Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological Contexts

Autores
Pérez, Agustina Ericlee; Guillemi, Eliana Carolina; Sarmiento, Nestor Fabian; Canton, German Jose; Farber, Marisa Diana
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bovine anaplasmosis is a disease caused by Anaplasma marginale, a tick-borne bacterial pathogen with global distribution, primarily determined by the range of its vector. In Argentina, Rhipicephalus microplus is the main species associated with A. marginale transmission, even though this bacterium can also be mechanically transmitted. We studied complex infections (more than one A. marginale variant) in naturally infected bovines from two different epidemiological contexts: a region with the tick vector and a tick-free region. In the tick-free area, symptomatic infections were associated with a single A. marginale genotype, while asymptomatic bovines from the same herd remained chronically infected with a low number of genotype variants. By contrast, in the region where R. microplus is present, the only symptomatic bovine showed highly diverse infections, with 19 distinctive genotypes. Additionally, A. marginale genotypes were also detected in tick tissues. These findings, together with previous data, indicate that R. microplus harbors A. marginale populations that are maintained through tick generations by means of transovarial transmission. Furthermore, this tick species is responsible for maintaining A. marginale diversity in the bovine host over time through coinfection and superinfection events
EEA Balcarce
Fil: Pérez, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Guillemi, Eliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Sarmiento, Néstor. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Farber, Marisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fuente
Pathogens 14 (2) : 160 (February 2025)
Materia
Anaplasma marginale
Epidemiología
Garrapata
Infección
Anaplasmosis Bovina
Epidemiology
Ticks
Infection
Bovine Anaplasmosis
Rhipicephalus microplus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/21234
Acceder
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oai_identifier_str oai:localhost:20.500.12123/21234
network_acronym_str INTADig
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network_name_str INTA Digital (INTA)
spelling Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological ContextsPérez, Agustina EricleeGuillemi, Eliana CarolinaSarmiento, Nestor FabianCanton, German JoseFarber, Marisa DianaAnaplasma marginaleEpidemiologíaGarrapataInfecciónAnaplasmosis BovinaEpidemiologyTicksInfectionBovine AnaplasmosisRhipicephalus microplusBovine anaplasmosis is a disease caused by Anaplasma marginale, a tick-borne bacterial pathogen with global distribution, primarily determined by the range of its vector. In Argentina, Rhipicephalus microplus is the main species associated with A. marginale transmission, even though this bacterium can also be mechanically transmitted. We studied complex infections (more than one A. marginale variant) in naturally infected bovines from two different epidemiological contexts: a region with the tick vector and a tick-free region. In the tick-free area, symptomatic infections were associated with a single A. marginale genotype, while asymptomatic bovines from the same herd remained chronically infected with a low number of genotype variants. By contrast, in the region where R. microplus is present, the only symptomatic bovine showed highly diverse infections, with 19 distinctive genotypes. Additionally, A. marginale genotypes were also detected in tick tissues. These findings, together with previous data, indicate that R. microplus harbors A. marginale populations that are maintained through tick generations by means of transovarial transmission. Furthermore, this tick species is responsible for maintaining A. marginale diversity in the bovine host over time through coinfection and superinfection eventsEEA BalcarceFil: Pérez, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Guillemi, Eliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaFil: Sarmiento, Néstor. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; ArgentinaFil: Farber, Marisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; ArgentinaMDPI2025-02-13T09:52:13Z2025-02-13T09:52:13Z2025-02-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/21234https://www.mdpi.com/2076-0817/14/2/16020760817 (online)https://doi.org/10.3390/pathogens14020160Pathogens 14 (2) : 160 (February 2025)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2023-PD-L01-I089, Microbiomas en ecosistemas agropecuarios: la conexión integradora del enfoque Una Saludinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:50:54Zoai:localhost:20.500.12123/21234instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:50:55.221INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological Contexts
title Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological Contexts
spellingShingle Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological Contexts
Pérez, Agustina Ericlee
Anaplasma marginale
Epidemiología
Garrapata
Infección
Anaplasmosis Bovina
Epidemiology
Ticks
