Geographic clusters of congenital anomalies in Argentina

Autores
Groisman, Boris; Gili, Juan Antonio; Gimenez, Lucas Gabriel; Poletta, Fernando Adrián; Bidondo, Maria Paz; Barbero, Pablo; Liascovich, Rosa; López Camelo, Jorge Santiago
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Geographical clusters are defined as the occurrence of an unusual number of cases higher than expected in a given geographical area in a certain period of time. The aim of this study was to identify potential geographical clusters of specific selected congenital anomalies (CA) in Argentina. The cases were ascertained from 703,325 births, examined in 133 maternity hospitals in the 24 provinces of Argentina. We used the spatial scan statistic to determine areas of Argentina which had statistically significant elevations of prevalence. Prenatal diagnosis followed by referral of high-risk pregnancies to high complexity hospitals in a hospital-based surveillance system can create artifactual clusters. We assessed the referral bias by evaluating the prevalence heterogeneity within each cluster. Eight clusters of selected CAs with unusually high birth prevalence were identified: anencephaly, encephalocele, spina bifida, diaphragmatic hernia, talipes equinovarus, omphalocele, Cleft lip with or without cleft palate (CL/P), and Down syndrome. The clusters of Down syndrome and CL/P observed in this study match the previously reported clusters. These findings support local targeted interventions to lower the prevalence of the CAs and/or further research on the cause of each cluster. The clusters of spina bifida, anencephaly, encephalocele, omphalocele, congenital diaphragmatic hernia, and talipes equinovarus may be influenced by prenatal diagnosis and referral to high complexity hospitals.
Fil: Groisman, Boris. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gili, Juan Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Gimenez, Lucas Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina. Instituto Nacional de Genética Médica Populacional; Brasil
Fil: Bidondo, Maria Paz. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Barbero, Pablo. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina
Fil: Liascovich, Rosa. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: López Camelo, Jorge Santiago. Instituto Nacional de Genética Médica Populacional; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Materia
BIRTH PREVALENCE;
CONGENITAL ANOMALIES;
GEOGRAPHIC CLUSTERS;
NATIONAL NETWORK OF CONGENITAL ANOMALIES OF ARGENTINA (RENAC)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/45138
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Geographic clusters of congenital anomalies in ArgentinaGroisman, BorisGili, Juan AntonioGimenez, Lucas GabrielPoletta, Fernando AdriánBidondo, Maria PazBarbero, PabloLiascovich, RosaLópez Camelo, Jorge SantiagoBIRTH PREVALENCE;CONGENITAL ANOMALIES;GEOGRAPHIC CLUSTERS;NATIONAL NETWORK OF CONGENITAL ANOMALIES OF ARGENTINA (RENAC)https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Geographical clusters are defined as the occurrence of an unusual number of cases higher than expected in a given geographical area in a certain period of time. The aim of this study was to identify potential geographical clusters of specific selected congenital anomalies (CA) in Argentina. The cases were ascertained from 703,325 births, examined in 133 maternity hospitals in the 24 provinces of Argentina. We used the spatial scan statistic to determine areas of Argentina which had statistically significant elevations of prevalence. Prenatal diagnosis followed by referral of high-risk pregnancies to high complexity hospitals in a hospital-based surveillance system can create artifactual clusters. We assessed the referral bias by evaluating the prevalence heterogeneity within each cluster. Eight clusters of selected CAs with unusually high birth prevalence were identified: anencephaly, encephalocele, spina bifida, diaphragmatic hernia, talipes equinovarus, omphalocele, Cleft lip with or without cleft palate (CL/P), and Down syndrome. The clusters of Down syndrome and CL/P observed in this study match the previously reported clusters. These findings support local targeted interventions to lower the prevalence of the CAs and/or further research on the cause of each cluster. The clusters of spina bifida, anencephaly, encephalocele, omphalocele, congenital diaphragmatic hernia, and talipes equinovarus may be influenced by prenatal diagnosis and referral to high complexity hospitals.Fil: Groisman, Boris. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gili, Juan Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; ArgentinaFil: Gimenez, Lucas Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; ArgentinaFil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina. Instituto Nacional de Genética Médica Populacional; BrasilFil: Bidondo, Maria Paz. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Barbero, Pablo. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; ArgentinaFil: Liascovich, Rosa. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: López Camelo, Jorge Santiago. Instituto Nacional de Genética Médica Populacional; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; ArgentinaSpringer2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/45138Groisman, Boris; Gili, Juan Antonio; Gimenez, Lucas Gabriel; Poletta, Fernando Adrián; Bidondo, Maria Paz; et al.; Geographic clusters of congenital anomalies in Argentina; Springer; Community Genetics; 8; 1; 8-2016; 1-71422-2795CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s12687-016-0276-2info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12687-016-0276-2info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:48Zoai:ri.conicet.gov.ar:11336/45138instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:48.324CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Geographic clusters of congenital anomalies in Argentina
title Geographic clusters of congenital anomalies in Argentina
