Cerebrovascular disease with and without stroke: Cognitive and clinical profiles

Autores
Dominguez, Raul O.; Marschoff, Enrique Ricardo; Bartolomé, Eduardo L.; Famulari, Arturo L.; Serra, Jorge Alberto
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cerebrovascular disease (CVD) patients with and without stroke were compared using clinical and neurological criteria, Magnetic Resonance Imaging (MRI) and cognitive impairment including dementia. The sample comprised 143 CVD outpatients (86 males, 60.14%): Stroke (n=88), Non-Stroke (n=55). Neurological and MRI assessment, the Clinical Dementia Rating (CDR: Normal, Questionable, non-demented; and Mild, Moderate, demented); the Alzheimer`s Disease Assessment Scale (ADAS-Cog), and the Trail Making Tests A (TMT-A) and B (TMT-B) were performed in all patients. Clinical, neurological and MRI results yielded statistically significant differences between patient groups (0.0001Fil: Dominguez, Raul O.. Hospital Sirio-Libanés; Argentina. Universidad de Buenos Aires; Argentina
Fil: Marschoff, Enrique Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Bartolomé, Eduardo L.. Hospital Sirio-Libanés; Argentina
Fil: Famulari, Arturo L.. Hospital Sirio-Libanés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Serra, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina
Materia
Cerebrovascular Disease
Stroke/Non-Stroke
Silent Brain Infarct
Incomplete White Matter Lesions
Magnetic Resonance Images
Cognitive Impairment
Dementia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67701
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67701
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cerebrovascular disease with and without stroke: Cognitive and clinical profilesDominguez, Raul O.Marschoff, Enrique RicardoBartolomé, Eduardo L.Famulari, Arturo L.Serra, Jorge AlbertoCerebrovascular DiseaseStroke/Non-StrokeSilent Brain InfarctIncomplete White Matter LesionsMagnetic Resonance ImagesCognitive ImpairmentDementiahttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cerebrovascular disease (CVD) patients with and without stroke were compared using clinical and neurological criteria, Magnetic Resonance Imaging (MRI) and cognitive impairment including dementia. The sample comprised 143 CVD outpatients (86 males, 60.14%): Stroke (n=88), Non-Stroke (n=55). Neurological and MRI assessment, the Clinical Dementia Rating (CDR: Normal, Questionable, non-demented; and Mild, Moderate, demented); the Alzheimer`s Disease Assessment Scale (ADAS-Cog), and the Trail Making Tests A (TMT-A) and B (TMT-B) were performed in all patients. Clinical, neurological and MRI results yielded statistically significant differences between patient groups (0.0001<P<0.05). Under Normal, Questionable and Mild CDR stages the Stroke group performed ADAS-Cog significantly worse (P<0.0001), showing non-significant differences in the Moderate stage. TMT time was always greater in the Stroke patients, while TMT errors resulted significantly greater in the Non-Stroke patient group (0.0001<P<0.002). The TMT-B/TMT-A ratio and the difference (B-A) were greater in the Non-Stroke patients (0.0001<P<0.001). At Moderate CDR the TMT’s showed no differences. Stroke and Non-Stroke CVD patients behave differently concerning several clinical, neurological and MRI results. Cognitive tests differ between groups when impairment has not reached the Moderate stage; further evolution turns both groups undistinguishable. Functional and cognitive impairment present a convincing linear association.Fil: Dominguez, Raul O.. Hospital Sirio-Libanés; Argentina. Universidad de Buenos Aires; ArgentinaFil: Marschoff, Enrique Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Bartolomé, Eduardo L.. Hospital Sirio-Libanés; ArgentinaFil: Famulari, Arturo L.. Hospital Sirio-Libanés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Serra, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; ArgentinaResearch Trends2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67701Dominguez, Raul O.; Marschoff, Enrique Ricardo; Bartolomé, Eduardo L. ; Famulari, Arturo L.; Serra, Jorge Alberto; Cerebrovascular disease with and without stroke: Cognitive and clinical profiles; Research Trends; Current Trends in Neurology; 3; 5-2010; 45-550972-8252CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=3&tid=47&aid=2809&pub=2009&type=3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:40Zoai:ri.conicet.gov.ar:11336/67701instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:41.163CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cerebrovascular disease with and without stroke: Cognitive and clinical profiles
title Cerebrovascular disease with and without stroke: Cognitive and clinical profiles
spellingShingle Cerebrovascular disease with and without stroke: Cognitive and clinical profiles
Dominguez, Raul O.
Cerebrovascular Disease
Stroke/Non-Stroke
Silent Brain Infarct
Incomplete White Matter Lesions
Magnetic Resonance Images
Cognitive Impairment
Dementia
title_short Cerebrovascular disease with and without stroke: Cognitive and clinical profiles
title_full Cerebrovascular disease with and without stroke: Cognitive and clinical profiles
title_fullStr Cerebrovascular disease with and without stroke: Cognitive and clinical profiles
title_full_unstemmed Cerebrovascular disease with and without stroke: Cognitive and clinical profiles
title_sort Cerebrovascular disease with and without stroke: Cognitive and clinical profiles
dc.creator.none.fl_str_mv Dominguez, Raul O.
