The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands
- Autores
- Hilton, Hugo G.; McMurtrey, Curtis P.; Han, Alex S.; Djaoud, Zakia; Guethlein, Lisbeth A.; Blokhuis, Jeroen H.; Pugh, Jason L.; Goyos, Ana; Horowitz, Amir; Buchli, Rico; Jackson, Ken W.; Bardet, Wilfred; Bushnell, David A.; Robinson, Philip J.; Mendoza, Juan L; Birnbaum, Michael E.; Nielsen, Morten; Garcia, K. Christopher; Hildebrand, William H.; Parham, Peter
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B∗46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B∗46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B∗46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The HLA-B∗46:01 peptidome is predicted to be enriched for peptide antigens derived from Mycobacterium leprae. Overall, the results indicate that the distinctive peptidome and functions of HLA-B∗46:01 provide carriers with resistance to leprosy, which drove its rapid rise in frequency in Southeast Asia.
Fil: Hilton, Hugo G.. University of Stanford; Estados Unidos
Fil: McMurtrey, Curtis P.. Oklahoma State University; Estados Unidos
Fil: Han, Alex S.. University of Stanford; Estados Unidos
Fil: Djaoud, Zakia. University of Stanford; Estados Unidos
Fil: Guethlein, Lisbeth A.. University of Stanford; Estados Unidos
Fil: Blokhuis, Jeroen H.. University of Stanford; Estados Unidos
Fil: Pugh, Jason L.. University of Stanford; Estados Unidos
Fil: Goyos, Ana. University of Stanford; Estados Unidos
Fil: Horowitz, Amir. University of Stanford; Estados Unidos
Fil: Buchli, Rico. Pure Protein LLC; Estados Unidos
Fil: Jackson, Ken W.. Oklahoma State University; Estados Unidos
Fil: Bardet, Wilfred. Oklahoma State University; Estados Unidos
Fil: Bushnell, David A.. University of Stanford; Estados Unidos
Fil: Robinson, Philip J.. University of Stanford; Estados Unidos
Fil: Mendoza, Juan L. University of Stanford; Estados Unidos
Fil: Birnbaum, Michael E.. University of Stanford; Estados Unidos
Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Garcia, K. Christopher. University of Stanford; Estados Unidos
Fil: Hildebrand, William H.. Oklahoma State University; Estados Unidos
Fil: Parham, Peter. University of Stanford; Estados Unidos - Materia
-
Antigen Presentation
Genetic Polymorphism
Hla Class I
Host-Pathogen Interactions
Kir
Mass Spectrometry
Modern Human Migration
Peptidome - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/48614
Ver los metadatos del registro completo
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The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 LigandsHilton, Hugo G.McMurtrey, Curtis P.Han, Alex S.Djaoud, ZakiaGuethlein, Lisbeth A.Blokhuis, Jeroen H.Pugh, Jason L.Goyos, AnaHorowitz, AmirBuchli, RicoJackson, Ken W.Bardet, WilfredBushnell, David A.Robinson, Philip J.Mendoza, Juan LBirnbaum, Michael E.Nielsen, MortenGarcia, K. ChristopherHildebrand, William H.Parham, PeterAntigen PresentationGenetic PolymorphismHla Class IHost-Pathogen InteractionsKirMass SpectrometryModern Human MigrationPeptidomehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B∗46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B∗46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B∗46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The HLA-B∗46:01 peptidome is predicted to be enriched for peptide antigens derived from Mycobacterium leprae. Overall, the results indicate that the distinctive peptidome and functions of HLA-B∗46:01 provide carriers with resistance to leprosy, which drove its rapid rise in frequency in Southeast Asia.Fil: Hilton, Hugo G.. University of Stanford; Estados UnidosFil: McMurtrey, Curtis P.. Oklahoma State University; Estados UnidosFil: Han, Alex S.. University of Stanford; Estados UnidosFil: Djaoud, Zakia. University of Stanford; Estados UnidosFil: Guethlein, Lisbeth A.. University of Stanford; Estados UnidosFil: Blokhuis, Jeroen H.. University of Stanford; Estados UnidosFil: Pugh, Jason L.. University of Stanford; Estados UnidosFil: Goyos, Ana. University of Stanford; Estados UnidosFil: Horowitz, Amir. University of Stanford; Estados UnidosFil: Buchli, Rico. Pure Protein LLC; Estados UnidosFil: Jackson, Ken W.. Oklahoma State University; Estados UnidosFil: Bardet, Wilfred. Oklahoma State University; Estados UnidosFil: Bushnell, David A.. University of Stanford; Estados UnidosFil: Robinson, Philip J.. University of Stanford; Estados UnidosFil: Mendoza, Juan L. University of Stanford; Estados UnidosFil: Birnbaum, Michael E.. University of Stanford; Estados UnidosFil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Garcia, K. Christopher. University of Stanford; Estados UnidosFil: Hildebrand, William H.. Oklahoma State University; Estados UnidosFil: Parham, Peter. University of Stanford; Estados UnidosElsevier Science2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48614Hilton, Hugo G.; McMurtrey, Curtis P.; Han, Alex S.; Djaoud, Zakia; Guethlein, Lisbeth A.; et al.; The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands; Elsevier Science; Cell Reports; 19; 7; 5-2017; 1394-14052211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2017.04.059info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124717305703info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:13Zoai:ri.conicet.gov.ar:11336/48614instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:13.733CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title |
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| spellingShingle |
