Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells
- Autores
- Ayllón, Nieves; Villar, Margarita; Busby, Ann T.; Kocan, Katherine M.; Blouin, Edmour F.; Bonzón Kulichenko, Elena; Galindo, Ruth C.; Mangold, Atilio Jose; Alberdi, Pilar; José M. Pérez de la Lastra; Vázquez, Jesús; De la Fuente, José
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Anaplasma phagocytophilum causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects gene expression in both the vertebrate host and the tick vector, Ixodes scapularis. Here, we identified new genes, including spectrin alpha chain or alpha-fodrin (CG8) and voltage-dependent anion-selective channel or mitochondrial porin (T2), that are involved in A. phagocytophilum infection/multiplication and the tick cell response to infection. The pathogen downregulated the expression of CG8 in tick salivary glands and T2 in both the gut and salivary glands to inhibit apoptosis as a mechanism to subvert host cell defenses and increase infection. In the gut, the tick response to infection through CG8 upregulation was used by the pathogen to increase infection due to the cytoskeleton rearrangement that is required for pathogen infection. These results increase our understanding of the role of tick genes during A. phagocytophilum infection and multiplication and demonstrate that the pathogen uses similar strategies to establish infection in both vertebrate and invertebrate hosts.
Fil: Ayllón, Nieves. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Villar, Margarita. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Busby, Ann T.. Oklahoma State University; Estados Unidos
Fil: Kocan, Katherine M.. Oklahoma State University; Estados Unidos
Fil: Blouin, Edmour F.. Oklahoma State University; Estados Unidos
Fil: Bonzón Kulichenko, Elena. Centro de Biología Molecular Severo Ochoa; España
Fil: Galindo, Ruth C.. Instituto de Investigación en Recursos Cinegéticos; España. Oklahoma State University; Estados Unidos
Fil: Mangold, Atilio Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina
Fil: Alberdi, Pilar. Instituto de Investigación en Recursos Cinegéticos; España
Fil: José M. Pérez de la Lastra. Instituto de Investigación en Recursos Cinegéticos; España
Fil: Vázquez, Jesús. Centro de Biología Molecular Severo Ochoa; Estados Unidos
Fil: De la Fuente, José. Instituto de Investigación en Recursos Cinegéticos; España. Oklahoma State University; Estados Unidos - Materia
-
Anaplasma Phagocytophilum
Human Granulocytic Anaplasmosis
Equine Granulocytic Anaplasmosis
Ixodes Scapularis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/26072
Ver los metadatos del registro completo
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Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick CellsAyllón, NievesVillar, MargaritaBusby, Ann T.Kocan, Katherine M.Blouin, Edmour F.Bonzón Kulichenko, ElenaGalindo, Ruth C.Mangold, Atilio JoseAlberdi, PilarJosé M. Pérez de la LastraVázquez, JesúsDe la Fuente, JoséAnaplasma PhagocytophilumHuman Granulocytic AnaplasmosisEquine Granulocytic AnaplasmosisIxodes ScapularisAnaplasma phagocytophilum causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects gene expression in both the vertebrate host and the tick vector, Ixodes scapularis. Here, we identified new genes, including spectrin alpha chain or alpha-fodrin (CG8) and voltage-dependent anion-selective channel or mitochondrial porin (T2), that are involved in A. phagocytophilum infection/multiplication and the tick cell response to infection. The pathogen downregulated the expression of CG8 in tick salivary glands and T2 in both the gut and salivary glands to inhibit apoptosis as a mechanism to subvert host cell defenses and increase infection. In the gut, the tick response to infection through CG8 upregulation was used by the pathogen to increase infection due to the cytoskeleton rearrangement that is required for pathogen infection. These results increase our understanding of the role of tick genes during A. phagocytophilum infection and multiplication and demonstrate that the pathogen uses similar strategies to establish infection in both vertebrate and invertebrate hosts.Fil: Ayllón, Nieves. Instituto de Investigación en Recursos Cinegéticos; EspañaFil: Villar, Margarita. Instituto de Investigación en Recursos Cinegéticos; EspañaFil: Busby, Ann T.. Oklahoma State University; Estados UnidosFil: Kocan, Katherine M.. Oklahoma State University; Estados UnidosFil: Blouin, Edmour F.. Oklahoma State University; Estados UnidosFil: Bonzón Kulichenko, Elena. Centro de Biología Molecular Severo Ochoa; EspañaFil: Galindo, Ruth C.. Instituto de Investigación en Recursos Cinegéticos; España. Oklahoma State University; Estados UnidosFil: Mangold, Atilio Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; ArgentinaFil: Alberdi, Pilar. Instituto de Investigación en Recursos Cinegéticos; EspañaFil: José M. Pérez de la Lastra. Instituto de Investigación en Recursos Cinegéticos; EspañaFil: Vázquez, Jesús. Centro de Biología Molecular Severo Ochoa; Estados UnidosFil: De la Fuente, José. Instituto de Investigación en Recursos Cinegéticos; España. Oklahoma State University; Estados UnidosAmerican Society for Microbiology2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26072Ayllón, Nieves; Villar, Margarita; Busby, Ann T.; Kocan, Katherine M.; Blouin, Edmour F.; et al.; Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells; American Society for Microbiology; Infection and Immunity; 81; 7; 7-2013; 24150019-9567CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/IAI.00194-13info:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/81/7/2415info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:51Zoai:ri.conicet.gov.ar:11336/26072instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:51.723CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells |
title |
Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells |
spellingShingle |
Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells Ayllón, Nieves Anaplasma Phagocytophilum Human Granulocytic Anaplasmosis Equine Granulocytic Anaplasmosis Ixodes Scapularis |
title_short |
Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells |
title_full |
Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells |
title_fullStr |
Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells |
title_full_unstemmed |
Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells |
title_sort |
Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells |
dc.creator.none.fl_str_mv |
Ayllón, Nieves Villar, Margarita Busby, Ann T. Kocan, Katherine M. Blouin, Edmour F. Bonzón Kulichenko, Elena Galindo, Ruth C. Mangold, Atilio Jose Alberdi, Pilar José M. Pérez de la Lastra Vázquez, Jesús De la Fuente, José |
author |
Ayllón, Nieves |
author_facet |
Ayllón, Nieves Villar, Margarita Busby, Ann T. Kocan, Katherine M. Blouin, Edmour F. Bonzón Kulichenko, Elena Galindo, Ruth C. Mangold, Atilio Jose Alberdi, Pilar José M. Pérez de la Lastra Vázquez, Jesús De la Fuente, José |
author_role |
author |
author2 |
Villar, Margarita Busby, Ann T. Kocan, Katherine M. Blouin, Edmour F. Bonzón Kulichenko, Elena Galindo, Ruth C. Mangold, Atilio Jose Alberdi, Pilar José M. Pérez de la Lastra Vázquez, Jesús De la Fuente, José |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Anaplasma Phagocytophilum Human Granulocytic Anaplasmosis Equine Granulocytic Anaplasmosis Ixodes Scapularis |
topic |
Anaplasma Phagocytophilum Human Granulocytic Anaplasmosis Equine Granulocytic Anaplasmosis Ixodes Scapularis |
dc.description.none.fl_txt_mv |
Anaplasma phagocytophilum causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects gene expression in both the vertebrate host and the tick vector, Ixodes scapularis. Here, we identified new genes, including spectrin alpha chain or alpha-fodrin (CG8) and voltage-dependent anion-selective channel or mitochondrial porin (T2), that are involved in A. phagocytophilum infection/multiplication and the tick cell response to infection. The pathogen downregulated the expression of CG8 in tick salivary glands and T2 in both the gut and salivary glands to inhibit apoptosis as a mechanism to subvert host cell defenses and increase infection. In the gut, the tick response to infection through CG8 upregulation was used by the pathogen to increase infection due to the cytoskeleton rearrangement that is required for pathogen infection. These results increase our understanding of the role of tick genes during A. phagocytophilum infection and multiplication and demonstrate that the pathogen uses similar strategies to establish infection in both vertebrate and invertebrate hosts. Fil: Ayllón, Nieves. Instituto de Investigación en Recursos Cinegéticos; España Fil: Villar, Margarita. Instituto de Investigación en Recursos Cinegéticos; España Fil: Busby, Ann T.. Oklahoma State University; Estados Unidos Fil: Kocan, Katherine M.. Oklahoma State University; Estados Unidos Fil: Blouin, Edmour F.. Oklahoma State University; Estados Unidos Fil: Bonzón Kulichenko, Elena. Centro de Biología Molecular Severo Ochoa; España Fil: Galindo, Ruth C.. Instituto de Investigación en Recursos Cinegéticos; España. Oklahoma State University; Estados Unidos Fil: Mangold, Atilio Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Santa Fe. Estación Experimental Agropecuaria Rafaela; Argentina Fil: Alberdi, Pilar. Instituto de Investigación en Recursos Cinegéticos; España Fil: José M. Pérez de la Lastra. Instituto de Investigación en Recursos Cinegéticos; España Fil: Vázquez, Jesús. Centro de Biología Molecular Severo Ochoa; Estados Unidos Fil: De la Fuente, José. Instituto de Investigación en Recursos Cinegéticos; España. Oklahoma State University; Estados Unidos |
description |
Anaplasma phagocytophilum causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects gene expression in both the vertebrate host and the tick vector, Ixodes scapularis. Here, we identified new genes, including spectrin alpha chain or alpha-fodrin (CG8) and voltage-dependent anion-selective channel or mitochondrial porin (T2), that are involved in A. phagocytophilum infection/multiplication and the tick cell response to infection. The pathogen downregulated the expression of CG8 in tick salivary glands and T2 in both the gut and salivary glands to inhibit apoptosis as a mechanism to subvert host cell defenses and increase infection. In the gut, the tick response to infection through CG8 upregulation was used by the pathogen to increase infection due to the cytoskeleton rearrangement that is required for pathogen infection. These results increase our understanding of the role of tick genes during A. phagocytophilum infection and multiplication and demonstrate that the pathogen uses similar strategies to establish infection in both vertebrate and invertebrate hosts. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/26072 Ayllón, Nieves; Villar, Margarita; Busby, Ann T.; Kocan, Katherine M.; Blouin, Edmour F.; et al.; Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells; American Society for Microbiology; Infection and Immunity; 81; 7; 7-2013; 2415 0019-9567 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/26072 |
identifier_str_mv |
Ayllón, Nieves; Villar, Margarita; Busby, Ann T.; Kocan, Katherine M.; Blouin, Edmour F.; et al.; Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells; American Society for Microbiology; Infection and Immunity; 81; 7; 7-2013; 2415 0019-9567 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1128/IAI.00194-13 info:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/81/7/2415 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613981701931008 |
score |
13.070432 |