Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species

Autores
Ugalde Arbizu, Maider; Aguilera Correa, John Jairo; San Sebastian, Eider; Páez, Paulina Laura; Nogales, Estela; Esteban, Jaime; Gómez Ruiz, Santiago
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, this study aimed to perform the synthesis and characterization of seven materials based on silica mesoporous nanoparticles functionalized with three types of fluoroquinolones, along with Cu2+ or Ag+ species to evaluate the antibacterial properties against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa, including clinical and multi-drug-resistant strains of S. aureus and P. aeruginosa. In addition, in order to obtain an effective material to promote wound healing, a well-known proliferative agent, phenytoin sodium, was adsorbed onto one of the silver-functionalized materials. Furthermore, biofilm studies and the generation of reactive oxygen species (ROS) were also carried out to determine the antibacterial potential of the synthesized materials. In this sense, the Cu2+ materials showed antibacterial activity against S. aureus and E. coli, potentially due to increased ROS generation (up to 3 times), whereas the Ag+ materials exhibited a broader spectrum of activity, even inhibiting clinical strains of MRSA and P. aeruginosa. In particular, the Ag+ material with phenytoin sodium showed the ability to reduce biofilm development by up to 55% and inhibit bacterial growth in a “wound-like medium” by up to 89.33%.
Fil: Ugalde Arbizu, Maider. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; España. Universidad del País Vasco; España. Universidad Rey Juan Carlos; España
Fil: Aguilera Correa, John Jairo. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; España. Instituto de Salud Carlos III; España
Fil: San Sebastian, Eider. Universidad del País Vasco; España
Fil: Páez, Paulina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Nogales, Estela. Universidad Rey Juan Carlos; España
Fil: Esteban, Jaime. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; España. Instituto de Salud Carlos III; España
Fil: Gómez Ruiz, Santiago. Universidad Rey Juan Carlos; España
Materia
BIOFILM
COPPER
FLUOROQUINOLONE
MSN
SILVER CHLORIDE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/226652
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver SpeciesUgalde Arbizu, MaiderAguilera Correa, John JairoSan Sebastian, EiderPáez, Paulina LauraNogales, EstelaEsteban, JaimeGómez Ruiz, SantiagoBIOFILMCOPPERFLUOROQUINOLONEMSNSILVER CHLORIDEhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, this study aimed to perform the synthesis and characterization of seven materials based on silica mesoporous nanoparticles functionalized with three types of fluoroquinolones, along with Cu2+ or Ag+ species to evaluate the antibacterial properties against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa, including clinical and multi-drug-resistant strains of S. aureus and P. aeruginosa. In addition, in order to obtain an effective material to promote wound healing, a well-known proliferative agent, phenytoin sodium, was adsorbed onto one of the silver-functionalized materials. Furthermore, biofilm studies and the generation of reactive oxygen species (ROS) were also carried out to determine the antibacterial potential of the synthesized materials. In this sense, the Cu2+ materials showed antibacterial activity against S. aureus and E. coli, potentially due to increased ROS generation (up to 3 times), whereas the Ag+ materials exhibited a broader spectrum of activity, even inhibiting clinical strains of MRSA and P. aeruginosa. In particular, the Ag+ material with phenytoin sodium showed the ability to reduce biofilm development by up to 55% and inhibit bacterial growth in a “wound-like medium” by up to 89.33%.Fil: Ugalde Arbizu, Maider. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; España. Universidad del País Vasco; España. Universidad Rey Juan Carlos; EspañaFil: Aguilera Correa, John Jairo. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; España. Instituto de Salud Carlos III; EspañaFil: San Sebastian, Eider. Universidad del País Vasco; EspañaFil: Páez, Paulina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Nogales, Estela. Universidad Rey Juan Carlos; EspañaFil: Esteban, Jaime. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; España. Instituto de Salud Carlos III; EspañaFil: Gómez Ruiz, Santiago. Universidad Rey Juan Carlos; EspañaMultidisciplinary Digital Publishing Institute2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/226652Ugalde Arbizu, Maider; Aguilera Correa, John Jairo; San Sebastian, Eider; Páez, Paulina Laura; Nogales, Estela; et al.; Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species; Multidisciplinary Digital Publishing Institute; Pharmaceuticals; 16; 7; 7-2023; 1-211424-8247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/ph16070961info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1424-8247/16/7/961info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:14:54Zoai:ri.conicet.gov.ar:11336/226652instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:14:55.146CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species
title Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species
spellingShingle Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species
Ugalde Arbizu, Maider
BIOFILM
COPPER
