Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia

Autores
Holubiec, Mariana Ines; Romero, Juan Ignacio; Blanco, Eduardo; Logica Tornatore, Tamara Maite Ayelén; Suarez, Juan; Rodríguez de Fonseca, Fernando; Galeano, Pablo; Capani, Francisco
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) in the main metabolic enzymes and receptors of the eCBs/AEs in the dorsal striatum of rats. To induce PA, we used a model developed by Bjelke et al. (1991). Immunohistochemical techniques were carried out to determine the expression of neuronal and glial markers (NeuN and GFAP), eCBs/AEs synthesis and degradation enzymes (DAGLα, NAPE-PLD and FAAH) and their receptors (CB1 and PPARα). We found a decrease in NAPE-PLD and PPARα expression. Since NAPE-PLD and PPARα take part in the production and reception of biochemical actions of AEs, such as oleoylethanolamide, these results may suggest that PA plays a key role in the regulation of this system. These data agree with previous results obtained in the hippocampus and encourage us to develop further studies using AEs as potential neuroprotective compounds.
Fil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Blanco, Eduardo. Universidad de Málaga; España. Universidad de Lleida; España
Fil: Logica Tornatore, Tamara Maite Ayelén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Suarez, Juan. Universidad de Málaga; España
Fil: Rodríguez de Fonseca, Fernando. Universidad de Málaga; España
Fil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Argentina "John F. Kennedy"; Argentina. Universidad de Chile; Chile
Materia
Cb1
Daglα
Dorsal Striatum
Nape-Pld
Perinatal Asphyxia
Pparα
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38529
Acceder
id CONICETDig_3b7aeee6423001670d91a99453d3e879
oai_identifier_str oai:ri.conicet.gov.ar:11336/38529
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxiaHolubiec, Mariana InesRomero, Juan IgnacioBlanco, EduardoLogica Tornatore, Tamara Maite AyelénSuarez, JuanRodríguez de Fonseca, FernandoGaleano, PabloCapani, FranciscoCb1DaglαDorsal StriatumNape-PldPerinatal AsphyxiaPparαhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) in the main metabolic enzymes and receptors of the eCBs/AEs in the dorsal striatum of rats. To induce PA, we used a model developed by Bjelke et al. (1991). Immunohistochemical techniques were carried out to determine the expression of neuronal and glial markers (NeuN and GFAP), eCBs/AEs synthesis and degradation enzymes (DAGLα, NAPE-PLD and FAAH) and their receptors (CB1 and PPARα). We found a decrease in NAPE-PLD and PPARα expression. Since NAPE-PLD and PPARα take part in the production and reception of biochemical actions of AEs, such as oleoylethanolamide, these results may suggest that PA plays a key role in the regulation of this system. These data agree with previous results obtained in the hippocampus and encourage us to develop further studies using AEs as potential neuroprotective compounds.Fil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Blanco, Eduardo. Universidad de Málaga; España. Universidad de Lleida; EspañaFil: Logica Tornatore, Tamara Maite Ayelén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Suarez, Juan. Universidad de Málaga; EspañaFil: Rodríguez de Fonseca, Fernando. Universidad de Málaga; EspañaFil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Argentina "John F. Kennedy"; Argentina. Universidad de Chile; ChileElsevier Ireland2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38529Holubiec, Mariana Ines; Romero, Juan Ignacio; Blanco, Eduardo; Logica Tornatore, Tamara Maite Ayelén; Suarez, Juan; et al.; Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia; Elsevier Ireland; Neuroscience Letters; 653; 7-2017; 269-2750304-39401872-7972CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304394017304743info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neulet.2017.05.068info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:05Zoai:ri.conicet.gov.ar:11336/38529instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:05.453CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
title Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
spellingShingle Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
Holubiec, Mariana Ines
Cb1
Daglα
Dorsal Striatum
Nape-Pld
Perinatal Asphyxia
Pparα
