Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes
- Autores
- Casas, Sebastian; Gonzalez Deniselle, Maria Claudia; Gargiulo Monachelli, Gisella Mariana; Pérez, Andrés Felipe; Tourreilles, Martin; Mattiazzi, Marcelo; Ojeda, Cristian; Lotero Polesel, Daniel; de Nicola, Alejandro Federico
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Despite several scientific and technological advances, there is no single neuroprotective treatment that can reverse the brain damage after acute ischemic stroke (AIS). Neuroactive steroids are cholesterol-derived hormones that have the ability to modulate the normal and pathologic nervous system employing genomic and nongenomic mechanisms. In this work, we first investigated if AIS affects the plasma concentration of 5 neuroactive steroids (cortisol, estradiol, progesterone, testosterone, and 3α-androstenediol glucuronide). Second, we studied if levels of circulating steroids associate with neurological, cognitive, and functional outcome in a cohort of 60- to 90 year-old male and female patients with AIS. For this purpose, we recruited patients who were hospitalized at the Emergency Room of the Central Military Hospital within the first 24 h after stroke onset. We designed 2 experimental groups, each one composed of 30 control subjects and 30 AIS patients, both males and females. The assessment of neurological deficit was performed with the NIHSS and the tests used for the functional and cognitive status were: (1) modified Rankin Scale; (2) Photo test, and (3) abbreviated Pfeiffer's mental status questionnaire. We observed a significant difference in plasma concentration of cortisol and estradiol between both experimental groups. In the AIS group, higher levels of these neuroactive steroids were associated with more pronounced neurological, cognitive and functional deficits in women compared to men. We propose that in elderly patients, high levels of circulating neuroactive steroids like cortisol and estradiol could potentiate AIS-mediated neuropathology in the ischemic and penumbra areas.
Fil: Casas, Sebastian. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina
Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Pérez, Andrés Felipe. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina
Fil: Tourreilles, Martin. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina
Fil: Mattiazzi, Marcelo. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina
Fil: Ojeda, Cristian. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina
Fil: Lotero Polesel, Daniel. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina
Fil: de Nicola, Alejandro Federico. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Acute Ischemic Stroke
Cognitive Impairment
Elderly Patients
Functional Impairment
Neuroactive Steroids - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/54011
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Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological OutcomesCasas, SebastianGonzalez Deniselle, Maria ClaudiaGargiulo Monachelli, Gisella MarianaPérez, Andrés FelipeTourreilles, MartinMattiazzi, MarceloOjeda, CristianLotero Polesel, Danielde Nicola, Alejandro FedericoAcute Ischemic StrokeCognitive ImpairmentElderly PatientsFunctional ImpairmentNeuroactive Steroidshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Despite several scientific and technological advances, there is no single neuroprotective treatment that can reverse the brain damage after acute ischemic stroke (AIS). Neuroactive steroids are cholesterol-derived hormones that have the ability to modulate the normal and pathologic nervous system employing genomic and nongenomic mechanisms. In this work, we first investigated if AIS affects the plasma concentration of 5 neuroactive steroids (cortisol, estradiol, progesterone, testosterone, and 3α-androstenediol glucuronide). Second, we studied if levels of circulating steroids associate with neurological, cognitive, and functional outcome in a cohort of 60- to 90 year-old male and female patients with AIS. For this purpose, we recruited patients who were hospitalized at the Emergency Room of the Central Military Hospital within the first 24 h after stroke onset. We designed 2 experimental groups, each one composed of 30 control subjects and 30 AIS patients, both males and females. The assessment of neurological deficit was performed with the NIHSS and the tests used for the functional and cognitive status were: (1) modified Rankin Scale; (2) Photo test, and (3) abbreviated Pfeiffer's mental status questionnaire. We observed a significant difference in plasma concentration of cortisol and estradiol between both experimental groups. In the AIS group, higher levels of these neuroactive steroids were associated with more pronounced neurological, cognitive and functional deficits in women compared to men. We propose that in elderly patients, high levels of circulating neuroactive steroids like cortisol and estradiol could potentiate AIS-mediated neuropathology in the ischemic and penumbra areas.Fil: Casas, Sebastian. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; ArgentinaFil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Pérez, Andrés Felipe. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; ArgentinaFil: Tourreilles, Martin. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; ArgentinaFil: Mattiazzi, Marcelo. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; ArgentinaFil: Ojeda, Cristian. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; ArgentinaFil: Lotero Polesel, Daniel. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; ArgentinaFil: de Nicola, Alejandro Federico. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaGeorg Thieme Verlag Kg2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/54011Casas, Sebastian; Gonzalez Deniselle, Maria Claudia; Gargiulo Monachelli, Gisella Mariana; Pérez, Andrés Felipe; Tourreilles, Martin; et al.; Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 49; 1; 1-2017; 16-220018-5043CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1055/s-0042-119201info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-119201info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:29Zoai:ri.conicet.gov.ar:11336/54011instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:30.053CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes |
title |
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes |
spellingShingle |
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes Casas, Sebastian Acute Ischemic Stroke Cognitive Impairment Elderly Patients Functional Impairment Neuroactive Steroids |
title_short |
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes |
title_full |
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes |
title_fullStr |
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes |
title_full_unstemmed |
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes |
title_sort |
Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes |
dc.creator.none.fl_str_mv |
Casas, Sebastian Gonzalez Deniselle, Maria Claudia Gargiulo Monachelli, Gisella Mariana Pérez, Andrés Felipe Tourreilles, Martin Mattiazzi, Marcelo Ojeda, Cristian Lotero Polesel, Daniel de Nicola, Alejandro Federico |
author |
Casas, Sebastian |
author_facet |
Casas, Sebastian Gonzalez Deniselle, Maria Claudia Gargiulo Monachelli, Gisella Mariana Pérez, Andrés Felipe Tourreilles, Martin Mattiazzi, Marcelo Ojeda, Cristian Lotero Polesel, Daniel de Nicola, Alejandro Federico |
author_role |
author |
author2 |
Gonzalez Deniselle, Maria Claudia Gargiulo Monachelli, Gisella Mariana Pérez, Andrés Felipe Tourreilles, Martin Mattiazzi, Marcelo Ojeda, Cristian Lotero Polesel, Daniel de Nicola, Alejandro Federico |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Acute Ischemic Stroke Cognitive Impairment Elderly Patients Functional Impairment Neuroactive Steroids |
topic |
Acute Ischemic Stroke Cognitive Impairment Elderly Patients Functional Impairment Neuroactive Steroids |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Despite several scientific and technological advances, there is no single neuroprotective treatment that can reverse the brain damage after acute ischemic stroke (AIS). Neuroactive steroids are cholesterol-derived hormones that have the ability to modulate the normal and pathologic nervous system employing genomic and nongenomic mechanisms. In this work, we first investigated if AIS affects the plasma concentration of 5 neuroactive steroids (cortisol, estradiol, progesterone, testosterone, and 3α-androstenediol glucuronide). Second, we studied if levels of circulating steroids associate with neurological, cognitive, and functional outcome in a cohort of 60- to 90 year-old male and female patients with AIS. For this purpose, we recruited patients who were hospitalized at the Emergency Room of the Central Military Hospital within the first 24 h after stroke onset. We designed 2 experimental groups, each one composed of 30 control subjects and 30 AIS patients, both males and females. The assessment of neurological deficit was performed with the NIHSS and the tests used for the functional and cognitive status were: (1) modified Rankin Scale; (2) Photo test, and (3) abbreviated Pfeiffer's mental status questionnaire. We observed a significant difference in plasma concentration of cortisol and estradiol between both experimental groups. In the AIS group, higher levels of these neuroactive steroids were associated with more pronounced neurological, cognitive and functional deficits in women compared to men. We propose that in elderly patients, high levels of circulating neuroactive steroids like cortisol and estradiol could potentiate AIS-mediated neuropathology in the ischemic and penumbra areas. Fil: Casas, Sebastian. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina Fil: Gonzalez Deniselle, Maria Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Gargiulo Monachelli, Gisella Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Pérez, Andrés Felipe. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina Fil: Tourreilles, Martin. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina Fil: Mattiazzi, Marcelo. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina Fil: Ojeda, Cristian. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina Fil: Lotero Polesel, Daniel. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina Fil: de Nicola, Alejandro Federico. Ministerio de Defensa. Ejército Argentino. Hospital Militar Central Cirujano Mayor ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Despite several scientific and technological advances, there is no single neuroprotective treatment that can reverse the brain damage after acute ischemic stroke (AIS). Neuroactive steroids are cholesterol-derived hormones that have the ability to modulate the normal and pathologic nervous system employing genomic and nongenomic mechanisms. In this work, we first investigated if AIS affects the plasma concentration of 5 neuroactive steroids (cortisol, estradiol, progesterone, testosterone, and 3α-androstenediol glucuronide). Second, we studied if levels of circulating steroids associate with neurological, cognitive, and functional outcome in a cohort of 60- to 90 year-old male and female patients with AIS. For this purpose, we recruited patients who were hospitalized at the Emergency Room of the Central Military Hospital within the first 24 h after stroke onset. We designed 2 experimental groups, each one composed of 30 control subjects and 30 AIS patients, both males and females. The assessment of neurological deficit was performed with the NIHSS and the tests used for the functional and cognitive status were: (1) modified Rankin Scale; (2) Photo test, and (3) abbreviated Pfeiffer's mental status questionnaire. We observed a significant difference in plasma concentration of cortisol and estradiol between both experimental groups. In the AIS group, higher levels of these neuroactive steroids were associated with more pronounced neurological, cognitive and functional deficits in women compared to men. We propose that in elderly patients, high levels of circulating neuroactive steroids like cortisol and estradiol could potentiate AIS-mediated neuropathology in the ischemic and penumbra areas. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/54011 Casas, Sebastian; Gonzalez Deniselle, Maria Claudia; Gargiulo Monachelli, Gisella Mariana; Pérez, Andrés Felipe; Tourreilles, Martin; et al.; Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 49; 1; 1-2017; 16-22 0018-5043 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/54011 |
identifier_str_mv |
Casas, Sebastian; Gonzalez Deniselle, Maria Claudia; Gargiulo Monachelli, Gisella Mariana; Pérez, Andrés Felipe; Tourreilles, Martin; et al.; Neuroactive Steroids in Acute Ischemic Stroke: Association with Cognitive, Functional, and Neurological Outcomes; Georg Thieme Verlag Kg; Hormone and Metabolic Research; 49; 1; 1-2017; 16-22 0018-5043 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0042-119201 info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-119201 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Georg Thieme Verlag Kg |
publisher.none.fl_str_mv |
Georg Thieme Verlag Kg |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613505998651392 |
score |
13.070432 |