Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria

Autores
Fabersani Marrades, Mario Emanuel; Russo, Matias Irineo; Márquez, María Antonela; Abeijon Mukdsi, Maria Claudia; Medina, Roxana Beatriz; Gauffin Cano, María Paola
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of this work was to evaluate the effect of a caloric restriction diet with and without the administration of Lactobacillus fermentum CRL1446, Lactobacillus casei CRL431 and Lactococcus lactis CRL1434, on immunemetabolic parameters and the composition of intestinal microbiota in mice. The supplementation of the caloric restriction diet with L. fermentum CRL1446 showed a bifidogenic effect and was able to maintain the abundance of the genus Lactobacillus over time. On the other hand, this strain showed hypocholesterolemic and hypoglycemic properties as well as inducing a decrease in plasma leptin levels. L. casei CRL431 administration increased the abundance of the Lactobacillus genera in the intestinal microbiota, which would improve the absorption of nutrients from the diet. This strain restores glucose values decreased by the diet in addition to inducing an increase in leptin and cytokines. Lac. lactis CRL1434 showed greater immunomodulatory capacity, without significantly affecting the composition of the intestinal microbiota. It had hypoglycemic properties and induced a decrease in leptin concentrations. L. fermentum CRL1446 and Lac. lactis CRL1434 could be potentially probiotic strains useful to correct the immuno-metabolic alterations associated with obesity, while L. casei CRL431 is a more suitable strain to be used in cases of malnutrition where it is sought to improve the absorption of nutrients and protection against infections, in addition to the stimulation of the immune system.
Fil: Fabersani Marrades, Mario Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina
Fil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Márquez, María Antonela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Abeijon Mukdsi, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad del Norte Santo Tomás de Aquino; Argentina
Fil: Medina, Roxana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina. Universidad del Norte Santo Tomás de Aquino; Argentina
Fil: Gauffin Cano, María Paola. Universidad del Norte Santo Tomás de Aquino; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Materia
Adipokines
Caloric Restriction
Microbiota
Probiotics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/81533
Acceder
id CONICETDig_7461327aacc973cba1262673b33e70a7
oai_identifier_str oai:ri.conicet.gov.ar:11336/81533
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteriaFabersani Marrades, Mario EmanuelRusso, Matias IrineoMárquez, María AntonelaAbeijon Mukdsi, Maria ClaudiaMedina, Roxana BeatrizGauffin Cano, María PaolaAdipokinesCaloric RestrictionMicrobiotaProbioticshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The objective of this work was to evaluate the effect of a caloric restriction diet with and without the administration of Lactobacillus fermentum CRL1446, Lactobacillus casei CRL431 and Lactococcus lactis CRL1434, on immunemetabolic parameters and the composition of intestinal microbiota in mice. The supplementation of the caloric restriction diet with L. fermentum CRL1446 showed a bifidogenic effect and was able to maintain the abundance of the genus Lactobacillus over time. On the other hand, this strain showed hypocholesterolemic and hypoglycemic properties as well as inducing a decrease in plasma leptin levels. L. casei CRL431 administration increased the abundance of the Lactobacillus genera in the intestinal microbiota, which would improve the absorption of nutrients from the diet. This strain restores glucose values decreased by the diet in addition to inducing an increase in leptin and cytokines. Lac. lactis CRL1434 showed greater immunomodulatory capacity, without significantly affecting the composition of the intestinal microbiota. It had hypoglycemic properties and induced a decrease in leptin concentrations. L. fermentum CRL1446 and Lac. lactis CRL1434 could be potentially probiotic strains useful to correct the immuno-metabolic alterations associated with obesity, while L. casei CRL431 is a more suitable strain to be used in cases of malnutrition where it is sought to improve the absorption of nutrients and protection against infections, in addition to the stimulation of the immune system.Fil: Fabersani Marrades, Mario Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; ArgentinaFil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Márquez, María Antonela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Abeijon Mukdsi, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad del Norte Santo Tomás de Aquino; ArgentinaFil: Medina, Roxana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina. Universidad del Norte Santo Tomás de Aquino; ArgentinaFil: Gauffin Cano, María Paola. Universidad del Norte Santo Tomás de Aquino; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaElsevier Science2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/81533Fabersani Marrades, Mario Emanuel; Russo, Matias Irineo; Márquez, María Antonela; Abeijon Mukdsi, Maria Claudia; Medina, Roxana Beatriz; et al.; Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria; Elsevier Science; Food Research International; 6-2018; 1-120963-99691873-7145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2018.06.014info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0963996918304599info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:59Zoai:ri.conicet.gov.ar:11336/81533instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:59.825CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria
title Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria
spellingShingle Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria
Fabersani Marrades, Mario Emanuel
Adipokines
Caloric Restriction
Microbiota
Probiotics
title_short Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria
title_full Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria
title_fullStr Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria
title_full_unstemmed Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria
title_sort Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria
dc.creator.none.fl_str_mv Fabersani Marrades, Mario Emanuel
Russo, Matias Irineo
Márquez, María Antonela
Abeijon Mukdsi, Maria Claudia
Medina, Roxana Beatriz
Gauffin Cano, María Paola
author Fabersani Marrades, Mario Emanuel
author_facet Fabersani Marrades, Mario Emanuel
Russo, Matias Irineo
Márquez, María Antonela
Abeijon Mukdsi, Maria Claudia
Medina, Roxana Beatriz
Gauffin Cano, María Paola
author_role author
author2 Russo, Matias Irineo
Márquez, María Antonela
Abeijon Mukdsi, Maria Claudia
Medina, Roxana Beatriz
Gauffin Cano, María Paola
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Adipokines
Caloric Restriction
Microbiota
Probiotics
topic Adipokines
Caloric Restriction
Microbiota
Probiotics
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The objective of this work was to evaluate the effect of a caloric restriction diet with and without the administration of Lactobacillus fermentum CRL1446, Lactobacillus casei CRL431 and Lactococcus lactis CRL1434, on immunemetabolic parameters and the composition of intestinal microbiota in mice. The supplementation of the caloric restriction diet with L. fermentum CRL1446 showed a bifidogenic effect and was able to maintain the abundance of the genus Lactobacillus over time. On the other hand, this strain showed hypocholesterolemic and hypoglycemic properties as well as inducing a decrease in plasma leptin levels. L. casei CRL431 administration increased the abundance of the Lactobacillus genera in the intestinal microbiota, which would improve the absorption of nutrients from the diet. This strain restores glucose values decreased by the diet in addition to inducing an increase in leptin and cytokines. Lac. lactis CRL1434 showed greater immunomodulatory capacity, without significantly affecting the composition of the intestinal microbiota. It had hypoglycemic properties and induced a decrease in leptin concentrations. L. fermentum CRL1446 and Lac. lactis CRL1434 could be potentially probiotic strains useful to correct the immuno-metabolic alterations associated with obesity, while L. casei CRL431 is a more suitable strain to be used in cases of malnutrition where it is sought to improve the absorption of nutrients and protection against infections, in addition to the stimulation of the immune system.
Fil: Fabersani Marrades, Mario Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina
Fil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Márquez, María Antonela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Abeijon Mukdsi, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad del Norte Santo Tomás de Aquino; Argentina
Fil: Medina, Roxana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán; Argentina. Universidad del Norte Santo Tomás de Aquino; Argentina
Fil: Gauffin Cano, María Paola. Universidad del Norte Santo Tomás de Aquino; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
description The objective of this work was to evaluate the effect of a caloric restriction diet with and without the administration of Lactobacillus fermentum CRL1446, Lactobacillus casei CRL431 and Lactococcus lactis CRL1434, on immunemetabolic parameters and the composition of intestinal microbiota in mice. The supplementation of the caloric restriction diet with L. fermentum CRL1446 showed a bifidogenic effect and was able to maintain the abundance of the genus Lactobacillus over time. On the other hand, this strain showed hypocholesterolemic and hypoglycemic properties as well as inducing a decrease in plasma leptin levels. L. casei CRL431 administration increased the abundance of the Lactobacillus genera in the intestinal microbiota, which would improve the absorption of nutrients from the diet. This strain restores glucose values decreased by the diet in addition to inducing an increase in leptin and cytokines. Lac. lactis CRL1434 showed greater immunomodulatory capacity, without significantly affecting the composition of the intestinal microbiota. It had hypoglycemic properties and induced a decrease in leptin concentrations. L. fermentum CRL1446 and Lac. lactis CRL1434 could be potentially probiotic strains useful to correct the immuno-metabolic alterations associated with obesity, while L. casei CRL431 is a more suitable strain to be used in cases of malnutrition where it is sought to improve the absorption of nutrients and protection against infections, in addition to the stimulation of the immune system.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/81533
Fabersani Marrades, Mario Emanuel; Russo, Matias Irineo; Márquez, María Antonela; Abeijon Mukdsi, Maria Claudia; Medina, Roxana Beatriz; et al.; Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria; Elsevier Science; Food Research International; 6-2018; 1-12
0963-9969
1873-7145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/81533
identifier_str_mv Fabersani Marrades, Mario Emanuel; Russo, Matias Irineo; Márquez, María Antonela; Abeijon Mukdsi, Maria Claudia; Medina, Roxana Beatriz; et al.; Modulation of intestinal microbiota and immunometabolic parameters by caloric restriction and lactic acid bacteria; Elsevier Science; Food Research International; 6-2018; 1-12
0963-9969
1873-7145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodres.2018.06.014
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0963996918304599
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268895688261632
score 13.13397

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