch, Jonathan A.
Ford, Christopher P.
author Marcott, Pamela F.
author_facet Marcott, Pamela F.
Gong, Sheng
Donthamsetti, Prashant
Grinnell, Steven G.
Nelson, Melissa N.
Newman, Amy H.
Birnbaumer, Lutz
Martemyanov, Kirill A.
Javitch, Jonathan A.
Ford, Christopher P.
author_role author
author2 Gong, Sheng
Donthamsetti, Prashant
Grinnell, Steven G.
Nelson, Melissa N.
Newman, Amy H.
Birnbaumer, Lutz
Martemyanov, Kirill A.
Javitch, Jonathan A.
Ford, Christopher P.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADDICTION
BASAL GANGLIA
DOPAMINE
GPCR
METABOTROPIC
SCHIZOPHRENIA
SENSITIZATION
STRIATUM
SYNAPTIC TRANSMISSION
topic ADDICTION
BASAL GANGLIA
DOPAMINE
GPCR
METABOTROPIC
SCHIZOPHRENIA
SENSITIZATION
STRIATUM
SYNAPTIC TRANSMISSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (MSNs) across striatal subregions. Here we examined the activation of D2 receptors following the synaptic release of dopamine in the dorsal striatum (DStr) and nucleus accumbens (NAc) shell. We found that D2 receptor-mediated synaptic currents were slower in the NAc and this difference occurred at the level of D2-receptor signaling. As a result of preferential coupling to Gαo, we also found that D2 receptors in MSNs demonstrated higher sensitivity for dopamine in the NAc. The higher sensitivity in the NAc was eliminated following cocaine exposure. These results identify differences in the sensitivity and timing of D2-receptor signaling across the striatum that influence how nigrostriatal and mesolimbic signals are encoded across these circuits. Marcott et al. identify that D2 receptors on MSNs differ in their sensitivity and rate of activation between the dorsal striatum and nucleus accumbens. These regional differences in signaling shape how D2 receptors encode dopamine release events in nigrostriatal and mesolimbic circuits.
Fil: Marcott, Pamela F.. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
Fil: Gong, Sheng. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
Fil: Donthamsetti, Prashant. Columbia University; Estados Unidos. University of California; Estados Unidos
Fil: Grinnell, Steven G.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados Unidos
Fil: Nelson, Melissa N.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados Unidos
Fil: Newman, Amy H.. National Institute of Drug Abuse – Intramural Research Program; Estados Unidos
Fil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences. Neurobiology Laboratory, ; Estados Unidos. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Martemyanov, Kirill A.. The Scripps Research Institute; Estados Unidos
Fil: Javitch, Jonathan A.. Columbia University. Department of Psychiatry. New York State Psychiatric Institute; Estados Unidos
Fil: Ford, Christopher P.. University of Colorado School of Medicine; Estados Unidos. Case Western Reserve University School of Medicine; Estados Unidos
description Dopamine input to the dorsal and ventral striatum originates from separate populations of midbrain neurons. Despite differences in afferent inputs and behavioral output, little is known about how dopamine release is encoded by dopamine receptors on medium spiny neurons (MSNs) across striatal subregions. Here we examined the activation of D2 receptors following the synaptic release of dopamine in the dorsal striatum (DStr) and nucleus accumbens (NAc) shell. We found that D2 receptor-mediated synaptic currents were slower in the NAc and this difference occurred at the level of D2-receptor signaling. As a result of preferential coupling to Gαo, we also found that D2 receptors in MSNs demonstrated higher sensitivity for dopamine in the NAc. The higher sensitivity in the NAc was eliminated following cocaine exposure. These results identify differences in the sensitivity and timing of D2-receptor signaling across the striatum that influence how nigrostriatal and mesolimbic signals are encoded across these circuits. Marcott et al. identify that D2 receptors on MSNs differ in their sensitivity and rate of activation between the dorsal striatum and nucleus accumbens. These regional differences in signaling shape how D2 receptors encode dopamine release events in nigrostriatal and mesolimbic circuits.
publishDate 2018
dc.date.none.fl_str_mv 2018-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/99341
Marcott, Pamela F.; Gong, Sheng; Donthamsetti, Prashant; Grinnell, Steven G.; Nelson, Melissa N.; et al.; Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens; Cell Press; Neuron; 98; 3; 5-2018; 575-587; e4
0896-6273
CONICET Digital
CONICET
url http://hdl.handle.net/11336/99341
identifier_str_mv Marcott, Pamela F.; Gong, Sheng; Donthamsetti, Prashant; Grinnell, Steven G.; Nelson, Melissa N.; et al.; Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens; Cell Press; Neuron; 98; 3; 5-2018; 575-587; e4
0896-6273
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2018.03.038
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0896627318302447
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.885934

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