Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug

Autores
Ugalde Arbizu, Maider; Aguilera Correa, John Jairo; García Almodóvar, Victoria; Ovejero Paredes, Karina; Díaz García, Diana; Esteban, Jaime; Páez, Paulina Laura; Prashar, Sanjiv; San Sebastian, Eider; Filice, Marco; Gómez Ruiz, Santiago
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified as excellent anticancer agents against triple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, with very poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells and excellent luminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of Staphylococcus aureus, the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. 2-MSN-Sn is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanoparticles are particularly suitable for oral or topical administration, and considering both its anticancer and antibacterial activity, 2-MSN-Sn represents a new dual-condition theranostic agent, based primarily on natural products or their derivatives and with only a minimum amount of a novel metallodrug.
Fil: Ugalde Arbizu, Maider. Universidad del País Vasco; España
Fil: Aguilera Correa, John Jairo. Universidad Autónoma de Madrid; España
Fil: García Almodóvar, Victoria. Universidad Rey Juan Carlos; España
Fil: Ovejero Paredes, Karina. Universidad Complutense de Madrid; España
Fil: Díaz García, Diana. Universidad Rey Juan Carlos; España
Fil: Esteban, Jaime. Universidad Rey Juan Carlos; España
Fil: Páez, Paulina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Prashar, Sanjiv. Universidad Rey Juan Carlos; España
Fil: San Sebastian, Eider. Universidad del País Vasco; España
Fil: Filice, Marco. Universidad Complutense de Madrid; España
Fil: Gómez Ruiz, Santiago. Universidad Rey Juan Carlos; España
Materia
BACTERIA
BIOFILM
BIOFILM
CANCER
LUMINESCENCE
ORAL
S. AUREUS
THERANOSIS
TOPICAL
WOUND HEALING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/226762
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/226762
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) MetallodrugUgalde Arbizu, MaiderAguilera Correa, John JairoGarcía Almodóvar, VictoriaOvejero Paredes, KarinaDíaz García, DianaEsteban, JaimePáez, Paulina LauraPrashar, SanjivSan Sebastian, EiderFilice, MarcoGómez Ruiz, SantiagoBACTERIABIOFILMBIOFILMCANCERLUMINESCENCEORALS. AUREUSTHERANOSISTOPICALWOUND HEALINGhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified as excellent anticancer agents against triple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, with very poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells and excellent luminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of Staphylococcus aureus, the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. 2-MSN-Sn is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanoparticles are particularly suitable for oral or topical administration, and considering both its anticancer and antibacterial activity, 2-MSN-Sn represents a new dual-condition theranostic agent, based primarily on natural products or their derivatives and with only a minimum amount of a novel metallodrug.Fil: Ugalde Arbizu, Maider. Universidad del País Vasco; EspañaFil: Aguilera Correa, John Jairo. Universidad Autónoma de Madrid; EspañaFil: García Almodóvar, Victoria. Universidad Rey Juan Carlos; EspañaFil: Ovejero Paredes, Karina. Universidad Complutense de Madrid; EspañaFil: Díaz García, Diana. Universidad Rey Juan Carlos; EspañaFil: Esteban, Jaime. Universidad Rey Juan Carlos; EspañaFil: Páez, Paulina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Prashar, Sanjiv. Universidad Rey Juan Carlos; EspañaFil: San Sebastian, Eider. Universidad del País Vasco; EspañaFil: Filice, Marco. Universidad Complutense de Madrid; EspañaFil: Gómez Ruiz, Santiago. Universidad Rey Juan Carlos; EspañaMDPI2023-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/226762Ugalde Arbizu, Maider; Aguilera Correa, John Jairo; García Almodóvar, Victoria; Ovejero Paredes, Karina; Díaz García, Diana; et al.; Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug; MDPI; Pharmaceutics; 15; 2; 2-2023; 1-221999-4923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/15/2/560info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics15020560info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:25:42Zoai:ri.conicet.gov.ar:11336/226762instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:25:42.442CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
title Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
spellingShingle Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
Ugalde Arbizu, Maider
BACTERIA
BIOFILM
BIOFILM
CANCER
LUMINESCENCE
ORAL
S. AUREUS
THERANOSIS
TOPICAL
WOUND HEALING
title_short Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
title_full Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
title_fullStr Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
