Can caloric restriction improve cognition in aging rats?

Autores
Altamirano, Fernando Gabriel; Ponce, Ivana Tamara; Castro Pascual, Ivanna Carla; Ferramola, Mariana Lucila; Delgado, Silvia Marcela; Anzulovich, Ana Cecilia; Lacoste, Maria Gabriela
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Can caloric restriction improve cognition in aging rats?Altamirano FG1, Ponce IT2, Castro Pascual IC1, Ferramola M2, Delgado SM2, Anzulovich AC1,2, Lacoste MG1,21Laboratorio de Cronobiología, IMIBIO, Universidad Nacional de San Luis, CONICET; 2 Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. San Luis, Argentina. E-mail: fergabalt@gmail.comCaloric restriction (CR) consists of reducing daily calorie intake without causing malnutrition. CR is the most effective non-pharmacological intervention in increasing longevity and reducing the effects of normal and pathological aging. Memory loss and cognitive impairment are one of the main features of aging and the effect of CR on these cognitive functions are still under study. Previous behavioral and molecular studies of our group showed that old animals had a low cognitive performance and loss of temporal expression of BDNF and TrkB, two proteins strongly linked to memory and learning processes, in hippocampus. Furthermore, we also demonstrate that CR treatment in old animals restored these temporal patterns of BDNF and TrkB in the hippocampus. Due to these antecedents, in the present work our objective was to evaluate if this restoration we previously observed at a molecular level is related to improvements in the cognitive performance of older animals under CR. Male Holtzman rats were separated into three experimental groups: young ad libitum (3-month-old, Y-AL group, n=10), older ad libitum (22-month-old, O-AL group, n=10), and older subjected to a 40% CR treatment during the last 3 months prior to the 22 months of age (O-CR group, n=5). Cognitive performance was assessed using the Barnes Maze (BM) test for spatial learning and memory and the New Object Recognition (NOR) test for contextual learning. In the BM test, we observed that the O-CR rats presented a shorter distance traveled on the platform, similar to Y-AL group. We did not find significant differences between O-CR and O-AL animals in the rest of the parameters analyzed with BM test (exploratory frequency of the target region, total exploratory activity, numbers of errors in reaching around the target hole, escape box latencies, percentage of exploration of the meta holes). In the case of NOR test, we also did not find significant differences between old animals and those subjected to CR. To date, the studies carried out on the effects of CR on cognitive functions are inconclusive and depend on the protocol used. The effects of CR depend on its intensity, the period of life in which the treatment begins and its duration. Our studies are preliminary, with a first group of animals in CR (n = 5), so increasing the number of animals studied could provide more conclusive data. CR could be a non-pharmacological alternative for maintaining mental and cognitive health during aging.
Fil: Altamirano, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Ponce, Ivana Tamara. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Castro Pascual, Ivanna Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Ferramola, Mariana Lucila. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Delgado, Silvia Marcela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Anzulovich, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Lacoste, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
IV Reunión Conjunta de Sociedades de Biología de la República Argentina
Virtual
Argentina
Sociedades de Biología de la Argentina
Materia
AGING
CALORIC RESTRICTION
MEMORY
LEARNIG
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182090
Acceder
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spelling Can caloric restriction improve cognition in aging rats?Altamirano, Fernando GabrielPonce, Ivana TamaraCastro Pascual, Ivanna CarlaFerramola, Mariana LucilaDelgado, Silvia MarcelaAnzulovich, Ana CeciliaLacoste, Maria GabrielaAGINGCALORIC RESTRICTIONMEMORYLEARNIGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Can caloric restriction improve cognition in aging rats?Altamirano FG1, Ponce IT2, Castro Pascual IC1, Ferramola M2, Delgado SM2, Anzulovich AC1,2, Lacoste MG1,21Laboratorio de Cronobiología, IMIBIO, Universidad Nacional de San Luis, CONICET; 2 Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. San Luis, Argentina. E-mail: fergabalt@gmail.comCaloric restriction (CR) consists of reducing daily calorie intake without causing malnutrition. CR is the most effective non-pharmacological intervention in increasing longevity and reducing the effects of normal and pathological aging. Memory loss and cognitive impairment are one of the main features of aging and the effect of CR on these cognitive functions are still under study. Previous behavioral and molecular studies of our group showed that old animals had a low cognitive performance and loss of temporal expression of BDNF and TrkB, two proteins strongly linked to memory and learning processes, in hippocampus. Furthermore, we also demonstrate that CR treatment in old animals restored these temporal patterns of BDNF and TrkB in the hippocampus. Due to these antecedents, in the present work our objective was to evaluate if this restoration we previously observed at a molecular level is related to improvements in the cognitive performance of older animals under CR. Male Holtzman rats were separated into three experimental groups: young ad libitum (3-month-old, Y-AL group, n=10), older ad libitum (22-month-old, O-AL group, n=10), and older subjected to a 40% CR treatment during the last 3 months prior to the 22 months of age (O-CR group, n=5). Cognitive performance was assessed using the Barnes Maze (BM) test for spatial learning and memory and the New Object Recognition (NOR) test for contextual learning. In the BM test, we observed that the O-CR rats presented a shorter distance traveled on the platform, similar to Y-AL group. We did not find significant differences between O-CR and O-AL animals in the rest of the parameters analyzed with BM test (exploratory frequency of the target region, total exploratory activity, numbers of errors in reaching around the target hole, escape box latencies, percentage of exploration of the meta holes). In the case of NOR test, we also did not find significant differences between old animals and those subjected to CR. To date, the studies carried out on the effects of CR on cognitive functions are inconclusive and depend on the protocol used. The effects of CR depend on its intensity, the period of life in which the treatment begins and its duration. Our studies are preliminary, with a first group of animals in CR (n = 5), so increasing the number of animals studied could provide more conclusive data. CR could be a non-pharmacological alternative for maintaining mental and cognitive health during aging.Fil: Altamirano, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Ponce, Ivana Tamara. