Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity

Autores
Arzeni, Carolina; Pérez, Oscar E.; Leblanc, Jean Guy Joseph; Pilosof, Ana Maria Renata
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The ability of egg white (EW) nanoparticles to bind folic acid (FA) and protect it through the gastrointestinal tract and the resulting properties of the mixtures as functional ingredient was investigated. Two kinds of EW nanoparticles (USN and TSN) were mixed with FA to generate nanocarriers (USF and TSF). The particle size distribution of USN remained unaltered after the binding of FA, while a little increase in particle size was observed for TSN. Zeta (ζ) potential and fluorescence intensity did not show any significant change after FA addition for both nanoparticles. The percentage of bound folic acid (% BFA) was 78.0 ± 9.1 and 79.7 ± 9.0, for USF and TSF, respectively. A slight formation of aggregates in the samples was observed after freeze-drying and redispersion of the nanocarriers, which was also confirmed by confocal laser scanning microscopy. Nanocarriers particle size did not change after adjusting the pH from 3 to 4, but strongly increased after adjusting it to 5, 6 or 7. The % BFA at pH 4 was similar to that at pH 3, but greatly decreased at pH 7. The bioavailability of FA for Lactobacillus rhamnosus was enhanced when the vitamin was incorporated in the form of digested nanocomplexes USF or TSF. The interaction of EW nanoparticles with FA has proven to be beneficial for the transport and release of FA after in vitro digestion.
Fil: Arzeni, Carolina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina
Fil: Pérez, Oscar E.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Pilosof, Ana Maria Renata. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina
Materia
BIOLOGICAL ACTIVITY
EGG WHITE
FOLIC ACID
NANOCOMPLEXES
NANOPARTICLES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/113193
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/113193
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activityArzeni, CarolinaPérez, Oscar E.Leblanc, Jean Guy JosephPilosof, Ana Maria RenataBIOLOGICAL ACTIVITYEGG WHITEFOLIC ACIDNANOCOMPLEXESNANOPARTICLEShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2The ability of egg white (EW) nanoparticles to bind folic acid (FA) and protect it through the gastrointestinal tract and the resulting properties of the mixtures as functional ingredient was investigated. Two kinds of EW nanoparticles (USN and TSN) were mixed with FA to generate nanocarriers (USF and TSF). The particle size distribution of USN remained unaltered after the binding of FA, while a little increase in particle size was observed for TSN. Zeta (ζ) potential and fluorescence intensity did not show any significant change after FA addition for both nanoparticles. The percentage of bound folic acid (% BFA) was 78.0 ± 9.1 and 79.7 ± 9.0, for USF and TSF, respectively. A slight formation of aggregates in the samples was observed after freeze-drying and redispersion of the nanocarriers, which was also confirmed by confocal laser scanning microscopy. Nanocarriers particle size did not change after adjusting the pH from 3 to 4, but strongly increased after adjusting it to 5, 6 or 7. The % BFA at pH 4 was similar to that at pH 3, but greatly decreased at pH 7. The bioavailability of FA for Lactobacillus rhamnosus was enhanced when the vitamin was incorporated in the form of digested nanocomplexes USF or TSF. The interaction of EW nanoparticles with FA has proven to be beneficial for the transport and release of FA after in vitro digestion.Fil: Arzeni, Carolina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; ArgentinaFil: Pérez, Oscar E.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; ArgentinaFil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Pilosof, Ana Maria Renata. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; ArgentinaElsevier2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/113193Arzeni, Carolina; Pérez, Oscar E.; Leblanc, Jean Guy Joseph; Pilosof, Ana Maria Renata; Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity; Elsevier; Journal of Functional Foods; 18; 10-2015; 379-3861756-4646CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S175646461500376Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2015.07.018info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:58:17Zoai:ri.conicet.gov.ar:11336/113193instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:58:17.67CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity
title Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity
spellingShingle Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity
Arzeni, Carolina
BIOLOGICAL ACTIVITY
EGG WHITE
FOLIC ACID
NANOCOMPLEXES
NANOPARTICLES
title_short Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity
title_full Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity
title_fullStr Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity
title_full_unstemmed Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity
title_sort Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity
dc.creator.none.fl_str_mv Arzeni, Carolina
Pérez, Oscar E.