Infection
Bovine Anaplasmosis
Rhipicephalus microplus
title_short Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological Contexts
title_full Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological Contexts
title_fullStr Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological Contexts
title_full_unstemmed Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological Contexts
title_sort Rhipicephalus microplus and Its Impact on Anaplasma marginale Multistrain Infections in Contrasting Epidemiological Contexts
dc.creator.none.fl_str_mv Pérez, Agustina Ericlee
Guillemi, Eliana Carolina
Sarmiento, Nestor Fabian
Canton, German Jose
Farber, Marisa Diana
author Pérez, Agustina Ericlee
author_facet Pérez, Agustina Ericlee
Guillemi, Eliana Carolina
Sarmiento, Nestor Fabian
Canton, German Jose
Farber, Marisa Diana
author_role author
author2 Guillemi, Eliana Carolina
Sarmiento, Nestor Fabian
Canton, German Jose
Farber, Marisa Diana
author2_role author
author
author
author
dc.subject.none.fl_str_mv Anaplasma marginale
Epidemiología
Garrapata
Infección
Anaplasmosis Bovina
Epidemiology
Ticks
Infection
Bovine Anaplasmosis
Rhipicephalus microplus
topic Anaplasma marginale
Epidemiología
Garrapata
Infección
Anaplasmosis Bovina
Epidemiology
Ticks
Infection
Bovine Anaplasmosis
Rhipicephalus microplus
dc.description.none.fl_txt_mv Bovine anaplasmosis is a disease caused by Anaplasma marginale, a tick-borne bacterial pathogen with global distribution, primarily determined by the range of its vector. In Argentina, Rhipicephalus microplus is the main species associated with A. marginale transmission, even though this bacterium can also be mechanically transmitted. We studied complex infections (more than one A. marginale variant) in naturally infected bovines from two different epidemiological contexts: a region with the tick vector and a tick-free region. In the tick-free area, symptomatic infections were associated with a single A. marginale genotype, while asymptomatic bovines from the same herd remained chronically infected with a low number of genotype variants. By contrast, in the region where R. microplus is present, the only symptomatic bovine showed highly diverse infections, with 19 distinctive genotypes. Additionally, A. marginale genotypes were also detected in tick tissues. These findings, together with previous data, indicate that R. microplus harbors A. marginale populations that are maintained through tick generations by means of transovarial transmission. Furthermore, this tick species is responsible for maintaining A. marginale diversity in the bovine host over time through coinfection and superinfection events
EEA Balcarce
Fil: Pérez, Agustina. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Guillemi, Eliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; Argentina
Fil: Sarmiento, Néstor. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; Argentina
Fil: Cantón, Germán José. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Farber, Marisa. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Agrobiotecnología y Biología Molecular; Argentina
description Bovine anaplasmosis is a disease caused by Anaplasma marginale, a tick-borne bacterial pathogen with global distribution, primarily determined by the range of its vector. In Argentina, Rhipicephalus microplus is the main species associated with A. marginale transmission, even though this bacterium can also be mechanically transmitted. We studied complex infections (more than one A. marginale variant) in naturally infected bovines from two different epidemiological contexts: a region with the tick vector and a tick-free region. In the tick-free area, symptomatic infections were associated with a single A. marginale genotype, while asymptomatic bovines from the same herd remained chronically infected with a low number of genotype variants. By contrast, in the region where R. microplus is present, the only symptomatic bovine showed highly diverse infections, with 19 distinctive genotypes. Additionally, A. marginale genotypes were also detected in tick tissues. These findings, together with previous data, indicate that R. microplus harbors A. marginale populations that are maintained through tick generations by means of transovarial transmission. Furthermore, this tick species is responsible for maintaining A. marginale diversity in the bovine host over time through coinfection and superinfection events
publishDate 2025
dc.date.none.fl_str_mv 2025-02-13T09:52:13Z
2025-02-13T09:52:13Z
2025-02-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/21234
https://www.mdpi.com/2076-0817/14/2/160
20760817 (online)
https://doi.org/10.3390/pathogens14020160
url http://hdl.handle.net/20.500.12123/21234
https://www.mdpi.com/2076-0817/14/2/160
https://doi.org/10.3390/pathogens14020160
identifier_str_mv 20760817 (online)
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2023-PD-L01-I089, Microbiomas en ecosistemas agropecuarios: la conexión integradora del enfoque Una Salud
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Pathogens 14 (2) : 160 (February 2025)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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