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Castro Pascual, Ivanna Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Ferramola, Mariana Lucila. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Delgado, Silvia Marcela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Anzulovich, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Lacoste, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaIV Reunión Conjunta de Sociedades de Biología de la República ArgentinaVirtualArgentinaSociedades de Biología de la ArgentinaSociedades de Biología de la Argentina2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182090Can caloric restriction improve cognition in aging rats?; IV Reunión Conjunta de Sociedades de Biología de la República Argentina; Virtual; Argentina; 2020; 104-1051667-5746CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.techscience.com/biocell/index.htmlNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:12:16Zoai:ri.conicet.gov.ar:11336/182090instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:12:16.391CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Can caloric restriction improve cognition in aging rats?
title Can caloric restriction improve cognition in aging rats?
spellingShingle Can caloric restriction improve cognition in aging rats?
Altamirano, Fernando Gabriel
AGING
CALORIC RESTRICTION
MEMORY
LEARNIG
title_short Can caloric restriction improve cognition in aging rats?
title_full Can caloric restriction improve cognition in aging rats?
title_fullStr Can caloric restriction improve cognition in aging rats?
title_full_unstemmed Can caloric restriction improve cognition in aging rats?
title_sort Can caloric restriction improve cognition in aging rats?
dc.creator.none.fl_str_mv Altamirano, Fernando Gabriel
Ponce, Ivana Tamara
Castro Pascual, Ivanna Carla
Ferramola, Mariana Lucila
Delgado, Silvia Marcela
Anzulovich, Ana Cecilia
Lacoste, Maria Gabriela
author Altamirano, Fernando Gabriel
author_facet Altamirano, Fernando Gabriel
Ponce, Ivana Tamara
Castro Pascual, Ivanna Carla
Ferramola, Mariana Lucila
Delgado, Silvia Marcela
Anzulovich, Ana Cecilia
Lacoste, Maria Gabriela
author_role author
author2 Ponce, Ivana Tamara
Castro Pascual, Ivanna Carla
Ferramola, Mariana Lucila
Delgado, Silvia Marcela
Anzulovich, Ana Cecilia
Lacoste, Maria Gabriela
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AGING
CALORIC RESTRICTION
MEMORY
LEARNIG
topic AGING
CALORIC RESTRICTION
MEMORY
LEARNIG
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Can caloric restriction improve cognition in aging rats?Altamirano FG1, Ponce IT2, Castro Pascual IC1, Ferramola M2, Delgado SM2, Anzulovich AC1,2, Lacoste MG1,21Laboratorio de Cronobiología, IMIBIO, Universidad Nacional de San Luis, CONICET; 2 Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. San Luis, Argentina. E-mail: fergabalt@gmail.comCaloric restriction (CR) consists of reducing daily calorie intake without causing malnutrition. CR is the most effective non-pharmacological intervention in increasing longevity and reducing the effects of normal and pathological aging. Memory loss and cognitive impairment are one of the main features of aging and the effect of CR on these cognitive functions are still under study. Previous behavioral and molecular studies of our group showed that old animals had a low cognitive performance and loss of temporal expression of BDNF and TrkB, two proteins strongly linked to memory and learning processes, in hippocampus. Furthermore, we also demonstrate that CR treatment in old animals restored these temporal patterns of BDNF and TrkB in the hippocampus. Due to these antecedents, in the present work our objective was to evaluate if this restoration we previously observed at a molecular level is related to improvements in the cognitive performance of older animals under CR. Male Holtzman rats were separated into three experimental groups: young ad libitum (3-month-old, Y-AL group, n=10), older ad libitum (22-month-old, O-AL group, n=10), and older subjected to a 40% CR treatment during the last 3 months prior to the 22 months of age (O-CR group, n=5). Cognitive performance was assessed using the Barnes Maze (BM) test for spatial learning and memory and the New Object Recognition (NOR) test for contextual learning. In the BM test, we observed that the O-CR rats presented a shorter distance traveled on the platform, similar to Y-AL group. We did not find significant differences between O-CR and O-AL animals in the rest of the parameters analyzed with BM test (exploratory frequency of the target region, total exploratory activity, numbers of errors in reaching around the target hole, escape box latencies, percentage of exploration of the meta holes). In the case of NOR test, we also did not find significant differences between old animals and those subjected to CR. To date, the studies carried out on the effects of CR on cognitive functions are inconclusive and depend on the protocol used. The effects of CR depend on its intensity, the period of life in which the treatment begins and its duration. Our studies are preliminary, with a first group of animals in CR (n = 5), so increasing the number of animals studied could provide more conclusive data. CR could be a non-pharmacological alternative for maintaining mental and cognitive health during aging.
