KIR receptors and HLA-C in the maintenance of pregnancy

Autores
Flores, Ana Claudia; Marcos, C. Y.; Paladino, Natalia; Arruvito, Maria Lourdes; Williams, F.; Middleton, D.; Fainboim, Leonardo
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin-like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction with C1 ligands and therefore a weaker inhibition. The present study might support that in RSA patients, the balance between inhibitory and activating receptors present in natural killer cells is inclined toward an activating state that may contribute to pregnancy loss.
Fil: Flores, Ana Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marcos, C. Y.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina
Fil: Paladino, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina
Fil: Williams, F.. Belfast City Hospital; Irlanda
Fil: Middleton, D.. Belfast City Hospital; Irlanda
Fil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
KIR immunoglobulin-like receptors
recurrent spontaneous abortions
natural killer cells;
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/115966
Acceder
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network_name_str CONICET Digital (CONICET)
spelling KIR receptors and HLA-C in the maintenance of pregnancyFlores, Ana ClaudiaMarcos, C. Y.Paladino, NataliaArruvito, Maria LourdesWilliams, F.Middleton, D.Fainboim, LeonardoKIR immunoglobulin-like receptorsrecurrent spontaneous abortionsnatural killer cells;https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin-like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction with C1 ligands and therefore a weaker inhibition. The present study might support that in RSA patients, the balance between inhibitory and activating receptors present in natural killer cells is inclined toward an activating state that may contribute to pregnancy loss.Fil: Flores, Ana Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marcos, C. Y.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; ArgentinaFil: Paladino, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; ArgentinaFil: Williams, F.. Belfast City Hospital; IrlandaFil: Middleton, D.. Belfast City Hospital; IrlandaFil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley Blackwell Publishing, Inc2007-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/115966Flores, Ana Claudia; Marcos, C. Y.; Paladino, Natalia; Arruvito, Maria Lourdes; Williams, F.; et al.; KIR receptors and HLA-C in the maintenance of pregnancy; Wiley Blackwell Publishing, Inc; Tissue Antigens; 69; SUPPL. 1; 12-2007; 112-1130001-2815CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0039.2006.762_8.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1399-0039.2006.762_8.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:08Zoai:ri.conicet.gov.ar:11336/115966instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:09.156CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv KIR receptors and HLA-C in the maintenance of pregnancy
title KIR receptors and HLA-C in the maintenance of pregnancy
spellingShingle KIR receptors and HLA-C in the maintenance of pregnancy
Flores, Ana Claudia
KIR immunoglobulin-like receptors
recurrent spontaneous abortions
natural killer cells;
title_short KIR receptors and HLA-C in the maintenance of pregnancy
title_full KIR receptors and HLA-C in the maintenance of pregnancy
title_fullStr KIR receptors and HLA-C in the maintenance of pregnancy
title_full_unstemmed KIR receptors and HLA-C in the maintenance of pregnancy
title_sort KIR receptors and HLA-C in the maintenance of pregnancy
dc.creator.none.fl_str_mv Flores, Ana Claudia
Marcos, C. Y.
Paladino, Natalia
Arruvito, Maria Lourdes
Williams, F.
Middleton, D.
Fainboim, Leonardo
author Flores, Ana Claudia
author_facet Flores, Ana Claudia
Marcos, C. Y.
Paladino, Natalia
Arruvito, Maria Lourdes
Williams, F.
Middleton, D.
Fainboim, Leonardo
author_role author
author2 Marcos, C. Y.
Paladino, Natalia
Arruvito, Maria Lourdes
Williams, F.
Middleton, D.
Fainboim, Leonardo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv KIR immunoglobulin-like receptors
recurrent spontaneous abortions
natural killer cells;
topic KIR immunoglobulin-like receptors
recurrent spontaneous abortions
natural killer cells;
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin-like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction with C1 ligands and therefore a weaker inhibition. The present study might support that in RSA patients, the balance between inhibitory and activating receptors present in natural killer cells is inclined toward an activating state that may contribute to pregnancy loss.
Fil: Flores, Ana Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marcos, C. Y.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina
Fil: Paladino, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina
Fil: Williams, F.. Belfast City Hospital; Irlanda
Fil: Middleton, D.. Belfast City Hospital; Irlanda
Fil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The present study demonstrated that patients who have recurrent spontaneous abortions (RSA) presented a decreased number of killer immunoglobulin-like inhibitory receptors (KIR), in particular KIR2DL2. The KIR AA genotype was found increased in comparison with controls. Individuals AA will also be homozygous for 2DL3, which in contrast to 2DL2, show a weaker interaction with C1 ligands and therefore a weaker inhibition. The present study might support that in RSA patients, the balance between inhibitory and activating receptors present in natural killer cells is inclined toward an activating state that may contribute to pregnancy loss.
publishDate 2007
dc.date.none.fl_str_mv 2007-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/115966
Flores, Ana Claudia; Marcos, C. Y.; Paladino, Natalia; Arruvito, Maria Lourdes; Williams, F.; et al.; KIR receptors and HLA-C in the maintenance of pregnancy; Wiley Blackwell Publishing, Inc; Tissue Antigens; 69; SUPPL. 1; 12-2007; 112-113
0001-2815
CONICET Digital
CONICET
url http://hdl.handle.net/11336/115966
identifier_str_mv Flores, Ana Claudia; Marcos, C. Y.; Paladino, Natalia; Arruvito, Maria Lourdes; Williams, F.; et al.; KIR receptors and HLA-C in the maintenance of pregnancy; Wiley Blackwell Publishing, Inc; Tissue Antigens; 69; SUPPL. 1; 12-2007; 112-113
0001-2815
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-0039.2006.762_8.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1399-0039.2006.762_8.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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