title_short Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
title_full Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
title_fullStr Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
title_full_unstemmed Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
title_sort Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia
dc.creator.none.fl_str_mv Holubiec, Mariana Ines
Romero, Juan Ignacio
Blanco, Eduardo
Logica Tornatore, Tamara Maite Ayelén
Suarez, Juan
Rodríguez de Fonseca, Fernando
Galeano, Pablo
Capani, Francisco
author Holubiec, Mariana Ines
author_facet Holubiec, Mariana Ines
Romero, Juan Ignacio
Blanco, Eduardo
Logica Tornatore, Tamara Maite Ayelén
Suarez, Juan
Rodríguez de Fonseca, Fernando
Galeano, Pablo
Capani, Francisco
author_role author
author2 Romero, Juan Ignacio
Blanco, Eduardo
Logica Tornatore, Tamara Maite Ayelén
Suarez, Juan
Rodríguez de Fonseca, Fernando
Galeano, Pablo
Capani, Francisco
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cb1
Daglα
Dorsal Striatum
Nape-Pld
Perinatal Asphyxia
Pparα
topic Cb1
Daglα
Dorsal Striatum
Nape-Pld
Perinatal Asphyxia
Pparα
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) in the main metabolic enzymes and receptors of the eCBs/AEs in the dorsal striatum of rats. To induce PA, we used a model developed by Bjelke et al. (1991). Immunohistochemical techniques were carried out to determine the expression of neuronal and glial markers (NeuN and GFAP), eCBs/AEs synthesis and degradation enzymes (DAGLα, NAPE-PLD and FAAH) and their receptors (CB1 and PPARα). We found a decrease in NAPE-PLD and PPARα expression. Since NAPE-PLD and PPARα take part in the production and reception of biochemical actions of AEs, such as oleoylethanolamide, these results may suggest that PA plays a key role in the regulation of this system. These data agree with previous results obtained in the hippocampus and encourage us to develop further studies using AEs as potential neuroprotective compounds.
Fil: Holubiec, Mariana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Romero, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Blanco, Eduardo. Universidad de Málaga; España. Universidad de Lleida; España
Fil: Logica Tornatore, Tamara Maite Ayelén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Suarez, Juan. Universidad de Málaga; España
Fil: Rodríguez de Fonseca, Fernando. Universidad de Málaga; España
Fil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Argentina "John F. Kennedy"; Argentina. Universidad de Chile; Chile
description Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) in the main metabolic enzymes and receptors of the eCBs/AEs in the dorsal striatum of rats. To induce PA, we used a model developed by Bjelke et al. (1991). Immunohistochemical techniques were carried out to determine the expression of neuronal and glial markers (NeuN and GFAP), eCBs/AEs synthesis and degradation enzymes (DAGLα, NAPE-PLD and FAAH) and their receptors (CB1 and PPARα). We found a decrease in NAPE-PLD and PPARα expression. Since NAPE-PLD and PPARα take part in the production and reception of biochemical actions of AEs, such as oleoylethanolamide, these results may suggest that PA plays a key role in the regulation of this system. These data agree with previous results obtained in the hippocampus and encourage us to develop further studies using AEs as potential neuroprotective compounds.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38529
Holubiec, Mariana Ines; Romero, Juan Ignacio; Blanco, Eduardo; Logica Tornatore, Tamara Maite Ayelén; Suarez, Juan; et al.; Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia; Elsevier Ireland; Neuroscience Letters; 653; 7-2017; 269-275
0304-3940
1872-7972
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38529
identifier_str_mv Holubiec, Mariana Ines; Romero, Juan Ignacio; Blanco, Eduardo; Logica Tornatore, Tamara Maite Ayelén; Suarez, Juan; et al.; Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia; Elsevier Ireland; Neuroscience Letters; 653; 7-2017; 269-275
0304-3940
1872-7972
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304394017304743
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neulet.2017.05.068
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614084225400832
score 13.070432

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