Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all

Autores
Guidolin, Leticia Soledad; Arce Gorvel, Vilma; Ciocchini, Andres Eduardo; Comerci, Diego José; Gorvel, Jean-Pierre
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cyclic β‐1,2‐D‐glucans (CβG) are natural bionanopolymers present in the periplasmic space of many Proteobacteria. These molecules are sugar rings made of 17 to 25 D‐glucose units linked exclusively by β‐1,2‐glycosidic bonds. CβG are important for environmental sensing and osmoadaptation in bacteria, but most importantly, they play key roles in complex host–cell interactions such as symbiosis, pathogenesis, and immunomodulation. In the last years, the identification and characterisation of the enzymes involved in the synthesis of CβG allowed to know in detail the steps necessary for the formation of these sugar rings. Due to its peculiar structure, CβG can complex large hydrophobic molecules, a feature possibly related to its function in the interaction with the host. The capabilities of the CβG to function as molecular boxes and to solubilise hydrophobic compounds are attractive for application in the development of drugs, in food industry, nanotechnology, and chemistry. More importantly, its excellent immunomodulatory properties led to the proposal of CβG as a new class of adjuvants for vaccine development.
Fil: Guidolin, Leticia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Arce Gorvel, Vilma. Centre National de la Recherche Scientifique; Francia
Fil: Ciocchini, Andres Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Ezeiza; Argentina
Fil: Gorvel, Jean-Pierre. Centre National de la Recherche Scientifique; Francia
Materia
PROTEOBACTERIA
BRUCELLA
INMUNOMODULATOR
CYCLODEXTRIN
CYCLIC GLUCAN
INMUNOMODULATOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96576
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96576
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them allGuidolin, Leticia SoledadArce Gorvel, VilmaCiocchini, Andres EduardoComerci, Diego JoséGorvel, Jean-PierrePROTEOBACTERIABRUCELLAINMUNOMODULATORCYCLODEXTRINCYCLIC GLUCANINMUNOMODULATORhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cyclic β‐1,2‐D‐glucans (CβG) are natural bionanopolymers present in the periplasmic space of many Proteobacteria. These molecules are sugar rings made of 17 to 25 D‐glucose units linked exclusively by β‐1,2‐glycosidic bonds. CβG are important for environmental sensing and osmoadaptation in bacteria, but most importantly, they play key roles in complex host–cell interactions such as symbiosis, pathogenesis, and immunomodulation. In the last years, the identification and characterisation of the enzymes involved in the synthesis of CβG allowed to know in detail the steps necessary for the formation of these sugar rings. Due to its peculiar structure, CβG can complex large hydrophobic molecules, a feature possibly related to its function in the interaction with the host. The capabilities of the CβG to function as molecular boxes and to solubilise hydrophobic compounds are attractive for application in the development of drugs, in food industry, nanotechnology, and chemistry. More importantly, its excellent immunomodulatory properties led to the proposal of CβG as a new class of adjuvants for vaccine development.Fil: Guidolin, Leticia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Arce Gorvel, Vilma. Centre National de la Recherche Scientifique; FranciaFil: Ciocchini, Andres Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Ezeiza; ArgentinaFil: Gorvel, Jean-Pierre. Centre National de la Recherche Scientifique; FranciaWiley Blackwell Publishing, Inc2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96576Guidolin, Leticia Soledad; Arce Gorvel, Vilma; Ciocchini, Andres Eduardo; Comerci, Diego José; Gorvel, Jean-Pierre; Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all; Wiley Blackwell Publishing, Inc; Cellular Microbiology (print); 20; 6; 6-2018; 1-81462-5814CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.12850info:eu-repo/semantics/altIdentifier/doi/10.1111/cmi.12850info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:57Zoai:ri.conicet.gov.ar:11336/96576instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:58.072CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all
title Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all
spellingShingle Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all
Guidolin, Leticia Soledad
PROTEOBACTERIA
BRUCELLA
INMUNOMODULATOR
CYCLODEXTRIN
CYCLIC GLUCAN
INMUNOMODULATOR
