Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina

Autores
Astudillo, Analizia; Groisman, Boris; Barbero, Pablo; Bidondo, María Paz; Liascovich, Rosa; Aiello, Horacio Antonio; Trotta, Marianela; Brun, Paloma Laura
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Patiens with major congenital anomalies diagnosed prenatally should be referred to and delivered in institutions with the appropriate level of complexity, as this reduces morbidity and mortality. We aimed to assess the prevalence and prenatal diagnosis proportion of selected congenital abnormalities and the complexity levels of birth institutions in a sample of public maternity hospitals in Argentina. Data sources were (1) National Congenital Anomalies Registry, covering the period from 2013 to 2021; and (2) Categorization of birth institutions according to their complexity (high or low). Newborns with the following anomalies were selected for analysis: spina bifida, hydrocephalus, critical congenital heart defects, diaphragmatic hernia, gastroschisis, and omphalocele. Prevalences at birth and prenatal diagnosis proportions were calculated according to the birth institution complexity level. A total of 2.214.102 births across 131 institutions were evaluated, with 1.202.311 births in high-complexity institutions and 1.011.791 in low-complexity institutions. The prevalences per 10.000 births and the prenatal diagnosis proportions for the entire sample were: spina bifida 5,40(95%CI 5,10 − 5,71) 68,54%; hydrocephalus 6,96(95% CI 6,62 − 7,32) 78,92%; critical congenital heart defects 11,05(95% CI 10,62 − 11,49) 43,21%; diaphragmatic hernia 3,88(95%CI 3,62 − 4,14) 68,65%; gastroschisis 7,85(95%CI 7,48 − 8,22) 79,27%; omphalocele 2,01(95%CI 1,83 − 2,20) 76,18%. Prevalences and prenatal diagnosis porportions were significantly higher in high-complexity institutions. Prenatal diagnosis and perinatal care networks must be improved to ensure that patients with major congenital anomalies are delivered in high-complexity birth institutions. The prevalence and prenatal diagnosis porportion, stratified by the complexity level of institutions, can serve as management indicators to evaluate improvements in care quality.
Fil: Astudillo, Analizia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Groisman, Boris. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barbero, Pablo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Bidondo, María Paz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Liascovich, Rosa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aiello, Horacio Antonio. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Trotta, Marianela. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Brun, Paloma Laura. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Materia
congenital
anomalies
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/262864
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prenatal diagnosis of congenital anomalies and birth institution complexity levels in ArgentinaAstudillo, AnaliziaGroisman, BorisBarbero, PabloBidondo, María PazLiascovich, RosaAiello, Horacio AntonioTrotta, MarianelaBrun, Paloma Lauracongenitalanomalieshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Patiens with major congenital anomalies diagnosed prenatally should be referred to and delivered in institutions with the appropriate level of complexity, as this reduces morbidity and mortality. We aimed to assess the prevalence and prenatal diagnosis proportion of selected congenital abnormalities and the complexity levels of birth institutions in a sample of public maternity hospitals in Argentina. Data sources were (1) National Congenital Anomalies Registry, covering the period from 2013 to 2021; and (2) Categorization of birth institutions according to their complexity (high or low). Newborns with the following anomalies were selected for analysis: spina bifida, hydrocephalus, critical congenital heart defects, diaphragmatic hernia, gastroschisis, and omphalocele. Prevalences at birth and prenatal diagnosis proportions were calculated according to the birth institution complexity level. A total of 2.214.102 births across 131 institutions were evaluated, with 1.202.311 births in high-complexity institutions and 1.011.791 in low-complexity institutions. The prevalences per 10.000 births and the prenatal diagnosis proportions for the entire sample were: spina bifida 5,40(95%CI 5,10 − 5,71) 68,54%; hydrocephalus 6,96(95% CI 6,62 − 7,32) 78,92%; critical congenital heart defects 11,05(95% CI 10,62 − 11,49) 43,21%; diaphragmatic hernia 3,88(95%CI 3,62 − 4,14) 68,65%; gastroschisis 7,85(95%CI 7,48 − 8,22) 79,27%; omphalocele 2,01(95%CI 1,83 − 2,20) 76,18%. Prevalences and prenatal diagnosis porportions were significantly higher in high-complexity institutions. Prenatal diagnosis and perinatal care networks must be improved to ensure that patients with major congenital anomalies are delivered in high-complexity birth institutions. The prevalence and prenatal diagnosis porportion, stratified by the complexity level of institutions, can serve as management indicators to evaluate improvements in care quality.Fil: Astudillo, Analizia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Groisman, Boris. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barbero, Pablo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Bidondo, María Paz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Liascovich, Rosa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aiello, Horacio Antonio. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Trotta, Marianela. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaFil: Brun, Paloma Laura. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; ArgentinaSpringer Nature2025-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/262864Astudillo, Analizia; Groisman, Boris; Barbero, Pablo; Bidondo, María Paz; Liascovich, Rosa; et al.; Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina; Springer Nature; Journal of Community Genetics; 16; 2; 1-2025; 161-1661868-6001CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s12687-024-00766-zinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s12687-024-00766-zinfo:eu-repo/semantics/altIdentifier/url/https://pmc.ncbi.nlm.nih.gov/articles/PMC11979027/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:10Zoai:ri.conicet.gov.ar:11336/262864instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:10.298CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina
title Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina
spellingShingle Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina
Astudillo, Analizia
congenital
anomalies
title_short Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina
title_full Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina
title_fullStr Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina
title_full_unstemmed Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina
title_sort Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina
dc.creator.none.fl_str_mv Astudillo, Analizia
Groisman, Boris
Barbero, Pablo
Bidondo, María Paz
Liascovich, Rosa
Aiello, Horacio Antonio
Trotta, Marianela
Brun, Paloma Laura
author Astudillo, Analizia
author_facet Astudillo, Analizia
Groisman, Boris
Barbero, Pablo
Bidondo, María Paz
Liascovich, Rosa
Aiello, Horacio Antonio
Trotta, Marianela
Brun, Paloma Laura
author_role author
author2 Groisman, Boris
Barbero, Pablo
Bidondo, María Paz
Liascovich, Rosa
Aiello, Horacio Antonio
Trotta, Marianela
Brun, Paloma Laura
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv congenital
anomalies
topic congenital
anomalies
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Patiens with major congenital anomalies diagnosed prenatally should be referred to and delivered in institutions with the appropriate level of complexity, as this reduces morbidity and mortality. We aimed to assess the prevalence and prenatal diagnosis proportion of selected congenital abnormalities and the complexity levels of birth institutions in a sample of public maternity hospitals in Argentina. Data sources were (1) National Congenital Anomalies Registry, covering the period from 2013 to 2021; and (2) Categorization of birth institutions according to their complexity (high or low). Newborns with the following anomalies were selected for analysis: spina bifida, hydrocephalus, critical congenital heart defects, diaphragmatic hernia, gastroschisis, and omphalocele. Prevalences at birth and prenatal diagnosis proportions were calculated according to the birth institution complexity level. A total of 2.214.102 births across 131 institutions were evaluated, with 1.202.311 births in high-complexity institutions and 1.011.791 in low-complexity institutions. The prevalences per 10.000 births and the prenatal diagnosis proportions for the entire sample were: spina bifida 5,40(95%CI 5,10 − 5,71) 68,54%; hydrocephalus 6,96(95% CI 6,62 − 7,32) 78,92%; critical congenital heart defects 11,05(95% CI 10,62 − 11,49) 43,21%; diaphragmatic hernia 3,88(95%CI 3,62 − 4,14) 68,65%; gastroschisis 7,85(95%CI 7,48 − 8,22) 79,27%; omphalocele 2,01(95%CI 1,83 − 2,20) 76,18%. Prevalences and prenatal diagnosis porportions were significantly higher in high-complexity institutions. Prenatal diagnosis and perinatal care networks must be improved to ensure that patients with major congenital anomalies are delivered in high-complexity birth institutions. The prevalence and prenatal diagnosis porportion, stratified by the complexity level of institutions, can serve as management indicators to evaluate improvements in care quality.
Fil: Astudillo, Analizia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Groisman, Boris. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barbero, Pablo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Bidondo, María Paz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Liascovich, Rosa. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aiello, Horacio Antonio. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Trotta, Marianela. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
Fil: Brun, Paloma Laura. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud "Dr. C. G. Malbrán"; Argentina
description Patiens with major congenital anomalies diagnosed prenatally should be referred to and delivered in institutions with the appropriate level of complexity, as this reduces morbidity and mortality. We aimed to assess the prevalence and prenatal diagnosis proportion of selected congenital abnormalities and the complexity levels of birth institutions in a sample of public maternity hospitals in Argentina. Data sources were (1) National Congenital Anomalies Registry, covering the period from 2013 to 2021; and (2) Categorization of birth institutions according to their complexity (high or low). Newborns with the following anomalies were selected for analysis: spina bifida, hydrocephalus, critical congenital heart defects, diaphragmatic hernia, gastroschisis, and omphalocele. Prevalences at birth and prenatal diagnosis proportions were calculated according to the birth institution complexity level. A total of 2.214.102 births across 131 institutions were evaluated, with 1.202.311 births in high-complexity institutions and 1.011.791 in low-complexity institutions. The prevalences per 10.000 births and the prenatal diagnosis proportions for the entire sample were: spina bifida 5,40(95%CI 5,10 − 5,71) 68,54%; hydrocephalus 6,96(95% CI 6,62 − 7,32) 78,92%; critical congenital heart defects 11,05(95% CI 10,62 − 11,49) 43,21%; diaphragmatic hernia 3,88(95%CI 3,62 − 4,14) 68,65%; gastroschisis 7,85(95%CI 7,48 − 8,22) 79,27%; omphalocele 2,01(95%CI 1,83 − 2,20) 76,18%. Prevalences and prenatal diagnosis porportions were significantly higher in high-complexity institutions. Prenatal diagnosis and perinatal care networks must be improved to ensure that patients with major congenital anomalies are delivered in high-complexity birth institutions. The prevalence and prenatal diagnosis porportion, stratified by the complexity level of institutions, can serve as management indicators to evaluate improvements in care quality.
publishDate 2025
dc.date.none.fl_str_mv 2025-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/262864
Astudillo, Analizia; Groisman, Boris; Barbero, Pablo; Bidondo, María Paz; Liascovich, Rosa; et al.; Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina; Springer Nature; Journal of Community Genetics; 16; 2; 1-2025; 161-166
1868-6001
CONICET Digital
CONICET
url http://hdl.handle.net/11336/262864
identifier_str_mv Astudillo, Analizia; Groisman, Boris; Barbero, Pablo; Bidondo, María Paz; Liascovich, Rosa; et al.; Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina; Springer Nature; Journal of Community Genetics; 16; 2; 1-2025; 161-166
1868-6001
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s12687-024-00766-z
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12687-024-00766-z
info:eu-repo/semantics/altIdentifier/url/https://pmc.ncbi.nlm.nih.gov/articles/PMC11979027/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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