Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula

Autores
García Cordero, Indira Ruth; Sedeño, Lucas; Fraiman Borrazás, Daniel Edmundo; Craiem, Damian; de la Fuente de la Torre, Laura Alethia; Salamone, Paula Celeste; Serrano, Cecilia Mariela; Sposato, Luciano A.; Manes, Facundo Francisco; Ibañez, Agustin Mariano
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background and Purpose - Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods - Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results - Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions - Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.
Fil: García Cordero, Indira Ruth. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sedeño, Lucas. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fraiman Borrazás, Daniel Edmundo. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Craiem, Damian. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de la Fuente de la Torre, Laura Alethia. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salamone, Paula Celeste. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Serrano, Cecilia Mariela. Memory and Balance Clinic; Argentina
Fil: Sposato, Luciano A.. Western University; Canadá
Fil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. ARC Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia. ARC Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Cerebral Cortex
Dementia
Magnetic Resonance Imaging
Stroke
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/69288
Acceder
id CONICETDig_e24007cfe6e7dc962fa6790650e9537a
oai_identifier_str oai:ri.conicet.gov.ar:11336/69288
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the InsulaGarcía Cordero, Indira RuthSedeño, LucasFraiman Borrazás, Daniel EdmundoCraiem, Damiande la Fuente de la Torre, Laura AlethiaSalamone, Paula CelesteSerrano, Cecilia MarielaSposato, Luciano A.Manes, Facundo FranciscoIbañez, Agustin MarianoCerebral CortexDementiaMagnetic Resonance ImagingStrokehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background and Purpose - Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods - Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results - Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions - Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.Fil: García Cordero, Indira Ruth. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sedeño, Lucas. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fraiman Borrazás, Daniel Edmundo. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Craiem, Damian. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de la Fuente de la Torre, Laura Alethia. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salamone, Paula Celeste. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Serrano, Cecilia Mariela. Memory and Balance Clinic; ArgentinaFil: Sposato, Luciano A.. Western University; CanadáFil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. ARC Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ibáñez Barassi, Agustín Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia. ARC Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaLippincott Williams2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/69288García Cordero, Indira Ruth; Sedeño, Lucas; Fraiman Borrazás, Daniel Edmundo; Craiem, Damian; de la Fuente de la Torre, Laura Alethia; et al.; Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula; Lippincott Williams; Stroke; 46; 9; 9-2015; 2673-26770039-2499CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1161/STROKEAHA.115.009598info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/STROKEAHA.115.009598info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:07Zoai:ri.conicet.gov.ar:11336/69288instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:07.984CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
title Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
spellingShingle Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
García Cordero, Indira Ruth
Cerebral Cortex
Dementia
Magnetic Resonance Imaging
Stroke
title_short Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
title_full Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
title_fullStr Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
title_full_unstemmed Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
title_sort Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula
dc.creator.none.fl_str_mv García Cordero, Indira Ruth
Sedeño, Lucas
Fraiman Borrazás, Daniel Edmundo
Craiem, Damian
de la Fuente de la Torre, Laura Alethia
Salamone, Paula Celeste
Serrano, Cecilia Mariela
Sposato, Luciano A.
Manes, Facundo Francisco
Ibañez, Agustin Mariano
author García Cordero, Indira Ruth
author_facet García Cordero, Indira Ruth
Sedeño, Lucas
Fraiman Borrazás, Daniel Edmundo
Craiem, Damian
de la Fuente de la Torre, Laura Alethia
Salamone, Paula Celeste
Serrano, Cecilia Mariela
Sposato, Luciano A.
Manes, Facundo Francisco
Ibañez, Agustin Mariano
author_role author
author2 Sedeño, Lucas
Fraiman Borrazás, Daniel Edmundo
Craiem, Damian
de la Fuente de la Torre, Laura Alethia
Salamone, Paula Celeste
Serrano, Cecilia Mariela
Sposato, Luciano A.
Manes, Facundo Francisco
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cerebral Cortex
Dementia
Magnetic Resonance Imaging
Stroke
topic Cerebral Cortex
Dementia
Magnetic Resonance Imaging
Stroke
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background and Purpose - Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods - Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results - Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions - Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.
Fil: García Cordero, Indira Ruth. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sedeño, Lucas. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fraiman Borrazás, Daniel Edmundo. Universidad de San Andrés; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Craiem, Damian. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de la Fuente de la Torre, Laura Alethia. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salamone, Paula Celeste. Instituto de Neurología Cognitiva; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Serrano, Cecilia Mariela. Memory and Balance Clinic; Argentina
Fil: Sposato, Luciano A.. Western University; Canadá
Fil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. ARC Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ibáñez Barassi, Agustín Mariano. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia. ARC Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background and Purpose - Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. Methods - Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. Results - Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. Conclusions - Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/69288
García Cordero, Indira Ruth; Sedeño, Lucas; Fraiman Borrazás, Daniel Edmundo; Craiem, Damian; de la Fuente de la Torre, Laura Alethia; et al.; Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula; Lippincott Williams; Stroke; 46; 9; 9-2015; 2673-2677
0039-2499
CONICET Digital
CONICET
url http://hdl.handle.net/11336/69288
identifier_str_mv García Cordero, Indira Ruth; Sedeño, Lucas; Fraiman Borrazás, Daniel Edmundo; Craiem, Damian; de la Fuente de la Torre, Laura Alethia; et al.; Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the Insula; Lippincott Williams; Stroke; 46; 9; 9-2015; 2673-2677
0039-2499
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1161/STROKEAHA.115.009598
info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/STROKEAHA.115.009598
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082659901505536
score 13.22299

Publicaciones similares