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands Hilton, Hugo G. Antigen Presentation Genetic Polymorphism Hla Class I Host-Pathogen Interactions Kir Mass Spectrometry Modern Human Migration Peptidome |
| title_short |
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title_full |
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title_fullStr |
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title_full_unstemmed |
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| title_sort |
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands |
| dc.creator.none.fl_str_mv |
Hilton, Hugo G. McMurtrey, Curtis P. Han, Alex S. Djaoud, Zakia Guethlein, Lisbeth A. Blokhuis, Jeroen H. Pugh, Jason L. Goyos, Ana Horowitz, Amir Buchli, Rico Jackson, Ken W. Bardet, Wilfred Bushnell, David A. Robinson, Philip J. Mendoza, Juan L Birnbaum, Michael E. Nielsen, Morten Garcia, K. Christopher Hildebrand, William H. Parham, Peter |
| author |
Hilton, Hugo G. |
| author_facet |
Hilton, Hugo G. McMurtrey, Curtis P. Han, Alex S. Djaoud, Zakia Guethlein, Lisbeth A. Blokhuis, Jeroen H. Pugh, Jason L. Goyos, Ana Horowitz, Amir Buchli, Rico Jackson, Ken W. Bardet, Wilfred Bushnell, David A. Robinson, Philip J. Mendoza, Juan L Birnbaum, Michael E. Nielsen, Morten Garcia, K. Christopher Hildebrand, William H. Parham, Peter |
| author_role |
author |
| author2 |
McMurtrey, Curtis P. Han, Alex S. Djaoud, Zakia Guethlein, Lisbeth A. Blokhuis, Jeroen H. Pugh, Jason L. Goyos, Ana Horowitz, Amir Buchli, Rico Jackson, Ken W. Bardet, Wilfred Bushnell, David A. Robinson, Philip J. Mendoza, Juan L Birnbaum, Michael E. Nielsen, Morten Garcia, K. Christopher Hildebrand, William H. Parham, Peter |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Antigen Presentation Genetic Polymorphism Hla Class I Host-Pathogen Interactions Kir Mass Spectrometry Modern Human Migration Peptidome |
| topic |
Antigen Presentation Genetic Polymorphism Hla Class I Host-Pathogen Interactions Kir Mass Spectrometry Modern Human Migration Peptidome |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B∗46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B∗46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B∗46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The HLA-B∗46:01 peptidome is predicted to be enriched for peptide antigens derived from Mycobacterium leprae. Overall, the results indicate that the distinctive peptidome and functions of HLA-B∗46:01 provide carriers with resistance to leprosy, which drove its rapid rise in frequency in Southeast Asia. Fil: Hilton, Hugo G.. University of Stanford; Estados Unidos Fil: McMurtrey, Curtis P.. Oklahoma State University; Estados Unidos Fil: Han, Alex S.. University of Stanford; Estados Unidos Fil: Djaoud, Zakia. University of Stanford; Estados Unidos Fil: Guethlein, Lisbeth A.. University of Stanford; Estados Unidos Fil: Blokhuis, Jeroen H.. University of Stanford; Estados Unidos Fil: Pugh, Jason L.. University of Stanford; Estados Unidos Fil: Goyos, Ana. University of Stanford; Estados Unidos Fil: Horowitz, Amir. University of Stanford; Estados Unidos Fil: Buchli, Rico. Pure Protein LLC; Estados Unidos Fil: Jackson, Ken W.. Oklahoma State University; Estados Unidos Fil: Bardet, Wilfred. Oklahoma State University; Estados Unidos Fil: Bushnell, David A.. University of Stanford; Estados Unidos Fil: Robinson, Philip J.. University of Stanford; Estados Unidos Fil: Mendoza, Juan L. University of Stanford; Estados Unidos Fil: Birnbaum, Michael E.. University of Stanford; Estados Unidos Fil: Nielsen, Morten. Technical University of Denmark; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Garcia, K. Christopher. University of Stanford; Estados Unidos Fil: Hildebrand, William H.. Oklahoma State University; Estados Unidos Fil: Parham, Peter. University of Stanford; Estados Unidos |
| description |
HLA-B∗46:01 was formed by an intergenic mini-conversion, between HLA-B∗15:01 and HLA-C∗01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B∗46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B∗46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B∗46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The HLA-B∗46:01 peptidome is predicted to be enriched for peptide antigens derived from Mycobacterium leprae. Overall, the results indicate that the distinctive peptidome and functions of HLA-B∗46:01 provide carriers with resistance to leprosy, which drove its rapid rise in frequency in Southeast Asia. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-05 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/48614 Hilton, Hugo G.; McMurtrey, Curtis P.; Han, Alex S.; Djaoud, Zakia; Guethlein, Lisbeth A.; et al.; The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands; Elsevier Science; Cell Reports; 19; 7; 5-2017; 1394-1405 2211-1247 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/48614 |
| identifier_str_mv |
Hilton, Hugo G.; McMurtrey, Curtis P.; Han, Alex S.; Djaoud, Zakia; Guethlein, Lisbeth A.; et al.; The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands; Elsevier Science; Cell Reports; 19; 7; 5-2017; 1394-1405 2211-1247 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2017.04.059 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124717305703 |
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Elsevier Science |
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Elsevier Science |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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