FLUOROQUINOLONE
MSN
SILVER CHLORIDE
title_short Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species
title_full Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species
title_fullStr Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species
title_full_unstemmed Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species
title_sort Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species
dc.creator.none.fl_str_mv Ugalde Arbizu, Maider
Aguilera Correa, John Jairo
San Sebastian, Eider
Páez, Paulina Laura
Nogales, Estela
Esteban, Jaime
Gómez Ruiz, Santiago
author Ugalde Arbizu, Maider
author_facet Ugalde Arbizu, Maider
Aguilera Correa, John Jairo
San Sebastian, Eider
Páez, Paulina Laura
Nogales, Estela
Esteban, Jaime
Gómez Ruiz, Santiago
author_role author
author2 Aguilera Correa, John Jairo
San Sebastian, Eider
Páez, Paulina Laura
Nogales, Estela
Esteban, Jaime
Gómez Ruiz, Santiago
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOFILM
COPPER
FLUOROQUINOLONE
MSN
SILVER CHLORIDE
topic BIOFILM
COPPER
FLUOROQUINOLONE
MSN
SILVER CHLORIDE
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, this study aimed to perform the synthesis and characterization of seven materials based on silica mesoporous nanoparticles functionalized with three types of fluoroquinolones, along with Cu2+ or Ag+ species to evaluate the antibacterial properties against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa, including clinical and multi-drug-resistant strains of S. aureus and P. aeruginosa. In addition, in order to obtain an effective material to promote wound healing, a well-known proliferative agent, phenytoin sodium, was adsorbed onto one of the silver-functionalized materials. Furthermore, biofilm studies and the generation of reactive oxygen species (ROS) were also carried out to determine the antibacterial potential of the synthesized materials. In this sense, the Cu2+ materials showed antibacterial activity against S. aureus and E. coli, potentially due to increased ROS generation (up to 3 times), whereas the Ag+ materials exhibited a broader spectrum of activity, even inhibiting clinical strains of MRSA and P. aeruginosa. In particular, the Ag+ material with phenytoin sodium showed the ability to reduce biofilm development by up to 55% and inhibit bacterial growth in a “wound-like medium” by up to 89.33%.
Fil: Ugalde Arbizu, Maider. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; España. Universidad del País Vasco; España. Universidad Rey Juan Carlos; España
Fil: Aguilera Correa, John Jairo. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; España. Instituto de Salud Carlos III; España
Fil: San Sebastian, Eider. Universidad del País Vasco; España
Fil: Páez, Paulina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Nogales, Estela. Universidad Rey Juan Carlos; España
Fil: Esteban, Jaime. Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz; España. Instituto de Salud Carlos III; España
Fil: Gómez Ruiz, Santiago. Universidad Rey Juan Carlos; España
description Antibiotic resistance is a global problem and bacterial biofilms contribute to its development. In this context, this study aimed to perform the synthesis and characterization of seven materials based on silica mesoporous nanoparticles functionalized with three types of fluoroquinolones, along with Cu2+ or Ag+ species to evaluate the antibacterial properties against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa, including clinical and multi-drug-resistant strains of S. aureus and P. aeruginosa. In addition, in order to obtain an effective material to promote wound healing, a well-known proliferative agent, phenytoin sodium, was adsorbed onto one of the silver-functionalized materials. Furthermore, biofilm studies and the generation of reactive oxygen species (ROS) were also carried out to determine the antibacterial potential of the synthesized materials. In this sense, the Cu2+ materials showed antibacterial activity against S. aureus and E. coli, potentially due to increased ROS generation (up to 3 times), whereas the Ag+ materials exhibited a broader spectrum of activity, even inhibiting clinical strains of MRSA and P. aeruginosa. In particular, the Ag+ material with phenytoin sodium showed the ability to reduce biofilm development by up to 55% and inhibit bacterial growth in a “wound-like medium” by up to 89.33%.
publishDate 2023
dc.date.none.fl_str_mv 2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/226652
Ugalde Arbizu, Maider; Aguilera Correa, John Jairo; San Sebastian, Eider; Páez, Paulina Laura; Nogales, Estela; et al.; Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species; Multidisciplinary Digital Publishing Institute; Pharmaceuticals; 16; 7; 7-2023; 1-21
1424-8247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/226652
identifier_str_mv Ugalde Arbizu, Maider; Aguilera Correa, John Jairo; San Sebastian, Eider; Páez, Paulina Laura; Nogales, Estela; et al.; Antibacterial Properties of Mesoporous Silica Nanoparticles Modified with Fluoroquinolones and Copper or Silver Species; Multidisciplinary Digital Publishing Institute; Pharmaceuticals; 16; 7; 7-2023; 1-21
1424-8247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/ph16070961
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1424-8247/16/7/961
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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