Leblanc, Jean Guy Joseph
Pilosof, Ana Maria Renata
author Arzeni, Carolina
author_facet Arzeni, Carolina
Pérez, Oscar E.
Leblanc, Jean Guy Joseph
Pilosof, Ana Maria Renata
author_role author
author2 Pérez, Oscar E.
Leblanc, Jean Guy Joseph
Pilosof, Ana Maria Renata
author2_role author
author
author
dc.subject.none.fl_str_mv BIOLOGICAL ACTIVITY
EGG WHITE
FOLIC ACID
NANOCOMPLEXES
NANOPARTICLES
topic BIOLOGICAL ACTIVITY
EGG WHITE
FOLIC ACID
NANOCOMPLEXES
NANOPARTICLES
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The ability of egg white (EW) nanoparticles to bind folic acid (FA) and protect it through the gastrointestinal tract and the resulting properties of the mixtures as functional ingredient was investigated. Two kinds of EW nanoparticles (USN and TSN) were mixed with FA to generate nanocarriers (USF and TSF). The particle size distribution of USN remained unaltered after the binding of FA, while a little increase in particle size was observed for TSN. Zeta (ζ) potential and fluorescence intensity did not show any significant change after FA addition for both nanoparticles. The percentage of bound folic acid (% BFA) was 78.0 ± 9.1 and 79.7 ± 9.0, for USF and TSF, respectively. A slight formation of aggregates in the samples was observed after freeze-drying and redispersion of the nanocarriers, which was also confirmed by confocal laser scanning microscopy. Nanocarriers particle size did not change after adjusting the pH from 3 to 4, but strongly increased after adjusting it to 5, 6 or 7. The % BFA at pH 4 was similar to that at pH 3, but greatly decreased at pH 7. The bioavailability of FA for Lactobacillus rhamnosus was enhanced when the vitamin was incorporated in the form of digested nanocomplexes USF or TSF. The interaction of EW nanoparticles with FA has proven to be beneficial for the transport and release of FA after in vitro digestion.
Fil: Arzeni, Carolina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina
Fil: Pérez, Oscar E.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina
Fil: Leblanc, Jean Guy Joseph. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Pilosof, Ana Maria Renata. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Industrias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria; Argentina
description The ability of egg white (EW) nanoparticles to bind folic acid (FA) and protect it through the gastrointestinal tract and the resulting properties of the mixtures as functional ingredient was investigated. Two kinds of EW nanoparticles (USN and TSN) were mixed with FA to generate nanocarriers (USF and TSF). The particle size distribution of USN remained unaltered after the binding of FA, while a little increase in particle size was observed for TSN. Zeta (ζ) potential and fluorescence intensity did not show any significant change after FA addition for both nanoparticles. The percentage of bound folic acid (% BFA) was 78.0 ± 9.1 and 79.7 ± 9.0, for USF and TSF, respectively. A slight formation of aggregates in the samples was observed after freeze-drying and redispersion of the nanocarriers, which was also confirmed by confocal laser scanning microscopy. Nanocarriers particle size did not change after adjusting the pH from 3 to 4, but strongly increased after adjusting it to 5, 6 or 7. The % BFA at pH 4 was similar to that at pH 3, but greatly decreased at pH 7. The bioavailability of FA for Lactobacillus rhamnosus was enhanced when the vitamin was incorporated in the form of digested nanocomplexes USF or TSF. The interaction of EW nanoparticles with FA has proven to be beneficial for the transport and release of FA after in vitro digestion.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/113193
Arzeni, Carolina; Pérez, Oscar E.; Leblanc, Jean Guy Joseph; Pilosof, Ana Maria Renata; Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity; Elsevier; Journal of Functional Foods; 18; 10-2015; 379-386
1756-4646
CONICET Digital
CONICET
url http://hdl.handle.net/11336/113193
identifier_str_mv Arzeni, Carolina; Pérez, Oscar E.; Leblanc, Jean Guy Joseph; Pilosof, Ana Maria Renata; Egg albumin-folic acid nanocomplexes: Performance as a functional ingredient and biological activity; Elsevier; Journal of Functional Foods; 18; 10-2015; 379-386
1756-4646
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S175646461500376X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jff.2015.07.018
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.229304

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