A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient

Autores
García, Adolfo Martín; Sedeño, Lucas; Herrera Murcia, Eduar; Couto, Juan Blas Marcos; Ibáñez Barassi, Agustín Mariano
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this study, we report an unusual case of mutidimensional sensorimotor, cognitive, and socio-affective preservation in an adult with extensive, acquired bilateral brain damage. At age 43, patient CG sustained a cerebral hemorrhage and a few months later, she suffered a second (ischemic) stroke. As a result, she exhibited extensive damage of the right hemisphere (including frontal, temporal, parietal, and occipital regions), left Sylvian and striatal areas, bilateral portions of the insula and the amygdala, and the splenium. However, against all probability, she was unimpaired across a host of cognitive domains, including executive functions, attention, memory, language, sensory perception (e.g., taste recognition and intensity discrimination), emotional processing (e.g., experiencing of positive and negative emotions), and social cognition skills (prosody recognition, theory of mind, facial emotion recognition, and emotional evaluation). Her functional integrity was further confirmed through neurological examination and contextualized observation of her performance in real-life tasks. In sum, CG's case resists straightforward classifications, as the extent and distribution of her lesions would typically produce pervasive, multidimensional deficits. We discuss the rarity of this patient against the backdrop of other reports of atypical cognitive preservation, expound the limitations of several potential accounts, and highlight the challenges that the case poses for current theories of brain organization and resilience.
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Herrera Murcia, Eduar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Icesi; Colombia
Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council; Australia
Materia
Bilateral Lesions
Cognitive Reserve
Multimodal Preservation
Stroke
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66670
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patientGarcía, Adolfo MartínSedeño, LucasHerrera Murcia, EduarCouto, Juan Blas MarcosIbáñez Barassi, Agustín MarianoBilateral LesionsCognitive ReserveMultimodal PreservationStrokehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In this study, we report an unusual case of mutidimensional sensorimotor, cognitive, and socio-affective preservation in an adult with extensive, acquired bilateral brain damage. At age 43, patient CG sustained a cerebral hemorrhage and a few months later, she suffered a second (ischemic) stroke. As a result, she exhibited extensive damage of the right hemisphere (including frontal, temporal, parietal, and occipital regions), left Sylvian and striatal areas, bilateral portions of the insula and the amygdala, and the splenium. However, against all probability, she was unimpaired across a host of cognitive domains, including executive functions, attention, memory, language, sensory perception (e.g., taste recognition and intensity discrimination), emotional processing (e.g., experiencing of positive and negative emotions), and social cognition skills (prosody recognition, theory of mind, facial emotion recognition, and emotional evaluation). Her functional integrity was further confirmed through neurological examination and contextualized observation of her performance in real-life tasks. In sum, CG's case resists straightforward classifications, as the extent and distribution of her lesions would typically produce pervasive, multidimensional deficits. We discuss the rarity of this patient against the backdrop of other reports of atypical cognitive preservation, expound the limitations of several potential accounts, and highlight the challenges that the case poses for current theories of brain organization and resilience.Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Nacional de Cuyo; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; ArgentinaFil: Herrera Murcia, Eduar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Icesi; ColombiaFil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; ArgentinaFil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council; AustraliaFrontiers Media S.A.2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66670García, Adolfo Martín; Sedeño, Lucas; Herrera Murcia, Eduar; Couto, Juan Blas Marcos; Ibáñez Barassi, Agustín Mariano; A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 8; JAN; 1-2017; 1-101663-4365CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnagi.2016.00335info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnagi.2016.00335info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:24Zoai:ri.conicet.gov.ar:11336/66670instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:24.426CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient
title A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient
spellingShingle A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient
García, Adolfo Martín
Bilateral Lesions
Cognitive Reserve
Multimodal Preservation
Stroke
title_short A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient
title_full A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient
title_fullStr A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient
title_full_unstemmed A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient
title_sort A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient
dc.creator.none.fl_str_mv García, Adolfo Martín
Sedeño, Lucas
Herrera Murcia, Eduar
Couto, Juan Blas Marcos
Ibáñez Barassi, Agustín Mariano
author García, Adolfo Martín
author_facet García, Adolfo Martín
Sedeño, Lucas
Herrera Murcia, Eduar
Couto, Juan Blas Marcos
Ibáñez Barassi, Agustín Mariano
author_role author
author2 Sedeño, Lucas
Herrera Murcia, Eduar
Couto, Juan Blas Marcos
Ibáñez Barassi, Agustín Mariano
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bilateral Lesions
Cognitive Reserve
Multimodal Preservation
Stroke
topic Bilateral Lesions
Cognitive Reserve
Multimodal Preservation
Stroke
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In this study, we report an unusual case of mutidimensional sensorimotor, cognitive, and socio-affective preservation in an adult with extensive, acquired bilateral brain damage. At age 43, patient CG sustained a cerebral hemorrhage and a few months later, she suffered a second (ischemic) stroke. As a result, she exhibited extensive damage of the right hemisphere (including frontal, temporal, parietal, and occipital regions), left Sylvian and striatal areas, bilateral portions of the insula and the amygdala, and the splenium. However, against all probability, she was unimpaired across a host of cognitive domains, including executive functions, attention, memory, language, sensory perception (e.g., taste recognition and intensity discrimination), emotional processing (e.g., experiencing of positive and negative emotions), and social cognition skills (prosody recognition, theory of mind, facial emotion recognition, and emotional evaluation). Her functional integrity was further confirmed through neurological examination and contextualized observation of her performance in real-life tasks. In sum, CG's case resists straightforward classifications, as the extent and distribution of her lesions would typically produce pervasive, multidimensional deficits. We discuss the rarity of this patient against the backdrop of other reports of atypical cognitive preservation, expound the limitations of several potential accounts, and highlight the challenges that the case poses for current theories of brain organization and resilience.
Fil: García, Adolfo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Nacional de Cuyo; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Herrera Murcia, Eduar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Icesi; Colombia
Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Instituto de Neurología Cognitiva; Argentina. Universidad Autónoma del Caribe; Colombia. Universidad Adolfo Ibañez; Chile. Australian Research Council; Australia
description In this study, we report an unusual case of mutidimensional sensorimotor, cognitive, and socio-affective preservation in an adult with extensive, acquired bilateral brain damage. At age 43, patient CG sustained a cerebral hemorrhage and a few months later, she suffered a second (ischemic) stroke. As a result, she exhibited extensive damage of the right hemisphere (including frontal, temporal, parietal, and occipital regions), left Sylvian and striatal areas, bilateral portions of the insula and the amygdala, and the splenium. However, against all probability, she was unimpaired across a host of cognitive domains, including executive functions, attention, memory, language, sensory perception (e.g., taste recognition and intensity discrimination), emotional processing (e.g., experiencing of positive and negative emotions), and social cognition skills (prosody recognition, theory of mind, facial emotion recognition, and emotional evaluation). Her functional integrity was further confirmed through neurological examination and contextualized observation of her performance in real-life tasks. In sum, CG's case resists straightforward classifications, as the extent and distribution of her lesions would typically produce pervasive, multidimensional deficits. We discuss the rarity of this patient against the backdrop of other reports of atypical cognitive preservation, expound the limitations of several potential accounts, and highlight the challenges that the case poses for current theories of brain organization and resilience.
publishDate 2017
dc.date.none.fl_str_mv 2017-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66670
García, Adolfo Martín; Sedeño, Lucas; Herrera Murcia, Eduar; Couto, Juan Blas Marcos; Ibáñez Barassi, Agustín Mariano; A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 8; JAN; 1-2017; 1-10
1663-4365
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66670
identifier_str_mv García, Adolfo Martín; Sedeño, Lucas; Herrera Murcia, Eduar; Couto, Juan Blas Marcos; Ibáñez Barassi, Agustín Mariano; A lesion-proof brain? Multidimensional sensorimotor, cognitive, and socio-affective preservation despite extensive damage in a stroke patient; Frontiers Media S.A.; Frontiers in Aging Neuroscience; 8; JAN; 1-2017; 1-10
1663-4365
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fnagi.2016.00335
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnagi.2016.00335
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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