spellingShingle Geographic clusters of congenital anomalies in Argentina
Groisman, Boris
BIRTH PREVALENCE;
CONGENITAL ANOMALIES;
GEOGRAPHIC CLUSTERS;
NATIONAL NETWORK OF CONGENITAL ANOMALIES OF ARGENTINA (RENAC)
title_short Geographic clusters of congenital anomalies in Argentina
title_full Geographic clusters of congenital anomalies in Argentina
title_fullStr Geographic clusters of congenital anomalies in Argentina
title_full_unstemmed Geographic clusters of congenital anomalies in Argentina
title_sort Geographic clusters of congenital anomalies in Argentina
dc.creator.none.fl_str_mv Groisman, Boris
Gili, Juan Antonio
Gimenez, Lucas Gabriel
Poletta, Fernando Adrián
Bidondo, Maria Paz
Barbero, Pablo
Liascovich, Rosa
López Camelo, Jorge Santiago
author Groisman, Boris
author_facet Groisman, Boris
Gili, Juan Antonio
Gimenez, Lucas Gabriel
Poletta, Fernando Adrián
Bidondo, Maria Paz
Barbero, Pablo
Liascovich, Rosa
López Camelo, Jorge Santiago
author_role author
author2 Gili, Juan Antonio
Gimenez, Lucas Gabriel
Poletta, Fernando Adrián
Bidondo, Maria Paz
Barbero, Pablo
Liascovich, Rosa
López Camelo, Jorge Santiago
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BIRTH PREVALENCE;
CONGENITAL ANOMALIES;
GEOGRAPHIC CLUSTERS;
NATIONAL NETWORK OF CONGENITAL ANOMALIES OF ARGENTINA (RENAC)
topic BIRTH PREVALENCE;
CONGENITAL ANOMALIES;
GEOGRAPHIC CLUSTERS;
NATIONAL NETWORK OF CONGENITAL ANOMALIES OF ARGENTINA (RENAC)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Geographical clusters are defined as the occurrence of an unusual number of cases higher than expected in a given geographical area in a certain period of time. The aim of this study was to identify potential geographical clusters of specific selected congenital anomalies (CA) in Argentina. The cases were ascertained from 703,325 births, examined in 133 maternity hospitals in the 24 provinces of Argentina. We used the spatial scan statistic to determine areas of Argentina which had statistically significant elevations of prevalence. Prenatal diagnosis followed by referral of high-risk pregnancies to high complexity hospitals in a hospital-based surveillance system can create artifactual clusters. We assessed the referral bias by evaluating the prevalence heterogeneity within each cluster. Eight clusters of selected CAs with unusually high birth prevalence were identified: anencephaly, encephalocele, spina bifida, diaphragmatic hernia, talipes equinovarus, omphalocele, Cleft lip with or without cleft palate (CL/P), and Down syndrome. The clusters of Down syndrome and CL/P observed in this study match the previously reported clusters. These findings support local targeted interventions to lower the prevalence of the CAs and/or further research on the cause of each cluster. The clusters of spina bifida, anencephaly, encephalocele, omphalocele, congenital diaphragmatic hernia, and talipes equinovarus may be influenced by prenatal diagnosis and referral to high complexity hospitals.
Fil: Groisman, Boris. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gili, Juan Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Gimenez, Lucas Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina. Instituto Nacional de Genética Médica Populacional; Brasil
Fil: Bidondo, Maria Paz. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Barbero, Pablo. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina
Fil: Liascovich, Rosa. Ministerio de Salud de la Nación. Centro Nacional de Genética Médica. Registro Nacional de Anomalías Congénitas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: López Camelo, Jorge Santiago. Instituto Nacional de Genética Médica Populacional; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
description Geographical clusters are defined as the occurrence of an unusual number of cases higher than expected in a given geographical area in a certain period of time. The aim of this study was to identify potential geographical clusters of specific selected congenital anomalies (CA) in Argentina. The cases were ascertained from 703,325 births, examined in 133 maternity hospitals in the 24 provinces of Argentina. We used the spatial scan statistic to determine areas of Argentina which had statistically significant elevations of prevalence. Prenatal diagnosis followed by referral of high-risk pregnancies to high complexity hospitals in a hospital-based surveillance system can create artifactual clusters. We assessed the referral bias by evaluating the prevalence heterogeneity within each cluster. Eight clusters of selected CAs with unusually high birth prevalence were identified: anencephaly, encephalocele, spina bifida, diaphragmatic hernia, talipes equinovarus, omphalocele, Cleft lip with or without cleft palate (CL/P), and Down syndrome. The clusters of Down syndrome and CL/P observed in this study match the previously reported clusters. These findings support local targeted interventions to lower the prevalence of the CAs and/or further research on the cause of each cluster. The clusters of spina bifida, anencephaly, encephalocele, omphalocele, congenital diaphragmatic hernia, and talipes equinovarus may be influenced by prenatal diagnosis and referral to high complexity hospitals.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/45138
Groisman, Boris; Gili, Juan Antonio; Gimenez, Lucas Gabriel; Poletta, Fernando Adrián; Bidondo, Maria Paz; et al.; Geographic clusters of congenital anomalies in Argentina; Springer; Community Genetics; 8; 1; 8-2016; 1-7
1422-2795
CONICET Digital
CONICET
url http://hdl.handle.net/11336/45138
identifier_str_mv Groisman, Boris; Gili, Juan Antonio; Gimenez, Lucas Gabriel; Poletta, Fernando Adrián; Bidondo, Maria Paz; et al.; Geographic clusters of congenital anomalies in Argentina; Springer; Community Genetics; 8; 1; 8-2016; 1-7
1422-2795
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s12687-016-0276-2
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12687-016-0276-2
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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