title_short Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all
title_full Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all
title_fullStr Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all
title_full_unstemmed Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all
title_sort Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all
dc.creator.none.fl_str_mv Guidolin, Leticia Soledad
Arce Gorvel, Vilma
Ciocchini, Andres Eduardo
Comerci, Diego José
Gorvel, Jean-Pierre
author Guidolin, Leticia Soledad
author_facet Guidolin, Leticia Soledad
Arce Gorvel, Vilma
Ciocchini, Andres Eduardo
Comerci, Diego José
Gorvel, Jean-Pierre
author_role author
author2 Arce Gorvel, Vilma
Ciocchini, Andres Eduardo
Comerci, Diego José
Gorvel, Jean-Pierre
author2_role author
author
author
author
dc.subject.none.fl_str_mv PROTEOBACTERIA
BRUCELLA
INMUNOMODULATOR
CYCLODEXTRIN
CYCLIC GLUCAN
INMUNOMODULATOR
topic PROTEOBACTERIA
BRUCELLA
INMUNOMODULATOR
CYCLODEXTRIN
CYCLIC GLUCAN
INMUNOMODULATOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cyclic β‐1,2‐D‐glucans (CβG) are natural bionanopolymers present in the periplasmic space of many Proteobacteria. These molecules are sugar rings made of 17 to 25 D‐glucose units linked exclusively by β‐1,2‐glycosidic bonds. CβG are important for environmental sensing and osmoadaptation in bacteria, but most importantly, they play key roles in complex host–cell interactions such as symbiosis, pathogenesis, and immunomodulation. In the last years, the identification and characterisation of the enzymes involved in the synthesis of CβG allowed to know in detail the steps necessary for the formation of these sugar rings. Due to its peculiar structure, CβG can complex large hydrophobic molecules, a feature possibly related to its function in the interaction with the host. The capabilities of the CβG to function as molecular boxes and to solubilise hydrophobic compounds are attractive for application in the development of drugs, in food industry, nanotechnology, and chemistry. More importantly, its excellent immunomodulatory properties led to the proposal of CβG as a new class of adjuvants for vaccine development.
Fil: Guidolin, Leticia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Arce Gorvel, Vilma. Centre National de la Recherche Scientifique; Francia
Fil: Ciocchini, Andres Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Comerci, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Ezeiza; Argentina
Fil: Gorvel, Jean-Pierre. Centre National de la Recherche Scientifique; Francia
description Cyclic β‐1,2‐D‐glucans (CβG) are natural bionanopolymers present in the periplasmic space of many Proteobacteria. These molecules are sugar rings made of 17 to 25 D‐glucose units linked exclusively by β‐1,2‐glycosidic bonds. CβG are important for environmental sensing and osmoadaptation in bacteria, but most importantly, they play key roles in complex host–cell interactions such as symbiosis, pathogenesis, and immunomodulation. In the last years, the identification and characterisation of the enzymes involved in the synthesis of CβG allowed to know in detail the steps necessary for the formation of these sugar rings. Due to its peculiar structure, CβG can complex large hydrophobic molecules, a feature possibly related to its function in the interaction with the host. The capabilities of the CβG to function as molecular boxes and to solubilise hydrophobic compounds are attractive for application in the development of drugs, in food industry, nanotechnology, and chemistry. More importantly, its excellent immunomodulatory properties led to the proposal of CβG as a new class of adjuvants for vaccine development.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96576
Guidolin, Leticia Soledad; Arce Gorvel, Vilma; Ciocchini, Andres Eduardo; Comerci, Diego José; Gorvel, Jean-Pierre; Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all; Wiley Blackwell Publishing, Inc; Cellular Microbiology (print); 20; 6; 6-2018; 1-8
1462-5814
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96576
identifier_str_mv Guidolin, Leticia Soledad; Arce Gorvel, Vilma; Ciocchini, Andres Eduardo; Comerci, Diego José; Gorvel, Jean-Pierre; Cyclic β-glucans at the bacteria–host cells interphase: One sugar ring to rule them all; Wiley Blackwell Publishing, Inc; Cellular Microbiology (print); 20; 6; 6-2018; 1-8
1462-5814
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.12850
info:eu-repo/semantics/altIdentifier/doi/10.1111/cmi.12850
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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