One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics

Autores
Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Ponce Alvarez, Adrián; Tagliazucchi, Enzo Rodolfo; Whybrow, Peter C.; Fuster, Joaquín; Kringelbach, Morten L.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Surviving and thriving in a complex world require intricate balancing of higher order brain functions with essential survival-related behaviours. Exactly how this is achieved is not fully understood but a large body of work has shown that different regions in the prefrontal cortex (PFC) play key roles for diverse cognitive and emotional tasks including emotion, control, response inhibition, mental set shifting and working memory. We hypothesised that the key regions are hierarchically organised and we developed a framework for discovering the driving brain regions at the top of the hierarchy, responsible for steering the brain dynamics of higher brain function. We fitted a time-dependent whole-brain model to the neuroimaging data from large-scale Human Connectome Project with over 1000 participants and computed the entropy production for rest and seven tasks (covering the main domains of cognition). This thermodynamics framework allowed us to identify the main common, unifying drivers steering the orchestration of brain dynamics during difficult tasks; located in key regions of the PFC (inferior frontal gyrus, lateral orbitofrontal cortex, rostral and caudal frontal cortex and rostral anterior cingulate cortex). Selectively lesioning these regions in the whole-brain model demonstrated their causal mechanistic importance. Overall, this shows the existence of a ‘ring’ of specific PFC regions ruling over the orchestration of higher brain function.
Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España
Fil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitat Pompeu Fabra; España. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Ponce Alvarez, Adrián. Universitat Pompeu Fabra; España
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Whybrow, Peter C.. University of Oxford; Reino Unido. University of California; Estados Unidos
Fil: Fuster, Joaquín. University of California; Estados Unidos. University of Oxford; Reino Unido
Fil: Kringelbach, Morten L.. University of Oxford; Reino Unido. University Aarhus; Dinamarca
Materia
BRAIN DYNAMICS
COREPERIPHERY
NEUROIMAGING
THERMODYNAMICS
WHOLE-BRAIN MODELLING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/228575
Acceder
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network_name_str CONICET Digital (CONICET)
spelling One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamicsDeco, GustavoSanz Perl Hernandez, YonatanPonce Alvarez, AdriánTagliazucchi, Enzo RodolfoWhybrow, Peter C.Fuster, JoaquínKringelbach, Morten L.BRAIN DYNAMICSCOREPERIPHERYNEUROIMAGINGTHERMODYNAMICSWHOLE-BRAIN MODELLINGhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Surviving and thriving in a complex world require intricate balancing of higher order brain functions with essential survival-related behaviours. Exactly how this is achieved is not fully understood but a large body of work has shown that different regions in the prefrontal cortex (PFC) play key roles for diverse cognitive and emotional tasks including emotion, control, response inhibition, mental set shifting and working memory. We hypothesised that the key regions are hierarchically organised and we developed a framework for discovering the driving brain regions at the top of the hierarchy, responsible for steering the brain dynamics of higher brain function. We fitted a time-dependent whole-brain model to the neuroimaging data from large-scale Human Connectome Project with over 1000 participants and computed the entropy production for rest and seven tasks (covering the main domains of cognition). This thermodynamics framework allowed us to identify the main common, unifying drivers steering the orchestration of brain dynamics during difficult tasks; located in key regions of the PFC (inferior frontal gyrus, lateral orbitofrontal cortex, rostral and caudal frontal cortex and rostral anterior cingulate cortex). Selectively lesioning these regions in the whole-brain model demonstrated their causal mechanistic importance. Overall, this shows the existence of a ‘ring’ of specific PFC regions ruling over the orchestration of higher brain function.Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; EspañaFil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitat Pompeu Fabra; España. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Ponce Alvarez, Adrián. Universitat Pompeu Fabra; EspañaFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad Adolfo Ibañez; ChileFil: Whybrow, Peter C.. University of Oxford; Reino Unido. University of California; Estados UnidosFil: Fuster, Joaquín. University of California; Estados Unidos. University of Oxford; Reino UnidoFil: Kringelbach, Morten L.. University of Oxford; Reino Unido. University Aarhus; DinamarcaPergamon-Elsevier Science Ltd2023-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/228575Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Ponce Alvarez, Adrián; Tagliazucchi, Enzo Rodolfo; Whybrow, Peter C.; et al.; One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 227; 102468; 8-2023; 1-130301-0082CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301008223000692info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pneurobio.2023.102468info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:58:34Zoai:ri.conicet.gov.ar:11336/228575instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:58:34.398CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
title One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
spellingShingle One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
Deco, Gustavo
BRAIN DYNAMICS
COREPERIPHERY
NEUROIMAGING
THERMODYNAMICS
WHOLE-BRAIN MODELLING
title_short One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
title_full One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
title_fullStr One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
title_full_unstemmed One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
title_sort One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics
dc.creator.none.fl_str_mv Deco, Gustavo
Sanz Perl Hernandez, Yonatan
Ponce Alvarez, Adrián
Tagliazucchi, Enzo Rodolfo
Whybrow, Peter C.
