Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments

Autores
Acevedo, María E.; Fernandez, Adriana; Pasquali, Ricardo C.; Sorichetti, Patricia A.; Serrao, Rosa; Bregni, Carlos; Mouriño, Viviana Silvia Lourdes
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Non-irritant, non-comedogenic and non-polar emollients were pre-selected for determinations of relative dielectric permittivity and solubility of benzoyl peroxide (BP). Those solvents capable of solubilizing BP in concentrations commonly utilised in topical formulations (between 1 and 10 %) were taken into account for stability studies. The developed pre-formulations were also studied for acute irritation both clinically and instrumentally. Even though the solubility of BP in the solvents studied had relatively low values; in some cases, such as with caprylic/capric triglyceride (CapCap) and dicaprylyl carbonate (DicCar) it has been possible to obtain acceptable concentrations of BP from a therapeutic viewpoint (19.9 and 19.5 mg/mL, respectively). Two BP pre-formulations (PBCapCap and PBDicCar) with enhanced stability and with the capability to decrease adverse application site reaction by maintaining moisture in the stratum corneum were developed with potential application in topical formulations of BP with solvents of low relative dielectric permittivity (CapCap and DicCar, respectively
Fil: Acevedo, María E.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Fernandez, Adriana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Pasquali, Ricardo C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Sorichetti, Patricia A.. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Fisica; Argentina
Fil: Serrao, Rosa. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Imperial College London; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Benzoyl Peroxide
Pre-Formulation
Solubility
Stability
Thermodynamic Activity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13324
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation DevelopmentsAcevedo, María E.Fernandez, AdrianaPasquali, Ricardo C.Sorichetti, Patricia A.Serrao, RosaBregni, CarlosMouriño, Viviana Silvia LourdesBenzoyl PeroxidePre-FormulationSolubilityStabilityThermodynamic Activityhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Non-irritant, non-comedogenic and non-polar emollients were pre-selected for determinations of relative dielectric permittivity and solubility of benzoyl peroxide (BP). Those solvents capable of solubilizing BP in concentrations commonly utilised in topical formulations (between 1 and 10 %) were taken into account for stability studies. The developed pre-formulations were also studied for acute irritation both clinically and instrumentally. Even though the solubility of BP in the solvents studied had relatively low values; in some cases, such as with caprylic/capric triglyceride (CapCap) and dicaprylyl carbonate (DicCar) it has been possible to obtain acceptable concentrations of BP from a therapeutic viewpoint (19.9 and 19.5 mg/mL, respectively). Two BP pre-formulations (PBCapCap and PBDicCar) with enhanced stability and with the capability to decrease adverse application site reaction by maintaining moisture in the stratum corneum were developed with potential application in topical formulations of BP with solvents of low relative dielectric permittivity (CapCap and DicCar, respectivelyFil: Acevedo, María E.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Fernandez, Adriana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Pasquali, Ricardo C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Sorichetti, Patricia A.. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Fisica; ArgentinaFil: Serrao, Rosa. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Imperial College London; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaColegio Farmaceuticos Provincia de Buenos Aires2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13324Acevedo, María E.; Fernandez, Adriana; Pasquali, Ricardo C.; Sorichetti, Patricia A.; Serrao, Rosa; et al.; Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments; Colegio Farmaceuticos Provincia de Buenos Aires; Latin American Journal of Pharmacy; 30; 9; 9-2011; 1737-17430326-2383enginfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=30&num=9info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:13Zoai:ri.conicet.gov.ar:11336/13324instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:13.43CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments
title Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments
spellingShingle Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments
Acevedo, María E.
Benzoyl Peroxide
Pre-Formulation
Solubility
Stability
Thermodynamic Activity
title_short Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments
title_full Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments
title_fullStr Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments
title_full_unstemmed Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments
title_sort Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments
dc.creator.none.fl_str_mv Acevedo, María E.
Fernandez, Adriana
Pasquali, Ricardo C.
Sorichetti, Patricia A.
Serrao, Rosa
Bregni, Carlos
Mouriño, Viviana Silvia Lourdes
author Acevedo, María E.
author_facet Acevedo, María E.