title_full_unstemmed Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
title_sort Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug
dc.creator.none.fl_str_mv Ugalde Arbizu, Maider
Aguilera Correa, John Jairo
García Almodóvar, Victoria
Ovejero Paredes, Karina
Díaz García, Diana
Esteban, Jaime
Páez, Paulina Laura
Prashar, Sanjiv
San Sebastian, Eider
Filice, Marco
Gómez Ruiz, Santiago
author Ugalde Arbizu, Maider
author_facet Ugalde Arbizu, Maider
Aguilera Correa, John Jairo
García Almodóvar, Victoria
Ovejero Paredes, Karina
Díaz García, Diana
Esteban, Jaime
Páez, Paulina Laura
Prashar, Sanjiv
San Sebastian, Eider
Filice, Marco
Gómez Ruiz, Santiago
author_role author
author2 Aguilera Correa, John Jairo
García Almodóvar, Victoria
Ovejero Paredes, Karina
Díaz García, Diana
Esteban, Jaime
Páez, Paulina Laura
Prashar, Sanjiv
San Sebastian, Eider
Filice, Marco
Gómez Ruiz, Santiago
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BACTERIA
BIOFILM
BIOFILM
CANCER
LUMINESCENCE
ORAL
S. AUREUS
THERANOSIS
TOPICAL
WOUND HEALING
topic BACTERIA
BIOFILM
BIOFILM
CANCER
LUMINESCENCE
ORAL
S. AUREUS
THERANOSIS
TOPICAL
WOUND HEALING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified as excellent anticancer agents against triple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, with very poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells and excellent luminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of Staphylococcus aureus, the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. 2-MSN-Sn is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanoparticles are particularly suitable for oral or topical administration, and considering both its anticancer and antibacterial activity, 2-MSN-Sn represents a new dual-condition theranostic agent, based primarily on natural products or their derivatives and with only a minimum amount of a novel metallodrug.
Fil: Ugalde Arbizu, Maider. Universidad del País Vasco; España
Fil: Aguilera Correa, John Jairo. Universidad Autónoma de Madrid; España
Fil: García Almodóvar, Victoria. Universidad Rey Juan Carlos; España
Fil: Ovejero Paredes, Karina. Universidad Complutense de Madrid; España
Fil: Díaz García, Diana. Universidad Rey Juan Carlos; España
Fil: Esteban, Jaime. Universidad Rey Juan Carlos; España
Fil: Páez, Paulina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Prashar, Sanjiv. Universidad Rey Juan Carlos; España
Fil: San Sebastian, Eider. Universidad del País Vasco; España
Fil: Filice, Marco. Universidad Complutense de Madrid; España
Fil: Gómez Ruiz, Santiago. Universidad Rey Juan Carlos; España
description Five different silica nanoparticles functionalized with vitamin B12, a derivative of coumarin found in green plants and a minimum content of an organotin(IV) fragment (1-MSN-Sn, 2-MSN-Sn, 2-SBA-Sn, 2-FSPm-Sn and 2-FSPs-Sn), were identified as excellent anticancer agents against triple negative breast cancer, one of the most diagnosed and aggressive cancerous tumors, with very poor prognosis. Notably, compound 2-MSN-Sn shows selectivity for cancer cells and excellent luminescent properties detectable by imaging techniques once internalized. The same compound is also able to interact with and nearly eradicate biofilms of Staphylococcus aureus, the most common bacteria isolated from chronic wounds and burns, whose treatment is a clinical challenge. 2-MSN-Sn is efficiently internalized by bacteria in a biofilm state and destroys the latter through reactive oxygen species (ROS) generation. Its internalization by bacteria was also efficiently monitored by fluorescence imaging. Since silica nanoparticles are particularly suitable for oral or topical administration, and considering both its anticancer and antibacterial activity, 2-MSN-Sn represents a new dual-condition theranostic agent, based primarily on natural products or their derivatives and with only a minimum amount of a novel metallodrug.
publishDate 2023
dc.date.none.fl_str_mv 2023-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/226762
Ugalde Arbizu, Maider; Aguilera Correa, John Jairo; García Almodóvar, Victoria; Ovejero Paredes, Karina; Díaz García, Diana; et al.; Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug; MDPI; Pharmaceutics; 15; 2; 2-2023; 1-22
1999-4923
CONICET Digital
CONICET
url http://hdl.handle.net/11336/226762
identifier_str_mv Ugalde Arbizu, Maider; Aguilera Correa, John Jairo; García Almodóvar, Victoria; Ovejero Paredes, Karina; Díaz García, Diana; et al.; Dual Anticancer and Antibacterial Properties of Silica-Based Theranostic Nanomaterials Functionalized with Coumarin343, Folic Acid and a Cytotoxic Organotin(IV) Metallodrug; MDPI; Pharmaceutics; 15; 2; 2-2023; 1-22
1999-4923
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/15/2/560
info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics15020560
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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