Marschoff, Enrique Ricardo
Bartolomé, Eduardo L.
Famulari, Arturo L.
Serra, Jorge Alberto
author Dominguez, Raul O.
author_facet Dominguez, Raul O.
Marschoff, Enrique Ricardo
Bartolomé, Eduardo L.
Famulari, Arturo L.
Serra, Jorge Alberto
author_role author
author2 Marschoff, Enrique Ricardo
Bartolomé, Eduardo L.
Famulari, Arturo L.
Serra, Jorge Alberto
author2_role author
author
author
author
dc.subject.none.fl_str_mv Cerebrovascular Disease
Stroke/Non-Stroke
Silent Brain Infarct
Incomplete White Matter Lesions
Magnetic Resonance Images
Cognitive Impairment
Dementia
topic Cerebrovascular Disease
Stroke/Non-Stroke
Silent Brain Infarct
Incomplete White Matter Lesions
Magnetic Resonance Images
Cognitive Impairment
Dementia
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cerebrovascular disease (CVD) patients with and without stroke were compared using clinical and neurological criteria, Magnetic Resonance Imaging (MRI) and cognitive impairment including dementia. The sample comprised 143 CVD outpatients (86 males, 60.14%): Stroke (n=88), Non-Stroke (n=55). Neurological and MRI assessment, the Clinical Dementia Rating (CDR: Normal, Questionable, non-demented; and Mild, Moderate, demented); the Alzheimer`s Disease Assessment Scale (ADAS-Cog), and the Trail Making Tests A (TMT-A) and B (TMT-B) were performed in all patients. Clinical, neurological and MRI results yielded statistically significant differences between patient groups (0.0001<P<0.05). Under Normal, Questionable and Mild CDR stages the Stroke group performed ADAS-Cog significantly worse (P<0.0001), showing non-significant differences in the Moderate stage. TMT time was always greater in the Stroke patients, while TMT errors resulted significantly greater in the Non-Stroke patient group (0.0001<P<0.002). The TMT-B/TMT-A ratio and the difference (B-A) were greater in the Non-Stroke patients (0.0001<P<0.001). At Moderate CDR the TMT’s showed no differences. Stroke and Non-Stroke CVD patients behave differently concerning several clinical, neurological and MRI results. Cognitive tests differ between groups when impairment has not reached the Moderate stage; further evolution turns both groups undistinguishable. Functional and cognitive impairment present a convincing linear association.
Fil: Dominguez, Raul O.. Hospital Sirio-Libanés; Argentina. Universidad de Buenos Aires; Argentina
Fil: Marschoff, Enrique Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Bartolomé, Eduardo L.. Hospital Sirio-Libanés; Argentina
Fil: Famulari, Arturo L.. Hospital Sirio-Libanés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Serra, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina
description Cerebrovascular disease (CVD) patients with and without stroke were compared using clinical and neurological criteria, Magnetic Resonance Imaging (MRI) and cognitive impairment including dementia. The sample comprised 143 CVD outpatients (86 males, 60.14%): Stroke (n=88), Non-Stroke (n=55). Neurological and MRI assessment, the Clinical Dementia Rating (CDR: Normal, Questionable, non-demented; and Mild, Moderate, demented); the Alzheimer`s Disease Assessment Scale (ADAS-Cog), and the Trail Making Tests A (TMT-A) and B (TMT-B) were performed in all patients. Clinical, neurological and MRI results yielded statistically significant differences between patient groups (0.0001<P<0.05). Under Normal, Questionable and Mild CDR stages the Stroke group performed ADAS-Cog significantly worse (P<0.0001), showing non-significant differences in the Moderate stage. TMT time was always greater in the Stroke patients, while TMT errors resulted significantly greater in the Non-Stroke patient group (0.0001<P<0.002). The TMT-B/TMT-A ratio and the difference (B-A) were greater in the Non-Stroke patients (0.0001<P<0.001). At Moderate CDR the TMT’s showed no differences. Stroke and Non-Stroke CVD patients behave differently concerning several clinical, neurological and MRI results. Cognitive tests differ between groups when impairment has not reached the Moderate stage; further evolution turns both groups undistinguishable. Functional and cognitive impairment present a convincing linear association.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67701
Dominguez, Raul O.; Marschoff, Enrique Ricardo; Bartolomé, Eduardo L. ; Famulari, Arturo L.; Serra, Jorge Alberto; Cerebrovascular disease with and without stroke: Cognitive and clinical profiles; Research Trends; Current Trends in Neurology; 3; 5-2010; 45-55
0972-8252
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67701
identifier_str_mv Dominguez, Raul O.; Marschoff, Enrique Ricardo; Bartolomé, Eduardo L. ; Famulari, Arturo L.; Serra, Jorge Alberto; Cerebrovascular disease with and without stroke: Cognitive and clinical profiles; Research Trends; Current Trends in Neurology; 3; 5-2010; 45-55
0972-8252
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=3&tid=47&aid=2809&pub=2009&type=3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Research Trends
publisher.none.fl_str_mv Research Trends
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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