Fil: Altamirano, Fernando Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Ponce, Ivana Tamara. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Castro Pascual, Ivanna Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Ferramola, Mariana Lucila. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Delgado, Silvia Marcela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Anzulovich, Ana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Lacoste, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
IV Reunión Conjunta de Sociedades de Biología de la República Argentina
Virtual
Argentina
Sociedades de Biología de la Argentina
description Can caloric restriction improve cognition in aging rats?Altamirano FG1, Ponce IT2, Castro Pascual IC1, Ferramola M2, Delgado SM2, Anzulovich AC1,2, Lacoste MG1,21Laboratorio de Cronobiología, IMIBIO, Universidad Nacional de San Luis, CONICET; 2 Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. San Luis, Argentina. E-mail: fergabalt@gmail.comCaloric restriction (CR) consists of reducing daily calorie intake without causing malnutrition. CR is the most effective non-pharmacological intervention in increasing longevity and reducing the effects of normal and pathological aging. Memory loss and cognitive impairment are one of the main features of aging and the effect of CR on these cognitive functions are still under study. Previous behavioral and molecular studies of our group showed that old animals had a low cognitive performance and loss of temporal expression of BDNF and TrkB, two proteins strongly linked to memory and learning processes, in hippocampus. Furthermore, we also demonstrate that CR treatment in old animals restored these temporal patterns of BDNF and TrkB in the hippocampus. Due to these antecedents, in the present work our objective was to evaluate if this restoration we previously observed at a molecular level is related to improvements in the cognitive performance of older animals under CR. Male Holtzman rats were separated into three experimental groups: young ad libitum (3-month-old, Y-AL group, n=10), older ad libitum (22-month-old, O-AL group, n=10), and older subjected to a 40% CR treatment during the last 3 months prior to the 22 months of age (O-CR group, n=5). Cognitive performance was assessed using the Barnes Maze (BM) test for spatial learning and memory and the New Object Recognition (NOR) test for contextual learning. In the BM test, we observed that the O-CR rats presented a shorter distance traveled on the platform, similar to Y-AL group. We did not find significant differences between O-CR and O-AL animals in the rest of the parameters analyzed with BM test (exploratory frequency of the target region, total exploratory activity, numbers of errors in reaching around the target hole, escape box latencies, percentage of exploration of the meta holes). In the case of NOR test, we also did not find significant differences between old animals and those subjected to CR. To date, the studies carried out on the effects of CR on cognitive functions are inconclusive and depend on the protocol used. The effects of CR depend on its intensity, the period of life in which the treatment begins and its duration. Our studies are preliminary, with a first group of animals in CR (n = 5), so increasing the number of animals studied could provide more conclusive data. CR could be a non-pharmacological alternative for maintaining mental and cognitive health during aging.
publishDate 2021
dc.date.none.fl_str_mv 2021
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info:eu-repo/semantics/conferenceObject
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info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182090
Can caloric restriction improve cognition in aging rats?; IV Reunión Conjunta de Sociedades de Biología de la República Argentina; Virtual; Argentina; 2020; 104-105
1667-5746
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182090
identifier_str_mv Can caloric restriction improve cognition in aging rats?; IV Reunión Conjunta de Sociedades de Biología de la República Argentina; Virtual; Argentina; 2020; 104-105
1667-5746
CONICET Digital
CONICET
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language eng
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dc.publisher.none.fl_str_mv Sociedades de Biología de la Argentina
publisher.none.fl_str_mv Sociedades de Biología de la Argentina
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