Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine

Autores
de Rosa, Maria Jose; Veuthey, Tania Vanesa; Aguirre, Nicolás; Blanco, Maria Gabriela; Lemus, Constanza; Rayes, Diego Hernán
Año de publicación
2014
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
In nature, animals are frequently exposed to physiological and environmental challenges. The individual cellular response to these unfavorable conditions should be finely coordinated in multicellular organisms. The neural control of the systemic stress response was first evidenced in the free-living nematode C.elegans. However, the identity of the systemic neural signal that integrates stress perception with the response in non-neuronal tissues remains unknown. Our analysis of the C.elegans neuronal wiring diagram reveals that the circuits activated upon exposure to stressful situations converge in the only tyraminergic neuron, RIM. Tyramine is the invertebrate counterpart for adrenaline. Here we found that tyraminedeficient animals are resistant to thermal stress, starvation and pathogen infection. Moreover, these mutant strains exhibit molecular hallmarks of stressed worms, such as autophagy and lypolisis induction, even when they are grown under favorable conditions. Our results suggest that inhibition of the basal release of tyramine is a neuroendocrine signal required for a coordinated triggering of the stress response in C. elegans. This study contributes to a better understanding of the neurohormonal signaling that controls the systemic processes in multicellular organisms
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Aguirre, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Lemus, Constanza. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XXX Annual Meeting and Sociedad Argentina de Investigación en Neurociencias -International Society for Neurochemistry Small Conference and Course
Mar del Plata
Argentina
Sociedad Argentina de Investigación en Neurociencias
International Society for Neurochemistry
Materia
C.elegans
stress response
tyramine
hormesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/237927
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyraminede Rosa, Maria JoseVeuthey, Tania VanesaAguirre, NicolásBlanco, Maria GabrielaLemus, ConstanzaRayes, Diego HernánC.elegansstress responsetyraminehormesishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In nature, animals are frequently exposed to physiological and environmental challenges. The individual cellular response to these unfavorable conditions should be finely coordinated in multicellular organisms. The neural control of the systemic stress response was first evidenced in the free-living nematode C.elegans. However, the identity of the systemic neural signal that integrates stress perception with the response in non-neuronal tissues remains unknown. Our analysis of the C.elegans neuronal wiring diagram reveals that the circuits activated upon exposure to stressful situations converge in the only tyraminergic neuron, RIM. Tyramine is the invertebrate counterpart for adrenaline. Here we found that tyraminedeficient animals are resistant to thermal stress, starvation and pathogen infection. Moreover, these mutant strains exhibit molecular hallmarks of stressed worms, such as autophagy and lypolisis induction, even when they are grown under favorable conditions. Our results suggest that inhibition of the basal release of tyramine is a neuroendocrine signal required for a coordinated triggering of the stress response in C. elegans. This study contributes to a better understanding of the neurohormonal signaling that controls the systemic processes in multicellular organismsFil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Aguirre, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Lemus, Constanza. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaXXX Annual Meeting and Sociedad Argentina de Investigación en Neurociencias -International Society for Neurochemistry Small Conference and CourseMar del PlataArgentinaSociedad Argentina de Investigación en NeurocienciasInternational Society for NeurochemistrySociedad Argentina de Investigaciones en Neurociencias2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/237927Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine; XXX Annual Meeting and Sociedad Argentina de Investigación en Neurociencias -International Society for Neurochemistry Small Conference and Course; Mar del Plata; Argentina; 2015; 268-268CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/congresos-san-2/Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:21Zoai:ri.conicet.gov.ar:11336/237927instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:21.835CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine
title Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine
spellingShingle Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine
de Rosa, Maria Jose
C.elegans
stress response
tyramine
hormesis
title_short Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine
title_full Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine
title_fullStr Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine
title_full_unstemmed Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine
title_sort Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine
dc.creator.none.fl_str_mv de Rosa, Maria Jose
Veuthey, Tania Vanesa
Aguirre, Nicolás
Blanco, Maria Gabriela
Lemus, Constanza
Rayes, Diego Hernán
author de Rosa, Maria Jose
author_facet de Rosa, Maria Jose
Veuthey, Tania Vanesa
Aguirre, Nicolás
Blanco, Maria Gabriela
Lemus, Constanza
Rayes, Diego Hernán
author_role author
author2 Veuthey, Tania Vanesa
Aguirre, Nicolás
Blanco, Maria Gabriela
Lemus, Constanza
Rayes, Diego Hernán
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv C.elegans
stress response
tyramine
hormesis
topic C.elegans
stress response
tyramine
hormesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In nature, animals are frequently exposed to physiological and environmental challenges. The individual cellular response to these unfavorable conditions should be finely coordinated in multicellular organisms. The neural control of the systemic stress response was first evidenced in the free-living nematode C.elegans. However, the identity of the systemic neural signal that integrates stress perception with the response in non-neuronal tissues remains unknown. Our analysis of the C.elegans neuronal wiring diagram reveals that the circuits activated upon exposure to stressful situations converge in the only tyraminergic neuron, RIM. Tyramine is the invertebrate counterpart for adrenaline. Here we found that tyraminedeficient animals are resistant to thermal stress, starvation and pathogen infection. Moreover, these mutant strains exhibit molecular hallmarks of stressed worms, such as autophagy and lypolisis induction, even when they are grown under favorable conditions. Our results suggest that inhibition of the basal release of tyramine is a neuroendocrine signal required for a coordinated triggering of the stress response in C. elegans. This study contributes to a better understanding of the neurohormonal signaling that controls the systemic processes in multicellular organisms
Fil: de Rosa, Maria Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Veuthey, Tania Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Aguirre, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Blanco, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Lemus, Constanza. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Rayes, Diego Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XXX Annual Meeting and Sociedad Argentina de Investigación en Neurociencias -International Society for Neurochemistry Small Conference and Course
Mar del Plata
Argentina
Sociedad Argentina de Investigación en Neurociencias
International Society for Neurochemistry
description In nature, animals are frequently exposed to physiological and environmental challenges. The individual cellular response to these unfavorable conditions should be finely coordinated in multicellular organisms. The neural control of the systemic stress response was first evidenced in the free-living nematode C.elegans. However, the identity of the systemic neural signal that integrates stress perception with the response in non-neuronal tissues remains unknown. Our analysis of the C.elegans neuronal wiring diagram reveals that the circuits activated upon exposure to stressful situations converge in the only tyraminergic neuron, RIM. Tyramine is the invertebrate counterpart for adrenaline. Here we found that tyraminedeficient animals are resistant to thermal stress, starvation and pathogen infection. Moreover, these mutant strains exhibit molecular hallmarks of stressed worms, such as autophagy and lypolisis induction, even when they are grown under favorable conditions. Our results suggest that inhibition of the basal release of tyramine is a neuroendocrine signal required for a coordinated triggering of the stress response in C. elegans. This study contributes to a better understanding of the neurohormonal signaling that controls the systemic processes in multicellular organisms
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/237927
Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine; XXX Annual Meeting and Sociedad Argentina de Investigación en Neurociencias -International Society for Neurochemistry Small Conference and Course; Mar del Plata; Argentina; 2015; 268-268
CONICET Digital
CONICET
url http://hdl.handle.net/11336/237927
identifier_str_mv Neuronal regulation of the stress response in C.elegans: Role of the neurotransmitter tyramine; XXX Annual Meeting and Sociedad Argentina de Investigación en Neurociencias -International Society for Neurochemistry Small Conference and Course; Mar del Plata; Argentina; 2015; 268-268
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://saneurociencias.org.ar/congresos-san-2/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Sociedad Argentina de Investigaciones en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigaciones en Neurociencias
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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