Fuster, Joaquín
Kringelbach, Morten L.
author Deco, Gustavo
author_facet Deco, Gustavo
Sanz Perl Hernandez, Yonatan
Ponce Alvarez, Adrián
Tagliazucchi, Enzo Rodolfo
Whybrow, Peter C.
Fuster, Joaquín
Kringelbach, Morten L.
author_role author
author2 Sanz Perl Hernandez, Yonatan
Ponce Alvarez, Adrián
Tagliazucchi, Enzo Rodolfo
Whybrow, Peter C.
Fuster, Joaquín
Kringelbach, Morten L.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BRAIN DYNAMICS
COREPERIPHERY
NEUROIMAGING
THERMODYNAMICS
WHOLE-BRAIN MODELLING
topic BRAIN DYNAMICS
COREPERIPHERY
NEUROIMAGING
THERMODYNAMICS
WHOLE-BRAIN MODELLING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Surviving and thriving in a complex world require intricate balancing of higher order brain functions with essential survival-related behaviours. Exactly how this is achieved is not fully understood but a large body of work has shown that different regions in the prefrontal cortex (PFC) play key roles for diverse cognitive and emotional tasks including emotion, control, response inhibition, mental set shifting and working memory. We hypothesised that the key regions are hierarchically organised and we developed a framework for discovering the driving brain regions at the top of the hierarchy, responsible for steering the brain dynamics of higher brain function. We fitted a time-dependent whole-brain model to the neuroimaging data from large-scale Human Connectome Project with over 1000 participants and computed the entropy production for rest and seven tasks (covering the main domains of cognition). This thermodynamics framework allowed us to identify the main common, unifying drivers steering the orchestration of brain dynamics during difficult tasks; located in key regions of the PFC (inferior frontal gyrus, lateral orbitofrontal cortex, rostral and caudal frontal cortex and rostral anterior cingulate cortex). Selectively lesioning these regions in the whole-brain model demonstrated their causal mechanistic importance. Overall, this shows the existence of a ‘ring’ of specific PFC regions ruling over the orchestration of higher brain function.
Fil: Deco, Gustavo. Universitat Pompeu Fabra; España. Institució Catalana de Recerca i Estudis Avancats; España
Fil: Sanz Perl Hernandez, Yonatan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitat Pompeu Fabra; España. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Ponce Alvarez, Adrián. Universitat Pompeu Fabra; España
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Universidad Adolfo Ibañez; Chile
Fil: Whybrow, Peter C.. University of Oxford; Reino Unido. University of California; Estados Unidos
Fil: Fuster, Joaquín. University of California; Estados Unidos. University of Oxford; Reino Unido
Fil: Kringelbach, Morten L.. University of Oxford; Reino Unido. University Aarhus; Dinamarca
description Surviving and thriving in a complex world require intricate balancing of higher order brain functions with essential survival-related behaviours. Exactly how this is achieved is not fully understood but a large body of work has shown that different regions in the prefrontal cortex (PFC) play key roles for diverse cognitive and emotional tasks including emotion, control, response inhibition, mental set shifting and working memory. We hypothesised that the key regions are hierarchically organised and we developed a framework for discovering the driving brain regions at the top of the hierarchy, responsible for steering the brain dynamics of higher brain function. We fitted a time-dependent whole-brain model to the neuroimaging data from large-scale Human Connectome Project with over 1000 participants and computed the entropy production for rest and seven tasks (covering the main domains of cognition). This thermodynamics framework allowed us to identify the main common, unifying drivers steering the orchestration of brain dynamics during difficult tasks; located in key regions of the PFC (inferior frontal gyrus, lateral orbitofrontal cortex, rostral and caudal frontal cortex and rostral anterior cingulate cortex). Selectively lesioning these regions in the whole-brain model demonstrated their causal mechanistic importance. Overall, this shows the existence of a ‘ring’ of specific PFC regions ruling over the orchestration of higher brain function.
publishDate 2023
dc.date.none.fl_str_mv 2023-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/228575
Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Ponce Alvarez, Adrián; Tagliazucchi, Enzo Rodolfo; Whybrow, Peter C.; et al.; One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 227; 102468; 8-2023; 1-13
0301-0082
CONICET Digital
CONICET
url http://hdl.handle.net/11336/228575
identifier_str_mv Deco, Gustavo; Sanz Perl Hernandez, Yonatan; Ponce Alvarez, Adrián; Tagliazucchi, Enzo Rodolfo; Whybrow, Peter C.; et al.; One ring to rule them all: The unifying role of prefrontal cortex in steering task-related brain dynamics; Pergamon-Elsevier Science Ltd; Progress In Neurobiology; 227; 102468; 8-2023; 1-13
0301-0082
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301008223000692
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pneurobio.2023.102468
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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