Fernandez, Adriana
Pasquali, Ricardo C.
Sorichetti, Patricia A.
Serrao, Rosa
Bregni, Carlos
Mouriño, Viviana Silvia Lourdes
author_role author
author2 Fernandez, Adriana
Pasquali, Ricardo C.
Sorichetti, Patricia A.
Serrao, Rosa
Bregni, Carlos
Mouriño, Viviana Silvia Lourdes
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Benzoyl Peroxide
Pre-Formulation
Solubility
Stability
Thermodynamic Activity
topic Benzoyl Peroxide
Pre-Formulation
Solubility
Stability
Thermodynamic Activity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Non-irritant, non-comedogenic and non-polar emollients were pre-selected for determinations of relative dielectric permittivity and solubility of benzoyl peroxide (BP). Those solvents capable of solubilizing BP in concentrations commonly utilised in topical formulations (between 1 and 10 %) were taken into account for stability studies. The developed pre-formulations were also studied for acute irritation both clinically and instrumentally. Even though the solubility of BP in the solvents studied had relatively low values; in some cases, such as with caprylic/capric triglyceride (CapCap) and dicaprylyl carbonate (DicCar) it has been possible to obtain acceptable concentrations of BP from a therapeutic viewpoint (19.9 and 19.5 mg/mL, respectively). Two BP pre-formulations (PBCapCap and PBDicCar) with enhanced stability and with the capability to decrease adverse application site reaction by maintaining moisture in the stratum corneum were developed with potential application in topical formulations of BP with solvents of low relative dielectric permittivity (CapCap and DicCar, respectively
Fil: Acevedo, María E.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Fernandez, Adriana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Pasquali, Ricardo C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Sorichetti, Patricia A.. Universidad de Buenos Aires. Facultad de Ingenieria. Departamento de Fisica; Argentina
Fil: Serrao, Rosa. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Bregni, Carlos. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Imperial College London; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Non-irritant, non-comedogenic and non-polar emollients were pre-selected for determinations of relative dielectric permittivity and solubility of benzoyl peroxide (BP). Those solvents capable of solubilizing BP in concentrations commonly utilised in topical formulations (between 1 and 10 %) were taken into account for stability studies. The developed pre-formulations were also studied for acute irritation both clinically and instrumentally. Even though the solubility of BP in the solvents studied had relatively low values; in some cases, such as with caprylic/capric triglyceride (CapCap) and dicaprylyl carbonate (DicCar) it has been possible to obtain acceptable concentrations of BP from a therapeutic viewpoint (19.9 and 19.5 mg/mL, respectively). Two BP pre-formulations (PBCapCap and PBDicCar) with enhanced stability and with the capability to decrease adverse application site reaction by maintaining moisture in the stratum corneum were developed with potential application in topical formulations of BP with solvents of low relative dielectric permittivity (CapCap and DicCar, respectively
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13324
Acevedo, María E.; Fernandez, Adriana; Pasquali, Ricardo C.; Sorichetti, Patricia A.; Serrao, Rosa; et al.; Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments; Colegio Farmaceuticos Provincia de Buenos Aires; Latin American Journal of Pharmacy; 30; 9; 9-2011; 1737-1743
0326-2383
url http://hdl.handle.net/11336/13324
identifier_str_mv Acevedo, María E.; Fernandez, Adriana; Pasquali, Ricardo C.; Sorichetti, Patricia A.; Serrao, Rosa; et al.; Solubility and Stability Studies of Benzoyl Peroxide in Non-Polar, Non-Comedogenic Solvents for Use in Topical Pharmaceutical Formulation Developments; Colegio Farmaceuticos Provincia de Buenos Aires; Latin American Journal of Pharmacy; 30; 9; 9-2011; 1737-1743
0326-2383
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/previous_issue.php?vol=30&num=9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Colegio Farmaceuticos Provincia de Buenos Aires
publisher.none.fl_str_mv Colegio Farmaceuticos Provincia de Buenos Aires
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613133795065856
score 13.070432

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